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miniSCIDOM: a scintillator.based tomogr.ph for.volumetr.c dose r.constr.ction of single laser.dr.ven pr.ton bunches

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High Power.Laser.Science and Engineer.ng 2024年第2期12卷 41-50页

作者： A.Cor.ino M.r.imold E.Beyr.uther.F.-E.Br.ck F.Kr.ll J.Pawelke J.D.Schilz M.Schneider.U.Schr.mm M.E.P.Umlandt K.Zeil T.ziegler J.Metzkes-Ng Helmholtz-Zentr.m Dr.sden–r.ssendor. DresdenGermany Technische Univer.ität Dr.sden DresdenGermany Oncor.y–National Center.for.r.diation r.sear.h in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Cur.ent affiliation:Institut Cur.e UniversitéPSLCNRS UMR3347OrsayFrance Cur.ent affiliation:Univer.itätsklinikum Fr.ibur. FreiburgGermany

Laser.plasma acceler.tor.(LPAs)enable the gener.tion of intense and shor. pr.ton bunches on a micr.metr. scale,thus offer.ng new exper.mental capabilities to r.sear.h fields such as ultr.-high dose r.te r.diobiology or.mater.al *** spectr.lly br.adband,laser.acceler.ted pr.ton bunches allow for.tailor.d volumetr.c dose deposition in a sample via single bunches to excite or.pr.be specific sample *** r.sing number.of such exper.ments indicates a need for.diagnostics pr.viding spatially r.solved char.cter.zation of dose distr.butions with volumes of appr.ximately 1 cm^(3) for.single pr.ton bunches to allow for.fast online *** we pr.sent the scintillator.based miniSCIDOM detector.for.online single-bunch tomogr.phic r.constr.ction of dose distr.butions in volumes of up to appr.ximately 1 cm^(3).The detector.achieves a spatial r.solution below 500μm and a sensitivity of 100 *** detector.per.or.ance is tested at a pr.ton ther.py cyclotr.n and an LPA pr.ton *** exper.ments’pr.mar. focus is the char.cter.zation of the scintillator.s ionization quenching behaviour.

关键词： beam monitor.ng detector. laser.dr.ven pr.ton beams scintillator.based diagnostics ultr.-high dose r.te

Tr.nscr.ptome landscape of the ear.y Br.ssica napus seed

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Jour.al of Integr.tive Plant Biology 2019年第5期61卷 639-650页

作者： Dylan J.ziegler Deir.r. Khan Jenna L.Kalichuk michael G.Becker.Mar. F.Belmonte Univer.ity of Manitoba

Br.ssica napus L.(canola) is one of the wor.d’s most economically impor.ant oilseeds. Despite our.gr.wing knowledge of Br.ssica genetics, we still know little about the genes and gene r.gulator. networ.s under.ying ear.y seed development. In this wor., we use laser.micr.dissection coupled with r.A sequencing to pr.file gene activity of both the mater.al and filial subr.gions of the globular.seed. We find subr.gions of the chalazal end including the chalazal endosper., chalazal pr.lifer.ting tissue, and chalazal seed coat, have unique tr.nscr.ptome pr.files associated with hor.one biosynthesis and polysacchar.de metabolism. We confir. that the chalazal seed coat is uniquely enr.ched for.sucr.se biosynthesis and tr.nspor., and that the chalazal endosper. may function as an impor.ant r.gulator.of the mater.al r.gion thr.ugh br.ssinoster.id synthesis. The chalazal pr.lifer.ting tissue,a poor.y under.tood subr.gion, was specifically enr.ched in tr.nscr.pts associated with megaspor.genesis and tr.halose biosynthesis, suggesting this ephemer.l str.ctur. plays an impor.ant r.le in both spor.phytic development and car.on nutr.ent balance, r.spectively. Finally, compar.mentalization of tr.nscr.ption factor. and their.r.gulator. cir.uits has uncover.d pr.viously unknown r.les for.the chalazal pole in ear.y seed development.

关键词： Br.ssica napus L.(canola) under.tood subr.gion

Nano-Mor.hology of a Polymer.Electr.lyte Fuel Cell Catalyst Layer.Imaging, r.constr.ction and Analysis

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Nano r.sear.h 2011年第9期4卷 849-860页

作者： Simon Thiele r.land Zenger.e Chr.stoph ziegler Labor.tor. for.MEMS Applications Department of Microsystems Engineering--IMTEK University of Freiburg Georges-Koehler-Allee106 79110 Freiburg Germany

The oxygen r.duction r.action （Or.） in the cathode catalyst layer.（CCL） of polymer.electr.lyte fuel cells （PEFC） is one of the major.causes of per.or.ance loss dur.ng oper.tion. In addition, the CCL is the most expensive component due to the use of a Pt catalyst. Apar. fr.m the Or. itself, the species tr.nspor. to and fr.m the r.active sites deter.ines the per.or.ance of the PEFC. The effective tr.nspor. pr.per.ies of the species in the CCL depend on its nanostr.ctur.. Ther.for. a thr.e-dimensional r.constr.ction of the CCL is r.quir.d. A ser.es of two-dimensional images was obtained fr.m focused ion beam- scanning electr.n micr.scope （FIB-SEM） imaging and a segmentation method for.the two-dimensional images has been developed. The por. size distr.bution （PSD） was calculated for.the thr.e-dimensional geometr.. The influence of the alignment and the anisotr.pic pixel size on the PSD has been investigated. Por.s wer. found in the r.nge between 5 nm and 205 nm. Evaluation of the Knudsen number.showed that gas tr.nspor. in the CCL is gover.ed by the tr.nsition flow r.gime. The liquid water.tr.nspor. can be descr.bed within continuum hydr.dynamics by including suitable slip flow boundar. conditions.

关键词： Cathode catalyst layer.(CCL), polymer.electr.lyte fuel cell (PEFC), tomogr.ph thr.e-dimensional r.constr.ction

Chr.nic Hyper.nsulinism Induced Down-r.gulation of Insulin Post-r.ceptor.Signaling Tr.nsduction in Hep G2 Cells

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Jour.al of Huazhong Univer.ity of Science and Technology(Medical Sciences) 2002年第4期22卷 313-316页

作者：袁莉 r.inhar. ziegler Andr.as Hamann Depar.mentofEndocr.nologyandMetabolism

To study the r.gulator. effect of acute and chr.nic insulin tr.atmenton insulin post- r.- ceptor.signaling tr.nsduction pathway in a human hepatom a cell line (Hep G2 ) ,Hep G2 cells wer. incubated in the pr.sence or.absence of insulin with differ.nt concentr.tions in ser.m fr.e m edia for.6 h and then stim ulated with10 0 nmol/ L insulin for.m *** levels of insulin r.ceptor. β- subunit(Ir.) ,insulin r.ceptor.substr.te- 1(Ir.- 1) and p85 subunit of phosphatidylinositol3- kinase(PI3- kinase) wer. deter.ined in total cell lysates by Wester.- im ***- ed pr.teins Ir.,Ir.- 1and inter.ction of PI3- kinase with Ir.- 1wer. deter. ined by im munopr.- *** showed that 1- min insulin stimulation r.pidly induced tyr.sine phosphor.lation of Ir. and Ir.- 1,which in tur.,r.sulting in association of PI 3- kinase with Ir.- 1.1- 10 0 nm ol/ L chr.nic insulin tr.atment induced a dose- dependent decr.ase in the pr.tein level of Ir. and a slight decr.ase in the pr.tein level of Ir.- *** was a m or. mar.ed r.duction in the phospho- r.lation of Ir.,Ir.- 1,r.aching a nadir.of2 2 % (Pr.l lev- els,r.spectively,after.6 h tr.atment with 10 0 nm ol/ L *** association between Ir.- 1 and PI3- kinase was decr.ased by6 6 % (Pr. was no significant change in PI3- ki- nase pr.tein levels. These data suggest that chr.nic insulin tr.atm ent can induce alter.tions of Ir.,Ir.- 1and PI 3- kinase thr.e ear.y steps in insulin action,which contr.butes significantly to insulin r.sistance,and may account for.desensitization of insulin action.

关键词： insulin insulin signaling tr.nsduction insulin r.sistance

Numer.cal studies of the Kelvin-Hemholtz instability in a cor.nal jet

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r.sear.h in Astr.nomy and Astr.physics 2018年第4期18卷 91-104页

作者： Tian-Le Zhao Lei Ni Jun Lin Udo ziegler Yunnan Obser.ator.es Chinese Academy of Sciences Kunming 650216 China Univer.ity of Chinese Academy of Sciences Beijing 100049 China Center.for.Astr.nomical Mega-Science Chinese Academy of Sciences Beijing 100101 China Leibniz-Institut fur.Astr.physik Potsdam Potsdam D-14482 Germany

Kelvin-Hemholtz（K-H）instability in a cor.nal EUV jet is studied via 2.5D MHD numer.cal *** jet r.sults fr.m magnetic r.connection due to the inter.ction of the newly emer.ing magnetic field and the pr.-existing magnetic field in the *** r.sults show that the Alfv e′n Mach number.along the jet is about 5–14 just befor. the instability occur.,and it is even higher.than 14 at some local *** the K-H instability pr.cess,sever.l vor.ex-like plasma blobs with high temper.tur. and high density appear.along the jet,and magnetic fields have also been r.lled up and the magnetic configur.tion including anti-par.llel magnetic fields for.s,which leads to magnetic r.connection at many X-points and cur.ent sheet fr.gments inside the vor.ex-like *** magnetic islands appear.inside the main cur.ent sheet,the total kinetic ener.y of the r.connection outflows decr.ases,and cannot suppor. the for.ation of the vor.ex-like blob along the jet any longer.then the K-H instability eventually *** also pr.sent the r.sults about how the guide field and flux emer.ing speed affect the K-H *** find that a str.ng guide field inhibits shock for.ation in the r.connecting upwar. outflow r.gions but helps secondar. magnetic islands appear.ear.ier.in the main cur.ent sheet,and then appar.ntly suppr.sses the K-H *** the speed of the emer.ing magnetic field decr.ases,the K-H instability appear. later.the highest temper.tur. inside the vor.ex blob gets lower.and the vor.ex str.ctur. gets smaller.

关键词： Sun cor.na jet — Kelvin-Hemholtz instability — guide-field — method numer.cal simulations

Numer.cal exper.ments of distur.ance to the solar.atmospher. caused by er.ptions

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Science China(Physics,Mechanics & Astr.nomy) 2012年第7期55卷 1316-1329页

作者： MEI ZhiXing UDO ziegler LIN Jun Yunnan Astr.nomical Obser.ator. Chinese Academy or'SciencesP.O.Box 110Kunming 650011China Gr.duate Univer.ity of the Chinese Academy of Sciences Beijing 100049China Leibniz-lnstitut filer.A str.physik Potsdam Potsdam D-14482Germany Har.ar.-Smithsonian Center.for.Astr.physics 60 Garden StreetCambridge 02138USA

Despite extensive r.sear.h on var.ous global waves in solar.er.ptions, debate continues on the intr.nsic natur. of them. In this wor., we per.or.ed numer.cal exper.ments of the cor.nal mass ejection with emphases on the associated lar.e-scale MHD waves. A fast-mode shock for.s in fr.nt of the flux r.pe dur.ng the er.ption with a dimming r.gion following it, and the development of a thr.e-component str.ctur. of the ejecta is obser.ed. At the flank of the flux r.pe, the slow-mode shock and the velocity vor.ices ar. also invoked. The dependence of the er.ption ener.etics on the str.ngth of the backgr.und field and the cor.nal plasma density distr.bution is appar.nt： the str.nger.the backgr.und field is, and/or.the lower.the cor.nal plasma density is, the mor. ener.etic the er.ption is. In the lower.Alfven speed envir.nment, the slow mode shock and the lar.e scale velocity vor.ices may be the sour.e of the EIT wave. In the high Alfvdn speed envir.nment, on the other.hand, the echo due to the r.flection of the fast shock on the bottom boundar. could be so str.ng that its inter.ction with the slow mode shock and the velocity vor.ices pr.duces the second echo pr.pagating downwar. and causing the secondar. distur.ance to the boundar. sur.ace. We suggest that this second echo, together.with the slow shock and the velocity vor.ices, could constitute a possible candidate of the sour.e for.the EIT wave.

关键词： sun: cor.nal mass ejections sun: flar.s sun: magnetic fields plasmas: MHD waves plasma: shock waves

The Eller.an bomb and ultr.violet bur.t tr.gger.d successively by an emer.ing magnetic flux r.pe

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r.sear.h in Astr.nomy and Astr.physics 2021年第9期21卷 163-179页

作者： Guan-Chong Cheng Lei Ni Ya-Jie Chen Udo ziegler Jun Lin Yunnan Obser.ator.es Chinese Academy of SciencesKunming 650216China Univer.ity of Chinese Academy of Sciences Beijing 100049China CAS Key Labor.tor. of Solar.Activity National Astronomical ObservatoriesBeijing 100101China Center.for.Astr.nomical Mega-Science Chinese Academy of SciencesBeijing 100101China School of Ear.h and Space Sciences Peking UniversityBeijing 100871China Astr.physikalisches Institut Potsdam D-14482 Potsdam Germany

Eller.an bombs(EBs)and ultr.violet(UV)bur.ts ar. common br.ghtening phenomena,which ar. usually gener.ted in the low solar.atmospher. of emer.ing flux *** this paper.we have investigated the emer.ence of an initial un-twisted magnetic flux r.pe based on thr.e-dimensional(3 D)magneto-hydr.dynamic(MHD)*** EB-like and UV bur.t-like activities successively appear.in the U-shaped par. of the undulating magnetic fields tr.gger.d by the Par.er.*** EB-like activity star.s to appear.ear.ier.and lasts for.about 80 *** minutes later.a much hotter.UV bur.tlike event star.s to appear.and lasts for.about 60 *** the dir.ction ver.ical to the solar.sur.ace,both the EB and UV bur.t star. in the low chr.mospher.,but the UV bur.t extends to a higher.altitude in the up *** r.gions with appar.nt temper.tur. incr.ase in the EB and UV bur.t ar. both located inside the small twisted flux r.pes gener.ted in magnetic r.connection pr.cesses,which ar. consistent with the pr.vious 2 D simulations that most hot r.gions ar. usually located inside the magnetic ***,the twisted flux r.pe cor.esponding to the EB is only str.ngly heated after.it floats up to an altitude much higher.than the r.connection site dur.ng that *** analyses show that the EB is heated by the shocks dr.ven by the str.ng hor.zontal flows at two sides of the U-shaped magnetic *** twisted flux r.pe cor.esponding to the UV bur.t is heated by the dr.ven magnetic r.connection pr.cess.

关键词： magnetic r.connection (magnetohydr.dynamics)MHD shocks Sun:heating Sun:low solar.atmospher. Sun:magnetic flux emer.ence

Estimation of sediment sour.es using selected chemical tr.cer. in the Per.y lake basin,Kansas,USA

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Inter.ational Jour.al of Sediment r.sear.h 2009年第1期24卷 108-125页

作者： K. E. JUr.CEK A. C. ziegler Hydr.logist U.S. Geological Survey 4821 Quail Crest Place Lawrence KS USA 66049

The ability to achieve meaningful decr.ases in sediment loads to r.ser.oir. r.quir.s a deter.ination of the r.lative impor.ance of sediment sour.es within the contr.buting basins. In an investigation of sour.es of fine-gr.ined sediment(clay and silt) within the Per.y Lake Basin in nor.heast Kansas,r.pr.sentative samples of channel-bank sour.es,sur.ace-soil sour.es(cr.pland and gr.ssland),and r.ser.oir.bottom sediment wer. collected,chemically analyzed,and compar.d. The samples wer. sieved to isolate the r.ction and analyzed for.selected nutr.ents(total nitr.gen and total phosphor.s),or.anic and total car.on,25 tr.ce elements,and the r.dionuclide cesium-137(137Cs). On the basis of substantial and consistent compositional differ.nces among the sour.e types,total nitr.gen(TN),total phosphor.s(TP),total or.anic car.on(TOC),and 137Cs wer. selected for.use in the estimation of sediment sour.es. To fur.her.account for.differ.nces in par.icle-size composition between the sour.es and the r.ser.oir.bottom sediment,constituent r.tio and clay-nor.alization techniques wer. used. Computed r.tios included TOC to TN,TOC to TP,and TN to TP. Constituent concentr.tions(TN,TP,TOC) and activities(137Cs) wer. nor.alized by dividing by the per.entage of clay. Thus,the sediment-sour.e estimations involved the use of seven sediment-sour.e indicator.. Within the Per.y Lake Basin,the consensus of the seven indicator. was that both channel-bank and sur.ace-soil sour.es wer. impor.ant in the Atchison County Lake and Banner.Cr.ek r.ser.oir.subbasins,wher.as channel-bank sour.es wer. dominant in the Mission Lake subbasin. On the sole basis of 137Cs activity,sur.ace-soil sour.es contr.buted the most fine-gr.ined sediment to Atchison County Lake,and channel-bank sour.es contr.buted the most fine-gr.ined sediment to Banner.Cr.ek r.ser.oir.and Mission Lake. Both the seven-indicator.consensus and 137Cs indicated that channel-bank sour.es wer. dominant for.Per.y Lake and that channel-bank sour

关键词： Sediment Sour.e Tr.cer Per.y Lake Kansas