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Knowledge management and the entrepreneur:Insights from Ikujiro Nonaka's Dynamic Knowledge Creation model(SECI)

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International Journal of Innovation Studies 2017年第3期1卷 163-174页

作者： Cesar Bandera Fazel Keshtkar michael R.Bartolacci Shiromani Neerudu Katia Passerini New Jersey Institute of Technology NewarkNJUSA St.John's University QueensNYUSA Penn State Universityd Berks ReadingPAUSA

A key goal of knowledge management(KM)is to foster innovation through the ceation of new ***,there is little research on KM in the context of entrepre-neurship,a domain where innovation is considered *** paper extends estab-lished theories and frameworks for KM to the understudied context of KM in small and medium entrepreneurial firms,particularly young *** KM fr ameworks,such as the widely studied SECI model,into the entrepreneurial domain could eventually help startups in their quest for sustainability and *** SECI model is an aspir ational process with which to build new knowledge,including the explicit knowledge assets that startups commonly ***,an aspiration is only useful if the subject knows where he or she stands in relation to *** study focuses on understanding whether entre-preneurial activities embed into,and can further enable,the"virtuous"knowledge-creation *** secondary objective of this paper is to acknowledge Ikujiro Nonaka's contribution to western and eastern KM theories,and extend his seminal theories into other domains,such as small and medium *** work pilots the use of a content analysis technique largely used in psychology to analyze the connection between entrepreneurship and *** this method,the study highlights how the four phases of the SECI model apply to startup firms in a business incubator in the United *** provides insights into the knowledge-creation process of entrepreneurs,and suggests how entrepreneurs can improve startup survival through greater awareness and use of KM in their business planning and operational activities.

关键词： Entrepreneurship SECI Knowledge management(KM)Linguistic inquiry and word count(LIwC) Innovation

Uptake of prostate cancer screening and associated factors among Chinese men aged 50 or more: a population-based survey

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Cancer Biology & Medicine 2014年第1期11卷 56-63页

作者： winnie K.w.So Kai Chow Choi winnie P.Y.Tang Paul C.w.Lee Ann T.Y.Shiu Simone S.M.Ho Helen Y.L.Chan wendy w.T.Lam william B.Goggins Carmen w.H.Chan The Nethersole School of Nursing The Chinese University of Hong Kong Department of Community Medicine The University of Hong Kong The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong

Objective: To investigate the uptake rate of prostate specific antigen(PSA) testing among Hong Kong Chinese males aged 50 or above, and identify factors associated with the likelihood of undergoing a PSA ***: A population-based telephone survey was conducted in Hong Kong in 2007. The survey covered demographic information, perceived health status, use of complementary therapy, cancer screening behavior, perceived susceptibility to cancer and family history of cancer. Descriptive statistics, percentages and logistic regression analysis were used for data ***: A total of 1,002 men aged 50 or above took part in the study(response rate =67%), and the uptake rate of PSA testing was found to be 10%. Employment status, use of complementary therapy, perceiving regular visits to a doctor as good for health and the recommendations of health professionals were significant factors associated with PSA ***: The uptake rate of PSA testing in the study population was very low. Among all the factors identified, recommendations from health professionals had the strongest association with the uptake of PSA testing, and they should therefore take an active role in educating this population about cancer prevention and detection.

关键词： Prostatic neoplasms early detection of cancer prostate-specific antigen (PSA) population-based survey

Two-photon lithography for 3D magnetic nanostructure fabrication

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Nano Research 2018年第2期11卷 845-854页

作者： Gwilym williams Matthew Hunt Benedikt Boehm Andrew May michael Taverne Daniel Ho Sean Giblin Dan Read John Rarity Rolf Allenspach Sam Ladak School of Physics and Astronomy Cardiff University Cardiff UK IBM Research - Zurich Rüschlikon Switzerland Department of Electrical and Electronic Engineering University of Bristol Bristol UK

Ferromagnetic materials have been utilized as recording media in data storage devices for many decades. The confinement of a material to a two-dimensional plane is a significant bottleneck in achieving ultra-high recording densities, and this has led to the proposition of three-dimensional （3D） racetrack memories that utilize domain wall propagation along the nanowires. However, the fabrication of 3D magnetic nanostructures of complex geometries is highly challenging and is not easily achieved with standard lithography techniques. Here, we demonstrate a new approach to construct 3D magnetic nanostructures of complex geometries using a combination of two-photon lithography and electrochemical deposition. The magnetic properties are found to be intimately related to the 3D geometry of the structure, and magnetic imaging experiments provide evidence of domain wall pinning at the 3D nanostructured junction.

关键词： magnetism spintronics nanomagnefism three-dimensional (3D)lithography

Tissue-specific Tregs in cancer metastasis:opportunities for precision immunotherapy

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Cellular & Molecular Immunology 2022年第1期19卷 33-45页

作者： Laura A.Huppert michael D.Green Luke Kim Christine Chow Yan Leyfman Adil I.Daud James C.Lee Division of Hematology/Oncology Department of MedicineUniversity of CaliforniaSan FranciscoSan FranciscoCAUSA Department of Radiation Oncology University of Michigan School of MedicineAnn ArborMIUSA Veterans Affairs Ann Arbor Healthcare System Ann ArborMIUSA University of California San Francisco School of MedicineSan FranciscoCAUSA Penn State College of Medicine HersheyPAUSA Parker Institute for Cancer Immunotherapy San FranciscoCAUSA

Decades of advancements in immuno-oncology have enabled the development of current immunotherapies,which provide longterm treatment responses in certain metastatic cancer ***,cures remain infrequent,and most patients ultimately succumb to treatment-refractory metastatic *** insights suggest that tumors at certain organ sites exhibit distinctive response patterns to immunotherapy and can even reduce antitumor immunity within anatomically distant tumors,suggesting the activation of tissue-specific immune tolerogenic mechanisms in some cases of therapy *** immune cells known as regulatory T cells(Tregs)are present within all tissues in the body and coordinate the suppression of excessive immune activation to curb autoimmunity and maintain immune *** the high volume of research on Tregs,the findings have failed to reconcile tissue-specific Treg functions in organs,such as tolerance,tissue repair,and regeneration,with their suppression of local and systemic tumor immunity in the context of immunotherapy *** improve the understanding of how the tissue-specific functions of Tregs impact cancer immunotherapy,we review the specialized role of Tregs in clinically common and challenging organ sites of cancer metastasis,highlight research that describes Treg impacts on tissue-specific and systemic immune regulation in the context of immunotherapy,and summarize ongoing work reporting clinically feasible strategies that combine the specific targeting of Tregs with systemic cancer *** knowledge of Tregs in the framework of their tissue-specific biology and clinical sites of organ metastasis will enable more precise targeting of immunotherapy and have profound implications for treating patients with metastatic cancer.

关键词： Tissue Tregs Immunotherapy Organ-specific tolerance Metastasis Cancer

The Impact of Non—Gaussian Distribution Traffic on Network Performnce

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Journal of Computer Science & Technology 2002年第1期17卷 106-111页

作者：金志刚 Oliverw.w.Yang 等 DepartmentofComputerScience TianjinUniversityTianjin300072P.R.China SchoolofInformationTechnologyandEngineering UniversityofOttawaOttawaOntarioCanadaK1N6N5

Recent extensive measurements of real-life traffic demonstrate that the probability density function of the traffic in *** a traffic model does not capture this characteristics,any analytical or simulation results will not be *** this work,we study the impact of non-Gaussian traffic on network performance,and present an approach that can accurately model the marginal distribution of real-life *** the long-and short-range autocorrelations are also *** show that the removal of non-Gaussian components of the process does not change its correlation structure,and we validate our promising procedure by simulations.

关键词： non-Gaussian self-similarity performance

A review of adjuvants forLeishmania vaccine candidates

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The Journal of Biomedical Research 2010年第1期24卷 16-25页

作者： Joshua M.Mutiso John C.Macharia michael M.Gicheru Department of Tropical and Infectious Diseases Institute of Primate ResearchNational Museums of Kenya Department of Zoological Sciences School of Pure and Applied SciencesKenyatta University

Over the last decade, there has been a flurry of research on adjuvants for vaccines, and several novel adjuvants are now licensed products or in late stage clinical development. The success of adjuvants in enhancing the immune response to antigens has led many researchers to re-focus their vaccine development programs. Although several vaccine candidates have been tested against leishmaniasis, there is yet no effective vaccine against this parasitic disease. Recent research has documented that efforts to develop effective Leishmania vaccine have been limited due to lack of an appropriate adjuvant. In view of this, this review paper outlines some of the adjuvants that have been used in Leishmania vaccine candidates and cites a few of the responses obtained from these studies. The aim of the present review is to consolidate these findings to facilitate the application of these adjuvants in general and experimental vaccinology.

关键词： adjuvants Leishmania vaccines immune responses leishmaniasis.

COVID-19 vaccine-associated myocarditis

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world Journal of Cardiology 2022年第7期14卷 382-391页

作者： michael C Morgan Lavannya Atri Sean Harrell wael Al-Jaroudi Adam Berman Division of Cardiology Medical College of GeorgiaAugustaGA 30912United States Baptist Heart Baptist Medical CenterJacksonMS 39202United States Department of Population Health Sciences Medical College of GeorgiaAugustaGA 30912United States

Myocarditis is now recognized as a rare complication of coronavirus disease 2019(COVID-19)mRNA vaccination,particularly in adolescent and young adult *** the authorization of the Pfizer-BioNTech^(TM)and Moderna^(TM)mRNA vaccines targeting the severe acute respiratory syndrome coronavirus-2(SARSCoV-2)spike protein,the Centers for Disease Control and Prevention(CDC)has reported 1175 confirmed cases of myocarditis after COVID-19 vaccination in individuals ages 30 years and younger as of January *** to CDC data in June 2021,the incidence of vaccine-mediated myocarditis in males ages 12-29 years old was estimated to be 40.6 cases per million second doses of COVID-19 mRNA vaccination *** with cases of COVID-19 vaccinemediated myocarditis typically present with acute chest pain and elevated serum troponin levels,often within one week of receiving the second dose of mRNA COVID-19 *** cases follow a benign clinical course with prompt resolution of *** mechanisms of COVID-19 vaccine myocarditis include molecular mimicry between SARS-CoV-2 spike protein and self-antigens and the triggering of preexisting dysregulated immune pathways in predisposed *** higher incidence of COVID-19 vaccine myocarditis in young males may be explained by testosterone and its role in modulating the immune response in *** is limited data on long-term outcomes in these cases given the recency of their *** CDC continues to recommend COVID-19 vaccination for everyone 5 years of age and older given the greater risk of serious complications related to natural COVID-19 infection including hospitalization,multisystem organ dysfunction,and *** study is needed to better understand the immunopathology and long-term outcomes behind COVID-19 mRNA vaccine-mediated myocarditis.

关键词： COVID-19 SARS-CoV-2 mRNA vaccine Myocarditis Pericarditis

Supramolecular approaches for insulin stabilization without prolonged duration of action

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2281-2290页

作者： Rolande Meudom Yanxian Zhang michael A.VandenBerg Lei Zou Yi wolf Zhang Matthew J.webber Danny Hung-Chieh Chou Division of Endocrinology and Diabetes Department of PediatricsSchool of MedicineStanford UniversityPalo AltoCA 94305USA Department of Biochemistry School of MedicineUniversity of UtahSalt Lake CityUT 84112USA Department of Chemical Engineering University of Notre DameNotre DameIN 46556USA

Aggregation represents a significant challenge for the long-term formulation stability of insulin *** supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol(CB[7]-PEG)has been shown to stabilize insulin formulations by reducing aggregation *** prolonged in vivo duration of action,arising from sustained complex formation in the subcutaneous depot,limits the application scope for meal-time insulin uses and could increase hypoglycemic risk several hours after a *** affinity of CB[7]in binding the B1-Phe residue on insulin is central to supramolecular PEGylation using this ***,here we synthesized N-terminal acid-modified insulin analogs to reduce CB[7]interaction affinity at physiological pH and reduce the duration of action by decreasing the subcutaneous depot effect of the *** insulin analogs show weak to no interaction with CB[7]-PEG at physiological pH but demonstrate high formulation stability at reduced ***,N-terminal modified analogs have in vitro and in vivo bioactivity comparable to native ***,in a rat model of diabetes,the acid-modified insulin formulated with CB[7]-PEG offers a reduced duration of action compared to native insulin formulated with CB[7]-*** work extends the application of supramolecular PEGylation of insulin to achieve enhanced stability while reducing the risks arising from a subcutaneous depot effect prolonging in vivo duration of action.

关键词： Diabetes mellitus Insulin aggregation Supramolecular PEGylation Selective N-Terminal modification N-terminal acid-modified insulin Subcutaneous depot Hypoglycemia Subcutaneous administration

Characteristics of patients with erectile dysfunction in a family physicianled erectile dysfunction clinic:Retrospective case series

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Family Medicine and Community Health 2017年第1期5卷 85-91页

作者： Lap Kin Chiang Cheuk-wai Kam Kin-Chung michael Yau Lorna Ng Family Medicine and General Outpatient Department Kwong Wah HospitalMongkokHong KongChina

Objectives:*** examine the characteristics of patients with erectile dysfunction in a family physician led erectile dysfunction clinic;*** review association of chronic disease spectrum and erectile dysfunction;*** review initial treatment pattern and ***:Retrospective case series ***:All consecutive patients seen in a regional hospital family physician led erectile dysfunction clinic from April 2014 to March *** outcome measures:*** severity of erectile dysfunction,based on International Index of Erectile Function(IIEF-5).*** associated chronic comorbidities of *** patterns and patient ***:One hundred and eighty three patients presented with erectile dysfunction(ED)with mean age 58.7(range 23 to 82)years old were seen during the study *** hundred and twenty seven patients(69.4%)had comorbidity of chronic diseases,including 50.8%had hypertension,38.8%had diabetes mellitus and 33.9%had *** mean body mass index was 25.2 kg/m2,the mean blood pressure was 137.3/79.5 mm Hg(1 mm Hg=0.133 kPa).According to IIEF-5 score,50.3%,30.6%and 18.6%had severe,moderate and mild erectile dysfunction *** average duration of ED before seeking medical help was 3.9 *** 5(PDE5)inhibitors were prescribed to 119 patients(65%),and 57.1%of them achieved good *** nine patients(15.8%)were referred to other specialty for further management,including 27.6%had contraindication for PDE5 ***:High proportion of erectile dysfunction patients had comorbitiy of chronic dis-eases.57.1%of those patients receiving PDE5 inhibitors showed good response.

关键词： Erectile dysfunction chronic diseases family physician