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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National clinical Research center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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Structural and microwave absorption properties of coFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun zhang Shengtao Gao Xingzhao zhang Dacheng Ma chuanlei Zhu Jun He Joint National-Local Engineering Research centre for Safe and Precise coal Mining Anhui University of Science and TechnologyHuainan 232001China School of chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,coFe_(2)O_(4)/residual carbon from coal gasification fine slag(cFO/Rc)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the cFO/Rc-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,cFO/Rc-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption coFe_(2)O_(4)

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Thermodynamics of voltage-gated ion channels

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Biophysics Reports 2018年第6期4卷 300-319页

作者： Xuejun c.zhang Hanting Yang Zhenfeng Liu Fei Sun National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences college of Life Science University of Chinese Academy of Sciences

Ion channels are essential for cellular signaling. Voltage-gated ion channels(VGIcs) are the largest and most extensively studied superfamily of ion channels. They possess modular structural features such as voltage-sensing domains that encircle and form mechanical connections with the pore-forming domains. Such features are intimately related to their function in sensing and responding to changes in the membrane potential. In the present work, we discuss the thermodynamic mechanisms of the VGIc superfamily, including the two-state gating mechanism, sliding-rocking mechanism of the voltage sensor, subunit cooperation, lipid-infiltration mechanism of inactivation, and the relationship with their structural features.

关键词： Gating mechanism Inactivation Ion channel Membrane potential Sliding-rocking model Voltage sensor

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A quasi-in-situ EBSD study of the thermal stability and grain growth mechanisms of cocrNi medium entropy alloy with gradient-nanograined structure

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Journal of Materials Science & Technology 2022年第14期109卷 54-63页

作者： P.-c.Zhao B.Guan Y.-G.Tong R.-Z.Wang X.Li X.-c.zhang S.-T.Tu Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China college of Materials Science and Engineering Chongqing UniversityChongqing 400044China college of Automobile and Mechanical Engineering Changsha University of Science and TechnologyChangshaChina

The thermal stability and mechanical properties of a gradient-nanograined structure(GNS)cocrNi medium entropy alloy(MEA)processed by ultrasonic surface rolling were studied by using isothermal/isochronal annealing tests combined with quasi-in-situ electron backscatter diffraction(EBSD)characterization and Vickers micro-hardness(HV)measurements.A layer by layer high-throughput investigation method was used to quantitatively study the grain growth kinetics and grain boundary evolution with different initial grain sizes,which could effectively save specimen and time *** grain nucleation and growth,as well as shrink and disappearance process throughΣ3 coincidence site lattice boundary migration with slightly lattice rotation during annealing were directly *** layer by layer grain growth kinetics and calculated activation energy indicate that the thermal stability of nanograined top surface layer is relatively higher than that of nano-twined subsurface layer for the gradient cocrNi MEA processed by ultrasonic surface *** analysis show that the grain boundary relaxation and dynamic recrystallization of the topmost nano-grains led to the decrease of grain boundary energy,thus improving their thermal *** present work provided theoretical basis for the application of cocrNi MEA at high ***,the high-throughput method on the investigation of grain stability by using gradient structure can be easily extended to other materials and it is of great significance for understanding the microstructural evolution of gradient materials.

关键词： Medium entropy alloy Grain growth Gradient materials Nanostructured materials Annealing High throughput

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Analysis of hydro-mechanical processes in a ventilated tunnel in an argillaceous rock on the basis of different modelling approaches

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第1期5卷 1-17页

作者： B.Garitte A.Bond A.Millard c.zhang c.Mcdermott S.Nakama A.Gens Universidad Politécnica de catalunya Quintessa WarringtonUK commissariat à l'Energie Atomique Gif-sur-Yvette France chinese Academy of Sciences EcOSSE University of Edinburgh Japan Atomic Energy Agency

In this paper, a modelling benchmark exercise from the DEcOVALEX-2011 project is presented. The bench- mark is based on the performance and results of a laboratory drying test and of the ventilation experiment （VE） carried out in the Mont Terri Underground Rock Laboratory （URL）. Both tests involve Opalinus clay. The work aims at the identification, understanding and quantification of mechanisms taking place during the ventilation of a gallery in argillaceous host rocks on one hand and at investigating the capacity of different codes and individuals to reproduce these processes on the other hand. The 4-year in situ VE took place in a 1.3 m diameter unlined tunnel and included two resaturation-desaturation cycles. The test area was equipped with over one hundred sensors （including the global water mass balance of the system, relative humidity （RH）, water content, liquid pressure, relative displacement and concentration of some chemical species） to monitor the rock behaviour during ventilation. The laboratory drying experiment, carried out before the VE, was designed to mimic the in situ conditions. The work was organized in a progressive manner in terms of complexity of the computations to be performed, geared towards the full hydro-mechano-chemical （HMc） understanding of the VE, the final objective. The main results from the modelling work reported herein are that the response of the host rock to ventilation in argillaceous rocks is mainly governed by hydraulic processes （advective Darcy flow and non-advective vapour diffu- sion） and that the hydro-mechanical （TM） back coupling is weak. A ventilation experiment may thus be regarded as a large scale-long time pump test and it is used to determine the hydraulic conductivity of the rock mass.

关键词： Hydro-mechanical (HM) couplingNumerical modellingMont Terri Underground Rock Laboratory(URL)Ventilation experiment (VE)ArgilliteWater permeability

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Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua zhang Kailu Guo Lanyue zhang Gening Du Hao You Junfeng Huang Mudong Tu Hua Li Yong Peng Wei Dou cailing Xu State Key Laboratory of Applied Organic chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University college of chemistry and chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction catalytic mechanism Oxygen evolution reaction

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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan chen Hongxia Deng Nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan zhang Yuan Liang Yixue Gu International Medical college Chongqing Medical UniversityChongqingChina college of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional chinese medicine treatment

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli zhang Tian Li Jie Miao Zhina zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang college Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hcMEc/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Single-molecule fluorescence studies on the conformational change of the ABc transporter MsbA

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Biophysics Reports 2018年第3期4卷 153-165页

作者： Yanqing Liu Yue Liu Lingli He Yongfang Zhao Xuejun c.zhang National Laboratory of Biomacromolecules National CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences college of Life Science University of Chinese Academy of Sciences

ATP-binding cassette(ABc) transporters are found in all forms of life from microbes to humans, and transport a wide variety of substrates across the cell membrane using the energy released from ATP hydrolysis and an alternating-access mechanism. Msb A is a homodimeric ABc exporter from Gramnegative bacteria, and transports amphipathic substrates including precursors of lipopolysaccharides from the inner leaflet to the outer leaflet of the cytoplasmic membrane. Despite extensive structural and functional studies, controversies remain regarding the dynamic properties of the conformational changes of Msb A during its transport cycle in the lipid environment. Here, we used single-molecule fluorescence resonance energy transfer(sm FRET) to explore the dynamic behaviors of Msb A in detergent micelles, nanodiscs, and proteoliposomes. Msb A reconstituted into liposomes showed higher transition frequency between different states on the cytoplasmic side, whereas detergent-solubilized Msb A showed higher transition frequency on the periplasmic side. Three major states were identified from this sm FRET study in the functional cycle of Msb A, including an intermediate conformation between the fully opened and fully closed cytoplasmic conformations, associated with both ATP binding and hydrolysis.

关键词： ABc transporter conformational change Single-molecule fluorescence resonance energy transfer (smFRET)

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