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Targeting PP2A for cancer therapeutic modulation

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Cancer Biology & Medicine 2022年第10期19卷 1428-1439页

作者： Halle Ronk Jared S.rosenblum Timothy Kung Zhengping Zhuang Neuro-Oncology Branch National Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA

Protein phosphatases play essential roles as negative regulators of kinases and signaling cascades involved in cytoskeletal *** phosphatase 2A(PP2A)is highly conserved and is the predominant serine/threonine phosphatase in the nervous system,constituting more than 70%of all neuronal ***2A is involved in diverse regulatory functions,including cell cycle progression,apoptosis,and DNA *** PP2A has historically been identified as a tumor suppressor,inhibition of PP2A has paradoxically demonstrated potential as a therapeutic target for various ***100,a water-soluble,small-molecule competitive inhibitor of PP2A,has shown particular promise as a chemo-and radio-sensitizing *** success has led to a profusion of clinical trials on LB100 adjuvant therapies,including a phase I trial in extensive-stage small-cell lung cancer,a phase I/II trial in myelodysplastic syndrome,a phase II trial in recurrent glioblastoma,and a completed phase I trial assessing the safety of LB100 and docetaxel in various relapsed solid ***,we review the development of LB100,the role of PP2A in cancer biology,and recent advances in targeting PP2A inhibition in immunotherapy.

关键词： Chemo-sensitization clinical trials colorectal cancer glioblastoma immunotherapy LB100 protein phosphatase 2A PP2A inhibition radio-sensitization small molecule inhibitor

Asymmetrical mate preference in recently adapted White Sands and black lava populations of Sceloporus undulatus

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Current Zoology 2013年第1期59卷 20-30页

作者： Kayla M. HARDWICK Jeanne M. ROBERTSON Erica Bree rosenblum Department of Biological Sciences University of Idaho Moscow ID 83844 USA Department of Biology California State University Northridge CA 91330 USA Department of Environmental Science Policy and Management University of California Berkeley CA 94720 USA

Speciation can proceed rapidly when natural and sexual selection act in concert. For example speciation can be ac- celerated when traits that confer a selective advantage in a particular habitat also influence mate preference. Studying parallel but evolutionarily independent instances of ecological divergence can illuminate the interaction between natural and sexual selection during speciation. Locally adapted populations of the eastern fence lizard Sceloporus undulatus have recently evolved in three different habitats in the Chihuahuan desert： blanched color morphs occur on the gypsum dunes of White Sands, melanic color morphs occur on the Carrizozo lava flow, and brown color morphs occur in the surrounding desert scrubland. In addition to dif- ferences in cryptic dorsal coloration, populations also differ in the size and color of ventral patches used for social signaling. This system therefore provides an opportunity to investigate the interplay of natural and sexual selection during rapid ecological speci- ation. We used mate preference experiments to determine whether locally adapted populations may exhibit the early stages of be- havioral reproductive isolation. We observed an asymmetrical mate preference in this system; White Sands males preferentially courted local females, while males from dark soils and black lava populations did not exhibit a preference for local mates. We also found that female behavior and ventral patch phenotype were associated with male courtship. Our results suggest that the observed preference for local mates evolved at White Sands, and we discuss the possible link between local adaptation and traits involved in mate preference in this system [Current Zoology 59 （1）： 20-30, 2013].

关键词： Eastem fence lizard Magic trait Ecological speciation Sexual signaling Courtship Mate preference asymmetry

The Impact of Inoculum-Substrate Ratios on Microbial Levels during Psychrophilic Anaerobic Digestion

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Journal of Environmental Science and Engineering(A) 2013年第10期2卷 625-636页

作者： James rosenblum Juan Castano Jiyoung Lee Jay Martin michael Bisesi Division of Environmental Health Sciences College of Public Health The Ohio State University Columbus Ohio 43210 USA Department of Food Agriculture and Biological Engineering The Ohio State University Columbus Ohio 43210 USA Universidad Tecnologica de Pereira ApartadoAereo 097 Pereira Colombia Department of Food Science and Technology the Ohio State University Columbus Ohio 43210 USA

The study evaluated impact of psychrophilic anaerobic digestion on levels of viable populations of fecal indicator bacteria using various inoculum-to-substrate ratios （I：S）. Laboratory-scale batch reactors were maintained at 10 ℃ and 20 ℃ for 25 days with dairy manure substrate. Five treatments included inoculum （control inoculum; inoculum only [CI]）, manure （control manure; substrate only [CM]）, and 3I：1S, II：IS, and 1I：3S. E. coli decreased in all treatments, while Enterococci decreased in only a few treatments. Treatment 1 I： 1S achieved highest E. coli decrease at 20 ℃ （3.11 log）; CM showed highest E. coli decrease at 10 ℃ （2.33 log）. The 1I：3 Streatment showed highest decrease of Enterococci at 20 ℃ （1.82 log）, whereas CM had highest, but less substantial, decrease at 10 ℃ （0.49 log）. These decreases may be the result of environmental conditions, namely substrate limitation for E. coli, and, increased VFA （volatile fatty acid） levels for Enterococci. Lower I：S showed higher levels of indicator organisms; less stable conditions with more acidic pH, higher VFAs, and lower biogas production. Results suggest II：IS is ideal for starting a digester at 20 ℃, whereas 3I：1S appears optimal for 10 ℃, Overall, I：S influenced chemical parameters and fecal indicators during batch psychrophilic anaerobic digestion of manure.

关键词： Biogas psychrophilic anaerobic digestion fecal indicators inoculum-to-substrate ratio.

Altered Fire Regimes and the Persistence of Quaking Aspen in the Rocky Mountains: A Literature Review

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Open Journal of Forestry 2015年第5期5卷 563-567页

作者： Aaron rosenblum Colorado State University Fort Collins USA

The persistence of quaking aspen (Populus tremuloides Michx.) is of significant importance to land managers in the Rocky Mountain region. Fire suppression in the past century has been implicated as a mechanism influencing aspen population dynamics, as aspen are generally considered an early seral disturbance adapted species. The heterogeneity of aspen community assemblages and fire regimes makes it difficult to discern what the result of fire suppression has been at large spatial and temporal scales. Decision makers should investigate the questions at hand at the stand level in their study location to best determine the mechanisms at play, as well as consider future potential changes to the system.

关键词： Quaking Aspen Populus Tremuloides Fire Fire Regimes Rocky Mountains

Ultrasound-Guided Peri-Lymphatic and Peri-Neural Corticosteroid Injection as an Adjuvant to Pain and Lymphedema Management in Terminal Cancer: Two Case Reports

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Open Journal of Anesthesiology 2012年第5期2卷 230-233页

作者： Clark K. Choi David I. rosenblum Department of Anesthesiology Maimonides Medical Center New York USA.

We are reporting two patients presented with intractable cancer pain that was treated with a novel application of an ultrasound-guided peripheral nerve block using corticosteroid. This technique offered relief to both patients whom otherwise their cancer pain was difficult to manage. The first patient developed lymphedema to the right axilla from metastatic squamous cell carcinoma. After multiple injections were deposited around the brachial plexus, lymphedema on the right axilla decreased slightly in size;however, range of motion improved post-procedure prior to his discharge one week later. In the second patient with left inguinal lymphadenopathy from metastatic left ureteral transitional cell carcinoma, there was a dramatic reduction in lymphedema in the left groin and leg as well as a considerable decrease in pain score during a two week follow-up after the peri-neural and peri-lymphatic femoral block. A 75% improvement in patient satisfaction was reported in the office visit’s questionnaire form. Corticosteroids can be used as an adjuvant to peripheral nerve block to decrease the pain secondary to lymphedema caused by the inflammatory response from metastatic cancer. This application can provide an alternative way to manage severe cancer-related pain caused by lymphedema in both upper and lower limbs.

关键词： Corticosteroids Adjuvant Cancer Pain Lymphedema Peripheral Nerve Block

Russell & Rubinstein's Pathology of Tumors of the Nervous System 7th

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丛书名： Contemporary Neurology

2006年

作者： McLendon, Roger E. rosenblum, Marc Bigner, Darell

ISBN: (纸本)9780340810071

Beautifully illustrated in color throughout and comprehensively referenced, this seventh edition is a clearly organized volume, integrating basic sciences within sections devoted to individual tumor entities. Entirely revised and updated throughout by a wide range of internationally revered authorities, the content reflects the latest tumour classification and grading while neuroradiologic correlation via state of the art neuroimaging techniques continues to be emphasised in all diagnostic entities.

关键词： Nervous systemTumors.

来源：畅想之星图书光盘版（南... 评论

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***的入侵

商业周刊（中文版） 2013年第25期 74-79页

作者： Emma rosenblum

这家学院风服装公司重新定义了美国时尚。CEO德雷克斯勒的愿景能否在大西洋彼岸获得成功？

关键词：入侵德雷克斯勒服装公司大西洋 CEO

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明星梦——想说爱你不容易

疯狂英语（初中天地） 2014年第2期 16-19页

作者： Emma rosenblum 芥子

如今选秀节目遍地开花，越来越多人报考艺校，一夜成名的例子让很多人怀揣起“明星梦”——许多年轻人离乡背井，成为各种“漂一族”，梦想着成为下一个明星。但我们往往只看到明星光鲜的外表，却忽视了他们在背后付出的努力。再者，普... 详细信息

如今选秀节目遍地开花，越来越多人报考艺校，一夜成名的例子让很多人怀揣起“明星梦”——许多年轻人离乡背井，成为各种“漂一族”，梦想着成为下一个明星。但我们往往只看到明星光鲜的外表，却忽视了他们在背后付出的努力。再者，普通人成为明星的例子其实少之又少——这世上有多少个王宝强？只有一个!与其做不切实际的明星梦，不如脚踏实地，发展自己所长更加实际。

关键词：明星选秀节目年轻人王宝强普通人

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皮特布的嘻哈商业帝国

商业周刊（中文版） 2014年第16期 98-103页

作者： Emma rosenblum Christopher Leaman 杜然

皮特布（Pitbull），本名阿曼多·佩雷斯，自封为“环球先生”。在距离南滩大概25分钟车程的某酒店餐厅里，皮特布在椅子上一屁股坐下。这里远离迈阿密的派对和狗仔队，或许是故意弄得很复古——椅子是上世纪二三十年代流行的装饰派艺... 详细信息

皮特布（Pitbull），本名阿曼多·佩雷斯，自封为“环球先生”。在距离南滩大概25分钟车程的某酒店餐厅里，皮特布在椅子上一屁股坐下。这里远离迈阿密的派对和狗仔队，或许是故意弄得很复古——椅子是上世纪二三十年代流行的装饰派艺术风格，

关键词：皮特帝国商业二三十年代艺术风格佩雷斯迈阿密椅子