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Multimode vibrational strong coupling in direct laser written mid-IR plasmonic MIM nano-patch antennas

Photonics Research 2023年第12期11卷 2136-2148页

作者： NICHOLAS V.PROSCIA michael a.meeker NICHOLAS SHARAC FRANK K.PERKINS CHASE T.ELLIS PAUL D.CUNNINGHAM JOSEPH G.TISCHLER NRC Postdoc residing at U.S.Naval Research Laboratory WashingtonD.C.20375USA U.S.Naval Research Laboratory WashingtonD.C.20375USA Current address:Rigetti Computing FreemontCalifornia 94538USA Current address:Homer L.Dodge Department of Physics and Astronomy The University of OklahomaNormanOklahoma 73019USA

Strong coupling of mid-infrared(mid-IR)vibrational transitions to optical cavities provides a means to modify and control a material’s chemical reactivity and offers a foundation for novel chemical detection ***,the relatively large volumes of the mid-IR photonic cavities and weak oscillator strengths of vibrational transitions restrict vibrational strong coupling(VSC)studies and devices to large ensembles of molecules,thus representing a potential limitation of this nascent ***,we experimentally and theoretically investigate the mid-IR optical properties of 3D-printed multimode metal-insulator-metal(MIM)plasmonic nanoscale cavities for enabling strong light-matter interactions at a deep subwavelength *** observe strong vibration-plasmon coupling between the two dipolar modes of the L-shaped cavity and the carbonyl stretch vibrational transition of the polymer *** cavity mode volume is half the size of a typical square-shaped MIM geometry,thus enabling a reduction in the number of vibrational oscillators to achieve strong *** resulting three polariton modes are well described by a fully coupled multimode oscillator model where all coupling potentials are *** 3D printing technique of the cavities is a highly accessible and versatile means of printing arbitrarily shaped submicron-sized mid-IR plasmonic cavities capable of producing strong light–matter interactions for a variety of photonic or photochemical ***,similar MIM structures fabricated with nanoscopic voids within the insulator region could constitute a promising microfluidic plasmonic cavity device platform for applications in chemical sensing or photochemistry.

关键词： coupling vibrational shaped

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The new wave of p75 neurotrophin receptor targeted therapies

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Neural Regeneration Research 2022年第1期17卷 95-96页

作者： Amanda M.Crooks Rick B.meeker UNC School of Medicine University of North CarolinaChapel HillNCUSA(Crooks AM)Department of NeurologyUniversity of North CarolinaChapel HillNCUSA

Neurotrophins have been recognized for decades for their beneficial effects on growth,survival,and maintenance in the central nervous system,all of which suggest potential therapeutic *** understanding and harnessing the activity of neurotrophins has proven difficult,the past several years have seen significant strides in the development of deliverable therapies that modulate neurotrophin activity(Shen et al.,2019;Yang et al.,2020;Xie et al.,2021).These recent studies have primarily focused on the multifunctional p75 neurotrophin receptor(p75NTR)which is upregulated in central nervous system disease and injury,thus offering a unique target for intervention.

关键词： al. therapies p75

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The p75 neurotrophin receptor:at the crossroad of neural repair and death

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Neural Regeneration Research 2015年第5期10卷 721-725页

作者： Rick B.meeker Kimberly S.Williams Department of Neurology University of North Carolina Curriculum in Neurobiology University of North Carolina

The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease. However, difficulties with the clinical implementation of neurotrophin therapies have prompted the search for treatments that are stable, easier to deliver and allow more precise regula- tion of neurotrophin actions. Recently, the p75 neurotrophin receptor （p75wrR） has emerged as a potential target for pharmacological control of neurotrophin activity, supported in part by stud- ies demonstrating 1） regulation of neural plasticity in the mature nervous system, 2） promotion of adult neurogenesis and 3） increased expression in neurons, macrophages, microglia, astro- cytes and/or Schwann cells in response to injury and neurodegenerative diseases. Although the receptor has no intrinsic catalytic activity it interacts with and modulates the function of TrkA, TrkB, and TrkC, as well as sortilin and the Nogo receptor. This provides substantial cellular and molecular diversity for regulation of neuron survival, neurogenesis, immune responses and pro- cesses that support neural function. Upregulation of the p75^NTR under pathological conditions places the receptor in a key position to control numerous processes necessary for nervous system recovery. Support for this possibility has come from recent studies showing that small, non-pep- tide p75^NTR ligands can selectively modify pro-survival and repair functions. While a great deal remains to be discovered about the wide ranging functions of the p75^NTR, studies summarized in this review highlight the immense potential for development of novel neuroprotective and neu- rorestorative therapies.

关键词： injury plasticity neurodegenerative disease brain therapy neuron microglia neuralprogenitor

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Association between tourniquet use and intraoperative blood loss during below-knee amputation

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World Journal of Orthopedics 2022年第7期13卷 644-651页

作者： Alden E Wyland Erik Woelber Liam H Wong Jordan Arakawa Zachary M Working James meeker School of Medicine Oregon Health and Sciences UniversityPortlandOR 97239United States Department of Orthopaedics and Rehabilitation Oregon Health and Sciences UniversityPortlandOR 97239United States

BACKGROUND Despite over 150000 amputations of lower limbs annually,there remains a wide variation in tourniquet practice patterns and no consensus on their necessity,especially among orthopedic patient *** purpose of this study was to determine whether tourniquet use in orthopedic patients undergoing below knee amputation(BKA) was associated with a difference in calculated blood loss relative to no tourniquet *** To determine if tourniquet use in orthopedic patients undergoing BKA was associated with a difference in calculated blood loss relative to no tourniquet *** We performed a retrospective review of consecutive patients undergoing BKA by orthopedic surgeons at a tertiary care hospital from 2008 through *** loss was calculated using a combination of the Nadler equation for preoperative blood volume and a novel formula utilizing preoperative and postoperative hemoglobin levels and *** and forwards step-wise multivariate linear regressions were performed to determine the association between tourniquet use and blood loss.A Wilcoxon was used to determine the univariate relationship between tourniquet use and blood loss for in the restricted subgroups of patients who underwent BKA for trauma,tumor,and *** Of 97 eligible patients identified,67 underwent surgery with a tourniquet and 30 did *** multivariate regression,tourniquet use was associated with a 488 mL decrease in calculated blood loss(CI 119-857,P = 0.01).In subgroup analysis,no individual group showed a statistically significant decrease in blood loss with tourniquet *** was no significant association between tourniquet use and either postoperative transfusions or reoperation at one *** We found that tourniquet use during BKA is associated with decreased calculated intraoperative blood *** recommend that surgeons performing this procedure use a tourniquet to minimize blood loss.

关键词： Amputation Tourniquet Blood loss Hemostasis

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小鼠SmX5基因mRNA的选择性剪接(英文)

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Acta Genetica Sinica 2003年第6期30卷 515-520页

作者：张毅张杰程慧 Nanthan D meeker Cory Teuscher 马润林中国科学院遗传与发育生物学研究所北京100101 DepartmentofVeterinaryPathobiology

通过RT PCR技术 ,发现小鼠SmX5基因的另外 3种选择性剪接体 ,分别命名为SmX5a、b和c。小鼠SmX5acDNA具有完整的内含子 1,而SmX5bcDNA含有部分内含子 2。SmX5c的保留片断和SmX5b在相同位置起始 ,但保留部分延伸经过余下的内含子 2。余下... 详细信息

通过RT PCR技术 ,发现小鼠SmX5基因的另外 3种选择性剪接体 ,分别命名为SmX5a、b和c。小鼠SmX5acDNA具有完整的内含子 1,而SmX5bcDNA含有部分内含子 2。SmX5c的保留片断和SmX5b在相同位置起始 ,但保留部分延伸经过余下的内含子 2。余下的DNA序列在所有内含子外显子边界处都符合剪接的“GT AG”规则。RT PCR的表达分析显示这 3种异构体都是稳定的转录产物 ,均通过剪接体特异性引物的PCR反应在mRNA水平上得到证实。和SmX5相比较 ,剪接体的出现频率都很低。RT PCR表达分析提示 ,SmX5和它的 3种异构体存在于小鼠的脑、肾、睾丸、胸腺、肝、脾和心脏。SmX5a主要在胸腺中表达 ,而SmX5b和c在所有组织都可以检测到。SmX5不同选择剪接体及其组织特异的不同剪接方式的存在 ,表明SmX5的表达是复杂的 ,并且所有 4种SmX5mR

关键词：自免疫睾丸炎差异剪接内含子保留 snRNP相关蛋白

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Protective links between vitamin D,inflammatory boweldisease and colon cancer

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World Journal of Gastroenterology 2016年第3期22卷 933-948页

作者： Stacey meeker Audrey Seamons Lillian Maggio-Price Jisun Paik Department of Comparative Medicine University of WashingtonSeattleWA 98195United States

Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease(IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer.

关键词： Vitamin D Inflammatory bowel disease Colitis Colon cancer Inflammation-associated coloncancer Mouse models

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12岁,我成了大学生

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少年文摘 2005年第8期 13-15页

作者： Jessica.meeker 杨柳岸

从小,我就被认为是个天才儿童。我并没有刻意地去追求这一切,比如说,16岁就从大学里毕业,可是,事情就是这样自然而然地发生了。

关键词：天才儿童大学校园大学毕业生大学生发生学习美国实在回答担心

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Inhibition of both TLR7 and TLR9 in lupus prone mice lead to reduction of autoantibody production and amelioration of disease symptoms

Inhibition of both TLR7 and TLR9 in lupus prone mice lead to...

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The 8th International Congress on SLE

作者： Thea.meeker Cristiana Guiducci Jean H.Chan Robert L.Coffman Franck J.Barrat Dynavax Technologies 2929 Seventh StreetSuite 100BerkeleyCA 94710USA Dynavax Technologies 2929 Seventh StreetSuite 100BerkeleyCA 94710USA Dynavax Technologies 2929 Seventh StreetSuite 100BerkeleyCA 94710USA Dynavax Technologies 2929 Seventh StreetSuite 100BerkeleyCA 94710USA Dynavax Technologies 2929 Seventh StreetSuite 100BerkeleyCA 94710USA

＜正＞Purpose:The presence of autoantibodies specific for nucleic acid-associated antigens is the hallmark of Systemic Lupus Erythematosus（SLE）.The implication of Toll-like receptor （TLR）-7 and TLR9 in the disease process has been increasingly scrutinized in both human and mouse systems, this latter by introducing either TLR9 or TLR7 deficiencies onto the MRL/lpr *** studies have lead to

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能适应宇宙环境工作的微波管的技术研究

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真空电子技术 1966年第3期 8-18页

作者： John G.meeker A.G.Peifer 钟曼莉

说明这篇报告共分5章描述,限于篇幅,仅选译了最有关的一章——第4章:"宇宙用微波管的设计"。译文中所用的章、节、段符号均按照原文。

关键词：电子注电流降压收集极导流系数行波放大器行波管放大器宇宙环境微波管超高频电子管

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格陵兰冰芯记录的大气环流变化及其与南极冰芯的比较(英)

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冰川冻土 1998年第4期20卷 398-407页

作者： P.A.Mayewski L.D.meeker M.S.Twickler S.Whitlow Q.Yang K.Kreutz D.Reusch University of New Hampshire 美国

The GISP2, central Greealand, glaciochemical series (sodium, potassium, ammonium,calcium, magnesium, sulfate, nitrate and chloride) provides a unique view of the chemistry of the atmosphere and the history of atmospheric circulation over much of the Northern Hemisphere. Interpretation of this record reveals the controls on both high and low frequency climate events of the last 110 000 *** in insolation on the order of the major orbital cycles control the long-term behavior of atmospheric circulation patterns through changes in ice volume (sea level) and related positive *** such as the Heinrich events (massive discharges of icebergs first identified in the marine record)are found to operate on a 6 100 year cycle due largely to the lagged response of ice sheets to changes in insolation and consequent glacier dynamics Rapid climate change events (massive reorganizations of atmospheric circulation) are demonstrated to operate on 1 450 year cycle possibly in response to internal oscillations in the ocean-atmosphere system or due to changes in solar output. Changes in insolation and associated positive feedbacks related to ice sheets assist in explaining favorable time periods and controls on the amplitude of these massive rapid climate change *** of the GISP2 glaciochemical series with an ice record from Taylor Dome in Antarctica indicates considerable similarity suggesting that both polar regions experience marked changes in climate. While preliminary evidence points to similar phasing of several major climate events in the two polar regions exact phasing cannot as yet be determined, because dating of Antarctic ice core records is not as well-established as the dating for Greenland ice cores.

关键词：古气候大气环流变化南极冰芯格陵兰冰芯

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