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Deep learning-driven interval uncertainty propagation for aeronautical structures

Chinese Journal of Aeronautics 2024年第12期37卷 71-86页

作者： Yan SHI michael BEER Institute for Risk and Reliability Leibniz Universitat HannoverHannover 30167Germany Department of Civil and Environmental Engineering University of LiverpoolLiverpool L693BXUnited Kingdom International Joint Research Center for Resilient Infrastructure&International Joint Research Center for Engineering Reliability and Stochastic Mechanics Tongji UniversityShanghai 200092China

Interval Uncertainty Propagation(IUP)holds significant importance in quantifying uncertainties in structural outputs when confronted with interval input *** the aviation field,the precise determination of probability models for input parameters of aeronautical structures entails substantial costs in both time and *** an alternative,the use of interval variables to describe input parameter uncertainty becomes a pragmatic *** complex task of solving the IUP for aeronautical structures,particularly in scenarios marked by pronounced nonlinearity and multiple outputs,necessitates innovative *** study introduces an efficient deep learning-driven approach to address the challenges associated with *** proposed approach combines the Deep Neural Network(DNN)with intelligent optimization algorithms for dealing with the IUP in aeronautical *** inventive extremal value-oriented weighting technique is presented,assigning varying weights to different training samples within the loss function,thereby enhancing the computational accuracy of the DNN in predicting extremal values of structural ***,an adaptive framework is established to strategically balance the global exploration and local exploitation capabilities of the DNN,resulting in a predictive model that is both robust and *** illustrate the effectiveness of the developed approach,various applications are explored,including a high-dimensional numerical example and two aeronautical *** obtained results highlight the high computational accuracy and efficiency achieved by the proposed approach,showcasing its potential for addressing complex IUP challenges in aeronautical engineering.

关键词： Uncertainty propagation Interval variable Deep learning Optimization algorithm Aeronautical structure

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Preventing roof fall fatalities during pillar recovery:A ground control success story

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International Journal of Mining Science and Technology 2017年第1期27卷 107-113页

作者： Mark Christopher Gauna michael MSHA Pittsburgh Safety and Health Technology CenterPittsburghPA 15236USA

For decades, pillar recovery accounted for a quarter of all roof fall fatalities in underground coal *** showed that a miner on a pillar recovery section was at least three times more likely to be killed by a roof fall than other coal miners. Since 2007, however, there has been just one fatal roof fall on a pillar line. This paper describes the process that resulted in this historic achievement. It covers both the key research findings and the ways in which those insights, beginning in the early 2000 s, were implemented in mining practice. One key finding was that safe pillar recovery requires both global and local *** stability is addressed primarily through proper pillar design, and became a major focus after the2007 Crandall Canyon mine disaster. But the most significant improvements resulted from detailed studies that showed that local stability, defined as roof control in the immediate work area, could be achieved with three interventions:(1) leaving an engineered final stump, rather than extracting the entire pillar,(2) enhancing roof bolt support, particularly in intersections, and(3) increasing the use of mobile roof supports(MRS). A final component was an emphasis on better management of pillar recovery *** included a focus on worker positioning, as well as on the pillar and lift sequences, MRS operations,and hazard identification. As retreat mines have incorporated these elements into their roof control plans,it has become clear that pillar recovery is not ‘‘inherently unsafe." The paper concludes with a discussion of the challenges that remain, including the problems of rib falls and coal bursts.

关键词： Retreat mining Roof support Room-and-pillar Ground control

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Inequalities for Sums and Products of Complex Zeros of Solutions to ODE with Polynomial Right Parts

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Communications on Applied Mathematics and Computation 2023年第4期5卷 1524-1533页

作者： michael Gil’ The Department of Mathematics Ben-Gurion University of the NegevBeer-Sheva84105Israel

The paper is devoted to non-homogeneous second-order differential equations with polynomial right parts and polynomial *** derive estimates for the partial sums and products of the zeros of solutions to the considered *** estimates give us bounds for the function counting the zeros of solutions and information about the zero-free domains.

关键词： Ordinary differential equations Linear equations Zeros of solutions

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Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the German Cancer Research Center (DKFZ) and its partnerships with university medical centers

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Cancer Biology & Medicine 2022年第11期19卷 1517-1522页

作者： michael Baumann German Cancer Research Center(DKFZ) Heidelberg 69120Germany

This issue of Cancer Biology & Medicine, a premium Chinese international scientific journal in this field, focuses on cooperation between Chinese and German cancer research, particularly between the Tianjin Medical University Cancer Institute & Hospital and the German Cancer Research Center(DKFZ) with its networking partners. This editorial provides a brief overview on DKFZ’s research strategy with a focus on how a national integrated cancer research and care ecosystem is evolving that benefits patients and society.

关键词： Cancer landscape centers

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Would male hormonal contraceptives affect cardiovascular risk？

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Asian Journal of Andrology 2018年第2期20卷 145-148页

作者： michael Zitzmann Center for Andrology and Reproductive Medicine University Clinics Muenster Muenster Germany

The aim of hormonal male contraception is to prevent unintended pregnancies by suppressing spermatogenesis. Hormonal male contraception is based on the principle that exogenous administration of androgens and other hormones such as progestins suppress circulating gonadotropin concentrations, decreasing testicular Leydig cell and Sertoli cell activity and spermatogenesis. In order to achieve more complete suppression of circulating gonadotropins and spermatogenesis, a progestin has been added testosterone to the most recent efficacy trials of hormonal male contraceptives. This review focusses on the potential effects of male hormonal contraceptives on cardiovascular risk factors, iipids and body composition, mainly in the target group of younger to middle-aged men. Present data suggest that hormonal male contraception can be reasonably regarded as safe in terms of cardiovascular risk. However, as all trials have been relatively short （〈 3 years）, a final statement regarding the cardiovascular safety of hormonal male contraception, especially in long-term use, cannot be made. Older men with at high risk of cardiovascular event might not be good candidates for hormonal male contraception. The potential adversSeffects of hormonal contraceptives on cardiovascular risk appear to depend greatly on the choice of the progestin in regimens for hormonal male contrai：eptives. In the development of prospective hormonal male contraception, data on longer-term cardiovascular safety will be essential.

关键词： cardiovascular risk male contraception progestins testosterone

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Screening and efficacy of radical prostatectomy

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Asian Journal of Andrology 2013年第4期15卷 441-442页

作者： michael Froehner Department of Urology University Hospital Carl GustavCarus Dresden University of Technology Fetscher-strasse 74 Dresden D-01307 Germany

I n a recently published study, the results of the Prostate Cancer Intervention ver-sus Observation Trial （PIVOT） trial were compared with that of the Scandinavian Prostate Cancer Group Study Number 4 （SPCG-4）. The authors concluded that the discrepancy of the mortality rates between both studies may be explained by screen- related lead time and over-diagnosis. In this comment, some potential biases are dis- cussed and the limited applicability of the results of both randomized trials to healthy candidates for radical prostatectomy is underlined. The results of the Prostate Cancer Inter- vention versus Observation Trial （PWOT）1 raised questions on the efficacy of radical prostatectomy in men with low-risk prostate cancer. Xia and co-workers2 used simulation modeling to determine whether the reduced absolute survival benefit in the PIVOT trial1 compared with Scandinavian Prostate Cancer Group Study Number 43 may be explained by the high prevalence of screen-detected prostate cancers in the PIVOT study. The authors concluded that the discrepancy of the mortality rates between both studies may largdy be explained by screen-rdated lead time and over-diagnosis and should not be considered as an argument against the efficacy of radical prostatectomy even in the presence of screening. The authors emphasized that there is a subset of patients that should not be treated by radical prosta- tectomy which needs to be identified in the future,z There are further features of the PIVOT study making it appropriate to interpret the lack of survival differences in this trial with caution. With more than 30% dying of other causes by 10 years, the competing mortalityrate was three times as high as usually observed in contemporary radical prostatec- tomy series： 10%,4 4%-12%s and 11%.6 The PIVOT study sample obviously contained an over-proportionally large proportion of cases with a high risk of early competing mortality. This observation is particularly remarkable because it was as

关键词： Screening efficacy prostatectomy

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Semen quality analysis and the idea of normal fertility

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Asian Journal of Andrology 2010年第1期12卷 79-82页

作者： michael Joffe Department of Epidemiology and Public Health Imperial College London St Mary＇s Campus London W2 1PF UK

The World Health Organization （WHO） has extensively revised its manual for semen analysis, and seeks to provide reference limits for semen quality parameters. This raises the question of what is meant by ＇normal＇（excluding the use of this term to denote a Gaussian distribution）. It could be taken in a purely statistical sense, using a biologically arbitrary cut-off point to denote an abnormal level, typically the extreme 5 percent of the population. Alternatively, ＇normal＇ could be defined according to the biological concept of normality and abnormality, in terms of the point at which biological function becomes impaired. Either of these can be used in descriptive epidemiology, for example, to study trends, but in the case of fertility, both semen quality and functional fertility （time to pregnancy） are continuous variables with no clear threshold. The WHO manual uses the biological meaning of normal, in that it provides the semen parameter distributions for men who have recently fathered pregnancies that took 12 months or less to conceive. However, what is really needed is the same information the other way around： given a particular semen test result, what should be expected in terms of ability to conceive, and how long it is likely to take. In considering epidemiological research, the focus has been mainly on internal comparisons, rather than reference limits, but it would be beneficial if more attention were paid to the absolute levels and to what these mean in terms of function--in other words, if the data were better calibrated biologically.

关键词： fecundability fecundity fertility semen semen analysis subfecundity

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GANscan:continuous scanning microscopy using deep learning deblurring

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Light(Science & Applications) 2022年第10期11卷 2378-2387页

作者： michael John Fanous Gabriel Popescu Quantitative Light Imaging Laboratory Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Bioengineering University of Illinois at Urbana-Champaign306 N.Wright StreetUrbanaIL 61801USA Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign306 N.Wright StreetUrbanaIL 61801USA

Most whole slide imaging(WSI)systems today rely on the"stop-and-stare"approach,where,at each field of view,the scanning stage is brought to a complete stop before the camera snaps a *** procedure ensures that each image is free of motion blur,which comes at the expense of long acquisition *** order to speed up the acquisition process,especially for large scanning areas,such as pathology slides,we developed an acquisition method in which the data is acquired continuously while the stage is moving at high *** generative adversarial networks(GANs),we demonstrate this ultra-fast imaging approach,referred to as GANscan,which restores sharp images from motion blurred *** allows us to complete image acquisitions at 30x the throughput of stop-and-stare *** method is implemented on a Zeiss Axio Observer Z1 microscope,requires no specialized hardware,and accomplishes successful reconstructions at stage speeds of up to 5000 μm/*** validate the proposed method by imaging H&E stained tissue *** method not only retrieves crisp images from fast,continuous scans,but also adjusts for defocusing that occurs during scanning within+/-5 μ*** a consumer GPU,the inference runs at<20 ms/image.

关键词： hardware continuous image

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Does foraging mode affect metabolic responses to feeding？ A study of pygopodid lizards

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Current Zoology 2013年第5期59卷 618-625页

作者： michael WALL michael B. THOMPSON Richard SHINE School of Biological Sciences A08 University of Sydney NSW 2006 Australia Current address: 4940 Anza St. #4 San Francisco CA 94121 USA

Foraging mode （ambush vs. active） profoundly affects many aspects of organismal biology, including metabolic rates and their relationship with food intake. Previous studies on snakes suggest that ambushers tend to have lower standard metabolic rates （SMR） and higher energetic costs of digestion and assimilation of prey （specific dynamic action, or SDA） than do active foragers. However, phylogenetic considerations may be at least partly responsible for such patterns, as foraging mode is strongly conserved evolutionarily and most SDA studies have focused on species from only two lineages of ambush foragers （pythonid and viperid snakes） and one lineage of active foragers （colubrid snakes）. We sought to deconfound the effects of phylogeny and foraging mode, investigating SMR and SDA in two closely related pygopodid lizards, the common scaly-foot Pygopus lepidopo- dus （active forager） and Burton＇s legless lizard Lialis burtonis （ambush forager）. Consistent with the pattern seen in snakes, L. burtonis exhibits a significantly lower SMR and a higher SDA than does P lepidopodus. The magnitude of SDA in L. burtonis is comparable to that of some pythons and vipers, providing yet more evidence for the remarkable convergence between this species and ambush-foraging snakes [Current Zoology 59 （5）： 618-625, 2013].

关键词： Ecology Metabolic rates Reptile Specific dynamic action

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Advances in halide perovskite semiconductors for energy-integrated and energy-resolved X-ray detection

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第10期25卷 824-840页

作者： Yibin LAI Yang(michael)YANG State Key Laboratory of Modern Optical Instrumentation Institute for Advanced PhotonicsCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

X-ray andγ-ray detectors are widely used in medical,military,security,material analysis,and industrial *** recent years,perovskite materials have become promising materials for radiation detection owing to their strong stopping power,considerable carrier transportation ability,and simple synthesis *** studies have demonstrated both direct and indirect radiation detectors using perovskite *** this review,we aim to elucidate the mechanism by which X-rays andγ-rays interact with matter,explain the principles of the energy integrating mode and photon counting mode for direct detection,and discuss the key factors determining device ***,we summarize recent advances in perovskite-based radiation detectors for both ***,we identify challenges that need to be overcome to enable perovskite materials to be successfully commercialized.

关键词： Halide perovskite X-ray Direct detection Photo counting

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