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Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man chen Shuo zhang Shi-Qi Gao michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

P-type ATPases use a domain-association mechanism to couple ATP hydrolysis to conformational change

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Biophysics Reports 2019年第4期5卷 167-175页

作者： Xuejun c.zhang Hongwei zhang National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences University of chinese Academy of Sciences

INTRODUcTION Since J. Skou discovered the Na?–K?pump in peripheral nerves more than 60 years ago(Skou 1957), the number of isolated phosphorylation-type ATPases(P-type ATPases or P-ATPases) has grown largely(Palmgren and Nissen 2011). While over 160,000 entries of P-ATPases from both eukaryotes and prokaryotes have currently been documented in the Inter Pro database,they are especially widespread and rich in subtypes in eukaryotes(Kuhlbrandt 2004). A common function of the members from this family is to convert energy derived from ATP hydrolysis into electrochemical potential by transporting cations across plasma membranes or sequestrating them into membranecompartmented organelles. In turn,

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Two-state model explaining thermodynamic regulation of thermogating channels

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Biophysics Reports 2022年第4期8卷 205-211页

作者： Xuejun c.zhang Zhuoya Yu National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences college of Life Sciences University of Chinese Academy of Sciences

Temperature-sensitive ion channels, such as those from the TRP family(thermo-TRPs) present in all animal cells, serve to perceive heat and cold sensations. A considerable number of protein structures have been reported for these ion channels, providing a solid basis for revealing their structure–function relationship. Previous functional studies suggest that the thermosensing ability of TRP channels is primarily determined by the properties of their cytosolic domain. Despite their importance in sensing and wide interests in the development of suitable therapeutics, the precise mechanisms underlying acute and steep temperature-mediated channel gating remain enigmatic. Here, we propose a model in which the thermo-TRP channels directly sense external temperature through the formation and dissociation of metastable cytoplasmic domains. An open–close bistable system is described in the framework of equilibrium thermodynamics, and the middle-point temperature T? similar to the V?parameter for a voltage-gating channel is defined. Based on the relationship between channel opening probability and temperature, we estimate the change in entropy and enthalpy during the conformational change for a typical thermosensitive channel. Our model is able to accurately reproduce the steep activation phase in experimentally determined thermal-channel opening curves, and thus should greatly facilitate future experimental verification.

关键词： Temperature sensing Thermo-TRPs Thermo-gating channel Two-state model Differential conformation energy

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Nanomaterials for environmental burden reduction,waste treatment,and nonpoint source pollution control:a review

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Frontiers of Environmental Science & Engineering 2009年第3期3卷 249-264页

作者： Guobin SHAN Rao Y.SURAMPALLI Rajeshwar D.TYAGI Tian c.zhang INRS-ETE University of QuebecQuebecG1K 9A9Canada U.S.Environmental Protection Agency Kansas CityKS 66117USA civil Engineering University of Nebraska-LincolnOmahaNB 68182USA

Nanomaterials are applicable in the areas of reduction of environmental burden,reduction/treatment of industrial and agricultural wastes,and nonpoint source(NPS)pollution ***,environmental burden reduction involves green process and engineering,emissions control,desulfurization/denitrification of nonrenewable energy sources,and improvement of agriculture and food ***,reduction/treatment of industrial and agricultural wastes involves converting wastes into products,groundwater remediation,adsorption,delaying photocatalysis,and ***,NPS pollution control involves controlling water *** alter physical properties on a nanoscale due to their high specific surface area to volume *** are used as catalysts,adsorbents,membranes,and additives to increase activity and capability due to their high specific surface areas and nano-sized ***,nanomaterials are more effective at treating environmental wastes because they reduce the amount of material needed.

关键词： nanomaterials industrial agricultural nonpoint source pollution environmental burden reduction

A novel electrolytic-manganese-residues-and-serpentine-based composite(S-EMR) for enhanced cd(Ⅱ) and Pb(Ⅱ) adsorption in aquatic environment

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Rare Metals 2023年第1期42卷 346-358页

作者： Meng-Yu Ma Xuan Ke Yan-chang Liu Zhi-Hao Ha Ting Wang Jia Li Fan zhang Tian c.zhang college of Resources and Environmental Science South-Central Minzu UniversityWuhan430074China School of chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan430074China college of Engineering University of Nebraska-LincolnOmahaNE68182USA

Electrolytic manganese residue(EMR) is the waste slag generated from the electrolysis manganese *** a promising exploitable adsorbent,EMR has become a hot research ***,EMR’s low adsorption capacity has limited its applications as an efficient *** this study,the EMR was mixed with serpentine and calcined(at 800℃ for 2 h) to prepare a composite adsorbent(S-EMR) with its specific surface area of 11.998 m^(2)·g^(-1)(increased compared to the original EMR) and improved adsorption capacities for cd^(2+)(98.05 mg·g^(-1)) and Pb^(2+)(565.81 mg·g^(-1)).Kinetic studies have shown that the pseudo-first-order kinetics(PSO)model could best describe the adsorption kinetics of S-EMR for cd^(2+)/Pb^(2+),implying that the chemisorption process is the rate-limiting *** effects of different interfering ions on S-EMR’ s adsorption for cd^(2+)/Pb^(2+)may be due to the difference in their *** of response surface methodology tests showed that pH had the highest influence on adsorption,and the removal efficiency of S-EMR reached 99.92% for cd(Ⅱ) and 94.00%for Pb(Ⅱ).X-ray photoelectron spectroscopy(XPS) analyses revealed that chemical precipitation was the predominant mechanism for cd^(2+)/Pb^(2+)removal,and the adsorption mechanisms were associated with ion exchange and electrostatic *** results showed that S-EMR could be used as an effective adsorbent for the removal of cd(Ⅱ)/Pb(Ⅱ) from water bodies,rendering dual benefits of pollution control and resource recovery.

关键词： cadmium Lead Electrolytic manganese residue Serpentine Heavy metals

From waste to wealth:coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun Shen Xin zhang Lingcong chao Liang chen Ding zhang Tao Wei Shoudong Xu college of chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China college of chemistry Taiyuan University of TechnologyTaiyuan 030024China School of chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(cTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste cTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of cTR-derived carbons(cTRcs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of cTR-derived carbon carbonized at 900℃(cTRc-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(cV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of cTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of cTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

Towards understanding the mechanisms of proton pumps in complex-I of the respiratory chain

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Biophysics Reports 2019年第Z1期5卷 219-234页

作者： Xuejun c.zhang Bin Li National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences college of Life Science University of Chinese Academy of Sciences

INTRODUcTION complex-I(i.e., nicotinamide adenine dinucleotide(NADH):ubiquinone(quinone or Q) oxidoreductase) of the respiratory chain is crucial for converting energy from its redox form(i.e., electron transfer) to t...

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Microstructure and Mechanical Properties of Fe-based Amorphous composite coatings Reinforced by Stainless Steel Powders

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Journal of Materials Science & Technology 2015年第1期31卷 43-47页

作者： H.Zhou c.zhang W.Wang M.Yasir L.Liu School of Materials Science and Engineering State Key Lab for Materials Processing and Die &Mould TechnologyHuazhong University of Science and Technology Huazhong University of Science and Technology Research Institute in Shenzhen

In this study,a few Fe-based amorphous matrix composite coatings reinforced with various portions(4,8 and16 vol.%) of 31 6L stainless steel powders have been successfully produced through high velocity oxy-fuel(HVOF) *** microstructure of the composite coatings was systematically characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM) and transmission electron microscopy(TEM).The main structure of composite coatings remained amorphous while 31 6L stainless steel splats were distributed homogeneously in the amorphous matrix and well connected with surrounding amorphous *** strength of coatings to the substrate was determined by 'pull-off' tensile *** results revealed that the31 6L stainless steel phase effectively improved the bonding strength of amorphous coatings,which is mainly contributed by the strong metallurgical bonding between stainless steel and amorphous *** addition of31 6L stainless steel also enhanced the ductility and fracture resistance of the coatings due to the ductile stainless steel phases,which can arrest crack propagation and increase energy dissipation.

关键词： Thermal spraying Fe-based amorphous coating Stainl