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Target morphology and cell memory:a model of regenerative pattern formation

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Neural Regeneration Research 2015年第12期10卷 1901-1905页

作者： Nikolai Bessonov michael levin Nadya Morozova Natalia Reinberg Alen Tosenberger Vitaly Volpert Institute of Problems of Mechanical Engineering Russian Academy of Sciences Department of Biology Tufts Center for Regenerative & Developmental BiologyTufts University Laboratoire Epigénétique et Cancer Institut des Hautes Etudes Scientiques Unité de Chronobiologie Théorique Faculté des SciencesUniversité Libre de BruxellesCampus Plaine Institut Camille Jordan UMR 5208 CNRSUniversity Lyon 1

Despite the growing body of work on molecular components required for regenerative repair,we still lack a deep understanding of the ability of some animal species to regenerate their appropriate complex anatomical structure following damage.A key question is how regenerating systems know when to stop growth and remodeling-what mechanisms implement recognition of correct morphology that signals a stop condition？In this work,we review two conceptual models of pattern regeneration that implement a kind of pattern *** the first one,all cells communicate with each other and keep the value of the total signal received from the other *** a part of the pattern is amputated,the signal distribution *** difference fromthe original signal distribution stimulates cell proliferation and leads to pattern regeneration,in effect implementing an error minimization process that uses signaling memory to achieve pattern *** the second model,we consider a more complex pattern organization with different cell *** tissue contains a central（coordinator）cell that controls the tissue and communicates with the other central *** of them keeps memory about the signals received from other central *** values of these signals depend on the mutual cell location,and the memory allows regeneration of the structure when it is *** purpose of these models is to suggest possible mechanisms of pattern regeneration operating on the basis of cell memory which are compatible with diverse molecular implementation mechanisms within specific organisms.

关键词： target morphology pattern regeneration cell memory morphogenesis cell signaling mathematical modeling agent-based model

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细菌性脑膜炎和脑脓肿

国际内科双语杂志（中英文） 2006年第1期6卷 1-6,35-40页

作者： Saul N Faust Nazima Pathan michael levin 芦波（译）盛瑞媛（校）英国伦敦皇家大学医学校圣玛丽医院儿童传染病系临床讲师英国伦敦大奥蒙德街医院儿童重症监护的注册专家医师英国布赖顿的布赖顿和苏塞克斯医学院实验医学教授和研究部主任不详

流行病学和微生物学细菌性脑膜炎的年发病率约为2／10万～3／10万，以婴幼儿和青少年发病率为高。在英国，b型流感嗜血杆菌（Hib）免疫接种项目和近来C组脑膜炎球菌疫苗的应用，使这两种细菌性脑膜炎的病例数明显下降，且使细菌性脑膜... 详细信息

流行病学和微生物学细菌性脑膜炎的年发病率约为2／10万～3／10万，以婴幼儿和青少年发病率为高。在英国，b型流感嗜血杆菌（Hib）免疫接种项目和近来C组脑膜炎球菌疫苗的应用，使这两种细菌性脑膜炎的病例数明显下降，且使细菌性脑膜炎总发病率也显著下降。

关键词：细菌性脑膜炎脑脓肿 b型流感嗜血杆菌脑膜炎球菌疫苗年发病率微生物学流行病学免疫接种总发病率婴幼儿

Vitamin D and autoimmune thyroid diseases

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Cellular & Molecular Immunology 2011年第3期8卷 243-247页

作者： Shaye Kivity Nancy Agmon-levin michael Zisappl Yinon Shapira Endre V Nagy Katalin Danko Zoltan Szekanecz Pnina Langevitz Yehuda Shoenfeld The Zabludovicz Center for Autoimmune Diseases Sheba Medical CenterTel-Hashomeraffiliated to Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Medicine‘A&C’ Sheba Medical CenterTel-HashomerIsrael Rheumatic Disease Unit Sheba Medical CenterTel-HashomerIsrael Department of Medicine‘B’ Sheba Medical CenterTel-HashomerIsrael University of Debrecen.Medical and Health Science Center DebrecenHungary Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases Tel Aviv UniversityTel AvivIsrael

The role of vitamin D as an immune modulator has been emphasized in recent years,and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus *** D mediates its effect though binding to vitamin D receptor(VDR),and activation of VDR-responsive *** VDR gene polymorphism was found to associate with autoimmune thyroid diseases(AITDs),few studies examined levels of vitamin D in these patients and those that did yielded conflicting *** therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy *** vitamin D(25-OH)levels were measured in 50 patients with AITDs,42 patients with non-AITDs and 98 healthy subjects,utilizing the LIAISON chemiluminescence immunoassay(DiaSorin,Saluggia,Italy).VitaminD deficiency was designated at levels lower than 10 ng/*** antibodies,thyroid functions and demographic parameters were evaluated in all *** prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals(72% versus 30.6%;P<0.001),as well as in patients with Hashimoto’s thyroiditis compared to patients with non-AITDs(79% versus 52%;P<0.05).Vitamin D deficiency also correlated to the presence of antithyroid antibodies(P=0.01)and abnormal thyroid function tests(P=0.059).Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests,suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation.

关键词： autoantibodies autoimmune thyroid disease Graves’disease Hashimoto’s thyroiditis vitamin D

Peripheral vestibular system: Age-related vestibular loss and associated deficits

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Journal of Otology 2021年第4期16卷 258-265页

作者： Jennifer Coto Carmen L.Alvarez Ivette Cejas Brett M.Colbert Bonnie E.levin Joshua Huppert Tatjana Rundek Carey Balaban Susan H.Blanton David J.Lee David Loewenstein michael Hoffer Xue Zhong Liu University of Miami Miller School of Medicine Department of OtolaryngologyMiamiFLUSA San Juan Bautista Medical School CaguasPRUSA Medical Scientist Training Program University of Miami Miller School of MedicineMiamiFLUSA University of Miami Miller School of Medicine Department of Neurology and the Evelyn F.McKnight Brain InstituteMiamiFLUSA University of Pittsburgh Departments of OtolaryngologyNeurobiologyCommunication Sciences&Disordersand BioengineeringPittsburghPAUSA University of Miami Miller School of Medicine Dr.John T.Macdonald Department of Human GeneticsMiamiFLUSA University of Miami Miller School of Medicine Department of Public Health SciencesMiamiFLUSA University of Miami Miller School of Medicine Department of Psychiatry and Behavioral SciencesMiamiFLUSA

Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision,cognition), it is important to examine the individual contributions of these factors with ARVL. While therelationship between the vestibular and visual systems has been well studied (Bronstein et al., 2015),little is known about the association of the peripheral vestibular system with neurodegenerative disorders (Cronin et al., 2017). Further, emerging research developments implicate the vestibular system asan opportunity for examining brain function beyond balance, and into other areas, such as cognition andpsychological functioning. Additionally, the bidirectional impact of psychological functioning is understudied in ARVL. Recognition of ARVL as part of a multifaceted aging process will help guide thedevelopment of integrated interventions for patients who remain at risk for decline. In this review, wewill discuss a wide variety of characteristics of the peripheral vestibular system and ARVL, how it relatesto neurodegenerative diseases, and correlations between ARVL and balance, vision, cognitive, and psychological dysfunction. We also discuss clinical implications as well as future directions for research, withan emphasis on improving care for patients with ARVL.

关键词： Peripheral vestibular system Age-related vestibular loss Balance Vision Cognitive Psychological

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迈阿密市长大举招商吸引马斯克注意

商业周刊（中文版） 2021年第7期 30-32页

作者： Jonathan levin michael Smith 汪泽(译) 不详

迈阿密市长弗朗西斯·苏亚雷斯(Francis Suarez)摇身成为科技招募人员是在2020年12月4日,接近迈阿密时间晚上9点,那一刻如同病毒一般传播开去。在Twitter上,Founders Fund的风投资本家德利安·阿斯帕罗霍夫(Delian Asparouhov)灵光一现... 详细信息

迈阿密市长弗朗西斯·苏亚雷斯(Francis Suarez)摇身成为科技招募人员是在2020年12月4日,接近迈阿密时间晚上9点,那一刻如同病毒一般传播开去。在Twitter上,Founders Fund的风投资本家德利安·阿斯帕罗霍夫(Delian Asparouhov)灵光一现:“大家听我说,把硅谷迁到迈阿密怎么样?”“我能做点什么?”苏亚雷斯回复道。他的推文在互联网上广为传播。苏亚雷斯印制了带有这句话的T恤衫,采用《迈阿密风云》(Miami Vice)标志性的粉色和蓝色。

关键词：苏亚雷斯互联网迈阿密

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中央银行数字货币与货币政策的未来

中国货币市场 2021年第5期 75-79页

作者： michael D Bordo Andrew T levin 美国国家经济研究局(NBER)

文章分析了中央银行数字货币(CBDC)的关键功能,重点围绕CBDC付款应基于央行账户还是代币;应废除现金,还是央行制定CBDC与纸币间转账的费用表;CBDC是否应生息或锚定总价格指数,还是像现金那样恒定名义价值;CBDC对央行货币政策策略和操作... 详细信息

文章分析了中央银行数字货币(CBDC)的关键功能,重点围绕CBDC付款应基于央行账户还是代币;应废除现金,还是央行制定CBDC与纸币间转账的费用表;CBDC是否应生息或锚定总价格指数,还是像现金那样恒定名义价值;CBDC对央行货币政策策略和操作的影响;CBDC如何影响央行与财政当局间的互动等问题,探讨了CBDC和央行货币政策的未来。

关键词：中央银行数字货币央行 CBD 价格指数货币政策现金纸币

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隔离之下派对继续嘉年华在想什么

商业周刊（中文版） 2020年第8期 36-41页

作者： Jonathan levin michael Smith KOanh Ha 许诺(译) 不详

今年3月4曰一早,当消息传到“至尊公主号”上的时候,一开始并未引起人们的注意。在一封从客舱房门下面塞进来的信中,嘉年华公司(Carnival Corp.)的首席医务官格兰特塔林(Grant Tarling)通报说,美国国家疾控中心(CDC)已在加州开始“调... 详细信息

今年3月4曰一早,当消息传到“至尊公主号”上的时候,一开始并未引起人们的注意。在一封从客舱房门下面塞进来的信中,嘉年华公司(Carnival Corp.)的首席医务官格兰特塔林(Grant Tarling)通报说,美国国家疾控中心(CDC)已在加州开始“调查一起小规模聚集性的新冠病毒感染”事件,这些病例或许与他们这艘邮轮有关。受此影响,这艘2月19曰从旧金山出发前往夏威夷的邮轮在返程途中将取消原计划的墨西哥停靠点,提前驶回其在湾区的靠泊港。

关键词：嘉年华疾控中心格兰特邮轮病毒感染夏威夷聚集性旧金山

Evaluating indicators of human well-being for ecosystem-based management

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Ecosystem Health and Sustainability 2017年第12期3卷 2-19页

作者： Sara Jo Breslow Margaret Allen Danielle Holstein Brit Sojka Raz Barnea Xavier Basurto Courtney Carothers Susan Charnley arah Coulthard Nives Dolsak Jamie Donatuto Carlos Garcia-Quijano Christina C.Hicks Arielle levine michael B.Masci Karma Norman Melissa Poe Terre Satterfield Kevin St.Martin Phillip S.levin Center for Creative Conservation University of WashingtonSeattleWAUSA School of Marine and Environmental Affairs University of WashingtonSeattleWAUSA Nicholas School of the Environment Duke UniversityBeaufortNCUSA College of Fisheries and Ocean Sciences University of Alaska FairbanksAnchorageAKUSA Pacific Northwest Research Station USDA Forest ServicePortlandORUSA Department of Social Sciences and Languages Northumbria UniversityNewcastle upon TyneUK Community Environmental Health Program Swinomish Indian Tribal CommunityLa ConnerWAUSA Department of Sociology and Anthropology The University of Rhode IslandKingstonRI USA Center for Ocean Solutions Stanford UniversityMontereyCAUSA Lancaster Environment Center Lancaster UniversityLancasterUK Department of Geography San Diego State UniversitySan DiegoCAUSA Moore Center for Science Conservation InternationalArlingtonVAUS Northwest Fisheries Science Center National Oceanic and Atmospheric AdministrationSeattleWAUSA Washington Sea Grant University of WashingtonSeattleWAUSA Institute for Resources Environment and SustainabilityUniversity of British ColumbiaVancouverBCCanada Department of Geography RutgersThe State University of New JerseyPiscatawayNJUSA School of Environmental and Forest Sciences University of WashingtonSeattleWAUSA

Introduction:Interrelated social and ecological challenges demand an understanding of how environmental change and management decisions affect human *** paper out-lines a framework for measuring human well-being for ecosystem-based management(EBM).We present a prototype that can be adapted and developed for various scales and *** and managers use indicators to assess status and trends in integrated ecosystem assessments(IEAs).To improve the social science rigor and success of EBM,we developed a systematic and transparent approach for evaluating indicators of human well-being for an ***:Our process is based on a comprehensive conceptualization of human well-being,a scalable analysis of management priorities,and a set of indicator screening criteria tailored to the needs of *** tested our approach by evaluating more than 2000 existing social indicators related to ocean and coastal management of the US West *** focused on two foundational attributes of human well-being:resource access and *** and Discussion:Our results suggest that existing indicators and data are limited in their ability to reflect linkages between environmental change and human well-being,and extremely limited in their ability to assess social equity and *** reveal a critical need for new social indicators tailored to answer environmental questions and new data that are disaggregated by social variables to measure *** both,we stress the importance of collaborating with the people whose well-being is to be ***:Our framework is designed to encourage governments and communities to carefully assess the complex tradeoffs inherent in environmental decision-making.

关键词： Human well-being indicators ecosystem-based management integrated ecosystem assessment resource access self-determination

Analysis of Sustainable Materials Used in Ecovillages: Review of Progress in BedZED and Masdar City

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Journal of Wuhan University of Technology(Materials Science) 2012年第5期27卷 1004-1007页

作者：朱聃 michael Kung Bill Whiteford Alex Boswell-Ebersole College of Design Construction and PlanningUniversity of Florida College of Education University of Florida Florida 32611 USA College of Design Construction and Planning University of Florida Florida 32611 USA levin College of Law University of Florida Florida 32611 USA

This paper explores reclaimed and recycled material used in ecovillages. The models discussed in this paper include BedZED in the United Kingdom and Masdar City in the Middle East. These two communities contain features characterized by the sustainable principles of the ecovillage concept by using non-traditional building materials. The creations of more ecovillages, along with the growth of current ecovillages, play an important role in positively solvening environmental and social problems. The sustainable materials used in the ecovillages also act as a model for communities wishing to implement sustainable development.

关键词： reclaimed materials green supply chain sustainable development ecovillage