检索结果-南通市图书馆

In vitro activity and in vivo efficacy of a combination therapy of diminazene and chloroquine against murine visceral leishmaniasis

引用

The Journal of Biomedical Research 2015年第3期29卷 214-223页

作者： Samuel W.Mwololo Joshua M.Mutiso John C.Macharia Alain J.Bourdichon michael M.Gicheru Department of Zoological Sciences Kenyatta University Department of Tropical and Infectious Diseases Institute of Primate Research BpM Bulk Medicine and pharmaceuticals production TROPMED GMbH

The present study evaluated the in vitro activity and in vivo efficacy of diminazene combined with chloroquine as a potential drug against Leishmania donovani. Amphotericin B was used as a positive control drug. In vitro activity involved incubation of various drug concentrations with promastigotes or vero cells in culture before determination of parasite growth inhibition or cell death while in vivo evaluations involved infection of various mice groups with virulent L. donovani parasites and treatment with test drug compounds following disease establishment. Weight changes in experimental mice were also evaluated before infection and throughout the experiment. The results indicated that the diminazene-chloroquine combination was at least nine times more efficacious than individual drugs in killing promastigotes in culture. The diminazene-chloroquine combination was safer （Ld50=0.03±0.04） than Amphotericin B （Ld50=0.02±0.01）. Body weight in infected mice increased significantly （p=0.0007） from day 7 to day 37 following infection （p=0.026）. However, body weight remained comparable in all mice groups during treatment （p=0.16）. The diminazene-chloroquine combination significantly reduced splenic parasite numbers as compared to individual drug therapies （p=0.0001） although Amphotericin B was still more efficacious than any other treatment （p=0.0001）. Amongst the test compounds, the diminazene-chloroquine combination showed the lowest level of IgG antibody responses with results indicating significant negative correlation between antileishmanial antibody responses and protection against disease. These findings demonstrate the positive advantage and the potential use of a combined therapy of diminazene-chloroquine over the constituent drugs. Further evaluation is recommended to determine the most efficacious combination ratio of the two compounds.

关键词： efficacy diminazene-chloroquine combination therapy Leishmania donovani visceral leishmaniasis BALB/c mice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis and Simulation for Capacity of Time Division-Synchronous Code Division Multiple Access System

引用

Journal of Systems Engineering and Electronics 2002年第4期13卷 91-97页

作者： Sun Chengjun, Zhang Zhongzhao, Ba Yong2 & Cao pengzhi (Communication Research ("enter, Harbin Institute of Technology, Harbin 150001, p. R. China Department of Electronic Engineering, Tsinghua University, Beijing 100084, p. R. China Research and Development Division, Shanghai Bell Company Limited, Shanghai 200092, p. R. China) Communication Research Center Harbin Institute of Technology Harbin 150001 P. R. China Department ot Electronic Engineering Isinghua University Beijing 100084 P. R. China Research and Development Division Shanghai Bell Company Lirmted Shanghai 200092 P. R. China

Capcity both in uplink and downlink of TD-SCDMA (time division-synchronous code division multiple access) system is studied in a multi-cell environment. The theoretical expressions of the mean of intercell interference in uplink and the mean of sum of power allocation in downlink are given, by which uplink and downlink capacity is analyzed. Furthermore, we give the simulation models for both uplink and downlink capacity. The results from theoretical analysis and simulation fit very well. In the end, the maximum number of users that TD-SCDMA system can serve for 12.2 k speech service is given.

关键词： Code division multiple access probability Resource allocation Simulation Time division multiple access

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coal waste management practices in the USA:an overview

引用

International Journal of Coal Science & Technology 2014年第2期1卷 163-176页

作者： Yoginder p.Chugh paul T.Behum Mining and Mineral Resources Engineering Southern Illinois UniversityCarbondaleIL 62901USA Office of Surface Mining AltonILUSA

This paper provides an overview of coal waste management practices with two case studies and an estimate of management cost in 2010 US *** of as-mined coal typically results in considerable amount of coarse and fine coal processing wastes because of in-seam and out-of-seam dilution *** plant clean coal recovery values run typically 50%-80%.Trace metals and sulfur may be present in waste materials that may result in leachate water with corrosive *** discharges may require special measures such as liner and collection systems,and treatment to neutralize acid drainage and/or water quality for trace *** potential for variations in coal waste production and quality depends upon mining or processing,plus the long-term methods of waste *** changes in waste generation rates and engineering properties of the coal waste during the life of the facility must be ***,economical and environmentally acceptable management of coal waste involves consideration of geology,soil and rock mechanics,hydrology,hydraulics,geochemistry,soil science,agronomy and environmental *** support all aspects of the regulatory environment including the design and construction of earth and rock embankments and dams,as well as a wide variety of waste disposal *** of impoundments is critical and require considerations of typical water-impounding dams and additional requirements of coal waste disposal *** primary purpose of a coal waste disposal facility is to dispose of unusable waste materials from ***,at some sites coal waste impoundments serve to provide water storage capacity for processing and flood attenuation.

关键词： Coal waste Coarse coal processing waste Fine coal processing waste Coal refuse Out-of-seam dilution Dilution impacts Environmental impacts Reclamations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Using morphological analysis to tackle uncertainty at the design phase for a safety critical application

引用

propulsion and power Research 2015年第1期4卷 1-8页

作者： p.R.N.Childs B.Garvey Imperial College London South KensingtonSW72AZUK

The gas turbine engine internal air system provides cooling and sealing air to a series of critical subsystems and components such as high pressure gas turbine blades,as well as controlling the thrust load on the turbine and compressor spool *** potential variations for the internal air system are possible,depending on the requirement,expertise and command of intellectual *** subsystems,such as rim seals,pre-swirl systems,and rotating cavities have been the subject of extensive development and analysis leading to robust design *** there remains scope for further consideration of the overall system design,and this paper explores the use of a decision analysis tool called morphological analysis applied to the internal air *** analysis provides an effective means for tackling issues where there is uncertainty,as is the case with many design scenarios,including the internal air system,with some specific parameters and information not available until later in the design phase,after the key geometry has been *** problem space comprising seven principal parameters,and a cross consistency matrix which allows identification of compatible and incompatible states are presented.

关键词： Internal Air System Secondary Optimization Design Gas Turbine Engine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An innovation diffusion model for consumer durables with three parameters

引用

Journal of Management Analytics 2016年第3期3卷 240-265页

作者： Nitin Sachdeva p.K.Kapur Ompal Singh Department of Operational Research University of DelhiDelhi Center for Interdisciplinary Research Amity UniversityNoidaUttar PradeshIndia

Strategic innovation diffusion converts newly created knowledge into increasing a firm’s value primarily through innovative product *** this paper,we present a time-based adoption pattern with pricing and promotional expenditure as a three-dimensional innovation diffusion model(3D-IDM).In our proposed 3D-IDM,we assume that value of the product plays a crucial role of being the major driver of diffusion,and is classified into the following three main factors:(1)continuation time of the product in the market–representing goodwill of the product;(2)price of the product–indicating consumers’buying behaviour;and(3)marketing efforts of the firm.A special form of the Cobb–Douglas production function is used to design the three-dimensional *** empirical study is performed on number of consumer-durable sales data to validate and compare the proposed *** performance measures are treated uniquely using the Mahalanobis distance-based approach(DBA)to determine the relative strength of each model.

关键词： innovation diffusion model three-dimensional innovation diffusion model Cobb-Douglas production function

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spectrophotometric method for the determination of ketoconazole based on amplification reactions

引用

Journal of pharmaceutical Analysis 2012年第1期2卷 43-47页

作者： Shaligram S. Rane p. padmaja Department of Applied Chemistry Faculty of Technology and Engineering The Maharaja Sayajirao University of Baroda Department of Chemistry Faculty of Science The Maharaja Sayajirao University of Baroda

This paper describes a sensitive spectrophotometric method developed for determination of Ketoconazole (KC) in tablets based on amplification reactions. Ketoconazole was oxidized with periodate, resulting in formation of KC2t and iodate ions. After masking the excess periodate with molybdate, the iodate was treated with iodide to release iodine. The liberated iodine was transformed to ICl2 species and extracted as ion-pair with rhodamine 6G into toluene for spectrophotometric measurement at 535 nm. A linear calibration graph was obtained between 0.2136 mg/mL and 1.7088 mg/mL of Ketoconazole with a molar absorptivity of 5 105 mol L 1 cm 1. The procedure was successfully applied for the determination of ketoconazole in tablet formulation.

关键词： Ketoconazole Spectrophotometry Amplification periodate Oxidation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A High power Conversion Efficiency L-Band Erbium Doped Fiber Amplifier

引用

光学学报 2003年第S1期23卷 383-384页

作者： Z.G. Lu C.p. Grover Institute for National Measurement Standards National Research Council M-50 1200 Montreal Road Ottawa ON K1 A OR6 CanadaInstitute for National Measurement Standards National Research Council M-50 1200 Montreal Road Ottawa ON K1 A OR6 Canada

By using two sections of erbium doped fiber and a fiber optical reflector, a novel, highly efficient L-band amplifier is demonstrated with significantly power-conversion-efficiency enhancement and the gain increasing ... 详细信息

关键词： EDFA as of length high with A High power Conversion Efficiency L-Band Erbium Doped Fiber Amplifier ASE been for

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules

引用

Regenerative Biomaterials 2015年第1期2卷 31-45页

作者： Lingling Tian Molamma p.prabhakaran Seeram Ramakrishna Mechanical Engineering Faculty of EngineeringNational University of Singapore2 Engineering Drive 3Singapore 117576 Nanoscience and Nanotechnology Initiative National University of Singapore2 Engineering Drive 3Singapore 117576

Nerve diseases including acute injury such as peripheral nerve injury(pNI),spinal cord injury(SCI)and traumatic brain injury(TBI),and chronic disease like neurodegeneration disease can cause various function disorders of nervous system,such as those relating to memory and voluntary *** nerve diseases produce great burden for individual families and the society,for which a lot of efforts have been *** pathways represent a unidirectional and aligned architecture allowing systematic axonal development within the *** a traumatic injury,the intricate architecture suffers disruption leading to inhibition of growth and loss of *** to limited capacity of the body to regenerate axonal pathways,it is desirable to have biomimetic approach that has the capacity to graft a bridge across the lesion while providing optimal mechanical and biochemical cues for tissue *** for central nervous system injury,one more extra precondition is compulsory:creating a less inhibitory surrounding for axonal *** is a cost-effective and straightforward technique to fabricate extracellular matrix(ECM)-like nanofibrous structures,with various fibrous forms such as random fibers,aligned fibers,3D fibrous scaffold and core-shell fibers from a variety of *** diversity and versatility of electrospinning technique,together with functionalizing cues such as neurotrophins,ECM-based proteins and conductive polymers,have gained considerable success for the nerve tissue *** are convinced that in the future the stem cell therapy with the support of functionalized electrospun nerve scaffolds could be a promising therapy to cure nerve diseases.

关键词： electrospinning nerve tissue engineering nanofibers functionalized scaffolds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

立体定向脑电图相关并发症的系统评价

引用

癫痫杂志 2017年第4期3卷 354-363页

作者： Jeffrey p Mullin michael Shriver Soha Alomar 肖英凤慕洁

立体定向脑电图(SEEG)是针对难治性癫痫患者的一项术前评估手段,可定位致痫灶及可能相关的功能皮质区的解剖位置。避免大骨瓣开颅术及其植入精确性,SEEG可能减少相关并发症。然而,由于植入并发症相对较高,颅内电极被认为是具有过度侵入... 详细信息

立体定向脑电图(SEEG)是针对难治性癫痫患者的一项术前评估手段,可定位致痫灶及可能相关的功能皮质区的解剖位置。避免大骨瓣开颅术及其植入精确性,SEEG可能减少相关并发症。然而,由于植入并发症相对较高,颅内电极被认为是具有过度侵入性的操作。此前并无关于SEEG并发症的系统文献综述及Meta分析。该研究的目的是定量回顾文献中SEEG电极植入后各种手术并发症的发生率并进行汇总评估,以便内科医生能够就该术外侵入性监测的相关潜在并发症提供准确建议。此项系统评价是基于pRISMA实现的。通过检索MEDLINE,Scopus,Web of Science数据库,用逆方差加权的固定效应模型对并发症的发生率进行分析。Meta分析与森林图的制作都是通过成熟的制表软件完成的。主要结局指标是总效应量及其95%置信区间(CI)。检索到的1 901篇文献,除重787篇后,通过标题和摘要对1 114篇文章进行了筛选。在这一阶段,排除了没有提及SEEG术后并发症或未达到纳入标准的研究。在排除1 057篇文献后,对剩余的57篇文献进行全文阅读以确定合格标准。最常见的并发症是出血[合并患病率1.0%,95%CI(0.6,1.4)]或感染[合并患病率0.8%,95%CI(0.3,1.2)]。确定了5例死亡[合并患病率0.3%,95%CI(0.1,0.6)]。文章分析确定了与SEEG植入和监测相关的121例手术并发症[合并患病率1.3%,95%CI(0.9,1.7)]。对SEEG相关并发症的实际发生率的综合评估。相比其他术外侵入性监测方法,SEEG并发症的发生率实际上更低。这些数据可能减轻一些关于"立体定位"方法的安全性的担忧,在选择不同的侵入性监测方法时做出更好的决策,并减轻深度电极植入相关的恐惧。

关键词：癫痫手术立体定向脑电图立体定位安全性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

关于海洋中声传播的简正波模型的新方法

引用

声学技术 1978年第1期 1-16页

作者： J.michael Mckisic D.p.Hamm 陶笃纯加利福尼亚洛克希德海洋实验室

Newman 和 Thorson 最近提出并研究了一种新方法,用这种方法能够快速而且有效地解出与线性二阶微分方程相联系的本征值问题。这里介绍把这种方法应用于水声学中感兴趣的问题的一些结果。

关键词：线性组合简正波模型方程的解函数声传播波传播

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：