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PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation

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World Journal of Gastroenterology 2006年第7期12卷 1049-1055页

作者： Uwe Grutzner Melanie Keller michael bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar Institute for Surgical Research Klinikum GroBhadernUniversity of MunichD-81377 MunichGermany Department of Pharmacy University of MunichD-81377 MunichGermany Department Institute of Pathology University of MunichD-81377 MunichGermany

AIM： To investigate the in vivo effect of atrial natriuretic peptide （ANP） and its signaling pathway during orthotopic rat liver transplantation.METHODS： Rats were infused with NaCI, ANP （5 μg/ kg）, wortmannin （WH, 16μg/kg）, or a combination of both for 20 min. Livers were stored in UW solution （4℃） for 24 h, transplanted and reperfused. Apoptosis was examined by caspase-3 activity and TUNEL staining. Phosphorylation of Akt and Bad was visualized by Western blotting and phospho-Akt-localization by confocal microscopy.RESULTS： ANP-pretreatment decreased caspase-3 activity and TUNELopositive cells after cold ischemia, indicating antiapoptotic effects of ANP in vivo. The an- tiapoptotic signaling of ANP was most likely caused by phosphorylation of Akt and Bad, since pretreatment with PI 3-kinase inhibitor WM abrogated the ANP-induced reduction of caspase-3 activity. Interestingly, analysis of liver tissue by confocal microscopy showed translocation of phosphorylated Akt to the plasma membrane of hepa- tocytes evoked by ANP.CONCLUSION： ANP activates the PI-3-kinase pathway in the liver in vivo leading to phosphorylation of Bad an event triggering antiapoptotic signaling cascade in ischemic liver.

关键词： Bad Apoptosis Hormonal preconditioning Ischemia reperfusion injury

Stainless Steel Composite Integrated in Modern Facade Engineering

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Journal of Mechanics Engineering and Automation 2015年第8期5卷 427-434页

作者： Marc Tulke Jennifer Watzke michael Schomacker Alexander Brosius Janine bach Helmut Hachul TU Dresden Institute of Manufacturing Technology Chair of Forming and Machining Processes Dresden 01062 Germany University of Applied Science and Arts Dortmund Architecture and Metal Construction Dortmund 44227 Germany

This paper shows the results of characterising a stainless steel composite material for applications in facade engineering. A number of possible shapes generated with pneumatic stretch forming are presented as a result of simulation studies. In this context a model of a possible facade combined from different shapes is created to show the optical effect of the simulated shapes. Additionally, the manufacturing of a device for pneumatic stretch forming is discussed and first results of transforming the stainless steel composite material with pneumatic stretch forming are shown.

关键词： Composite design facades lightweight pneumatic forming

Body Composition and Performance Capabilities Based on Protein Intake in Collegiate Dancers： A Pilot Study

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Journal of Sports Science 2017年第4期5卷 189-197页

作者： Ann Frost Brown Christopher William bach Giuliana De Almeida Shawn Leonard Tom Welsh michael James Ormsbee Institute of Sports Sciences and Medicine Department of Nutrition Food and Exercise Sciences Florida State UniversityTallahassee FL 32306 USA Department of Movement Sciences University of Idaho Moscow ID 83843 USA University of Nebraska-Lincoln Nebraska Athletic Performance Laboratory Lincoln NE 68588 USA School of Dance Florida State University Tallahassee FL 32306 USA Department of Biokinetics Exercise and Leisure Sciences University of KwaZulu-Natal Durban 4000 South Africa

The aesthetic nature of dance places pressure on the athlete to have low body weight and fat and despite data showing higher protein intake improving body composition in numerous populations, a paucity of data exists on dancers. Therefore, the purpose of this study was to examine associations between protein intake, body composition and performance among dancers. Female dancers （n = 25; age 20.7 ± 1.8 years; mean ± SD） completed three-day diet logs, body composition （DXA）, and performance testing. Protein intake was expressed as g/kg/day and three equal tertiles were created （Low protein： LP, 〈 1.2 g/kg/day; Moderate protein： MP, 1.2-1.6 g/kg/day; High protein： HP, 〉 1.6 g/kg/day）. Data were analyzed using one-way ANOVA to compare group means with significance at P 〈 0.05. Protein and energy intake were greater in HP compared to LP （P = 0.001, 0.033, respectively）. The only performance difference observed was peak horizontal force （AMTI force platform） which was significantly greater in HP compared to LP （LP： 295.7 ± 111.1N, HP： 419.9 ± 76.7N; P = 0.029）. In conclusion, no significant differences were found between protein tertiles and body composition. Nevertheless, protein intake may be physiologically important to dancers when combined with evidence from other athletic .populations indicating high protein and energy intake may be beneficial to body composition.

关键词： Body composition nutrition protein performance dance.

Stem cell-based therapy for human diseases

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3242-3282页

作者： Duc M.Hoang Phuong T.Pham Trung Q.bach Anh T.L.Ngo Quyen T.Nguyen Trang T.K.Phan Giang H.Nguyen Phuong T.T.Le Van T.Hoang Nicholas R.Forsyth michael Heke Liem Thanh Nguyen Department of Research and Development Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Department of Cellular Therapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Institute for Science&Technology in Medicine Keele UniversityKeeleUK a Department of Biology Stanford UniversityStanfordCAUSA

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be *** cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative *** are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ *** are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(AT),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular ***,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical *** mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment.

关键词： diseases distress treatment

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全球漂白化学浆可能出现供应过剩和定价调整

生活用纸 2022年第12期22卷 39-40页

作者： michael J Long Pierre E bach 孙静(终审) 英国Hawkins Wright公司

目前,全球漂白化学浆(BCP)的年产能约为6,800万t,包括各种纸浆漂白针叶木硫酸盐浆(BSKP)2,810万t、漂白阔叶木硫酸盐浆(BHKP)3,960万t、亚硫酸盐浆30万t产能,另外还有460万t的高得率纸浆产能和400万t本色硫酸盐浆(UKP)产能。拉丁美洲的... 详细信息

目前,全球漂白化学浆(BCP)的年产能约为6,800万t,包括各种纸浆漂白针叶木硫酸盐浆(BSKP)2,810万t、漂白阔叶木硫酸盐浆(BHKP)3,960万t、亚硫酸盐浆30万t产能,另外还有460万t的高得率纸浆产能和400万t本色硫酸盐浆(UKP)产能。拉丁美洲的阔叶木浆产能持续增长,而针叶木浆领域的投资却在放缓,这一趋势意味着未来可能出现供应不足。

关键词：亚硫酸盐浆针叶木浆漂白化学浆阔叶木浆漂白针叶木硫酸盐浆漂白阔叶木硫酸盐浆供应过剩供应不足

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带双质量飞轮的动力传动系统各种工况的仿真

传动技术 2008年第3期22卷 3-16页

作者： Hartmut bach Wolfgang Kücks michael Triebel ZF Sachs AG Schweinfurt

节约实车试验和减少开发周期和成本的一个必不可少的工具是通过各种行驶条件下的仿真来确定双质量飞轮(DMF)的最优参数。另外,仿真还能确定应用于当前设计的新方法的效能。

关键词： X-CT技术扫描检测

Beck自杀意念量表中文版在社区成年人群中应用的信效度

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中国心理卫生杂志 2010年第4期24卷 250-255页

作者：李献云费立鹏童永胜李可进张亚利张艳萍徐东牛雅娟北京回龙观医院北京心理危机研究与干预中心WHO心理危机预防研究与培训合作中心北京100096

目的:评估Beck自杀意念量表中文版(Beck Scale for Suicide Ideation-Chinese Version,BSICV)在国内社区成年人群中的应用情况。方法:选定天津市区(城市)和山东省莱芜市莱城区(农村)作为调查现场,采用多阶段分层随机抽样方法抽取≥18岁... 详细信息

目的:评估Beck自杀意念量表中文版(Beck Scale for Suicide Ideation-Chinese Version,BSICV)在国内社区成年人群中的应用情况。方法:选定天津市区(城市)和山东省莱芜市莱城区(农村)作为调查现场,采用多阶段分层随机抽样方法抽取≥18岁的社区居民,由受过培训的调查员使用包含BSI-CV[评估最近1周及最消沉、最忧郁或自杀倾向最严重时(简称最严重时)的状况]在内的调查表进行一对一入户调查。569例城市居民和603例农村居民完成首次调查,以评估量表的内部一致性和效度;在首次调查后第5～8天,对调查前期完成首次调查的256例城市受试和504例农村受试依次进行了重测,以检验量表的重测一致性。结果:(1)量表的内部一致性。首次调查全部受试最近1周和最严重时量表总分的Cron-bachα值分别为0.68和0.87,城市受试0.72和0.84,农村受试0.57和0.88。(2)量表的重测一致性。最近一周和最严重时量表总分的ICC全部受试为0.64和0.76,城市受试0.84和0.76,农村受试0.39和0.76。(3)量表的效度。首次调查有自杀未遂史者(N=12)最严重时BSI-CV总分高于无自杀未遂史者(N=1146)[(9.75±9.79)vs.(0.86±3.17),P<0.001],但两组最近一周BSI-CV总分差异无统计学意义[(0.42±0.79)vs.(0.14±0.78),P=0.057]。结论:Beck自杀意念量表中文版在国内社区成年人群中应用的信效度较好,特别是最消沉、最忧郁或自杀倾向最严重时的状况评分。

关键词：量表自杀意念信度效度社区人群现况调查