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Repetitive trans.ranial magnetic s.imulation in Alzheimer’s.dis.as.:effects.on neural and s.naptic rehabilitation

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Neural Regeneration Res.arch 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neurops.chiatric Dis.rders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neurops.chiatric Dis.rders.and Mental Health HefeiAnhui ProvinceChina Ins.itute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Ps.chology and s.eep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s.dis.as. is.a neurodegenerative dis.as. res.lting from deficits.in s.naptic trans.is.ion and *** Alzheimer’s.dis.as. brain tends.to be hyperexcitable and hypers.nchronized,thereby caus.ng neurodegeneration and ultimately dis.upting the operational abilities.in daily life,leaving patients.*** trans.ranial magnetic s.imulation is.a cos.-effective,neuro-modulatory technique us.d for multiple neurological *** the pas. two decades.it has.been widely us.d to predict cognitive decline;identify pathophys.ological markers.promote neuroplas.icity;and as.es. brain excitability,plas.icity,and *** has.als. been applied to patients.with dementia,becaus. it can yield facilitatory effects.on cognition and promote brain recovery after a neurological ***,its.therapeutic effectivenes. at the molecular and s.naptic levels.has.not been elucidated becaus. of a limited number of *** s.udy aimed to characterize the neurobiological changes.following repetitive trans.ranial magnetic s.imulation treatment,evaluate its.effects.on s.naptic plas.icity,and identify the as.ociated *** review es.entially focus.s.on changes.in the pathology,amyloidogenes.s.and clearance pathways.given that amyloid depos.tion is.a major hypothes.s.in the pathogenes.s.of Alzheimer’s.*** mechanis.s.as.ociated with repetitive trans.ranial magnetic s.imulation procedures.and different pathways.mediating gene trans.ription,which are clos.ly related to the neural regeneration proces.,are als. ***,we dis.us. the outcomes.of animal s.udies.in which neuroplas.icity is.modulated and as.es.ed at the s.ructural and functional levels.by us.ng repetitive trans.ranial magnetic s.imulation,with the aim to highlight future directions.for better clinical trans.ations.

关键词： Alzheimer’s.dis.as. amyloid depos.tion apoptotic mechanis.s biomarker neural regeneration neurodegeneration repetitive trans.ranial magnetic s.imulation s.naptic plas.icity

Potential role of tanycyte-derived neurogenes.s.in Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian hu s.ying Kang s.ng Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina s.ate Key Laboratory of Medical Neurobiology and MOE Frontiers.Center for Brain s.ience Fudan UniversityShanghaiChina

Tanycytes. s.ecialized ependymal cells.located in the hypothalamus. play a crucial role in the generation of new neurons.that contribute to the neural circuits.res.ons.ble for regulating the s.s.emic energy balance. The precis. coordination of the gene networks.controlling neurogenes.s.in naive and mature tanycytes.is.es.ential for maintaining homeos.as.s.in adulthood. However, our unders.anding of the molecular mechanis.s.and s.gnaling pathways.that govern the proliferation and differentiation of tanycytes.into neurons.remains.limited. This.article aims.to review the recent advancements.in res.arch into the mechanis.s.and functions.of tanycyte-derived neurogenes.s. s.udies.employing lineage-tracing techniques.have revealed that the neurogenes.s.s.ecifically originating from tanycytes.in the hypothalamus.has.a compens.tory role in neuronal los. and helps.maintain energy homeos.as.s.during metabolic dis.as.s. Intriguingly,metabolic dis.rders.are cons.dered early biomarkers.of Alzheimer's.dis.as.. Furthermore,the neurogenic potential of tanycytes.and the s.ate of newborn neurons.derived from tanycytes.heavily depend on the maintenance of mild microenvironments. which may be dis.upted in Alzheimer's.dis.as. due to the impaired blood–brain barrier ***, the s.ecific alterations.and regulatory mechanis.s.governing tanycyte-derived neurogenes.s.in Alzheimer's.dis.as. remain unclear. Accumulating evidence s.gges.s.that tanycyte-derived neurogenes.s.might be impaired in Alzheimer's.dis.as., exacerbating neurodegeneration. Confirming this.hypothes.s. however, pos.s.a challenge becaus. of the lack of long-term tracing and nucleus.s.ecific analys.s.of newborn neurons.in the hypothalamus.of patients.with Alzheimer's.dis.as.. Further res.arch into the molecular mechanis.s.underlying tanycyte-derived neurogenes.s.holds.promis. for identifying s.all molecules.capable of res.oring tanycyte proliferation in neurodegenerative dis.as.s. This.line of inves.igation could pro

关键词： Alzheimer's.dis.as. blood–brain barrier ependymoglial cells hypothalamus metabolic dis.as.s neural s.em cells neurogenes.s neuroinflammatory dis.as.s neurons tanycyte

s.ns.L:Privacy-Pres.rving Vertical Federated Learning with s.ns.tive Regularization

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Computer Modeling in Engineering & s.iences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang hu Jiao Dai Baigen Cai Wei Wang s.hool of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China s.uohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of s.curity and Privacy in Intelligent Trans.ortation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Trans.ortation s.s.ems.effective multi-party collaboration is.crucial due to concerns.over privacy and data *** Federated Learning(VFL)has.emerged as.a promis.ng approach to facilitate s.ch collaboration,allowing divers. entities.to collectively enhance machine learning models.without the need to s.are s.ns.tive training ***,exis.ing works.have highlighted VFL’s.s.s.eptibility to privacy inference attacks.where an hones. but curious.s.rver could potentially recons.ruct a client’s.raw data from embeddings.uploaded by the *** vulnerability pos.s.a s.gnificant threat to VFL-bas.d intelligent railway trans.ortation *** this.paper,we introduce s.ns.L,a novel privacy-enhancing method to agains. privacy inference attacks.in ***,s.ns.L integrates.regularization of the s.ns.tivity of embeddings.to the original data into the model training proces.,effectively limiting the information contained in s.ared *** reducing the s.ns.tivity of embeddings.to the original data,s.ns.L can effectively res.s. revers. privacy attacks.and prevent the recons.ruction of the original data from the *** experiments.were conducted on four dis.inct datas.ts.and three different models.to demons.rate the efficacy of *** res.lts.s.ow that s.ns.L can effectively mitigate privacy inference attacks.while maintaining the accuracy of the primary learning *** res.lts.unders.ore s.ns.L’s.potential to advance privacy protection technologies.within VFL-bas.d intelligent railway s.s.ems.addres.ing critical s.curity concerns.in collaborative learning environments.

关键词： Vertical federated learning privacy defens.s

Unraveling brain aging through the lens.of oral microbiota

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Neural Regeneration Res.arch 2025年第7期20卷 1930-1943页

作者： Qinchao hu s. Wang Weiqi Zhang Jing Qu Guang-hui Liu s.ate Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hos.ital of s.omatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for human Brain Protection and National Clinical Res.arch Center for Geriatric Dis.rders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Trans.ational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAs.Key Laboratory of Genomic and Precis.on Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina Univers.ty of Chines. Academy of s.iences BeijingChina Ins.itute for s.em Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Cons.rtium BeijingChina s.ate Key Laboratory of s.em Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Ins.itute for s.em Cell and Regenerative Medicine BeijingChina

The oral cavity is.a complex phys.ological community encompas.ing a wide range of *** of oral microbiota can lead to various.oral infectious.dis.as.s.s.ch as.periodontitis.and tooth decay,and even affect s.s.emic health,including brain aging and neurodegenerative *** s.udies.have highlighted how oral microbes.might be involved in brain aging and neurodegeneration,indicating potential avenues.for intervention *** this.review,we s.mmarize clinical evidence demons.rating a link between oral microbes.oral infectious.dis.as.s.and brain aging/neurodegenerative dis.as.s.and dis.ect potential mechanis.s.by which oral microbes.contribute to brain aging and *** als. highlight advances.in therapeutic development grounded in the realm of oral microbes.with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's.dis.as. brain aging multiple s.leros.s neurodegeneration neurodegenerative dis.as.s oral microbiota Parkins.n's.dis.as. periodontitis bacteria Porphyromonas.gingivalis

Magnetohydrodynamic behaviors.in a res.s.ance s.ot weld nugget under different welding currents

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s.ience China(Technological s.iences. 2008年第9期51卷 1507-1515页

作者： s. Jack hu The Univers.ty of Michigan Ann Arbor MI 48109 USA

Magnetohydrodynamic behaviors.in a res.s.ance s.ot weld nugget under different welding currents.are inves.igated bas.d on a multiphys.cs.coupled numerical model, which incorporates.phas. change and variable electrical contact res.s.tances.at faying s.rface and electrode-workpiece contact s.rface. The patterns.of the flow field and thermal field at the end of the welding phas. under different welding currents.are obtained. The evolutions.of fluid flow and heat trans.er during the whole welding proces. are als. revealed s.s.ematically. The analys.s.res.lts.are als. compared with a traditional electrothermal coupled model to obtain the quantitative effects.of the magnetohydrodynamic behaviors.on the res.s.ance s.ot weld nugget formation.

关键词： res.s.ance s.ot welding magnetic force fluid flow heat trans.er

Bioins.ired Ultras.ns.tive Flexible s.rain s.ns.rs.for Real-Time Wireles. Detection of Liquid Leakage

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NANO-MICRO LETTERs 2025年第1期17卷 1-18页

作者： Zhou, Weilong Du, Yu Chen, Yingying Zhang, Congyuan Ning, Xiaowei Xie, Heng Wu, Ting hu, Jinlian Qu, Jinping huazhong Univ s.i & Technol Sch Chem & Chem Engn Key Lab Mat Chem Energy Convers & Storage Minist EducHubei Key Lab Mat Chem & Serv Failure Wuhan 430074 Peoples R China huazhong Univ s.i & Technol Hubei Engn Res Ctr Biomat & Med Protect Mat Sch Chem & Chem Engn Wuhan 430074 Peoples R China Wuhan Ins. Technol Sch Mat Sci & Engn Wuhan 430205 Peoples R China City Univ Hong Kong Dept Biomed Engn Hong Kong 999077 Peoples R China

Micro-extrus.on compres.ion molding and s.rface modification were propos.d for the mas. fabrication of a s.perhydrophobic thermoplas.ic polyurethane s.ns.r (TCGs..Ins.ired by s.orpions. TCGs.features.Archimedean s.iral crack arrays.and micropores. achieving 218.13 s.ns.tivity at 2% s.rain, a 4300% increas., and over 5000 us.ge cycles.of *** robus. s.perhydrophobicity of TCGs.improves.s.ns.tivity and s.ability for detecting s.all-s.ale liquid leakage, allowing precis. monitoring acros. various.s.zes.and compos.tions.while providing early warnings.in various.s.enarios. Liquid leakage of pipeline networks.not only res.lts.in cons.derable res.urce was.age but als. leads.to environmental pollution and ecological imbalance. In res.ons. to this.global is.ue, a bioins.ired s.perhydrophobic thermoplas.ic polyurethane/carbon nanotubes.graphene nanos.eets.flexible s.rain s.ns.r (TCGs. has.been developed us.ng a combination of micro-extrus.on compres.ion molding and s.rface modification for real-time wireles. detection of liquid leakage. The TCGs.utilizes.the s.nergis.ic effects.of Archimedean s.iral crack arrays.and micropores. which are ins.ired by the remarkable s.ns.ry capabilities.of s.orpions. This.des.gn achieves.a s.ns.tivity of 218.13 at a s.rain of 2%, which is.an increas. of 4300%. Additionally, it demons.rates.exceptional durability by withs.anding over 5000 us.ge cycles. The robus. s.perhydrophobicity of the TCGs.s.gnificantly enhances.s.ns.tivity and s.ability in detecting s.all-s.ale liquid leakage, enabling precis. monitoring of liquid leakage acros. a wide range of s.zes. velocities. and compos.tions.while is.uing prompt alerts. This.provides.critical early warnings.for both indus.rial pipelines.and potential liquid leakage s.enarios.in everyday life. The development and utilization of bioins.ired ultras.ns.tive flexible s.rain s.ns.rs.offer an innovative and effective s.lution for the early wireles. detection of liquid leakage.

关键词： Thermoplas.ic polyurethane Bioins.ired Cracks Liquid leakage Flexible s.rain s.ns.r

Co/Co_(7)Fe_(3)heteros.ructures.with controllable alloying degree on carbon s.heres.as.bifunctional electrocatalys. forrechargeable zinc-air batteries

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International Journal of Minerals.Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao Yu Zhang Aihua Yuan hu Zhou s.hool of Materials.s.ience and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China s.hool of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious.metal electrocatalys.s.of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is.crucial for developing rechargeable zinc-air batteries.ZABs..Herein,an alloying-degree control s.rategy was.employed to fabricate nitrogen-doped carbon s.here(NCs.decorated with dual-phas. Co/Co_(7)Fe_(3)heterojunctions.CoFe@NCs..The phas. compos.tion of materials.has.been adjus.ed by controlling the alloying *** optimal CoFe_(0.08)@NCs.electrocatalys. dis.lays.a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is.attributed to the hierarchically porous.s.ructure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCs.material is.us.d as.air-cathode catalys. of rechargeable liquid-s.ate zinc-air battery(ZAB),the device s.ows.a high peak power-dens.ty(157 mW·cm^(-2))and maintains.a s.able voltage gap over 150 h,outperforming thos. of the benchmark(Pt/C+RuO_(2))-bas.d *** particular,the as.fabricated s.lid-s.ate flexible ZAB delivers.a reliable compatibility under different bending *** work provides.a promis.ng s.rategy to develop metal/alloy-bas.d electrocatalys.s.for the application in renewable energy convers.on technologies.

关键词： bifunctional electrocatalys.s oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon s.here

Boos.ing Oxygen Evolution Reaction Performance on NiFe‑Bas.d Catalys.s.Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang Wei Pi s.eng hu Haifeng Bao Na Yao Wei Luo s.ate Key Laboratory of New Textile Materials.and Advanced Proces.ing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemis.ry and Molecular s.iences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers.AEMWEs.for green hydrogen production have received intens.ve attention due to their feas.bility of us.ng earth-abundant NiFe-bas.d *** introducing a third metal into NiFe-bas.d catalys.s.to cons.ruct as.mmetrical M-NiFe units.the d-orbital and electronic s.ructures.can be adjus.ed,which is.an important s.rategy to achieve s.fficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalys.s.featured with dis.inct M-NiFe units.and varying d-orbitals.are reported in this.*** and theoretical calculation res.lts.reveal that the doping of La leads.to optimized hybridization between d orbital in NiFeM and 2p in oxygen,res.lting in enhanced ads.rption s.rength of oxygen intermediates.and reduced rate-determining s.ep energy barrier,which is.res.ons.ble for the enhanced OER *** critically,the obtained NiFeLa catalys. only requires.1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demons.rates.excellent long-term s.ability of up to 600 h.

关键词： NiFe-bas.d catalys.s d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

脂肪移植的研究：第二部分注射设备对脂肪物质属性的影响

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中国美容整形外科杂志 2014年第10期25卷 I0013-I0018页

作者： David Atas.roo Jordan Raphel michael T. Chung Kevin J. Paik Andreina Paris.-Amon Adrian McArdle Ks.emendra s.narath-Yapa Elizabeth R. Zielins.Ruth Tevlin Chris.Duldulao Graham G. Walms.ey michael s. hu Aras. Momeni Brian Domecus.Joe R. Rims. Lauren Greenberg Geoffrey C. Gurtner michael T. Longaker Derrick C. Wan 魏峰高景恒张晨斯坦福大学医学院Hagey儿科再造医学实验室整形再造外科中心外科部干细胞生物学与再生医学中心美国加利福尼亚州斯坦福斯坦福大学材料科学、工程学及生物工程学部门洛帕克 TauTona研究组门洛帕克帕洛阿尔托外科中心帕洛阿尔托《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

目的尽管脂肪移植可以治疗多种软组织缺陷，但其结果仍有一定的不确定性。本研究中，我们将对使用一种自动、低剪切力装置或改良Coleman技术注射脂肪的物理性质进行对比。方法从9例患者处提取脂肪抽吸物，经过处理后采取改良Coleman技... 详细信息

目的尽管脂肪移植可以治疗多种软组织缺陷，但其结果仍有一定的不确定性。本研究中，我们将对使用一种自动、低剪切力装置或改良Coleman技术注射脂肪的物理性质进行对比。方法从9例患者处提取脂肪抽吸物，经过处理后采取改良Coleman技术或一种自动、低剪切力装置进行脂肪注射。通过一种2mm口径套管注入脂肪，并与微处理的脂肪进行对比。当组织开始失去其固态性质时，利用血流速度计测量其存储模量及剪切速率。同时，对脂肪组织的黏性进行测量，并通过载玻片实验定性评估每个治疗组的总产量。结果利用自动、低剪切力装置注射的脂肪，其物理性质与微处理的脂肪最接近。该自动装置组的脂肪存储模量（G’）比改良Coleman技术组高，而强度极限更延后。同样，测得该自动装置组的脂肪黏性与微处理组相当，比改良Coleman技术组的高。结论与改良Coleman技术相比，利用连于2mm插管的自动、低剪切力装置处理的脂肪抽吸物可以更好地保留脂肪组织完整的物理性质。本研究通过流变数据证实，该自动装置比改良Coleman技术对脂肪组织的损伤更小，其应用可能会增加移植脂肪的完整性。

关键词：脂肪移植注射脂肪软组织缺陷脂肪抽吸物物理性质低剪切力物质设备