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One year experience with computer-assisted propofol sedation for colonoscopy

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World Journal of Gastroenterology 2017年第16期23卷 2964-2971页

作者： Otto S Lin Danielle La Selva Richard A Kozarek Deborah Tombs Wade Weigel Ryan Beecher Johannes Koch Susan Mc Cormick michael Chiorean Fred Drennan michael Gluck Nanda Venu michael larsen Andrew Ross Digestive Disease Institute Virginia Mason Medical CenterSeattleWA 98101United States Department of Anesthesia Virginia Mason Medical CenterSeattleWA 98101United States

AIM To report our one-year experience with computer assisted propofol sedation(CAPS) for colonoscopy as the first United States Medical Center to adopt CAPS technology for routine clinical *** Between September 2014 and August 2015, 2677 patients underwent elective outpatient colonoscopy with CAPS at our center. All colonoscopies were performed by 1 of 17 gastroenterologists certified in the use of the CAPS system, with the assistance of a specially trained nurse. Procedural success rates, polyp detection rates, procedure times and recovery times were recorded and compared against corresponding historical measuresfrom 2286 colonoscopies done with midazolam and fentanyl from September 2013 to August 2014. Adverse events in the CAPS group were *** The mean age of the CAPS cohort was 59.9 years(48.7% male); 31.3% were ASA?Ⅰ, 67.3% ASA Ⅱ and 1.4% ASA Ⅲ. 45.1% of the colonoscopies were for screening, 31.5% for surveillance, and 23.4% for symptoms. The mean propofol dose administered was 250.7 mg(range 16-1470 mg), with a mean fentanyl dose of 34.1 mcg(0-100 mcg). The colonoscopy completion and polyp detection rates were similar to that of historical measures. Recovery times were markedly shorter(31 min vs 45.6 min, P < 0.001). In CAPS patients, there were 20(0.7%) cases of mild desaturation(< 90%) treated with a chin lift and reduction or temporary discontinuation of the propofol infusion, 21(0.8%) cases of asymptomatic hypotension(< 90 systolic blood pressure) treated with a reduction in the propofol rate, 4(0.1%) cases of marked agitation or discomfort due to undersedation, and 2 cases of pronounced transient desaturation requiring brief(< 1 min) mask ventilation. There were no sedation-related serious adverse events such as emergent intubation, unanticipated hospitalization or permanent injury. CONCLUSION CAPS appears to be a safe, effective and efficient means of providing moderate sedation for colonoscopy in relatively healthy patients. Recovery

关键词： Colonoscopy Propofol Sedation Colon cancer screening Anesthesia

Retinal Vessels Diameter Changes during Pregnancy in Type 1 Diabetes

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Open Journal of Ophthalmology 2013年第2期3卷 27-32页

作者： Aurore Mensah Afrouz Ahmadzadeh Ann-Sofie Svanbom Lene Ringholm Birgit Sander Henrik Lund-Andersen Elisabeth Mathiesen michael larsen Department of Endocrinology Rigshospitalet Copenhagen Denmark Department of Ophthalmology Glostrup Hospital Glostrup Denmark Faculty of Health Sciences University of Copenhagen Copenhagen Denmark

Objective: Investigate how pregnancy-induced hormonal and hemodynamic changes affect retinal vessels caliber dynamic and the course of diabetic retinopathy. Methods: Retinopathy grading and vessel diameter measurement using digital fundus photographs in women with diabetes type 1 taken no more than one year before conception, during week 10 and/or 22, week 34, and within one year after delivery. Calibers were measured using a custom-developed semi-automated computer algorithm which identified the six largest arteries and six largest veins and calculated the central retinal artery equivalent (CRAE) and central vein equivalent (CRVE) diameters. Glycemic control was assessed quarterly by HbA1c. Systolic and diastolic blood pressure was assessed at week 10, 22 and 34. Results: Photographs at baseline, weeks 10, 22, 34 and after delivery were available in 28 patients, of whom 24 did not progress in retinopathy. For those whose level of retinopathy remained stable CRAE constricted from 138.80 ± 21.27 μm at baseline to 129.88 ± 13.97 μm at week 10 (p = 0.0379) CRVE constricted from 195.16 ± 24.98 μm at baseline to 185.97 ± 21.96 μm at week 10 (p = 0.0400). The patients with retinopathy progression had a CRAE of 131.67 ± 13.37 μm at baseline and 132.08 ± 11.07 μm at week 10 (p = 0.34) while CRVE was 195.33 ± 24.92 μm at baseline and 204.27 ± 10.18 μm at week 10 (p = 0.16). Progressors had higher blood pressures at week 10. Conclusion: Retinal vessels constricted between prepregnancy and first trimester in women who did not experience diabetic retinopathy progression. The study suggests that the vessels constriction seen in early pregnancy contributes to reduce the risk of gestational microvascular complications and progression of diabetes in the eye.

关键词： Pregnancy and Diabetes Type 1 Diabetic Retinopathy Central Retinal Artery Equivalent Central Retinal Vein Equivalent.

东格陵兰盆地陆地石油地质特征对海区石油潜力研究的启示

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海洋地质 2008年第3期24卷 65-65页

作者： Lars Stemmerik michael larsen Jφrgen Bojesen- Koefoed Finn Surlyk 高红芳（译）邱燕（校对）丹麦哥本哈根大学丹麦石油天然气公司丹麦及格陵兰地质调查局不详

东格陵兰裂谷盆地因其异常良好的露头而闻名。该露头为厚达16km的连续沉积层，其地质年代从泥盆纪一直到白垩纪。陆地地质为研究大西洋两侧包括东格陵兰陆架盆地、巴伦支海陆架盆地和北挪威西部陆架盆地等海域的沉积盆地提供了有用的类... 详细信息

东格陵兰裂谷盆地因其异常良好的露头而闻名。该露头为厚达16km的连续沉积层，其地质年代从泥盆纪一直到白垩纪。陆地地质为研究大西洋两侧包括东格陵兰陆架盆地、巴伦支海陆架盆地和北挪威西部陆架盆地等海域的沉积盆地提供了有用的类比。而此露头的地层沉积序列包括了不同地质年代和特征的储集岩以及油源岩。

关键词：石油地质裂谷盆地格陵兰特征对石油潜力陆地海区陆架盆地

Taxonomic changes regarding three species of Zingiber (Zingiberaceae) from Thailand

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植物分类学报 2007年第3期45卷 403-404页

作者： Pramote TRIBOUN Pranom CHANTARANOTHAI Kai larsen Applied Taxonomic Research Center Department of BiologyFaculty of ScienceKhon Kaen University Khon KaenThailand 40002 The Herbarium University of AarhusBuilding 137UniversitetsparkenDK-8000 Aarhus CDenmark

Zingiber teres S. Q. Tong & Y. M. Xia and Z. xishuangbannaense S. Q. Tong are reduced to be synonyms of Z. smilesianum Craib and Z. thorelii Gagnep.,respectively. Z. cochinchinense Gagnep. is changed to be a subspecie... 详细信息

关键词：姜科泰国植物学分类新种

Bistability theorem in a cancer model

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International Journal of Biomathematics 2018年第1期11卷 61-98页

作者： Jens Christian larsen Vanlcse Alle 50 2. mr. tv2720 VanlCse Copenhagen Denmark

In this paper, I continue the study of the mathematical models presented in [J. C. larsen, Models of cancer growth, J. Appl. Math. Comput. 53（1-2）（2015） 613-645] and [J. C. larsen, The bistability theorem in a model of metastatic cancer, to appear in Appl. Math.]. I shall prove the bistability theorem for the ODE model from [larsen, 2015]. It is a mass action kinetic system in the variables C cancer, GF growth factor and GI growth inhibitor. This theorem says that for some values of the parameters, there exist two positive singular points c＊＋ = （C＊＋, GF＊., GI＊＋）, c＊2- = （C＊-, GF＊, GI＊-） of the vector field. Here C＊- 〈 C＊＋ and e. is stable and c＊＋ is unstable, see Sec. 2. There is also a discrete model in [larsen, 2015], it is a linear map （T） on three-dimensional Euclidean vector space with variables （C, GF, GI）, where these variables have the same meaning as in the ODE model above. In [larsen, 2015], I showed that one can sometimes find attine vector fields on three-dimensional Euclidean vector space whose time one map is T. I shall also show this in the present paper in a more general setting than in [larsen, 2015]. This enables me to find an expression for the rate of change of cancer growth on the coordinate hyperplane C = 0 in Euclidean vector space. I also present an ODE model of cancer metastasis with variables C, CM, CF,GI, where C is primary cancer and CM is metastatic cancer and GF, GI are growth factors and growth inhibitors, respectively.

关键词： Immunology cancer chemotherapy immune therapy discrete dynamicalsystem Gompertz function.

Surgery for Peyronie＇s disease

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Asian Journal of Andrology 2013年第1期15卷 27-34页

作者： Laurence A Levine Stephen M larsen Department of Urology Rush University Medical Center Chicago IL 60612 USA

Peymnie＇s disease （PD） is most simply referred to as a fibrotic wound-healing disorder of the tunica albuginea. It is both a physically and psychologically devastating disorder that causes penile deformity, curvature, hinging, narrowing and shortening, which may compromise sexual function. Although a variety of non-surgical treatments have been suggested, none to date offer a reliable and effective correction of the penile deformity. As a result, surgery remains the gold standard treatment option, offering the most rapid and reliable treatment which will be the focus of this article. We review the preoperative evaluation, surgical algorithm, graft materials and postoperative management of PD. Outcomes for tunical shortening, tunical lengthening and penile prosthesis placement for penile straightening are reviewed. Tunica albuginea plication is the preferred method of straightening for men with adequate rigidity and less severe disease defined as curvature less than 70° without narrowing/hinging. Men who have more severe, complex deformity, but maintain strong preoperative erectile function should be considered candidates for straightening with plaque incision or partial excision and grafting. Finally, for those men who have inadequate rigidity and PD, penile prosthesis placement with straightening is the best approach to address both problems.

关键词： penile prosthesis Peyronie's disease, penile reconstruction plaque excision and grafting plaque incision tunica albuginea plication

Large Eddy Simulation on Interaction Between in-Line and Cross-Flow Oscillation of A Circular Cylinder

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China Ocean Engineering 2010年第4期24卷 663-676页

作者：黄智勇 Carl M.larsen Center of Ship and Ocean Structures Department of Marine Technology Norwegian University of Science and Technology

This paper discusses numerical results from three-dimensional large eddy simulations of an oscillating cylinder under prescribed movements in uniform flow. Six cases, namely pure in-line, pure cross-flow and two groups of ＇Figure of Eight＇ oscillation patterns are under investigation at Reynolds number Re = 24000. The ＇ Figure of Eight＇ pattern in each group is with identical shape but oppusite orbital directions. The numerical results on hydrodynamic forces, higher order force components, and vortex shedding modes are extensively studied and compared with the measured experimental data. It is found that the fluid force in phase with the velocity, which represents the energy transfer between the fluid and the cylinder, has opposite sign and different magnitude due to the opposite orbital direction. Higher order force components in cross-flow direction are found to occur at odd nmnber times of the oscillating frequency, while even nmbers dominate the higher order force components in in-llne direction. The 2C and 2T vortex shedding modes are well reproduced due to the opposite orbital direction effect. Comparisons between numerical and experimental results indicate that the present numerical model could be a rational tool for the identification of hydrodynamic coefficients which are normally applied in empirical models to predict the vortex-induced vibrations of slender marine structures.

关键词： vortex-ivduced vibration large eddy simulation forced oscillation in-line cross-flow

Comparisons of JOULE 1 rocket thermospheric wind observations in high latitudes with GITM simulations

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Science China(Technological Sciences) 2017年第3期60卷 412-418页

作者： DENG Yue larsen Miguel F RIDLEY Aaron J ZHAN TianYu Department of Physics University of Texas at Arlington Department of Physics Clemson University Center for Space Environment Modeling The University of Michigan

4 Summary and conclusion The JOULE sounding rocket 1 experiment was carried out at Poker Flat Research Range in Alaska around 1200 UT on March 27th,2003 with two instrumented rockets and one chemical tracer *** the released TMA trails,neutral wind measurements from approximately 85 to 160 km altitude showed a vertically propagating wave and a jet structure around 120 km *** shears appeared at the bottom side of the jet with Richardson numbers close to or smaller than the critical value of 0.25,which implies the possible existence of Kelvin-Helmholtz instabilities caused by the vertical shear in the fast flows.

关键词： target tracking parallel vision processor MRID skipping searching image processing

Pyrolytic carbon resonators for micromechanical thermal analysis

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Microsystems & Nanoengineering 2019年第1期5卷 154-163页

作者： Long Quang Nguyen Peter Emil larsen Tom larsen Sanjukta Bose Goswami Luis Guillermo Villanueva Anja Boisen Stephan Sylvest Keller DNRF and Villum Fonden Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics IDUNTechnical University of Denmark2800 Kgs LyngbyDenmark DTU Nanolab Technical University of Denmark2800 Kgs LyngbyDenmark DTU Health Tech Technical University of Denmark2800 Kgs LyngbyDenmark Advanced NEMS Laboratory Ecole Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland

Thermal analysis is essential for the characterization of polymers and ***,the currently established methods require a large amount of ***,we present pyrolytic carbon resonators as promising tools for micromechanical thermal analysis(MTA)of nanograms of *** clamped pre-stressed beams with a resonance frequency of 233±4 kHz and a quality factor(Q factor)of 800±200 were *** of the electrical conductivity of the pyrolytic carbon allowed us to explore resistive heating for integrated temperature *** was achieved by monitoring the resonance frequency and quality factor of the carbon resonators with and without a deposited sample as a function of *** prove the potential of pyrolytic carbon resonators as thermal analysis tools,the glass transition temperature(T_(g))of semicrystalline poly(L-lactic acid)(PLLA)and the melting temperature(T_(m))of poly(caprolactone)(PCL)were *** results show that the T_(g) of PLLA and T_(m) of PCL are 61.0±0.8℃ and 60.0±1.0℃,respectively,which are in excellent agreement with the values measured by differential scanning calorimetry(DSC).

关键词： temperature carbon thermal