检索结果-南通市图书馆

The role of systemic therapy in borderline resectable and locally advanced pancreatic ductal adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer metastasis and Treatment 2022年第1期8卷 281-292页

作者： Victor C.K.Lo Rachel A.Goodwin michael m.vickers Department of medicine Division of Medical OncologyThe Ottawa Hospital Cancer CentreOttawaON K1H 8L6Canada

Pancreatic ductal adenocarcinoma(PDAC)remains a deadly disease,even in patients whose cancer is localized and *** resection provides the only option for cure,but long-term survival rates remain *** patients with borderline resectable(BR)disease who undergo upfront resection,many patients are either too unwell for subsequent adjuvant systemic therapy,develop recurrence soon after,or are found to have unresectable disease *** is increasing evidence for a neoadjuvant approach,using more conventional multi-agent chemotherapy regimens,which have demonstrated higher activity in the metastatic setting compared to single *** patients with locally advanced(LA)disease,which is unresectable by current definitions,there is mounting evidence that effective neoadjuvant systemic therapy is able to convert some patients’disease to a resectable state,offering the potential for long-term survival and *** we present a review of key trials focusing on prospective,randomized studies to provide high-level evidence supporting a neoadjuvant approach to both BR and LA ***,many knowledge gaps exist,such as the optimal neoadjuvant multi-agent chemotherapy regimen,the role of radiotherapy,and the safety and efficacy of adding immunotherapy to chemo/radiation *** challenges in determining the optimal approach to patients with BR or LA PDAC include not only overcoming the inherent difficulties in conducting complex,multidisciplinary,multicentre randomized trials in patients with a high-morbidity and mortality disease,but also trying to standardize disease definitions,treatment regimens,and outcome measures.

关键词： Borderline resectable locally advanced pancreatic ductal adenocarcinoma neoadjuvant chemotherapy

Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2)Heterojunction Anode for Decentralized Saline Wastewater Treatment and H_(2)Production

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-micro Letters 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon Kim Jaebeom Park Sunmi Im michael R.Hoffmann Kangwoo Cho Division of Environmental Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Laboratory California Institute of TechnologyPasadenaCA 91125USA Institute for Convergence Research and Education in Advanced Technology(I‑CREATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater electrolysis cells(WECs)for decentralized wastewater treatment/reuse coupled with H_(2)production can reduce the carbon footprint associated with transportation of water,waste,and energy *** study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2)overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment *** dilute(0.1 m)NaCl solutions,the NFI/TiO_(2)marks superior activity and selectivity for chlorine evolution reaction,outperforming the benchmark IrO_(2).Robust operation in near-neutral pH was *** including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the primary site for Cl−chemisorption and a protective layer for NFI as an ohmic *** electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO_(2)not only achieves quasi-stoichiometric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive *** scaled-up WEC with NFI/TiO_(2)was demonstrated for electrolysis of toilet wastewater.

关键词： Wastewater electrolysis cell Ir-doped NiFe_(2)O_(4) Reactive chlorine species Decentralized H_(2)production On-site wastewater treatment

Neuromyelitis optica and myelin oligodendrocyte glycoprotein

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Annals of Eye Science 2018年第1期3卷 147-157页

作者： Angela Huang Aroucha vickers Claudia m.Prospero Ponce Andrew G.Lee Baylor College of medicine HoustonTXUSA Department of Ophthalmology Blanton Eye InstituteHouston Methodist HospitalHoustonTXUSA Department of Ophthalmology and Visual Sciences The University of Texas Medical BranchGalvestonTXUSA Departments of Ophthalmology Neurologyand NeurosurgeryWeill Cornell MedicineNew York CityNYUSA The University of Texas mD Anderson Cancer Center HoustonTXUSA Texas A and m College of medicine College StationBryanTXUSA The University of Iowa Hospitals and Clinics Iowa CityIAUSA The University of Buffalo BuffaloNYUSA

Neuromyelitis optica(NmO)refers to an antibody mediated,inflammatory disorder of the central nervous system(CNS)characterized by recurrent or monophasic attacks of optic neuritis and *** patients with NmO possess a specific serum immunoglobin,NmO-IgG,which can serve as a biomarker for *** autoantibodies target aquaporin-4(AQP4),the main water channel protein found in the CNS including the brain,spinal cord,and optic *** remaining 10-25%of patients are seronegative for NmO-IgG despite meeting the diagnostic criteria for *** studies have shown that a subset of these patients is seropositive for antibodies against myelin oligodendrocyte glycoprotein(mOG).This paper will provide an overview of the current English scientific literature published regarding the history,epidemiology,AQP4 biomarker,mOG biomarker,diagnosis,clinical features,related diseases in NmO spectrum disorder(NmOSD),and treatments of NmO.

关键词： Neuromyelitis optica(NmO) Devic disease aquaporin-4 myelin oligodendrocyte glycoprotein(mOG)

On the experimental characterization of the fluid volume influence on the friction between rough surfaces

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2023年第7期11卷 1334-1348页

作者： Lukas STAHL michael mÜLLER Georg-Peter OSTERmEYER Institute of Dynamics and Vibrations Technische Universität BraunschweigBraunschweig 37106Germany

The load-bearing behaviour of lubricated contacts depends primarily on the normal force,the relative velocity,and the ***,with the aid of the Stribeck curve,it is usually well possible to characterize whether hydrodynamics,mixed friction,or boundary friction is more likely to be *** fact that the load regime can also depend on the fluid quantity is obvious,but has hardly been systematically investigated so *** for contacts with microscopic roughness,the defined application of a very small amount of fluid is a very challenging *** this paper,a very fundamental study shows how a pin-on-disc tribometer can be used to achieve the transition from dry friction via mixed friction to predominant hydrodynamics by the amount of supplied *** experiments are carried out on samples filed with different *** addition,the simultaneous influence of partial filling and normal force as well as relative velocity is also *** good reproducibility has been practically reached over the entire range of the *** the quantities for the coefficient of friction(COF),it was concluded that close to full filling,a reduction of the fluid quantity has a similar effect on the COF as the reduction of the *** property goes along with the common theory of starved lubricated *** behaviour was not observed to the same extent for the normal *** the vicinity of smaller fluid quantities,the COF increases very rapidly with further reduction in fluid quantity,far more disproportionately than that with reduction in *** a deeper understanding of this problem,various practical issues such as idling or the run-up process in bearings can also be studied in a more focused manner.

关键词： starved lubrication Stribeck curve pin-on-disc tribometer fluid supply experimental studies

The role of estradiol in male reproductive function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第3期18卷 435-440,I0009页

作者： michael Schulster Aaron m Bernie Ranjith Ramasamy Department of Urology New York-Presbyterian Hospital Weill Cornell Medical College New York USA Department of Urology Miller School of Medicine University of Miami Miami FL USA.

Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis. Estrogen receptors, as well as aromatase, the enzyme that converts testosterone to estrogen, are abundant in brain, penis, and testis, organs important for sexual function. In the brain, estradiol synthesis is increased in areas related to sexual arousal. In addition, in the penis, estrogen receptors are found throughout the corpus cavernosum with high concentration around neurovascular bundles. Low testosterone and elevated estrogen increase the incidence of erectile dysfunction independently of one another. In the testes, spermatogenesis is modulated at every level by estrogen, starting with the hypothalamus-pituitary-gonadal axis, followed by the Leydig, Sertoli, and germ cells, and finishing with the ductal epithelium, epididymis, and mature sperm. Regulation of testicular cells by estradiol shows both an inhibitory and a stimulatory influence, indicating an intricate symphony of dose-dependent and temporally sensitive modulation. Our goal in this review is to elucidate the overall contribution of estradiol to male sexual function by looking at the hormone＇s effects on erectile function, spermatogenesis, and libido.

关键词： estrogen testosterone spermatogenesis erectile function estrogen receptor aromatase

Structural development of vegetation on rehabilitated North Stradbroke Island:Above/belowground feedback may facilitate alternative ecological outcomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2013年第1期2卷 195-211页

作者： Patrick Audet Amanda Gravina Vanessa Glenn Phill mcKenna Helen vickers melina Gillespie David mulligan Centre for mined Land Rehabilitation Sustainable Minerals Institute The University of QueenslandBrisbane(St.Lucia)QLD 4072Australia

Introduction:This study depicts broad-scale revegetation patterns following sand mining on North Stradbroke Island,south-eastern Queensland,***:Based on an ecological timeline spanning 4–20 years post-rehabilitation,the structure of these ecosystems(n=146)was assessed by distinguishing between periods of‘older’(pre-1995)and‘younger’(post-1995)rehabilitation ***:The general rehabilitation outlook appeared promising,whereby an adequate forest composition and suitable levels of native biodiversity(consisting of mixed-eucalypt communities)were achieved across the majority of rehabilitated sites over a relatively short ***,older sites(n=36)appeared to deviate relative to natural analogues as indicated by their lack of under-storey heath and simplified canopy composition now characterised by mono-dominant black sheoak(Allocasuarina littoralis)reaching up to 60%of the total tree *** changes coincided with lower soil fertility parameters(e.g.,total carbon,total nitrogen,and nutrient holding capacity)leading us to believe that altered growth conditions associated with the initial mining disturbance could have facilitated an opportunistic colonisation by this *** established,it is suspected that the black sheoak’s above/belowground ecological behaviour(i.e.,relating to its leaf-litter allelopathy and potential for soil-nitrogen fixation)further exacerbated its mono-dominant distribution by inhibiting the development of other native ***:Although rehabilitation techniques on-site have undergone refinements to improve site management,our findings support that putative changes in edaphic conditions in combination with the competitive characteristics of some plant species can facilitate conditions leading to alternative ecological outcomes among rehabilitated *** on these outcomes,future studies would benefit from in depth spatio-temporal analyses to verify these mechanisms at finer investigative sc

关键词： Eucalypts mono-dominance Forest regeneration Ecological restoration mineral sands mining

Comparison of L-band and X-band differential interferometric synthetic aperture radar for mine subsidence monitoring in central Utah

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of mining Science and Technology 2017年第1期27卷 159-163页

作者： Jessica m.Wempen michael K.mcCarter Department of mining Engineering University of UtahSalt Lake City 84112USA

Differential interferometric synthetic aperture radar(DIn SAR), a satellite-based remote sensing technique, has potential application for measuring mine subsidence on a regional scale with high spatial and temporal resolutions. However, the characteristics of synthetic aperture radar(SAR) data and the effectiveness of DIn SAR for subsidence monitoring depend on the radar band(wavelength). This study evaluates the effectiveness of DIn SAR for monitoring subsidence due to longwall mining in central Utah using L-band(24 cm wavelength) SAR data from the advanced land observing satellite(ALOS)and X-band(3 cm wavelength) SAR data from the Terra SAR-X mission. In the Wasatch Plateau region of central Utah, which is characterized by steep terrain and variable ground cover conditions, areas affected by longwall mine subsidence are identifiable using both L-band and X-band DIn ***, using L-band data, subsidence magnitudes are measurable. Compared to X-band, L-band data are less affected by signal saturation due to large deformation gradients and by temporal decorrelation due to changes in the surface conditions over time. The L-band data tend to be stable over relatively long periods(months). Short wavelength X-band data are strongly affected by signal saturation and temporal decorrelation, but regions of subsidence are typically identifiable over short periods(days). Additionally,though subsidence magnitudes are difficult to precisely measure in the central Utah region using X-band data, they can often be reasonably estimated.

关键词： mine subsidence DInSAR Terra SAR-X ALOS Interferometry

A novel method of quantifying the coating progress in a three-dimensional prismatic spouted bed

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Particuology 2019年第1期17卷 137-145页

作者： Swantje Pietscha Finn Ole Poppinga Stefan Heinrich michael müller michael Schonherr Frank Kleine Jager Hamburg University of Technology Institute of Solids Process Engineering and Particle TechnologyDenickestraβe 1521073 HamburgGermany BASF SE RCP/TT67056 LudwigshafenGermany

An optical method of experimentally quantifying the coating progress in a laboratory prismatic spouted bed is presented. microcrystalline cellulose particles with size dp = 0.57 mm are used as core material. Waterborne coating suspensions with methylene blue as a dye are used and sprayed via a two-fluid nozzle in bottom-spray configuration. A high-speed camera with a color filter is positioned in front of the observation window of the three-dimensional plant and records the flow pattern in the process chamber with a certain frequency. With increasing surface coverage, the particles become bluer and darker. The change in brightness is detected by digital image analysis. In the implemented algorithm, the spherical particles are detected, cut from the background and normalized regarding their lighting and area. The detection of coated pixels on the single particles allows the calculation of the coating fraction and coating uniformity after a Kalman filter has been applied to reduce noise. It is shown that the method can be used to determine the time needed to reach the maximum blue value indicating a complete coating of the particle bed. Besides the minimum coating duration, information on the spraying performance (e.g., the time point of a possibly occurring blockage of the nozzle) can be obtained from the data. Two exemplary experiments are presented, showing a connection of the slope of the coating fraction and the uniformity of the coating of the particles in the apparatus that results in the recommendation of a slow liquid injection for obtaining consistent coating layers as desired in many applications.

关键词： Spouted bed Particle coating Granulation Digital image analysis

A survey of sub-inhibitory concentrations of antibiotics in the environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2021年第1期33卷 21-27页

作者： Louise K.m.Chow Timothy m.Ghaly michael R.Gillings Department of Biological Sciences Macquarie UniversityNSW 2109Australia ARC Centre of Excellence in Synthetic Biology Macquarie UniversityNSW 2109Australia

Antibiotics are poorly metabolized,and can enter the environment via human waste streams,agricultural run-off and pharmaceutical *** consequently expect to see a concentration gradient of antibiotic compounds radiating from areas of human *** antibiotics should be thought of as pollutants,as they can accumulate,and have biological *** antibiotic pollutants can increase rates of mutation and lateral transfer events,and continue to exert selection pressure even at sub-inhibitory ***,we conducted a literature survey on environmental concentrations of *** collated 887 data points from 40 peer-reviewed *** then determined whether these concentrations were biologically relevant by comparing them to their minimum selective concentrations,usually defined as between 1/4 and 1/230 of the minimum inhibitory *** concentrations of antibiotics surveyed often fall into this *** general,the antibiotic concentrations recorded in aquatic and sediment samples were *** findings indicate that environmental concentrations of antibiotics are likely to be influencing microbial ecology,and to be driving the selection of antibiotic resistant bacteria.

关键词： Antimicrobial Pollution Evolution microorganism Environment Antibiotic resistance