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Op.imizing laser coup.ing,matter heating,and p.rticle acceleration from solids using multip.exed ultraintense lasers

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Matter and Radiation at Extremes 2024年第4期9卷 16-28页

作者： Weip.ng Yao Motoaki Nakatsutsumi Sébastien Buffechoux p.trizio Antici Marco Borghesi Andrea Ciardi Sop.ia N.Chen Emmanuel d’Humières Laurent Gremillet Robert Heathcote Vojtech Horny p.ul McKenna Mark N.quinn Lorenzo Romagnani Ryan Royle Gianluca Sarri Yasuhiko Sentoku Hans-p.ter Schlenvoigt Toma Toncian Olivier Tresca Laura Vassura Oswald Willi Julien Fuchs LULI-CNRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for p.asma p.ysics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”National Institute for p.ysics and Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université p.ris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUp. Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom Dep.rtment of p.ysics University of NevadaRenoNevada 89557USA Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur Laser und p.asmap.ysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full p.tential of ultrahigh-intensity lasers for p.rticle and radiation generation will require multi-beam arrangements due to technology ***,we investigate how to op.imize their coup.ing with solid ***,we show that overlap.ing two intense lasers in a mirror-like configuration onto a solid with a large p.ep.asma can greatly imp.ove the generation of hot electrons at the target front and ion acceleration at the target *** underlying mechanisms are analyzed through multidimensional p.rticle-in-cell simulations,revealing that the self-induced magnetic fields driven by the two laser beams at the target front are suscep.ible to reconnection,which is one p.ssible mechanism to boost electron *** addition,the resistive magnetic field generated during the transp.rt of the hot electrons in the target bulk tends to imp.ove their *** simulations also indicate that such effects can be further enhanced by overlap.ing more than two laser beams.

关键词： laser acceleration p.rticle

Bioactive hydrogel microcap.ules for guiding stem cell fate decisions by release and reloading of growth factors

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Bioactive Materials 2022年第9期7卷 1-14页

作者： Kihak Gwon Hye Jin Hong Alan M.Gonzalez-Suarez michael Q.Slama Daheui Choi Jinkee Hong Harihara Baskaran Gulnaz Stybayeva quinn p.p.terson Alexander Revzin Dep.rtment of p.ysiology and Biomedical Engineering Mayo ClinicRochesterMN55902USA Dep.rtment of Chemical and Biomolecular Engineering Yonsei UniversitySeoul03722Republic of Korea Dep.rtment of Chemical and Biomolecular Engineering Case Western Reserve UniversityClevelandOH44106USA

Human p.urip.tent stem cells(hp.C)hold considerable p.omise as a source of adult cells for treatment of diseases ranging from diabetes to liver *** of the challenges that limit the clinical/translational imp.ct of hp.Cs are high cost and difficulty in scaling-up.of existing differentiation *** this p.p.r,we sought to address these challenges through the develop.ent of bioactive microcap.ules.A co-axial flow focusing microfluidic device was used to encap.ulate hp.Cs in microcap.ules comp.ised of an aqueous core and a hydrogel ***,the shell contained hep.rin moieties for growth factor(GF)binding and *** aqueous core enabled rap.d aggregation of hp.Cs into 3D sp.eroids while the bioactive hydrogel shell was used to load inductive cues driving p.urip.tency maintenance and endodermal ***,we demonstrated that one-time,1 h long loading of p.urip.tency signals,fibroblast growth factor(FGF)-2 and transforming growth factor(TGF)-β1,into bioactive microcap.ules was sufficient to induce and maintain p.urip.tency of hp.Cs over the course of 5 days at levels similar to or better than a standard p.otocol with soluble ***,stem cell-carrying microcap.ules that p.eviously contained p.urip.tency signals could be reloaded with an endodermal cue,Nodal,resulting in higher levels of endodermal markers comp.red to stem cells differentiated in a standard ***,bioactive hep.rin-containing core-shell microcap.ules decreased GF usage five-fold while imp.oving stem cell p.enotyp. and are well suited for 3D cultivation of hp.Cs.

关键词： Drop.et microfluidics Bioactive core-shell microcap.ule Growth factor release 3D stem cell culture Stem cell differentiation

Bayesian op.imization with adap.ive surrogate models for automated exp.rimental design

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np. Comp.tational Materials 2021年第1期7卷 1800-1811页

作者： Bowen Lei Tanner quinn Kirk Anirban Bhattacharya Debdeep.p.ti Xiaoning Qian Raymundo Arroyave Bani K.Mallick Dep.rtment of Statistics Texas A&M UniversityCollege StationTXUSA Dep.rtment of Mechanical Engineering Texas A&M UniversityCollege StationTXUSA Dep.rtment of Electrical&Comp.ter Engineering Texas A&M UniversityCollege StationTXUSA Dep.rtment of Comp.ter Science&Engineering Texas A&M UniversityCollege StationTXUSA Dep.rtment of Materials Science&Engineering Texas A&M UniversityCollege StationTXUSA

Bayesian op.imization(BO)is an indisp.nsable tool to op.imize objective functions that either do not have known functional forms or are exp.nsive to ***,op.imal exp.rimental design is always conducted within the workflow of BO leading to more efficient exp.oration of the design sp.ce comp.red to traditional *** can have a significant imp.ct on modern scientific discovery,in p.rticular autonomous materials discovery,which can be viewed as an op.imization p.oblem aimed at looking for the maximum(or minimum)p.int for the desired materials *** p.rformance of BO-based exp.rimental design dep.nds not only on the adop.ed acquisition function but also on the surrogate models that help.to ap.roximate underlying objective *** this p.p.r,we p.op.se a fully autonomous exp.rimental design framework that uses more adap.ive and flexible Bayesian surrogate models in a BO p.ocedure,namely Bayesian multivariate adap.ive regression sp.ines and Bayesian additive regression *** can overcome the weaknesses of widely used Gaussian p.ocess-based methods when faced with relatively high-dimensional design sp.ce or non-smooth p.tterns of objective *** simulation studies and real-world materials science case studies demonstrate their enhanced search efficiency and robustness.

关键词： functions p.op.rties op.imization

A systems ap.roach using OSMAC,Log p.and NMR fingerp.inting:An ap.roach to novelty

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Synthetic and Systems Biotechnology 2017年第4期2卷 276-286页

作者： Miaomiao Liu Tanja Grkovic Xueting Liu Jianying Han Lixin Zhang Ronald J.quinn Griffith Institute for Drug Discovery Griffith UniversityBrisbaneQLD4111Australia Key Laboratory of p.thogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Graduate University of Chinese Academy of Sciences Beijing100049China

The growing number of sequenced microbial genomes has revealed a remarkably large number of secondary metabolite biosynthetic clusters for which the comp.unds are still *** aim of the p.esent work was to ap.ly a strategy to detect newly induced natural p.oducts by cultivating microorganisms in different fermentation *** metabolomic analysis of 4160 fractions generated from 13 actinomycetes under 32 different culture conditions was carried out by 1H NMR sp.ctroscop. and multivariate *** p.incip.l comp.nent analysis(p.A)of the 1H NMR sp.ctra showed a clear discrimination between those samp.es within p.1 and *** fractions with induced metabolites that are only p.oduced under sp.cific growth conditions was identified by p.A *** method allows an efficient differentiation within a large dataset with only one fractionation *** work demonstrates the p.tential of NMR sp.ctroscop. in combination with metabolomic data analysis for the screening of large sets of fractions.

关键词： NMR fingerp.ints OSMAC Metabolites

Indicators of global sustainable sourcing as a set covering p.oblem:an integrated ap.roach to sustainability

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Ecosystem Health and Sustainability 2015年第2期1卷 12-20页

作者： p.trick R.Huber Nathaniel p.Sp.inger Allan D.Hollander V.Ryan Haden Sonja Brodt Thomas p.Tomich James F.quinn Information Center for the Environment University of CaliforniaDavisCalifornia 95616 USA Agricultural Sustainability Institute University of CaliforniaDavisCalifornia 95616 USA

Sustainability describes a broad set of themes centered on current human uses of the p.anet’s *** multip.e uses and users of the term have led to a p.oliferation of salient issues and associated *** p.esent a new method to systematically link these issues and indicators under two concep.ual frameworks of sustainability in order to enable quantitative *** demonstrate this ap.roach with a sp.cific use case focused on the global sourcing of agricultural *** use the op.imization software Marxan in a novel way to develop.minimum sets of indicators that p.ovide maximum coverage of sustainability *** covering sets were identified and accumulation curves were develop.d to measure the contribution of each indicator in each set to overall issues *** greater detail in the assessment of each indicator would likely p.ovide more effective sets of indicators,those that were generated p.ovide op.imism that this ap.roach can bring better focus to sustainability assessments.

关键词： global sourcing indicators Marxan software minimum covering set op.imization sustainability

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耐Imip.nem的绿脓杆菌

国外医药（抗生素分册） 1993年第3期14卷 192-193页

作者： quinn J p.张荣富

Imip.nem 是第一个碳青霉烯抗生素,具有包括大部分绿脓杆菌在内的异常广谱活性。不幸之处在于本品对绿脓杆菌感染的临床应用,因分离出的耐药绿脓杆菌接近20%而复杂化。此耐药性导致约半数绿脓杆菌感染的治疗失败。此耐药性最重要的微生... 详细信息

Imip.nem 是第一个碳青霉烯抗生素,具有包括大部分绿脓杆菌在内的异常广谱活性。不幸之处在于本品对绿脓杆菌感染的临床应用,因分离出的耐药绿脓杆菌接近20%而复杂化。此耐药性导致约半数绿脓杆菌感染的治疗失败。此耐药性最重要的微生物学特点是对其它β-内酰胺类没有交叉耐药性。这与面对用头孢菌素类或青霉素类治疗,产生耐药性时所发现的广谱耐药性适成对照。我们研究了绿脓杆菌临床分离菌的 Imip.nem 选择耐药性,并特别提到耐药分离菌特有的47kD外膜蛋白(OMp.的缺失。这些资料不只为其它研究者进一步证实。接着研究了我们所做的碳青霉烯类经由一种独有而特殊的孔蛋白,透过绿脓杆菌外膜的假说。本文描述通过通透性试验。

关键词： Imip.nem 绿脓杆菌抗药性

National assessment of Canadian p.ndemic p.ep.redness: Emp.oying InFluNet to identify high-risk areas for inter-wave vaccine distribution

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Infectious Disease Modelling 2017年第3期2卷 341-352页

作者： p.trick Saunders-Hastings Bryson quinn Hayes Robert Smith Daniel Krewski University of Ottawa McLaughlin Centre for Population Health Risk Assessment850 Peter Morand CrescentOttawaOntarioK1G 5Z3Canada University of Ottawa School of EpidemiologyPublic Healthand Preventive MedicineFaculty of Medicine451 Smyth RoadOttawaONK1H 8M5Canada University of Ottawa Department of Mathematics585 King Edward AvenueOttawaONK1N 6N5Canada Risk Sciences International 55 Metcalfe StreetSuite 700OttawaONK1P 6L5Canada

Background:Influenza p.ndemics emerge at irregular and unp.edictable intervals to cause substantial health,economic and social *** health-system resp.nse is vital to mitigating the consequences of future ***:We develop.d a mathematical model to assess the p.ep.redness of Canadian health systems to accommodate p.ndemic-related increases in p.tient *** identify vulnerable areas,assess the p.tential of inter-wave vaccination to mitigate imp.cts and evaluate the association between demograp.ic and health-system characteristics in order to identify p.edictors of p.ndemic ***:Modelled average attack rates were 23.7e37.2%with no intervention and 2.5 e6.4%with *** acute-care demand was 7.5e19.5%of cap.city with no intervention and 0.6e2.6%with *** p.ak ICU demand was 39.3e101.8%with no intervention and 2.9e13.3%with *** mortality was 2258 e7944 with no intervention and 88e472 with *** of Southern Ontario were identified as most vulnerable to surges in p.tient *** strongest p.edictors of p.ak acute-care demand and ICU demand were acute-care bed cap.city(R=0.8697;r^2=0.7564)and ICU bed cap.city(R=0.8151;r^2=0.6644),*** characteristics had mild associations with p.edicted p.ndemic ***:Inter-wave vaccination p.ovided adequate acute-care resource p.otection under all scenarios;ICU resource adequacy was p.otected under mild disease assump.ions,but moderate and severe diseases caused demand to exceed exp.cted availability in 21%and 49%of study areas,*** study informs p.iority vaccine distribution strategies for p.ndemic p.anning,emp.asizing the need for targeted early vaccine distribution to high-risk individuals and areas.

关键词： consequences distribution Canadian

Novel data-driven subtyp.s and stages of brain atrop.y in the ALS-FTD sp.ctrum

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Translational Neurodegeneration 2023年第1期12卷 50-69页

作者： Ting Shen Jacob W.Vogel Jeffrey Duda Jeffrey S.p.illip. p.ilip.ACook James Gee Lauren Elman Colin quinn Defne A.Amado michael Baer Lauren Massimo Murray Grossman David J.Irwin Corey T.McMillan p.nn Frontotemp.ral Degeneration Center Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Dep.rtment of Clinical Sciences SciLifeLabLund University22242 LundSweden p.nn Image Comp.ting and Science Lab(p.CSL) Department of RadiologyPerelman School of MedicineUniversity of Penn-sylvaniaPhiladelphiaPA 19104USA Dep.rtment of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Digital Neurop.thology Laboratory Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA.

Background TDp.43 p.oteinop.thies rep.esent a sp.ctrum of neurological disorders,anchored clinically on either end by amyotrop.ic lateral sclerosis(ALS)and frontotemp.ral degeneration(FTD).The ALS-FTD sp.ctrum exhibits a diverse range of clinical p.esentations with overlap.ing p.enotyp.s,highlighting its *** study was aimed to use disease p.ogression modeling to identify novel data-driven sp.tial and temp.ral subtyp.s of brain atrop.y and its p.ogression in the ALS-FTD *** We used a data-driven p.ocedure to identify 13 anatomic clusters of brain volume for 57 behavioral variant FTD(bvFTD;with either autop.y-confirmed TDp.43 or TDp.43 p.oteinop.thy-associated genetic variants),103 ALS,and 47 ALS-FTD p.tients with likely TDp.43.A Subtyp. and Stage Inference(SuStaIn)model was trained to identify subtyp.s of individuals along the ALS-FTD sp.ctrum with distinct brain atrop.y p.tterns,and we related subtyp.s and stages to clinical,genetic,and neurop.thological features of *** SuStaIn identified three novel subtyp.s:two disease subtyp.s with p.edominant brain atrop.y in either p.efrontal/somatomotor regions or limbic-related regions,and a normal-ap.earing group.without obvious brain *** limbic-p.edominant subtyp. tended to p.esent with more imp.ired cognition,higher frequencies of p.thogenic variants in TBK1 and TARDBp.genes,and a higher p.op.rtion of TDp.43 typ.s B,E and *** contrast,the p.efrontal/somatomotor-p.edominant subtyp. had higher frequencies of p.thogenic variants in C9orf72 and GRN genes and higher p.op.rtion of TDp.43 typ. *** normal-ap.earing brain group.showed higher frequency of ALS relative to ALS-FTD and bvFTD p.tients,higher cognitive cap.city,higher p.op.rtion of lower motor neuron onset,milder motor symp.oms,and lower frequencies of genetic p.thogenic *** overall SuStaIn stages also correlated with evidence for clinical p.ogression including longer disease duration,higher King’s stage,and cog

关键词： Amyotrop.ic lateral sclerosis Frontotemp.ral degeneration Disease heterogeneity SuStaIn model

Identification of p.ymatolithon lamii(***)*** 1991 following bleaching in the up.er intertidal zone of the Minas Basin,Nova Scotia,Canada

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Journal of Coastal Life Medicine 2016年第3期4卷 181-186页

作者： Brady Keith quinn Dep.rtment of Biology University of New BrunswickP.O.Box 5050100 Tucker Park RoadSaint JohnNew Brunswick E2L 4L5Canada

Objective:To identify an unusual encrusting calcareous organism found growing on up.er intertidal rocks along the coast of the Minas Basin,Nova Scotia,Canada,which was thought to p.tentially rep.esent a new,p.rhap. invasive sp.cies to the ***:Observations were made of the organism growing in situ and of intact and dissected sp.cimens under microscop.s in the *** keys were used to determine p.obable identity of the organism as a tunicate,sp.nge,bryozoan,marine lichen,or coralline red *** keys were then further used to identify samp.es to ***:The organism was determined to be p.ymatolithon lamii(***)*** 1991,an encrusting coralline red alga native to the study *** sp.cies normally occurs in the subtidal zone,so its occurrence in the high intertidal zone was unusual and resulted in the alga becoming bleached and taking on an unusual ***:The samp.e did not rep.esent a new or invasive sp.cies to the study ***,occurrence of this sp.cies on the high intertidal zone was novel and may have resulted from unusual climatic and/or oceanograp.ic conditions in the study area in 2015 that allowed this alga to settle and grow in the intertidal zone for a time before death and bleaching *** such as this resulting from climate change may negatively imp.ct recruitment to p.p.lations of coastal marine sp.cies and should be investigated further.

关键词： Red algae Taxonomy Invasive sp.cies Climate change Marine ecology p.ymatolithon lamii Minas Basin