检索结果-南通市图书馆

Trilineage Sequencing Reveals Complex TCRβTranscriptomes in Neutrophils and Monocytes Alongside T Cells

Genomics, Proteomics & Bioinformatics 2021年第6期19卷 926-936页

作者： Tina Fuchs Kerstin Puellmann Chunlin Wang Jian Han Alexander W.Beham michael neumaier Wolfgang E.Kaminski Institute for Clinical Chemistry University of Heidelberg Medical Faculty MannheimD-68167 MannheimGermany Aesculabor Hamburg D-22769 HamburgGermany iRepertoire Inc. HuntsvilleAL 35806USA HudsonAlpha Institute for Biotechnology HuntsvilleAL 35806USA Department of Surgery Hospital of SiegenD-57076 SiegenGermany Ingenium digital diagnostics D-87662 KaltentalGermany

Recent findings indicate the presence of T cell receptor(TCR)-based combinatorial immune receptors beyond T cells in neutrophils and monocytes/*** this study,using a semiquantitative trilineage immune repertoire sequencing approach as well as under rigorous bioinformatic conditions,we identify highly complex TCRβtranscriptomes in human circulating monocytes and neutrophils that separately encode repertoire diversities one and two orders of magnitude smaller than that of T *** transcriptomic analyses reveal that neutrophils,monocytes,and T cells express distinct TCRβrepertoires with less than 0.1%overall trilineage repertoire *** comparison shows that in all three leukocyte lineages,the vast majority of the expressed TCRβvariants are *** also find that differentiation of monocytes into macrophages induces dramatic individual-specific repertoire shifts,revealing a surprising degree of immune repertoire plasticity in the monocyte *** results uncover the remarkable complexity of the two phagocyte-based flexible immune systems which until now has been hidden in the shadow of T cells.

关键词： Monocyte Neutrophil T cell TCRβtranscriptome Next-generation sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Delivery of acupuncture in clinical trials:Research acupuncturists’perspectives

引用

Journal of Integrative Medicine 2023年第4期21卷 315-319页

作者： Joyce K.Anastasi Bernadette Capili Jessica neumaier Londa Hackett Division of Special Studies in Symptom Management New York UniversityNew YorkNY 10010USA Heilbrunn Family Center for Research Nursing the Rockefeller UniversityNew YorkNY 10065USA

Delivery of acupuncture in the setting of a clinical trial is a unique practice that diverges significantly from the delivery of acupuncture in a real-world clinical setting. Research acupuncturists, particularly those trained in traditional Chinese medicine(TCM), are often required to set aside valued precepts of traditional care, including diagnosing imbalances, individualizing treatment, and forging a therapeutic relationship with patients. TCM-trained acupuncturists express mixed feelings about participating in clinical trials. Many are eager to play a vital role in the advancement of acupuncture science and appreciate the need for strict protocol adherence to minimize bias. However, the acupuncturist(s) may also have concerns about clinical trial methodology, including but not limited to the delivery of a control condition, e.g., sham acupuncture. Investigators should anticipate certain questions and even a level of resistance to the requirements of research among acupuncturists and be prepared to address them. This manuscript presents a brief review of the subjective experience of the research acupuncturist within the available scientific literature as it pertains to the delivery of active and sham clinical research protocols. Our goals are to better understand the perspectives of acupuncturists who may participate in clinical research, so that their concerns may be addressed in study design and methodology. To that end, we suggest the creation of a novel training program specifically for clinical trial acupuncturists, intended for qualified TCM-and Western-trained practitioners, that would help to standardize the research acupuncturist’s role and help to strengthen the design and execution of acupuncture studies.

关键词： Acupuncture Traditional Chinese medicine Clinical protocols Health knowledge,attitudes,practice Researcher-subject relationship Placebos

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

臂丛神经MR成像:3.0 T MR DTI相关测量与纤维示踪技术的精确性及可重复性

引用

国际医学放射学杂志 2011年第5期 508-509页

作者： A.Tagliafico M.Calabrese M.Puntoni D.Pace G.Baio C.E.neumaier 蔡兆诚 Department of Radiology National Institute for Cancer Research(IST)

目的对无臂丛神经病理改变的志愿者进行3.0 T MRI检查,评估DTI相关测量与纤维示踪技术(FT)的组内与组间可重复性。方法本研究经机构伦理委员会批准并获得

关键词：扩散张量成像臂丛神经可重复性各向异性分数表观扩散系数 MRI 最小检测差异

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

门脉高压症的附加超声征——静脉导管开放(摘译)

引用

暨南大学学报(自然科学与医学版) 1984年第2期 90-90页

作者： neumaier CE et al 梁明锦

超声图是研究上腹部血管的一种极好的无创伤方法,它能显示扩张的门静脉和门脉系统的许多侧枝循环通道。例如胃静脉曲张,胃——肾静脉和脾——肾静脉的分流,胃左静脉扩张及未闭脐静脉等。静脉导脉是一种管道结构,胎儿期中它把脐静脉血输... 详细信息

超声图是研究上腹部血管的一种极好的无创伤方法,它能显示扩张的门静脉和门脉系统的许多侧枝循环通道。例如胃静脉曲张,胃——肾静脉和脾——肾静脉的分流,胃左静脉扩张及未闭脐静脉等。静脉导脉是一种管道结构,胎儿期中它把脐静脉血输送到下腔静脉,脐静脉和静脉导管于胎儿出生后的第二天至第五天间,完全闭合而变成两条纤维索。在成人,前者称为肝圆韧带,后者残存一细的纤维索——静脉韧带。

关键词：静脉导管超声图门脉高压症门脉高血压

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：