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Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques

World Journal of Gastroenterology 2015年第16期21卷 4894-4902页

作者： Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun michael trltzsch Johannes Wiegand Volker Keim IFB Adiposity Diseases Leipzig University Medical Center Department of Medicine Neurology and DermatologyDivision of Gastroenterology and RheumatologyUniversity Hospital Leipzig Department of Diagnostic and Interventional Radiology University Hospital Leipzig Internistische Hausarzt- und Diabetologische Schwerpunktpraxis Dr. Relke Department of Medicine Neurology and DermatologyDivision of Endocrinology and NephrologyUniversity Hospital Leipzig

AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver ***:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and *** parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP ***:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the *** ASQ parameters showed differences between healthy controls and diabetic patients(P0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver *** estimation with ASQ should be further evaluated in biopsy-controlled studies.

关键词： transient elastography Non-alcoholic fatty liver disease Liver stiffness Fibrosis score Controlled attenuation parameter

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Exploring commercial water electrolyser systems:a data-based analysis of product characteristics

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Clean Energy 2024年第1期8卷 126-133页

作者： Xin Jin Shi You Marianne Petersen Jonathan Riofrio Soumya Thakur Chresten træholt Zhijian Feng Department of Wind and Energy Systems Technical University of Denmark2800 Kgs.LyngbyDenmark Siemens Gamesa Renewable Energy A/S 7330 BrandeDenmark

The urgency for energy transition is evident through the increasing demand for new technologies such as water electrolysers(WEs),which have the potential to generate green hydrogen using renewable *** paper aims to provide a comprehensive overview of the technical capabilities of commercially available WE system *** analysis is based on publicly accessible data gathered from 28 WE manufacturers worldwide with a total of 186 products,focusing on technology types and various technical characteristics of each WE system,including capacity,footprint,hydrogen output pressure,hydrogen purity and conversion *** analysis reveals that the current WE system solutions in the market exhibit diverse and varied ***,there is a lack of standardized product specifications adopted by *** underscores the urgent need for the development of frameworks and *** such standards is crucial for enhancing clarity and understanding,facilitating efficient comparisons and selection processes,and supporting the future advancement of WE technologies and WE-enabled Power-to-X applications on a global scale.

关键词： data analysis hydrogen Power-to-X standards water electrolyser system

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Fabrication of sub-20 nm MoS_(2) horizontal nanowire on silicon substrates by inclusion of precursors into polystyrene-bpolyethylene oxide nanopatterns: Detailed structural investigation

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Nano Research 2024年第3期17卷 2145-2153页

作者： Tandra Ghoshal michael A.Morris School of Chemistry AMBER and CRANNTrinity College DublinDublinIrelandD02 AK60

Herein,we demonstrate the fabrication of sub-20 nm MoS_(2) horizontal nanowire arrays on silicon substrates using a self-assembled block copolymer assisted in situ inclusion *** separated long-range ordered polystyrene-b-polyethylene oxide(PS-b-PEO)block copolymer(BCP)line-space nanopatterns were achieved through thermo-solvent *** patterns produced had long-range order and domain sizes>1μ*** BCP structures were lightly etched and modified by anhydrous ethanol to facilitate insertion of molybdenum precursor within the film maintaining the parent BCP *** ordered molybdenum oxide nanowire arrays were then fabricated by ultraviolet(UV)/ozone treatment at room *** oxides were converted to sulphides by thermal evaporation at different temperatures in Ar/H_(2) environment.X-ray photoelectron spectroscopy revealed the composition and phases of the molybdenum oxide and sulphide *** mapping was performed to investigate the interfaces between the oxide and sulphide nanowires with the substrate *** formation and stability of the sulphide nanowires were studied at different *** photoluminescence and Raman properties were studied at different formation temperatures to investigate defects and estimate the number of layers.

关键词： MoS_(2) block copolymer nanowires inclusion X-ray photoelectron spectroscopy(XPS) mapping photoluminescence

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Towards a New Model of Teacher training in Europe

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Journalism and Mass Communication 2024年第4期14卷 260-266页

作者： Teodor Pătrăuță “Vasile Goldiș”Western University of Arad AradRoumania

The current situation of European educational systems leads to the lack of historical precedents,considering that it implies the end of educational systems based on exclusion,configuring a new conception of educational systems that we are still not able to appreciate at their true value,because we were educated by and in the previous educational *** other references,we inevitably tend to compare current problems with previous situations,without understanding that the generalization of education to 100%of the population implies a qualitative change that modifies the objectives,forms of work,and the very essence of the educational *** stage change,marked by the acceleration of social changes,including the pandemic situation,explains why,despite the best educational system so far,teachers with the best levels of training and a financial and material endowment unimaginable until recently,try a sense of crisis and a general feeling of confusion is manifested among the teachers and parents of the children,seeing that education is no longer what it used to be(Esteve,1998).The key to defuse this apparent paradox is in the tendency to judge the new education system by the mentality and standards of the former selective education,in which most of the adults present were ***,although we continue to apply to the new general education situation the parameters of the previous situation,in which the selective system excluded every year the students who had behavior problems in the class or had difficulties regarding the mastery of certain educational subjects(Esteve,1998).In this way,we are currently criticizing the school failure of a percentage of our students,without realizing that their schooling itself is a success,because,although their level is low,they had no level *** speaks of a low educational level,when,in reality,the educational level is increasing—the general level of the people and the individual level of the best students(Baudelo

关键词： education model teacher education exclusion selection schooling

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Neuronal trafficking as a key to functional recovery in immune-mediated neuropathies

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Neural Regeneration Research 2024年第11期19卷 2331-2332页

作者： Felix Kohle michael Schroeter Department of Neurology University of Cologne and University Hospital CologneCologneGermany

Immune-mediated neuropathies are rare diseases of the peripheral nervous system(PNS),substantially affecting patients’functionality and quality of *** are amenable to immunomodulatory treatments,which in many cases stabilize disease progression,but long-term deficits persist in many *** long-term deficits are particularly observed in monophasic autoimmune neuropathies like Guillain-Barrésyndrome and also in chronic variants,e.g.,chronic inflammatory demyelinating neuropathy(Fadia et al.,2019).

关键词： diseases autoimmune

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Rethinking the egg

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National Science Review 2024年第6期11卷 81-82页

作者： michael J.Benton School of Earth Sciences University of Bristol

Our image of early dinosaur eggs must change. Early dinosaur eggs are portrayed as soft-shelled, like those of modern lizards or snakes [1], and yet all the evidence is that early dinosaurs at least laid leathery-shel...

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Design of a Level-3 electric vehicle charging station using a 1-MW solar system via the distributed maximum power point tracking technique

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Clean Energy 2024年第1期8卷 23-35页

作者： Afshin Balal michael Giesselmann Department of Electrical and Computer Engineering Texas Tech UniversityLubbockTX 79409USA

Solar power is mostly influenced by solar irradiation,weather conditions,solar array mismatches and partial shading ***,before installing solar arrays,it is necessary to simulate and determine the possible power *** power point tracking is needed in order to make sure that,at any time,the maximum power will be extracted from the photovoltaic ***,maximum power point tracking is not a suitable solution for mismatches and partial shading *** overcome the drawbacks of maximum power point tracking due to mismatches and shadows,distributed maximum power point tracking is util-ized in this *** solar farm can be distributed in different ways,including one DC-DC converter per group of modules or per *** this paper,distributed maximum power point tracking per module is implemented,which has the highest *** technology is applied to electric vehicles(EVs)that can be charged with a Level 3 charging station intress on the power grid,and there is not always enough peak power reserve in the existing power grid to charge EVs at that ***,a Level 3(fast DC)EV charging station using a solar farm by implementing distributed maximum power point tracking is utilized to address this ***,the simulation result is reported using MATLAB®,LTSPICE and the System Advisor *** results show that the proposed 1-MW solar system will provide 5 MWh of power each day,which is enough to fully charge~120 EVs each ***,the use of the proposed photovoltaic system benefits the environment by removing a huge amount of greenhouse gases and hazardous *** example,instead of supplying EVs with power from coal-fired power plants,1989 pounds of CO_(2) will be eliminated from the air per hour.

关键词： electric vehicles(EVs) distributed maximum power point tracking solar farm DC fast-charging station step-up DC-DC converter System Advisor Model economic analysis

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transcranial photobiomodulation for the brain: a wide range of clinical applications

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Neural Regeneration Research 2024年第3期19卷 483-484页

作者： michael R.Hamblin Laser Research Centre Faculty of Health ScienceUniversity of Johannesburg-Doornfontein CampusDoornfonteinSouth Africa

Photobiomodulation therapy(PBMT)is a rapidly growing approach to the healing,stimulation,protection,and regeneration of many human organs and tissue *** started in the 1960s as low-level laser therapy for wound healing,but since then the introduction of light-emitting diodes(LEDs)has dramatically increased the number of applications and reports of positive *** generally uses red(620-700 nm)and/or near-infrared(780-1270 nm)wavelengths of light at an intensity that causes no tissue heating,and its activity is based on well-established biological and cellular mechanisms(de Freitas and Hamblin,2016).While laser therapists continue to use various types of laser in their office practice,LEDs are ideally suited for home use devices because they are completely safe and without any known significant adverse *** the various body parts on which PBMT has been shown to exert beneficial effects,the brain stands out as perhaps the most promising *** has been shown to reduce neuroinflammation,while increasing mitochondrial function,oxygen consumption,and blood flow within the brain(Hamblin,2016).Moreover,PBMT can stimulate the processes of synaptogenesis,neurogenesis,and neuroplasticity thus helping the brain to heal itself.

关键词： healing stimulation wound

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Odd-even effects in the structure and properties of aryl-substituted aliphatic self-assembled monolayers

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Nano Research 2024年第5期17卷 4231-4243页

作者： Piotr Cyganik Andreas Terfort michael Zharnikov Jagiellonian University Faculty of PhysicsAstronomy and Applied Computer ScienceSmoluchowski Institute of PhysicsŁojasiewicza 1130-348 KrakówPoland Institut für Anorganische und Analytische Chemie Universität FrankfurtMax-von-Laue-Straße 760438 FrankfurtGermany Applied Physical Chemistry Heidelberg UniversityIm Neuenheimer Feld 25369120 HeidelbergGermany

Self-assembled monolayers(SAMs)represent an important tool in context of nanofabrication and molecular engineering of surfaces and *** properties of functional SAMs depend not only on the character of the tail groups at the SAM-ambient interface,but are also largely defined by their *** its turn,the latter parameter results from a complex interplay of the structural forces and a variety of other factors,including so called odd-even effects,*** of the SAM structure and properties on the parity of the number(odd or even)of individual building blocks in the backbone of the SAM *** most impressive manifestation of the odd-even effects is the structure of aryl-substituted alkanethiolate SAMs on Au(111)and Ag(111),in which,in spite of the fact that the intermolecular interaction is mostly determined by the aryl part of the monolayers,one observes a pronounced dependence of molecular inclination and,consequently,the packing density of the SAM-forming molecules on the parity of number of methylene units in the alkyl *** we review the properties of the above systems as well as address fundamental reasons behind the odd-even effects,including the existence of a so-called bending potential,which is frequently disregarded in analysis of the structure-building *** generality of the odd-even effects in SAMs is additionally supported by the recent data for SAMs on GaAs,scanning tunneling microscopy data for SAMs on Ag(111),and the data for the monolayers with selenolate and carboxyl anchoring groups on Au(111)and Ag(111).The implications of these effects in terms of the control over the packing density and orientation of the tail groups at the SAM-ambient interface,structural perfection,polymorphism,temperature-driven phase transitions,and SAM stability toward such factors as ionizing radiation,exchange reaction,and electrochemical desorption are *** implications place the odd-even effects as an important tool

关键词： self-assembled monolayers molecular films surface and interface engineering odd-even-effects

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Increasing realism in modelling energy losses in railway vehicles and their impact to energy-efficient train control

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Railway Engineering Science 2024年第3期32卷 257-285页

作者： michael Nold Francesco Corman Institute for transport Planning and Systems ETH ZürichZürichSwitzerland

The reduction of energy consumption is an increasingly important topic of the railway ***-efficient train control(EETC)is one solution,which refers to mathematically computing when to accelerate,which cruising speed to hold,how long one should coast over a suitable space,and when to *** approaches in literature and industry greatly simplify a lot of nonlinear effects,such that they ignore mostly the losses due to energy conversion in traction components and *** fill this research gap,a series of increasingly detailed nonlinear losses is described and *** categorize an increasing detail in this representation as four *** study the impact of those levels of detail on the energy optimal speed *** do this,a standard approach based on dynamic programming is used,given constraints on total travel *** evaluation of multiple test cases highlights the influence of the dynamic losses and the power consumption of auxiliary components on railway trajectories,also compared to multiple *** results show how the losses can make up 50%of the total energy consumption for an exemplary *** them would though result in consistent but limited errors in the optimal ***,more complex trajectories can result in less energy consumption when including the complexity of nonlinear losses than when a simpler model is *** effects are stronger when the trajectory includes many acceleration and braking phases.

关键词： train trajectory optimization Energy-efficient train control(EETC) Dynamic efficiency Power losses in railway vehicles

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