检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

格式规范中的安全操作指导

现代制造 2021年第12期 28-29页

作者： michaela Wassenberg 不详

为了使机器能够灵活地工作,在使用包装设备时,人们需要尽可能容易地适应各个设备的格式。电子定位显示有助于半自动机器的转换过程,如包装设备制造商的例子所示。

关键词：格式规范包装设备操作指导设备制造商转换过程半自动机器

维普期刊数据库

Pilot Study on the Intercalibration of a Categorisation System for FAIRer Digital Objects Related to Sensitive Data in the Life Sciences

在线全文

学校读者我要写书评

暂无评论

Data Intelligence 2022年第2期4卷 196-211页

作者： Christian Ohmann Romain David Mónica Cano Abadia Florence Bietrix Jan-Willem Boiten Steve Canham Maria Luisa Chiusano Walter Dastrù Arnaud Laroquette Dario Longo michaela Theresia Mayrhofer Maria Panagiotopoulou Audrey Richard Pablo Emilio Verde European Clinical Research Infrastructure Network (ECRIN) 2. European Research Infrastructure on Highly Pathogenic Agents (ERINHA AISBL) 3. Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) 4. European Infrastructure for Translational Medicine (EATRIS) 5. European Advanced Translational Research Infrastructure (EATRIS)/Lygature European Marine Biological Resource Centre (EMBRC)—Department of Agricultural Sciences University Federico II of Naples via Università Department of Molecular Biotechnology and Health Sciences Molecular Imaging Center University of Torino European Marine Biological Resource Centre (EMBRC) 9. European Research Infrastructure for Biological and Biomedical Imaging (Euro-Bio Imaging) Coordination Centre for Clinical Trials Heinrich Heine University Düsseldorf Ringgold standard institution

Sharing sensitive data is a specific challenge for research infrastructures in the field of life sciences. For that reason a toolbox has been developed, providing resources for researchers who wish to share and use sensitive data, to support the workflows for handling these kinds of digital objects. Common and community approved annotations are required to be compliant with FAIR principles(Findability, Accessibility,Interoperability, Reusability). The toolbox makes use of a tagging(categorisation) system, allowing consistent labelling and categorisation of digital objects, in terms relevant to data sharing tasks and activities. A pilot study was performed within the Horizon 2020 project EOSC-Life, in which 2 experts from 6 life sciences research infrastructures were recruited to independently assign tags to the same set of 10 to 25 resources related to sensitive data management and data sharing(in total 110). Summary statistics of agreement and observer variation per research infrastructure are provided. The pilot study has shown that experts were able to attribute tags but in most cases with a considerable observer variation between experts. In the context of CWFR(Canonical Workflow Frameworks for Research), this indicates the necessity for careful definition,evaluation and validation of parameters and processes related to workflow descriptions. The results from this pilot study were used to tackle this issue by revising the categorisation system and providing an updated version.

关键词： Categorisation system CWFR EOSC-Life FAIR Life sciences Sensitive data Tagging Toolbox

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

《少年周刊》美国版：怎样打动“守门人”？

国际品牌观察 2021年第16期 40-41页

作者： michaela Jefferson 岳璐

年度100美元的订阅费用,超过市面上大多数同类杂志,《少年周刊》美国版却在不到一年的时间内,将读者规模扩大了50%,其高管团队透露了关键秘诀:注重可持续发展的内容思维、少儿视角、全球智慧。

关键词：丹尼斯《少年周刊》守门人

PDO公司的勘探战略和动态管理：一种以资产组合为基础的方法

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国外石油动态 2002年第8期 1-13页

作者： michaela.Naylor 谢力

The WNT1^(G177C) mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2021年第4期9卷 593-605页

作者： Nele Vollersen Wenbo Zhao Tim Rolvien Fabiola Lange Felix Nikolai Schmidt Stephan Sonntag Doron Shmerling Simon von Kroge Kilian Elia Stockhausen Ahmed Sharaf michaela Schweizer Meliha Karsak Bjorn Busse Ernesto Bockamp Oliver Semler Michael Amling Ralf Oheim Thorsten Schinke Timur Alexander Yorgan Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany PolyGene AG 8153 RumlangSwitzerland ETH Phenomics Center(EPIC) ETH Zurich8092 ZurichSwitzerland Neuronal and Cellular Signal Transduction Center for Molecular Neurobiology Hamburg(ZMNH)University Medical Center Hamburg-Eppendorf20246 HamburgGermany Center for Molecular Neurobiology Hamburg(ZMNH) University Medical CenterHamburg-Eppendorf20246 HamburgGermany Institute for Translational Immunology and Research Center for Immunotherapy University Medical CenterJohannes Gutenberg UniversityD 55131 MainzGermany Faculty of Medicine and University Hospital Cologne Department of PediatricsUniversity of Cologne50937 CologneGermany

The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming *** such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be ***,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 *** Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal *** increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix ***,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin ***,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix *** together,our data demonstrate that regulating bone matrix quality is a primary function of *** further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies.

关键词： WNT1 skeletal impaired

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

广告,应以推动品牌长期增长为要义

国际品牌观察 2022年第21期 43-45页

作者： michaela Jefferson 骆佳

通过广告来拉近消费者与品牌的距离,建立亲近感,方能促进品牌获得长期业绩增长,这是System 1多年来的研究所揭示的结论,也是宝洁公司长期实践的结果,而创意作为推动品牌增长核心力量的地位再度被提及并被强化。

关键词：

Dreaming of clean nukes——Can the Pentagon defend its plans for new nuclear bombs？

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界环境 2005年第2期 13-14页

作者： michaela.Levi atthetheBrookinasInstitution 1775MassachusettsAveNWWashinqtonDC

Is the US nuclear arsenal sufficient to address today's security challenges? The Pentagon apparently thinks not. A new report from its Defense Science Board (DSB) argues that """"nuclear weapons are needed that produce much lower collateral damage'. It lends support to proposals to build new nuclear weapons for attacking underground facilities. To a point, such 'bunker busters' are nothing new-the B-53 bomb, first deployed in the early 1960s, can destroy underground targets, although it creates lethal radioactive fallout that covers hundreds of thousands of square kilometres.

关键词： clean Can the its for new

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

“危机”解除，数字广告引领乐观未来

国际品牌观察 2022年第4期 34-36页

作者： michaela Jefferson 骆佳

近几年以来，行业关于“投放广告的ROI越来越低”的言论不绝于耳，但新的数据显示，在过去的五年中，ROI一直在上升。计量经济学公司Magic Numbers的一份新报告显示，网络广告的发展是广告营销支出的投资回报率增长之背后驱动因素。在...

近几年以来，行业关于“投放广告的ROI越来越低”的言论不绝于耳，但新的数据显示，在过去的五年中，ROI一直在上升。计量经济学公司Magic Numbers的一份新报告显示，网络广告的发展是广告营销支出的投资回报率增长之背后驱动因素。在《神秘博士》《豪斯医生》或《24小时》这些周播剧集中，每一集都是一个小故事，但角色之间却串联起了整个情节。每周发生的事情形成了整体的起承转合：问题出现、结论推导和整个旅程。

关键词：

Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第44期15卷 5549-5557页

作者： Mary Ann Cox James Jackson michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh Department of Tumor Biology Schering-Plough Research Institute Kenilworth NJ 07033 United States Department of Cardiovascular and Metabolic Disease Research Schering-Plough Research Institute Kenilworth NJ 07033 United States Department of Discovery Technologies Schering-Plough Research Institute Kenilworth NJ 07033 United States Department of Discovery Technologies Schering- Plough Research Institute Kenilworth NJ 07033 United States Department of Inflammation Schering-Plough Research Institute Kenilworth NJ 07033 United States

AIM： To investigate the effect of short-chain fatty acids （SCFAs） on production of prostaglandin E2 （PGE2）, cytokines and chemokines in human monocytes. METHODS： Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrichment Cocktail, respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative realtime polymerase chain reaction, The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect of SCFAs on human monocytes and peripheral blood mononuclear cells （PBMC） was studied by measuring PGE2, cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws. RESULTS： Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils, but not in human monocytes. In this study, we show that SCFAs can induce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysaccharide （LPS）. In addition, we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin, suggesting the involvement of a receptor-mediated mechanism. Furthermore, SCFAs can specifically inhibit constitutive monocyte chemotactic protein-1 （MCP-1） production and LPS-induced interleukin-10 （IL-10） production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2, MCP-1 and IL-10 after 5CFA treatment. In addition, SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-7 in human PBIVlC. Finally, we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws （P 〈 0.01）. CONCLUSION： SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2, cytokine and chemokine release from human

关键词： Short-chain fatty acids GPR43 GPR41 Human monocytes Prostaglandin E2 Chemokines Cytokines