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Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review

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World Journal of Gastroenterology 2022年第14期28卷 1455-1478页

作者： michael t le compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins Department of Surgical Oncology University of North CarolinaRaleighNC 27608United States Department of Radiology Stillwater Medical CenterStillwaterOK 74074United States Department of General Surgery Washington University St.LouisSt.LouisMO 63110-8109United States Department of Radiology Mayo ClinicPhoenixAZ 8505United States Department of Pathology and Immunology MD Anderson Cancer CenterHoustonTX 77030United States Department of Surgical Oncology Washington University School of MedicineSt.LouisMO 63110-8109United States Section of Hepatobiliary-Pancreatic and GI Surgery Washington University St.LouisSt.LouisMO 63110United States

BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal *** the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic *** of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the *** purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this *** to classify the common clinical manifestations of heterotopic *** A retrospective review was conducted of pathologic samples containing heterotopic pancreas from *** was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this *** patients were identified from review of the medical records and clinical symptoms were *** were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic *** describing symptomatic presentation of HP were selected for *** including demographics,symptoms,presentation and treatment were compiled and *** twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical *** manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet *** review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more *** and multi-patient studies were combined to form a cohort of 934 symptomatic *** majority of patients presented with abdominal pain(67%)combined with one of the following clinical catego

关键词： Heterotopic pancreas Ectopic pancreas Aberrant pancreas Pancreatic rest Groove pancreatitis

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Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1980-1995页

作者： Koki Nishihara Clothilde Villot Lautaro Cangiano le Luo Guan michael Steele Department of Animal Biosciences Animal Science and NutritionUniversity of GuelphGuelphON N1G 1Y2Canada Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada Lallemand SAS Blagnac F‑31702France Department of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Faculty of Land and Food Systems The University of British ColumbiaVancouverBC V6T 1Z4Canada Present Address:Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada

Background As Holstein calves are susceptible to gastrointestinal disorders during the first week of life,understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal *** probiotics in early life may contribute to host intestinal health by facilitating beneficial bacteria colonization and developing intestinal immune *** objective of this study was to characterize the impact of early life yeast supplementation and growth on colon mucosa-attached bacteria and host immune *** twenty Holstein bull calves received no supplementation(CON)or Saccharomyces cerevisiae boulardii(SCB)from birth to 5 d of *** tissue biopsies were taken within 2 h of life(D0)before the first colostrum feeding and 3 h after the morning feeding at d 5 of age(D5)to analyze mucosa-attached bacteria and colon *** sequencing showed that there was no difference inαandβdiversity of mucosa-attached bacteria between day and treatment,but bacteria related to diarrhea were more abundant in the colon mucosa on D0 compared to *** addition,q PCR indicated that the absolute abundance of Escherichia coli(***)decreased in the colon mucosa on D5 compared to D0;however,that of Bifidobacterium,Lactobacillus,and Faecalibacterium prausnitzii,which could competitively exclude ***,increased in the colon mucosa on D5 compared to ***-sequencing showed that there were no differentially expressed genes between CON and SCB,but suggested that pathways related to viral infection such as“Interferon Signaling”were activated in the colon mucosa of D5 compared to *** Growth affected mucosa-attached bacteria and host immune function in the colon mucosa during the first 5 d of life in dairy calves independently of SCB *** early life,opportunistic pathogens may decrease due to intestinal environmental changes by beneficial bacteria and/or host immune *** activation

关键词： Colon biopsy Dairy calves RNA-sequencing Saccharomyces cerevisiae boulardii 16S rRNA amplicon-sequencing

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Advancing Wound Filling Extraction on 3D Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： Duong Q.Nguyen thinh D.le Phuong D.Nguyen Nga t.K.le H.Nguyen-Xuan Department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRtECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3D facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3D-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3D facial ***,based on the segmentation model,we propose an improved approach for extracting 3D facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3D printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3D bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3D.

关键词： 3D printing technology face reconstruction 3D segmentation 3D printed model

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Contrasting physical mechanisms of yellowfin tuna fluctuations between the western and eastern Indian Ocean

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Journal of Oceanology and Limnology 2024年第3期42卷 960-971页

作者： Peng LIAN le GAO Key Laboratory of Ocean Observation and Forecasting and Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Laboratory for Ocean Dynamics and Climate Laoshan LaboratoryQingdao 266061China

As an economically critical pelagic migratory species,yellowfin tuna(thunnus albacores,YFt)is very sensible to physical and environmental conditions,such as sea surface temperature(SSt),ocean heat content(OHC),and the mixed layer depth(MLD).We investigated the impact of SSt,OHC,and MLD on fluctuations of YFt catch in the western/eastern Indian Ocean using the long time series of 63-year environmental and YFt *** found that the impact of SSt on YFt was heavily overestimated in the past,and MLD plays a more critical role in the YFt catch *** the MLD deepens(>34.8 m),SSt was more influential in predicting the catches of YFt than OHC in the western Indian Ocean,and OHC was more critical to YFt than SSt in the eastern Indian ***,when the MLD shallows(tal to predict the catch per unit effort(CPUE)of YFt than SSt/OHC in the *** 2000,there was an asynchronous pattern of YFt CPUE induced by higher frequency variations and ocean hiatus of SSt/OHC signals in the western and eastern Indian Oceans *** impact of the subsurface hiatus may induce the decrease of YFt in the eastern Indian *** above findings clarified a non-stationary relationship between the environmental factors and catches of YFt and provided new insights into variations in YFt abundance.

关键词： yellowfin tuna Indian Ocean sea surface temperature(SSt) ocean heat content(OHC) mixed layer depth(MLD) hiatus

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Impacts of central-Pacific El Niño and physical drivers on eastern Pacific bigeye tuna

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Journal of Oceanology and Limnology 2024年第3期42卷 972-987页

Bigeye tuna thunnus obesus is an important migratory species that forages deeply,and El Niño events highly influence its distribution in the eastern Pacific *** sea surface temperature is widely recognized as the main factor affecting bigeye tuna(BEt)distribution during El Niño events,the roles of different types of El Niño and subsurface oceanic signals,such as ocean heat content and mixed layer depth,remain *** conducted A spatial-temporal analysis to investigate the relationship among BEt distribution,El Niño events,and the underlying oceanic signals to address this knowledge *** used monthly purse seine fisheries data of BEt in the eastern tropical Pacific Ocean(EtPO)from 1994 to 2012 and extracted the central-Pacific El Niño(CPEN)indices based on Niño 3 and Niño ***,we employed Explainable Artificial Intelligence(XAI)models to identify the main patterns and feature importance of the six environmental variables and used information flow analysis to determine the causality between the selected factors and BEt ***,we analyzed Argo datasets to calculate the vertical,horizontal,and zonal mean temperature differences during CPEN and normal years to clarify the oceanic thermodynamic structure differences between the two types of *** findings reveal that BEt distribution during the CPEN years is mainly driven by advection feedback of subsurface warmer thermal signals and vertically warmer habitats in the CPEN domain area,especially in high-yield fishing *** high frequency of CPEN events will likely lead to the westward shift of fisheries centers.

关键词： bigeye tuna central-Pacific El Niño(CPEN) ocean heat content Argo explainable artificial intelligence(XAI) information flow

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A Graded Speed Control Method for Cyborg Rats Based on Electrical Stimulation of the Cuneiform Nucleus

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Journal of Bionic Engineering 2024年第3期21卷 1334-1346页

作者： Hanyi Ling le Han Nenggan Zheng Qiushi Academy for Advanced Studies(QAAS) Zhejiang UniversityHangzhou310007China the State Key Lab of Brain-Machine Intelligence Zhejiang UniversityHangzhou310007China College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310007China College of Computer Science and technology Zhejiang UniversityHangzhou310007China CCAI by MOE and Zhejiang Provincial Government(ZJU) Hangzhou310007China

the precise movement speed regulation is a key factor to improve the control effect and efficiency of the cyborg ***,the current stimulation techniques cannot realize the graded control of the *** this study,we achieved the multi-level speed regulation of cyborg rats in the large open field and treadmill by specifically targeting the Cuneiform Nucleus(CnF)of the Mesencephalic Locomotor Region(MLR).Detailed,we measured the influence of each stimulation parameter on the speed control process which included the real-time speed,accelerated speed,response time,and acceleration *** concluded that the pulse period and the pulse width were the main determinants influencing the accelerated speed of cyborg *** the amplitude of stimulation was found to affect the response time exhibited by the cyborg *** study provides valuable insights into the regulation of rat locomotion speed and highlights the potential for utilizing this approach in various experimental settings.

关键词： Cyborg rats Cuneiform nucleus Graded control Speed regulation

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Silent battles:immune responses in asymptomatic SARS-CoV-2 infection

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Cellular & Molecular Immunology 2024年第2期21卷 159-170页

作者： Nina le Bert taraz Samandari Program in Emerging Infectious Diseases Duke-NUS Medical SchoolSingaporeSingapore

SARS-CoV-2 infections manifest with a broad spectrum of presentations,ranging from asymptomatic infections to severe pneumonia and fatal *** review centers on asymptomatic infections,a widely reported phenomenon that has substantially contributed to the rapid spread of the *** such asymptomatic infections,we focus on the role of innate,humoral,and cellular ***,asymptomatic infections are characterized by an early and robust innate immune response,particularly a swift type 1 IFN reaction,alongside a rapid and broad induction of SARS-CoV-2-specific t ***,antibody levels tend to be lower or undetectable after asymptomatic infections,suggesting that the rapid control of viral replication by innate and cellular responses might impede the full triggering of humoral *** if antibody levels are present in the early convalescent phase,they wane rapidly below serological detection limits,particularly following asymptomatic ***,prevalence studies reliant solely on serological assays likely underestimate the extent of community exposure to the virus.

关键词： COVID-19 asymptomatic cellular immunity antibody

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Clinical validation of the early embryo viability assessment system: Analysis for the blastocyst morphology and pregnancy outcomes

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Asian pacific Journal of Reproduction 2024年第5期13卷 219-227页

作者： Vu D Hop An M Cuong Phi t t Anh Nguyen t L Huong le Hoang Nguyen V Hanh Assisted Reproductive technology Centre Tam Anh General HospitalHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:to determine the relationship between the early embryo viability assessment(EEVA)and blastocyst morphological parameters and pregnancy ***:this retrospective cohort study was conducted on 291 intracytoplasmic sperm injection cycles including 2522 embryos with indications of prolonging embryo culture to the blastocyst stage in the Genea embryo review incubator,and 511 single vitrified-warmed blastocyst transfer cycles from January 2020 to June *** EEVA system produced an EEVA score from E1(best)to E5(worse)for the potential of blastocyst *** morphology was *** association between the EEVA score and each type of blastocyst morphology,implantation rate,clinical pregnancy,and ongoing pregnancy were assessed using generalized estimating ***:the inner cell mass A(ICM A),trophectoderm A(tE A),blastocoele expansion degree of 3,4,5,6,7 rates were higher with lower the EEVA *** adjusted odd ratio(aOR)(E5 vs E1)was 0.3 for ICM A,0.174 for tE A and 0.210 for BL3,4,5,6,7(all Pting a significant association between lower EEVA scores and improved embryo *** implantation,clinical pregnancy,and ongoing pregnancy rate were also higher with lower the EEVA *** aOR of E5 vs E1 was 0.245 for implantation,0.185 for clinical pregnancy and 0.200 for ongoing pregnancy rate(Pthere were associations between blastocyst morphology,pregnancy outcome and EEVA *** good blastocyst morphology and pregnancy outcomes are higher with lower the EEVA score.

关键词： Automated embryo assessment Blastocyst Early embryo viability assessment Genea embryo review incubator

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Development of an ultrathin liquid sheet target for laser ion acceleration at high repetition rates in the kilohertz range

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High Power Laser Science and Engineering 2024年第3期12卷 134-145页

作者： M.Füle A.P.Kovács t.Gilinger M.Karnok P.Gaál S.Figul G.Marowsky K.Osvay National Laser-Initiated transmutation Laboratory University of SzegedSzegedHungary Department of Experimental Physics University of SzegedSzegedHungary ELI ALPS ELI-HU Non-Profit Ltd.SzegedHungary Department of Optics and Quantum Electronics University of SzegedSzegedHungary Advanced Microfluidic Systems GmbH GöttingenGermany

A colliding microjet liquid sheet target system was developed and tested for pairs of round nozzles of 10,11 and 18μm in *** sheet's position stability was found to be better than a few *** interaction with 50 mJ laser pulses,the 18μm jet has a resonance amplitude of 16μm at a repetition rate of 33 Hz,while towards 100 Hz it converges to 10μm for all nozzles.A white-light interferometric system was developed to measure the liquid sheet thickness in the target chamber both in air and in vacuum,with a measurement range of 182 nm±1μm and an accuracy of±3%.the overall shape and 3D shape of the sheet follow the Hasson±Peck model in *** vacuum versus air,the sheet gradually loses 10%of its thickness,so the thinnest sheet achieved was below 200 nm at a vacuum level of 10±4mbar,and remained stable for several hours of operation.

关键词： diagnostics laser ion acceleration nanometric liquid sheet targets vacuum test

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Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients

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Chronic Diseases and translational Medicine 2024年第3期10卷 195-204页

作者： Sarah t.Clarke michael le Grande Barbara M.Murphy Robert Hester Alun C.Jackson Melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Australian Centre for Heart Health MelbourneVictoriaAustralia Centre on Behavioral Health University of Hong KongPokfulamHong KongChina

Introduction: One in two cardiac patients fear having another heart event or their heart condition getting worse. Research in other chronic illnesses demonstrates that screening for fear of progression and recurrence is vital for adequately addressing such concerns in clinical care. the current project aims to develop and validate a measure for fear of progression and recurrence in cardiac ***: the Fear of Cardiac Recurrence and Progression Scale (FCRP) will be developed through a multistep process. An initial item pool will be generated through a review of the literature and existing measures and consultation with and feedback from key informants. the item pool will be tested in a sample of over 250 adults who have ever had an acute coronary event, undergone cardiac surgery, or a chronic cardiac condition. Exploratory factor analysis will be used to identify the underlying factors, and Rasch analysis will be used to reduce the number of items. A short form version of the FCRP will be developed for use as a brief screening tool, informed by clinical relevance and Rasch psychometric ***: While many cardiac patients experience fears related to the progression or recurrence of their illness, there remains the need for a validated tool with which these concerns can be identified and measured. It is expected that the design and validation of the FCRP will aid identification of cardiac patients suffering from clinically significant levels of fear of progression and recurrence and facilitate the design of tailored psychological interventions to target these fears.

关键词： anxiety cardiac anxiety cardiac recovery cardiac rehabilitation depression fear of progression fear of recurrence psychological measurement psychosocial screening

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