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Microscale shaping and rounding of ridge arrays and star pattern features on nickel mould via electrochemical polishing

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Advances in Manufacturing 2024年第2期12卷 207-226页

作者： Sana Zaki Nan Zhang michael d.Gilchrist School of Mechanical and Materials Engineering University College DublinBelfieldDublin 4Ireland

High quality micro mould tools are critical for ensuring defect-free production of micro injection moulded *** demoulding stage of the micro injection moulding can adversely affect the surface integrity due to friction,adhesion and thermal stresses between the metallic mould and polymeric replicated *** the present work,we propose the use of precision electropolishing(EP)as a shaping and polishing process to control the draft angle and fillet radius of micro features in order to ease *** defects that occur in replicated polymer parts include cracks,burrs and distorted features.A nickel mould having multiple linear ridges and star shape patterns was designed for the present investigation to have characteristic dimensions ranging from 10μm to 150μm and with various aspect ratios to study the effect of electropolishing on modifying the shape of micro features and surface morphology.A transient 2d computational analysis has been conducted to anticipate the effect of shaping on the Ni mould after electrochemical polishing with non-uniform material removal rates,based on the distribution of current *** experimental results indicate that after shaping using EP,the draft angle of star-patterns and linear patterns can be effectively increased by approximately 3.6°,while the fillet radius increases by up to 5.0μ*** controlling the electropolishing process,the surface roughness can be maintained under 50 *** work uses a green and environmental friendly nickel sulfamate electrolyte which can be effective for shaping of nickel micro features without causing any surface deposition.

关键词： Micro feature shaping and electropolishing Micro mould tools Green electrolyte demoulding micro patterns

BMPRⅡ^(+)neural precursor cells isolated and characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development

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Neural Regeneration Research 2024年第2期19卷 447-457页

作者： michael W.Weible II michael d.Lovelace Hamish d.Mundell Tsz Wai Rosita Pang Tailoi Chan-Ling Bosch Institute Discipline of Anatomy and Histology(F13)University of SydneySydneyNSWAustralia School of Environment and Science Griffith UniversityNathanQLDAustralia discipline of Medicine Nepean Clinical SchoolFaculty of Medicine and HealthUniversity of SydneyKingswoodNSWAustralia New South Wales Brain Tissue Resource Centre School of Medical SciencesFaculty of Medicine and HealthUniversity of SydneyCharles Perkins Centre(D17)SydneyNSWAustralia

Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well ***-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is *** was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory *** and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord and cortex by co-positivity with vascular lineage markers,Cd34/*** immunostaining identified a population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/Cd118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,*** neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent *** cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage ***-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in *** is the first isolation of BMPRⅡ^(+)hNPCs identified and characterized in human fetal spinal *** data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterize

关键词： BMPRⅡ bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor neurosphere organotypic reaggregate sensory columns

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静力和疲劳荷载下后锚固抗剪连接的性能研究

钢结构(中英文) 2010年第4期 81-81页

作者： Gunup Kwon michael d.engelhardt Richard E.Klingner

介绍了一系列试验研究方法,以研究将现有非复合楼板系统改建为复合楼板系统之后的复合作用。在静力和疲劳荷载下,对直径22mm的三种类型的后锚固抗剪连接进行了测试。将测试结果与先前对19mm直径的后锚固抗剪连接,以及传统的焊接抗剪螺... 详细信息

介绍了一系列试验研究方法,以研究将现有非复合楼板系统改建为复合楼板系统之后的复合作用。在静力和疲劳荷载下,对直径22mm的三种类型的后锚固抗剪连接进行了测试。将测试结果与先前对19mm直径的后锚固抗剪连接,以及传统的焊接抗剪螺栓的研究结果进行了对比。基于试验结果,对后锚固抗剪连接的静力和疲劳强度的设计提出了初步的计算公式。相比传统的焊接抗剪螺栓,后锚固抗剪连接表现出了极高的抗疲劳强度。这样,可以采用比传统焊接抗剪螺栓更少的抗剪连接,实现对现有桥梁的加固。

关键词：锚定桥梁部分复合后锚固抗剪连接改造

“digitalMe”in smart cities

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The Innovation 2024年第5期5卷 11-12页

作者： Seung-min Park Seunghun Hong Kyonghee Joo Soh Kim michael d.Lepech School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637459Singapore Walmart Connect HobokenNJ 07030USA LG CNS Seoul 07795South Korea department of Civil and Environmental Engineering Stanford UniversityStanfordCA 94305USA Stanford Center at the Incheon Global Campus(SCIGC) IncheonSouth Korea

PRECISION HEALTH ANd *** Continuous monitoring of high-value equipment,such as semiconductor production equipment and jet airplane engines,has become a standard practice across myriad commercial sectors.“digital twin”technologies enable such monitoring by providing sensor data for maintenance and other mission-critical operations in real *** continuous monitoring has become standard in some industry,its application to monitoring healthy adults globally remains underexplored,with many individuals seeking medical care only when *** gained from digital twin could be transferred to healthcare,revealing opportunities for more data-driven and personalized care.

关键词： gained seeking smart

Fabrication of sub-20 nm MoS_(2) horizontal nanowire on silicon substrates by inclusion of precursors into polystyrene-bpolyethylene oxide nanopatterns: detailed structural investigation

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Nano Research 2024年第3期17卷 2145-2153页

作者： Tandra Ghoshal michael A.Morris School of Chemistry AMBER and CRANNTrinity College DublinDublinIrelandD02 AK60

Herein,we demonstrate the fabrication of sub-20 nm MoS_(2) horizontal nanowire arrays on silicon substrates using a self-assembled block copolymer assisted in situ inclusion *** separated long-range ordered polystyrene-b-polyethylene oxide(PS-b-PEO)block copolymer(BCP)line-space nanopatterns were achieved through thermo-solvent *** patterns produced had long-range order and domain sizes>1μ*** BCP structures were lightly etched and modified by anhydrous ethanol to facilitate insertion of molybdenum precursor within the film maintaining the parent BCP *** ordered molybdenum oxide nanowire arrays were then fabricated by ultraviolet(UV)/ozone treatment at room *** oxides were converted to sulphides by thermal evaporation at different temperatures in Ar/H_(2) environment.X-ray photoelectron spectroscopy revealed the composition and phases of the molybdenum oxide and sulphide *** mapping was performed to investigate the interfaces between the oxide and sulphide nanowires with the substrate *** formation and stability of the sulphide nanowires were studied at different *** photoluminescence and Raman properties were studied at different formation temperatures to investigate defects and estimate the number of layers.

关键词： MoS_(2) block copolymer nanowires inclusion X-ray photoelectron spectroscopy(XPS) mapping photoluminescence

Neuronal trafficking as a key to functional recovery in immune-mediated neuropathies

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Neural Regeneration Research 2024年第11期19卷 2331-2332页

作者： Felix Kohle michael Schroeter department of Neurology University of Cologne and University Hospital CologneCologneGermany

Immune-mediated neuropathies are rare diseases of the peripheral nervous system(PNS),substantially affecting patients’functionality and quality of *** are amenable to immunomodulatory treatments,which in many cases stabilize disease progression,but long-term deficits persist in many *** long-term deficits are particularly observed in monophasic autoimmune neuropathies like Guillain-Barrésyndrome and also in chronic variants,e.g.,chronic inflammatory demyelinating neuropathy(Fadia et al.,2019).

关键词： diseases autoimmune

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Rethinking the egg

National Science Review 2024年第6期11卷 81-82页

作者： michael J.Benton School of Earth Sciences University of Bristol

Our image of early dinosaur eggs must change. Early dinosaur eggs are portrayed as soft-shelled, like those of modern lizards or snakes [1], and yet all the evidence is that early dinosaurs at least laid leathery-shel...

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design of a Level-3 electric vehicle charging station using a 1-MW solar system via the distributed maximum power point tracking technique

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Clean Energy 2024年第1期8卷 23-35页

作者： Afshin Balal michael Giesselmann department of Electrical and Computer Engineering Texas Tech UniversityLubbockTX 79409USA

Solar power is mostly influenced by solar irradiation,weather conditions,solar array mismatches and partial shading ***,before installing solar arrays,it is necessary to simulate and determine the possible power *** power point tracking is needed in order to make sure that,at any time,the maximum power will be extracted from the photovoltaic ***,maximum power point tracking is not a suitable solution for mismatches and partial shading *** overcome the drawbacks of maximum power point tracking due to mismatches and shadows,distributed maximum power point tracking is util-ized in this *** solar farm can be distributed in different ways,including one dC-dC converter per group of modules or per *** this paper,distributed maximum power point tracking per module is implemented,which has the highest *** technology is applied to electric vehicles(EVs)that can be charged with a Level 3 charging station ind,and there is not always enough peak power reserve in the existing power grid to charge EVs at that ***,a Level 3(fast dC)EV charging station using a solar farm by implementing distributed maximum power point tracking is utilized to address this ***,the simulation result is reported using MATLAB®,LTSPICE and the System Advisor *** results show that the proposed 1-MW solar system will provide 5 MWh of power each day,which is enough to fully charge~120 EVs each ***,the use of the proposed photovoltaic system benefits the environment by removing a huge amount of greenhouse gases and hazardous *** example,instead of supplying EVs with power from coal-fired power plants,1989 pounds of CO_(2) will be eliminated from the air per hour.

关键词： electric vehicles(EVs) distributed maximum power point tracking solar farm dC fast-charging station step-up dC-dC converter System Advisor Model economic analysis

Transcranial photobiomodulation for the brain: a wide range of clinical applications

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Neural Regeneration Research 2024年第3期19卷 483-484页

作者： michael R.Hamblin Laser Research Centre Faculty of Health ScienceUniversity of Johannesburg-Doornfontein CampusDoornfonteinSouth Africa

Photobiomodulation therapy(PBMT)is a rapidly growing approach to the healing,stimulation,protection,and regeneration of many human organs and tissue *** started in the 1960s as low-level laser therapy for wound healing,but since then the introduction of light-emitting diodes(LEds)has dramatically increased the number of applications and reports of positive *** generally uses red(620-700 nm)and/or near-infrared(780-1270 nm)wavelengths of light at an intensity that causes no tissue heating,and its activity is based on well-established biological and cellular mechanisms(de Freitas and Hamblin,2016).While laser therapists continue to use various types of laser in their office practice,LEds are ideally suited for home use devices because they are completely safe and without any known significant adverse *** the various body parts on which PBMT has been shown to exert beneficial effects,the brain stands out as perhaps the most promising *** has been shown to reduce neuroinflammation,while increasing mitochondrial function,oxygen consumption,and blood flow within the brain(Hamblin,2016).Moreover,PBMT can stimulate the processes of synaptogenesis,neurogenesis,and neuroplasticity thus helping the brain to heal itself.

关键词： healing stimulation wound

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