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Structure-function relationship comparison between retinal nerve fibre layer and Bruch's membrane opening-minimum rim width in glaucoma

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1534-1538页

作者： Lukas Reznicek Sophie Burzer Andrea Laubichler Ali Nasseri Chris P Lohmann Nikolaus Feucht michael ulbig Mathias Maier Department of Ophthalmology Technical University of Munich

AIM：To evaluate and compare structural optical coherence tomography（OCT）-based parameters,such as Bruch’s membrane opening-minimum rim width（BMO-MRW）,and retinal nerve fiber layer（RNFL）thickness in glaucoma patients with visual field（VF）defects,and to correlate both to mean deviation（MD）values of obtained standard achromatic perimetry（SAP）***：Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy *** study participants underwent a full ophthalmic examination and VF testing with *** RNFL thickness and BMO-MRW were acquired with *** analyses between obtained global functional and global as well as sectorial structural parameters were ***：A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36healthy right eyes of 36 individuals in the control *** MD of values correlated significantly with global RNFL（Pearson ***：0.632,P=0.001）and global BMO-MRW（Pearson ***：0.746,P〈0.001）values in the glaucoma *** MD and sectorial RNFL or BMO-MRW values correlated less *** the control group,MD values did not correlate with RNFL or BMO-MRW measurements.A subgroup analysis of myopic patients（〉4 diopters）within the glaucoma group（n=6）revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL ***：In a clinical setting,RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients.

关键词： glaucoma optical coherence tomography Bruch's membrane opening-minimum rim width retinal nerve fibre layer myopia standard automated perimetry visual field defects

糖尿病视网膜病变中微动脉瘤荧光素渗出与视网膜增厚的关系(英文)

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国际眼科杂志 2011年第7期11卷 1137-1139页

作者： Lukas Reznicek Marcus Kernt Christos Haritoglou michael ulbig Anselm Kampik Aljoscha S Neubauer Ludwig-Maximilians大学眼科

目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光... 详细信息

目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光素渗出与未渗出各1眼配对进行对比。在微动脉瘤和直径为1mm区域使用光学相干断层成像术(OCT)测量视网膜厚度。结果:微动脉瘤荧光素渗出眼视网膜厚度明显高于未渗出眼(356±69μmvs318±56μm,P<0.001),渗出眼平均增长厚度高于未渗出眼(95%的可信区间为25～51μm,P<0.001).在直径为1mm区域,渗出眼视网膜厚度和平均增长厚度均明显高于未渗出眼(351±67μmvs319±59μm;最小值311±62μmvs284±60μm;最大值389±78μmvs352±66μm)。结论:血管荧光素造影显示微动脉瘤荧光素渗出可以增加视网膜厚度,并运用高分辨率OCT测量。因此,对糖尿病视网膜病变患者早期诊断微动脉瘤荧光素是否渗出可以抑制视网膜增厚。

关键词：糖尿病视网膜病变微动脉瘤视网膜厚度 OCT

视网膜耳蜗脑微血管病并突发周边视野缺损及听力损失:Susac综合征1例(英文)

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国际眼科杂志 2010年第2期10卷 222-224页

作者： Marcus Kernt Aljoscha S Neubauer Stephan Thurau Mi-chael W ulbig 路德维希马克西米利安大学眼科

目的:报告1例25岁女性患Susac综合征(SS),突发周边视野缺损及听力丧失。方法:报告1例25岁女性患者突发周边视野缺损及听力丧失,并记录视网膜超广角血管造影检查结果之间的相互关系以及所展现的视野缺损。结果:患者显现出SS特有的临床三... 详细信息

目的:报告1例25岁女性患Susac综合征(SS),突发周边视野缺损及听力丧失。方法:报告1例25岁女性患者突发周边视野缺损及听力丧失,并记录视网膜超广角血管造影检查结果之间的相互关系以及所展现的视野缺损。结果:患者显现出SS特有的临床三联征。我们可以看出视网膜超广角血管造影检查结果和视野缺损之间的一些相互关系。结论:经证明超广角血管造影术是一个在临床治疗中检测和追踪SS周围病变的有价值的工具。

关键词： Susac综合征广角血管造影术欧宝全景照相系统眼底成像视网膜微血管病

Diabetic retinopathy-ocular complications of diabetes mellitus

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World Journal of Diabetes 2015年第3期6卷 489-499页

作者： Martin M Nentwich michael W ulbig Department of Ophthalmology Ludwig-Maximilians University

In industrialized nations diabetic retinopathy is the most frequent microvascular complication of diabetes mellitus and the most common cause of blindness in the workingage *** the next 15 years,the number of patients suffering from diabetes mellitus is expected to increase *** the year 2030,about 440 million people in the age-group 20-79 years are estimated to be suffering from diabetes mellitus worldwide(prevalence 7.7%),while in 2010 there were 285 million people with diabetes mellitus(prevalence 6.4%).This accounts for an increase in patients with diabetes in industrializednations by 20% and in developing countries by 69% until the year *** to the expected rise in diabetic patients,the need for ophthalmic care of patients(i.e.,exams and treatments) will also increase and represents a challenge for eye-care *** of optimized screening programs,which respect available resources of the ophthalmic infrastructure,will become even more *** reasons for loss of vision in patients with diabetes mellitus are diabetic macular edema and proliferative diabetic *** or progression of these potentially blinding complications can be greatly reduced by adequate control of blood glucose and blood pressure ***,regular ophthalmic exams are mandatory for detecting ocular complications and initiating treatments such as laser photocoagulation in case of clinical significant diabetic macular edema or early proliferative diabetic *** this way,the risk of blindness can considerably be *** advanced stages of diabetic retinopathy,pars-plana vitrectomy is performed to treat vitreous hemorrhage and tractional retinal *** recent years,the advent of intravitreal medication has improved therapeutic options for patients with advanced diabetic macular edema.

关键词： Laser photocoagulation Diabetic macularedema Diabetic retinopathy Intravitreal injection Prevention

Fabrication of sub-20 nm MoS_(2) horizontal nanowire on silicon substrates by inclusion of precursors into polystyrene-bpolyethylene oxide nanopatterns: Detailed structural investigation

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Nano Research 2024年第3期17卷 2145-2153页

作者： Tandra Ghoshal michael A.Morris School of Chemistry AMBER and CRANNTrinity College DublinDublinIrelandD02 AK60

Herein,we demonstrate the fabrication of sub-20 nm MoS_(2) horizontal nanowire arrays on silicon substrates using a self-assembled block copolymer assisted in situ inclusion *** separated long-range ordered polystyrene-b-polyethylene oxide(PS-b-PEO)block copolymer(BCP)line-space nanopatterns were achieved through thermo-solvent *** patterns produced had long-range order and domain sizes>1μ*** BCP structures were lightly etched and modified by anhydrous ethanol to facilitate insertion of molybdenum precursor within the film maintaining the parent BCP *** ordered molybdenum oxide nanowire arrays were then fabricated by ultraviolet(UV)/ozone treatment at room *** oxides were converted to sulphides by thermal evaporation at different temperatures in Ar/H_(2) environment.X-ray photoelectron spectroscopy revealed the composition and phases of the molybdenum oxide and sulphide *** mapping was performed to investigate the interfaces between the oxide and sulphide nanowires with the substrate *** formation and stability of the sulphide nanowires were studied at different *** photoluminescence and Raman properties were studied at different formation temperatures to investigate defects and estimate the number of layers.

关键词： MoS_(2) block copolymer nanowires inclusion X-ray photoelectron spectroscopy(XPS) mapping photoluminescence

Neuronal trafficking as a key to functional recovery in immune-mediated neuropathies

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Neural Regeneration Research 2024年第11期19卷 2331-2332页

作者： Felix Kohle michael Schroeter Department of Neurology University of Cologne and University Hospital CologneCologneGermany

Immune-mediated neuropathies are rare diseases of the peripheral nervous system(PNS),substantially affecting patients’functionality and quality of *** are amenable to immunomodulatory treatments,which in many cases stabilize disease progression,but long-term deficits persist in many *** long-term deficits are particularly observed in monophasic autoimmune neuropathies like Guillain-Barrésyndrome and also in chronic variants,e.g.,chronic inflammatory demyelinating neuropathy(Fadia et al.,2019).

关键词： diseases autoimmune

Design of a Level-3 electric vehicle charging station using a 1-MW solar system via the distributed maximum power point tracking technique

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CLEAN ENERGY 2024年第1期8卷 23-35页

作者： Balal, Afshin Giesselmann, michael Texas Tech Univ Dept Elect & Comp Engn Lubbock TX 79409 USA

Solar power is mostly influenced by solar irradiation, weather conditions, solar array mismatches and partial shading conditions. Therefore, before installing solar arrays, it is necessary to simulate and determine the possible power generated. Maximum power point tracking is needed in order to make sure that, at any time, the maximum power will be extracted from the photovoltaic system. However, maximum power point tracking is not a suitable solution for mismatches and partial shading conditions. To overcome the drawbacks of maximum power point tracking due to mismatches and shadows, distributed maximum power point tracking is utilized in this paper. The solar farm can be distributed in different ways, including one DC-DC converter per group of modules or per module. In this paper, distributed maximum power point tracking per module is implemented, which has the highest efficiency. This technology is applied to electric vehicles (EVs) that can be charged with a Level 3 charging station in <1 hour. However, the problem is that charging an EV in <1 hour puts a lot of stress on the power grid, and there is not always enough peak power reserve in the existing power grid to charge EVs at that rate. Therefore, a Level 3 (fast DC) EV charging station using a solar farm by implementing distributed maximum power point tracking is utilized to address this issue. Finally, the simulation result is reported using MATLAB((R)), LTSPICE and the System Advisor Model. Simulation results show that the proposed 1-MW solar system will provide 5 MWh of power each day, which is enough to fully charge similar to 120 EVs each day. Additionally, the use of the proposed photovoltaic system benefits the environment by removing a huge amount of greenhouse gases and hazardous pollutants. For example, instead of supplying EVs with power from coal-fired power plants, 1989 pounds of CO2 will be eliminated from the air per hour.

关键词： electric vehicles (EVs) distributed maximum power point tracking solar farm DC fast-charging station step-up DC-DC converter System Advisor Model economic analysis MPPT ENERGY ALGORITHM ARRAYS

Transcranial photobiomodulation for the brain: a wide range of clinical applications

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Neural Regeneration Research 2024年第3期19卷 483-484页

作者： michael R.Hamblin Laser Research Centre Faculty of Health ScienceUniversity of Johannesburg-Doornfontein CampusDoornfonteinSouth Africa

Photobiomodulation therapy(PBMT)is a rapidly growing approach to the healing,stimulation,protection,and regeneration of many human organs and tissue *** started in the 1960s as low-level laser therapy for wound healing,but since then the introduction of light-emitting diodes(LEDs)has dramatically increased the number of applications and reports of positive *** generally uses red(620-700 nm)and/or near-infrared(780-1270 nm)wavelengths of light at an intensity that causes no tissue heating,and its activity is based on well-established biological and cellular mechanisms(de Freitas and Hamblin,2016).While laser therapists continue to use various types of laser in their office practice,LEDs are ideally suited for home use devices because they are completely safe and without any known significant adverse *** the various body parts on which PBMT has been shown to exert beneficial effects,the brain stands out as perhaps the most promising *** has been shown to reduce neuroinflammation,while increasing mitochondrial function,oxygen consumption,and blood flow within the brain(Hamblin,2016).Moreover,PBMT can stimulate the processes of synaptogenesis,neurogenesis,and neuroplasticity thus helping the brain to heal itself.

关键词： healing stimulation wound

Odd-even effects in the structure and properties of aryl-substituted aliphatic self-assembled monolayers

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Nano Research 2024年第5期17卷 4231-4243页

作者： Piotr Cyganik Andreas Terfort michael Zharnikov Jagiellonian University Faculty of PhysicsAstronomy and Applied Computer ScienceSmoluchowski Institute of PhysicsŁojasiewicza 1130-348 KrakówPoland Institut für Anorganische und Analytische Chemie Universität FrankfurtMax-von-Laue-Straße 760438 FrankfurtGermany Applied Physical Chemistry Heidelberg UniversityIm Neuenheimer Feld 25369120 HeidelbergGermany

Self-assembled monolayers(SAMs)represent an important tool in context of nanofabrication and molecular engineering of surfaces and *** properties of functional SAMs depend not only on the character of the tail groups at the SAM-ambient interface,but are also largely defined by their *** its turn,the latter parameter results from a complex interplay of the structural forces and a variety of other factors,including so called odd-even effects,*** of the SAM structure and properties on the parity of the number(odd or even)of individual building blocks in the backbone of the SAM *** most impressive manifestation of the odd-even effects is the structure of aryl-substituted alkanethiolate SAMs on Au(111)and Ag(111),in which,in spite of the fact that the intermolecular interaction is mostly determined by the aryl part of the monolayers,one observes a pronounced dependence of molecular inclination and,consequently,the packing density of the SAM-forming molecules on the parity of number of methylene units in the alkyl *** we review the properties of the above systems as well as address fundamental reasons behind the odd-even effects,including the existence of a so-called bending potential,which is frequently disregarded in analysis of the structure-building *** generality of the odd-even effects in SAMs is additionally supported by the recent data for SAMs on GaAs,scanning tunneling microscopy data for SAMs on Ag(111),and the data for the monolayers with selenolate and carboxyl anchoring groups on Au(111)and Ag(111).The implications of these effects in terms of the control over the packing density and orientation of the tail groups at the SAM-ambient interface,structural perfection,polymorphism,temperature-driven phase transitions,and SAM stability toward such factors as ionizing radiation,exchange reaction,and electrochemical desorption are *** implications place the odd-even effects as an important tool

关键词： self-assembled monolayers molecular films surface and interface engineering odd-even-effects