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Socioeconomic, environmental, and geographic factors and US lung cancer mortality, 1999-2009

Family Medicine and Community Health 2017年第1期5卷 3-12页

作者： Maria C.Mejia de Grubb Barbara Kilbourne Katy Kilbourne michael langston Lisa Gittner Roger J.Zoorob Robert Levine Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Sociology Department Tennessee State UniversityNashvilleTNUSA Department of Family and Community Medicine Meharry Medical CollegeNashvilleTNUSA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTNUSA Department of Political Science Texas Tech University College of Arts and SciencesLubbockTXUSA

Background:The American Cancer Society estimates that about 25%of all US cancer deaths will be due to lung cancer-more than from cancers of the colon,breast,and prostate ***:We ascertained county-level age-adjusted and age-specific death rates and 95%confidence intervals from the Centers for Disease Control and Prevention Compressed Mortality *** regression analyses were used to estimate the strength and direction of relationships between county poverty,smoking,fine particulate matter(PM2.5)air pollution,and US Census divisions and race-and sex-specific lung cancer ***:Poverty,smoking,and particulate matter air pollution were positively and signifi-cantly related to lung cancer deaths among white men,but of these,only poverty and smoking were significantly associated with lung cancer deaths among white *** in the South Atlantic,East South Central,and West South Central US Census divisions at the time of death was significantly associated with lung cancer deaths for both white men and white *** with white men,poverty and smoking were associated with lung cancer deaths among black men,but of these,only adult smoking had a statistically significant association among black ***:The results support the need for further research,particularly in high-risk areas,to better differentiate factors specific to race and sex and to understand the impact of local risk factors.

关键词： Lung cancer mortality geographic risk factors environmental hot spot

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Rural congestive heart failure mortality among US elderly, 1999-2013: Identifying counties with promising outcomes and opportunities for implementation research

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Family Medicine and Community Health 2015年第2期3卷 27-38页

作者： Maria C.Mejia de Grubb Robert S.Levine Barbara Kilbourne Baqar A.Husaini Tyler Skelton Lisa Gittner michael A.langston George E.Rust Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Department of Sociology Tennessee State UniversityNashvilleTennesseeUSA Center for PreventionResearch Tennessee State University College of AgricultureNashvilleTennesseeUSA Department of Political Science Texas Tech UniversityLubbockTXUSA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTennesseeUSA Department of Family Medicine National Center for Primary CareMorehouse School of MedicineAtlantaGeorgiaUSA

Objective:Describe modern trends in congestive heart failure(CHF)among elderly(>65 years of age)in the United States,to identify potentially successful rural *** CHF mortality using multiple-(MCOD)versus underlying-(UCOD)cause of death ***:*** for Disease Control and Prevention mortality files(WONDER internet site).Results:Using MCOD data,overall mortality rates/100,000 population(and 95%confidence intervals)for CHF among persons>65 years of age(1999-2013)were 482.0(481.2-482.8)for large central and large fringe metropolitan(LCLF)counties,549.6(548.6-550.7)in small and medium metropolitan(SM)counties,and 652.6(650.9-654.0)in micropolitan and non-core,non-metropolitan(MNCNM)*** positive deviance NCNM counties(collectively including 198,581 residents>65 years of age)had an overall CHF rate of 300.9(275.0-326.9)in *** was significantly lower than the LCLF rate for 2013(482.0[481.2-482.8]),and rep-resented a reduction of 47%since *** CHF occurrence as estimated with MCOD was 3.4-fold higher than that obtained with ***:These data illustrate underestimation of CHF by UCOD data and the importance of correct death *** CHF mortality rates are higher than urban rates,but some positive deviance counties demonstrate that this is not *** research is needed to understand the relative contribution of research innovation,medical care,and public health to rural-urban disparities and the relative success of positive deviance counties.

关键词： Congestive heart failure elderly mortality rural

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Glycerol phosphate shuttle enzyme GPD2 drives glucose oxidation to regulate macrophage inflammatory responses

Glycerol phosphate shuttle enzyme GPD2 drives glucose oxidat...

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第三届中国生物物理学会代谢生物学分会学术研讨会

作者： P.Kent langston Aya Nambu Jonathan Jung Munehiko Shibata H.Ibrahim Aksoylar Jiahui Lei Peining Xu Mary T.Doan Helen Jiang michael R.MacArthur Xia Gao Yong Kong Edward T.Chouchani Jason W.Locasale Nathaniel W.Synder Tiffany Horng Department of Genetics & Complex Diseases Harvard T.H.Chan School of Public Health School of Medicine University of Glasgow A.J.Drexel Autism Institute Drexel University Department of Pharmacology & Cancer Biology Duke University School of Medicine Depart of Immunobiology Yale University School of Medicine Department of Cell Biology Harvard Medical School School of Life Sciences and Technology ShanghaiTech University

＜正＞Macrophages are activated during microbial infection to coordinate inflammatory responses and host *** we show that in macrophages activated by bacterial lipopolysaccharide （LPS）,mitochondrial glycerol 3-phosphate dehydrogenase （GPD2） regulates glucose oxidation to drive inflammatory ***2,a component of the glycerol 3-phosphate shuttle （GPS）,boosts glucose oxidation to fuel Acetyl-CoA production,histone acetylation and inflammatory gene

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