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Neural regeneration research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone michael r.hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Transcranial photobiomodulation for the brain: a wide range of clinical applications

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Neural regeneration research 2024年第3期19卷 483-484页

作者： michael r.hamblin Laser research Centre Faculty of Health ScienceUniversity of Johannesburg-Doornfontein CampusDoornfonteinSouth Africa

Photobiomodulation therapy(PBMT)is a rapidly growing approach to the healing,stimulation,protection,and regeneration of many human organs and tissue *** started in the 1960s as low-level laser therapy for wound healing,but since then the introduction of light-emitting diodes(LEDs)has dramatically increased the number of applications and reports of positive *** generally uses red(620-700 nm)and/or near-infrared(780-1270 nm)wavelengths of light at an intensity that causes no tissue heating,and its activity is based on well-established biological and cellular mechanisms(de Freitas and hamblin,2016).While laser therapists continue to use various types of laser in their office practice,LEDs are ideally suited for home use devices because they are completely safe and without any known significant adverse *** the various body parts on which PBMT has been shown to exert beneficial effects,the brain stands out as perhaps the most promising *** has been shown to reduce neuroinflammation,while increasing mitochondrial function,oxygen consumption,and blood flow within the brain(hamblin,2016).Moreover,PBMT can stimulate the processes of synaptogenesis,neurogenesis,and neuroplasticity thus helping the brain to heal itself.

关键词： healing stimulation wound

Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization

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Burns & Trauma 2021年第1期9卷 299-310页

作者： Zengjun Yang Xiaohong Hu Lina Zhou Yaxiong He Xiaorong Zhang Jiacai Yang Zhenyu Ju Yih-Cherng Liou Han-Ming Shen Gaoxing Luo michael r.hamblin Weifeng He rui Yin Department of Dermatology Southwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China State Key Laboratory of Trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Chongqing Key Laboratory for Disease Proteomics No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Department of Endocrinology Southwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Key Laboratory of regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityNo.601 Huangpu StreetTianhe DistrictGuangzhouGuangdong Province510632China Department of Biological Sciences National University of Singapore14 Science Drive 4117543Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of Singapore14 Science Drive 4117543Singapore Wellman Center for Photomedicine Massachusetts General HospitalHarvard Medical School40 Blossom StreetBostonMA02114USA Laser research Centre Faculty of Health ScienceUniversity of JohannesburgDoornfontein 202817011 South Africa

Background:Epidermal stem cells(EpSCs)that reside in cutaneous hair follicles and the basal layer of the epidermis are indispensable for wound healing and skin *** is known about the effects of photochemical activation on EpSC differentiation,proliferation and migration during wound *** present study aimed to determine the effects of photodynamic therapy(PDT)on wound healing in vivo and in ***:We created mouse full-thickness skin resection models and applied 5-aminolevulinic acid(ALA)for PDT to the wound *** healing was analysed by gross evaluation and haematoxylin–eosin staining in *** cultured EpSCs,protein expression was measured using flow cytometry and *** migration was examined using a scratch model;apoptosis and differentiation were measured using flow ***:PDT accelerated wound closure by enhancing EpSC differentiation,proliferation and migration,thereby promoting re-epithelialization and *** inhibited inflammatory infiltration and expression of proinflammatory cytokines,whereas the secretion of growth factors was greater than in other *** proportion of transient amplifying cells was significantly greater in vivo and in vitro in the PDT *** migration was markedly enhanced after ALAinduced ***:Topical ALA-induced PDT stimulates wound healing by enhancing re-epithelialization,promoting angiogenesis as well as modulating skin *** work provides a preliminary theoretical foundation for the clinical administration of topical ALA-induced PDT in skin wound healing.

关键词： Photodynamic therapy Wound healing 5-aminolevulinic acid re-epithelialization Epidermal stem cells Transient amplifying cells

Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2) Heterojunction Anode for Decentralized Saline Wastewater Treatment and H_(2) Production

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Nano-Micro Letters 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon Kim Jaebeom Park Sunmi Im michael r.Hoffmann Kangwoo Cho Division of Environmental Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Laboratory California Institute of TechnologyPasadenaCA 91125USA Institute for Convergence research and Education in Advanced Technology(I‑CrEATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater electrolysis cells(WECs)for decentralized wastewater treatment/reuse coupled with H_(2) production can reduce the carbon footprint associated with transportation of water,waste,and energy *** study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2) overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment *** dilute(0.1 M)NaCl solutions,the NFI/TiO_(2) marks superior activity and selectivity for chlorine evolution reaction,outperforming the benchmark IrO_(2).robust operation in near-neutral pH was *** including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the primary site for Cl−chemisorption and a protective layer for NFI as an ohmic *** electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO_(2)not only achieves quasi-stoichiometric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive *** scaled-up WEC with NFI/TiO_(2)was demonstrated for electrolysis of toilet wastewater.

关键词： Wastewater electrolysis cell Ir-doped NiFe_(2)O_(4) reactive chlorine species Decentralized H_(2)production On-site wastewater treatment

The hydrodynamic rAM effect:review of historic experiments,model developments and simulation

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Defence Technology(防务技术) 2025年第2期44卷 150-178页

作者： Georg A.Heilig michael May Fraunhofer Institute for High-Speed Dynamics Ernst-Mach-Institute(EMI)Ernst-Zermelo-Strasse 4Freiburg 79104Germany

The Hydrodynamic ram(HrAM)effect occurs when a high kinetic energy projectile penetrates a fluid filled area,e.g.,a liquid filled *** projectile transfers its momentum and kinetic energy to the fluid,what causes a sudden,local pressure rise,further expanding as primary shock wave in the fluid and developing a *** is possible that the entire tank ruptures due to the loads transferred through the fluid to its surrounding *** the past decades,additionally to experimental investigations,HrAM has been studied using various computational approaches particularly focusing on the description of the Fluid-Structure Interaction(FSI).This article reviews the published experimental,analytical and numerical results and delivers a chronological overview since the end of World War ***,HrAM mitigation measures are highlighted,which have been developed with the experimental,analytical and numerical toolboxes matured over the past 80 years.

关键词： Fluid-structure-interaction(FSI) Euler-Lagrange-Coupling Hydrodynamic rAM effect HrAM

Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

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Neural regeneration research 2025年第7期20卷 2001-2002页

作者： Tim Aberle michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCr)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural regeneration research 2025年第1期20卷 174-180页

作者： Yinglong Miao michael S.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Demonstrating the Transient System Impact of Cyber-Physical Events Through Scalable Transmission and Distribution (T&D) Co-Simulation

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 329-339页

作者： Mengmeng Cai Wenbo Wang Xin Fang Anthony r.Florita michael Ingram Dane Christensen National renewable Energy Laboratory GoldenCO15013USA Department of Electrical and Computer Engineering Mississippi State UniversityUSA

Modern power systems become more vulnerable to cyber threats due to their growing interconnectivity, interdependence, and complexity. Widespread deployment of distributed energy resources (DErs) further expands the threat landscape to the grid edge, where fewer cybersecurity protections exist. In this article, a systematic cyber-physical events demonstration, enabled by an integrated transmission, distribution, and communication co-simulation framework, is performed. It analyzes cyber risks to power grid under DEr-enabled automatic generation control from different angles. Unlike existing works, the simulation captures millisecond-to-minutes frequency and voltage transient dynamics at a cross-region system scale.

关键词： Cyber-physical events distributed energy resources T&D dynamic co-simulation

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural regeneration research 2025年第5期20卷 1236-1243页

作者： Diones Bueno michael K.E.Schafer Sudena Wang michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Investigation of a NO_(x) emission from coal power plants in Texas, United States and its impact on the environment

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China Geology 2025年第1期8卷 107-116页

作者： Mikalai Filonchyk michael P.Peterson Faculty of Geomatics Lanzhou Jiaotong UniversityLanzhou 730070China Gansu Provincial Engineering Laboratory for National Geographic State Monitoring Lanzhou 730070China Department of Geography and Geology University of Nebraska OmahaOmaha NE 68182USA

Texas is the largest state by area in the US after Alaska,and one of the top states in the production and consumption of electricity with many coal-fired ***-fired power plants emit greater than 70% of pollutants in the energy *** coal is burned to produce electricity,nitrogen oxides(NO_(x))are released into the air,one of the main pollutants that threaten human health and lead to a large number of premature *** key to effective air quality management is the strict compliance of all plants with emission ***,not all Texas coal plants have the environmental equipment to lower pollutant *** dioxide(NO2)observations from the TrOPOspheric Monitoring Instrument(TrOPOMI)were used to evaluate the emissions for Texas power *** from both the Emissions and Generation resource Integrated Database(EGrID)and the Emissions Database for Global Atmospheric research(EDGAr)were used to examine *** was found that NOx emissions for Texas power plants range from 1.53 kt/year to 10.99 kt/year,with the Martin Lake,Limestone and Fayette Power Project stations being the top *** Parish and Martin Lake stations have the strongest NOx fluxes,with both exhibiting significant seasonal *** of bottom-up inventories for EDGAr and EGrID show a high correlation(r=0.956)and a low root mean square error(0.766).A more reasonable control policy would lead to much reduced NOx emissions.

关键词： NO_(x)emission Enironmental pollution Power plants TrOPOMI EDGAr Human health EGrID. Texas