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Railway Engineering Science 2024年第3期32卷 257-285页

作者： michael nold Francesco Corman Institute for Transport Planning and Systems ETH ZürichZürichSwitzerland

The reduction of energy consumption is an increasingly important topic of the railway ***-efficient train control(EETC)is one solution,which refers to mathematically computing when to accelerate,which cruising speed to hold,how long one should coast over a suitable space,and when to *** approaches in literature and industry greatly simplify a lot of nonlinear effects,such that they ignore mostly the losses due to energy conversion in traction components and *** fill this research gap,a series of increasingly detailed nonlinear losses is described and *** categorize an increasing detail in this representation as four *** study the impact of those levels of detail on the energy optimal speed *** do this,a standard approach based on dynamic programming is used,given constraints on total travel *** evaluation of multiple test cases highlights the influence of the dynamic losses and the power consumption of auxiliary components on railway trajectories,also compared to multiple *** results show how the losses can make up 50%of the total energy consumption for an exemplary *** them would though result in consistent but limited errors in the optimal ***,more complex trajectories can result in less energy consumption when including the complexity of nonlinear losses than when a simpler model is *** effects are stronger when the trajectory includes many acceleration and braking phases.

关键词： Train trajectory optimization Energy-efficient train control(EETC) Dynamic efficiency Power losses in railway vehicles

Thirteen years to get from b to a:one of the neglected isoforms of IL-37 enters the stage

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Cellular & Molecular Immunology 2024年第2期21卷 201-202页

作者： Steven X.Cho Ina Rudloff Andrew M.Ellisdon Claudia A.nold-Petry Marcel F.nold Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Pediatrics Monash UniversityMelbourneVICAustralia Cancer Program Biomedicine Discovery InstituteMonash UniversityMelbourneVICAustralia Monash Newborn Monash Children’s HospitalMelbourneVICAustralia

Interleukin(IL)-37 is one of the few anti-inflammatory members of the predominantly pro-inflammatory IL-1 cytokine ***-37 possesses alarmin-like properties[1]and exerts its activities via intracellular[2]as well as cell surface receptor-dependent mechanisms,and the latter involves IL-1R8 and IL-18Rα[3].Because of its powerful and broad-spectrum“peacemaking”[4]functions,considerable efforts have been invested in developing IL-37-based anti-inflammatory therapeutics[5,6].

关键词： Interleukin neglected cytokine

Interleukin-1:an important target for perinatal neuroprotection?

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中国神经再生研究：英文版 2023年第1期18卷 47-50页

作者： Sharmony B.Kelly Elys Green Rod W.Hunt Claudia A.nold-Petry Alistair J.Gunn Marcel F.nold Robert Galinsky The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVictoriaAustralia Department of Obstetrics and Gynaecology Monash UniversityVictoriaAustralia Department of Pediatrics Monash UniversityVictoriaAustralia Monash Newborn Monash Children’s HospitalMelbourneAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Perinatal inflammation is a significant risk factor for lifelong neurodevelopmental impairments such as cerebral *** clinical and preclinical evidence links the severity and pattern of perinatal inflammation to impaired maturation of white and grey matters and reduced brain *** pathways are involved in the pathogenesis of perinatal ***,studies of human and experimental perinatal encephalopathy have demonstrated a strong causative link between perinatal encephalopathy and excessive production of the pro-inflammatory effector cytokine *** this review,we summarize clinical and preclinical evidence that underpins interleukin-1 as a critical factor in initiating and perpatuating systemic and central nervous system inflammation and subsequent perinatal brain *** also highlight the important role of endogenous interleukin-1 receptor antagonist in mitigating interleukin-1-driven neuroinflammation and tissue damage,and summarize outcomes from clinical and mechanistic animal studies that establish the commercially available interleukin-1 receptor antagonist,anakinra,as a safe and effective therapeutic *** reflect on the evidence supporting clinical translation of interleukin-1 receptor antagonist for infants at the greatest risk of perinatal inflammation and impaired neurodevelopment,and suggest a path to advance interleukin-1 receptor antagonist along the translational path for perinatal neuroprotection.

关键词： brain inflammation interleukin-1 receptor antagonist interleukin-1 interleukin-1β neonatal encephalopathy neuroprotection preterm brain injury

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砂浆行业中合理经济的生产系统

砂浆行业中合理经济的生产系统

Health Risks Assessment in Three Urban Farms of Paris Region for Different Scenarios of Urban Agricultural Users:A Case of Soil Trace Metals Contamination

首届全国商品砂浆学术会议

作者： Peter nold Klaus Frey 德国古斯塔夫爱立许机械制造有限公司

2003年德国约有150家砂浆生产企业,10000名员工共生产了280万t抹面砂浆,210 万t砌筑砂浆,180万t地坪砂浆,及约300万t其他种类的砂浆。其中有很大部分的生产系统运用了最高的技术规格。在这种技术的支持下可以经济地生产出高品质的产品... 详细信息

2003年德国约有150家砂浆生产企业,10000名员工共生产了280万t抹面砂浆,210 万t砌筑砂浆,180万t地坪砂浆,及约300万t其他种类的砂浆。其中有很大部分的生产系统运用了最高的技术规格。在这种技术的支持下可以经济地生产出高品质的产品。在此我们将讨论混合技术,因为它是整套生产设备中与质量最为息息相关的元素。本文将讨论用于本行业不同的混合系统的优点和缺点。另外本文还将列举不同的系统。小型和大型称量,塔式和水平布置等,并将解释交钥匙工厂的各个组成单元。本文介绍的现代化生产模式及系统为企业生产高品质的产品提供帮助并使其在竞争中立于不败之地。

关键词：砂浆混合圆柱型混合机强力混合机整厂

来源： cnki会议评论

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Agricultural Sciences 2019年第3期10卷 352-370页

作者： Anne Barbillon Christine Aubry Francois nold Stéphane Besancon Nastaran Manouchehri UMR SAD-APT INRAUniversitéParis-SaclayParisFrance Laboratory of Agronomy of the Paris City Paris Green Space and Environmental Division(DEVE)Parc Floral-Pavillon 5—Rond-Point de la PyramideParisFrance UMR Ingénierie Procédés Aliments AgroParisTechINRAUniversitéParis-SaclayMassyFrance

Within the context of a worldwide emergence of various forms of urban agriculture, there is a growing awareness concerning the health risks associated to the presence of different pollutants influencing the urban products safety. Among the most common pollutants found in soils and vegetables grown in the city, Trace Metals (TM’s) are of major concern. This paper deals with risks assessment associated with the presence of TM’s in soil, via two main exposure path ways: soil and vegetables ingestions. Risks assessments were conducted for various types of real scenarios encountered in three forms of urban farms near Paris (Ile-de-France Region). The farms have soil TM’s levels in abnormally high concentrations (Pb (Lead), Cd (Cadmium), Hg (Mercury), Cu (Copper) and Zn (Zinc) contents higher than geochemical backgrounds and threshold values for sludge spreading, often used as reference values in France). The results of the Hazard Quotient (HQ)-based risk assessment approach (HQ defined as the ratio of estimated daily intake/tolerable daily intake) show that the most risky scenarios concern urban farmers (HQtot = 1.02, because of the on-site working on a daily basis all year round), children gardeners (HQtot = 1.29) and regular children consumers (HQtot = 1.6 in maximalist scenario, where the consumer would exclusively consume the vegetables of the farm). Next would be the adult gardener scenario (HQtot= 0.9), while the least risky are adult consumer scenarios (HQtot = 0.62) and the farm workers (HQtot = 0.45). For the highest risk scenarios (urban farmers and children), specific and drastic measures may be considered, such as reducing the site frequentation by sensitive populations (child and pregnant women) or proceeding to control analysis of TM’s levels in blood for the most exposed peoples. The choice of parameters used in HQ-based method must be appropriated to the specificities of urban agricultural activities. The uncertainties in the choice of some parameters suc

关键词： Urban Agriculture Pollutants

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森林教育赋予孩子无限可能

动漫界（幼教365） 2022年第8期 23-26页

作者： [德]贝恩德·诺尔德不详

2021年12月9日至10日,由《动漫界·幼教365》杂志编辑部、南京师大文创教育培训中心共同主办,今日童心乐生态教育研究中心、北京今日创新教育文化有限公司承办的“2021年第三届幼儿园自然生态教育学术研讨会”成功举办。在全球疫情大环... 详细信息

2021年12月9日至10日,由《动漫界·幼教365》杂志编辑部、南京师大文创教育培训中心共同主办,今日童心乐生态教育研究中心、北京今日创新教育文化有限公司承办的“2021年第三届幼儿园自然生态教育学术研讨会”成功举办。在全球疫情大环境下,本次会议邀请了国内外多名自然生态教育专家学者进行了线上研讨,突破了场域局限,更好地满足了一线教师在生态教育方面的学习需求,真正实现中国幼儿园生态教育的常态化、专业化、系统化。同时,本次会议继续秉承第一届和第二届研讨会的思路,将自然生态教育理念与实践相融合,更加注重多元化、多领域的融合与共通,为生态教育的开展提供真正实操性的方案展示,深耕自然生态教育理念在中国幼儿园的落地,为园所引灯前行。本期“幼儿园自然生态教育学术研讨会”专栏已征得与会专家的允许,将其会议报告采撷成文,以飨广大幼教同人。

关键词：教育研究中心教育培训中心南京师大一线教师自然生态幼教幼儿园专业化

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美国西北部爱达荷钴带：元古代变质喷气矿区

吉林地质科技情报 1994年第3期 35-38,25页

作者： nold.,JL 张竹青