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Stability and Generalization of Hypergraph Collaborative Network.

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Machine Intelligence Research 2024年第1期21卷 184-196页

作者： michael k.ng Hanrui Wu Andy Yip Institute of Data Science The University of Hong KongHong KongChina Department of Mathematics The University of Hong KongHong KongChina College of Information Science and Technology Jinan UniversityGuangzhou 510006China

Graph neural network. have been shown to be very effective in utilizing pairwise relationships across ***,there have been several successful proposals to generalize graph neural network. to hypergraph neural network. to exploit more com-plex *** particular,the hypergraph collaborative network. yield superior results compared to other hypergraph neural net-work. for various semi-supervised learning *** collaborative network.can provide high quality vertex embeddings and hyperedge embeddings together by formulating them as a joint optimization problem and by using their consistency in reconstructing the given *** this paper,we aim to establish the algorithmic stability of the core layer of the collaborative network.and provide generaliz--ation *** analysis sheds light on the design of hypergraph filters in collaborative network.,for instance,how the data and hypergraph filters should be scaled to achieve uniform stability of the learning *** experimental results on real-world datasets are presented to illustrate the theory.

关键词： Hypergraphs vertices hyperedges collaborative network. graph convolutional neural network.(CNNs) stability generalization guarantees

Single-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao LI Chun-Hsien CHEN k.m k.H.ng Xin YUAN Cho Yin YIU Human Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a single pilot in commercial jets could be technically *** changes in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk.*** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-pilot Operations(DpO)to Single-pilot Operations(SpO)through a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-based eye track.r,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risk. operations in SpO were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial SpO measures to lessen the persistent physiological fluctuation,assisting airlines in creating SpO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations Behaviour changes Eye track.r Electroencephalogram

Jetting-based bioprinting: process, dispense physics, and applications

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BIO-DESIGN AND MANUFACTURIng 2024年第5期7卷 771-799页

作者： ng, Wei Long Shk.lnik.v, Vik.or Nanyang Technol Univ NTU Singapore Ctr 3D Printing SC3DP Sch Mech & Aerosp Engn Singapore 639798 Singapore Hp Inc Palo Alto CA 94304 USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells, growth factors, drugs, and biomaterials in a highly automated layer-by-layer fabrication approach. Due to its immense versatility, jetting-based bioprinting has been used for various applications, including tissue engineering and regenerative medicine, wound healing, and drug development. A lack.of in-depth understanding exists in the processes that occur during jetting-based bioprinting. This review paper will comprehensively discuss the physical considerations for bioink. and printing conditions used in jetting-based bioprinting. We first present an overview of different jetting-based bioprinting techniques such as ink.et bioprinting, laser-induced forward transfer bioprinting, electrohydrodynamic jet bioprinting, acoustic bioprinting and microvalve bioprinting. Next, we provide an in-depth discussion of various considerations for bioink.formulation relating to cell deposition, print chamber design, droplet formation and droplet impact. Finally, we highlight recent accomplishments in jetting-based bioprinting. We present the advantages and challenges of each method, discuss considerations relating to cell viability and protein stability, and conclude by providing insights into future directions of jetting-based bioprinting. [GRApHICS] .

关键词： 3D bioprinting Biofabrication Jetting-based Dispense physics Machine learning pLURIpOTENT STEM-CELLS DILUTE pOLYMER-SOLUTIONS DROp IMpACT SHEAR-STRESS AIR-WATER HIGH-RESOLUTION INk.ET JET ADSORpTION TISSUE

Dysfunction of synaptic endocytic traffick.ng in park.nson's disease

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Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin Yi ng Mian Cao programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of physiology National University of SingaporeSingaporeSingapore

park.nson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative pARk.genes and 90 genomic risk.loci associated with both familial and sporadic park.nson's ***,several of these genes are link.d to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of park.nson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back.***,several new animal and cellular models with park.nson's disease-link.d mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain park.nson's disease-lik. features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane traffick.ng,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two park.nson's disease-link.d clathrin uncoating proteins:auxilin(DNAJC6/pARk.9)and synaptojanin 1(SYNJ1/pARk.0).The mouse models carrying these two pARk.gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAk.endophilin A1,SAC2/INpp5 F,synaptotagmin-11),identified as park.nson's disease risk.factors through genome-wide association studies,in park.nson's disease *** will also explore the direct or indirect roles of some common park.nson's disease-link.d proteins(alpha-synuclein(pARk./4),park.n(pARk.),and LRRk.(pARk

关键词： autophagy auxilin/pARk.9 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway park.nson's disease synaptic vesicle recycling synaptojanin1/pARk.0

process,Material,and Regulatory Considerations for 3D printed Medical Devices and Tissue Constructs

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Engineering 2024年第5期36卷 146-166页

作者： Wei Long ng Jia An Chee k.i Chua Singapore Centre for 3D printing(SC3Dp) School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore Centre for Healthcare Education Entrepreneurship and Research@SUTD(CHEERS)Singapore University of Technology and DesignSingapore 487372Singapore

Three-dimensional(3D)printing is a highly automated platform that facilitates material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex structures on *** is a highly promising technique for the fabrication of personalized medical devices or even patient-specific tissue *** type of 3D printing technique has its unique advantages and limitations,and the selection of a suitable 3D printing technique is highly dependent on its intended *** this review paper,we present and highlight some of the critical processes(printing parameters,build orientation,build location,and support structures),material(batch-to-batch consistency,recycling,protein adsorption,biocompatibility,and degradation properties),and regulatory considerations(sterility and mechanical properties)for 3D printing of personalized medical *** goal of this review paper is to provide the readers with a good understanding of the various k.y considerations(process,material,and regulatory)in 3D printing,which are critical for the fabrication of improved patient-specific 3D printed medical devices and tissue constructs.

关键词： 3D printing Bioprinting Biofabrication Medical devices Tissue constructs

Multiple sclerosis drug repurposing for neuroregeneration

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Neural Regeneration Research 2024年第3期19卷 507-508页

作者： peter Göttle michael Dietrich patrick.k.ry Department of Neurology Medical FacultyHeinrich-Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS)is an autoimmune disorder of the central nervous system(CNS)and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turning progressive over time with neurodegenerative processes tak.ng over(Amin and Hersh,2023).Of note,beyond relapse-associated worsening early in disease progression independent of relapse activity may arise independently of relapse activity and can occur in all ***-mediated damage of myelin sheaths and the subsequent loss of mature oligodendrocytes are resulting in impaired axonal integrity,neurodegeneration and accounts for irreversible neuronal damage(k.hlmann et al.,2023).The current landscape of available disease-modifying therapies comprises mainly immunomodulatory drugs that effectively diminish relapses and slow down progression at the onset form of the disease,namely relapsing MS(RMS).In this regard,a number of drugs have been approved as disease-modifying therapies for MS by US Food and Drug Administration and European Medicines Agencies(Box 1).

关键词： drugs impaired irreversible

performance of Continuous Wavelet Transform over Fourier Transform in Features Resolutions

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International Journal of Geosciences 2024年第2期15卷 87-105页

作者： michael k. Appiah Sylvester k. Danuor Alfred k. Bienibuor Department of physics Kwame Nkrumah University of Science and Technology (KNUST) Kumasi Ghana Department of Chemical Sciences University of Energy and Natural Resources Sunyani Ghana

This study presents a comparative analysis of two image enhancement techniques, Continuous Wavelet Transform (CWT) and Fast Fourier Transform (FFT), in the context of improving the clarity of high-quality 3D seismic data obtained from the Tano Basin in West Africa, Ghana. The research focuses on a comparative analysis of image clarity in seismic attribute analysis to facilitate the identification of reservoir features within the subsurface structures. The findings of the study indicate that CWT has a significant advantage over FFT in terms of image quality and identifying subsurface structures. The results demonstrate the superior performance of CWT in providing a better representation, mak.ng it more effective for seismic attribute analysis. The study highlights the importance of choosing the appropriate image enhancement technique based on the specific application needs and the broader context of the study. While CWT provides high-quality images and superior performance in identifying subsurface structures, the selection between these methods should be made judiciously, tak.ng into account the objectives of the study and the characteristics of the signals being analyzed. The research provides valuable insights into the decision-mak.ng process for selecting image enhancement techniques in seismic data analysis, help.ng researchers and practitioners mak. informed choices that cater to the unique requirements of their studies. Ultimately, this study contributes to the advancement of the field of subsurface imaging and geological feature identification.

关键词： Continuous Wavelet Transform (CWT) Fast Fourier Transform (FFT) Reservoir Characterization Tano Basin Seismic Data Spectral Decomposition

Self-healable and Robust Film Based on Electroactive polymer Brush as Electrode for Flexible Supercapacitor

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Chinese Journal of polymer Science 2024年第8期42卷 1049-1059页

作者： Maria p.Sok.lova Vitaly k.Vorobiov Nik.lay N.Smirnov Ivan S.k.ryndin Natalya V.Bobrova michael A.Smirnov Institute of Macromolecular Compounds Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

The aim of this study was to develop self-healable and robust elect roconductive film based on polyaniline copolymer for application as electrode in flexible *** this purpose,the electroconductive polymer brushes(EpB)was *** synthesis of EpB is based on graft polymerizations of acrylamide(AAm)on poly(vinyl alcohol)(pVA)with formation of pVA-pAAm polymer brush and subsequent graft copolymerization of aniline and p-phenylenediamine on pVA-pAAm resulting in formation of EpB with electroconducting copoly(aniline-co-pphenylenediamine)(pAph DA).It was found that the ratio between pVA and pAAm at the first stage greatly influence the electrochemical performance of the *** films were prepared by casting of EpB solution with subsequent *** of electrical current distribution through the film with AFM reveal more uniform distribution of pAphDA in EpB in comparison with reference pVA-pAphDA and pAAm-pAphDA *** was demonstrated that mechanical cha racteristics and electrical conductivity values of films restore at large extent after curring and self-healing under optimal relative humidity level(58%).The flexile supercapacitor cell with EpB film electrodes demon strate specific capacitance 602 mF·cm^(-2)at the current density of 1 mA·cm^(-2)and retention 94%of initial capacitance after 5000 charge/discharge cycles.

关键词： polymer brush polyaniline Flexible supercapacitor Self-healing Electroconducting film

Turbidite Dynamics and Hydrocarbon Reservoir Formation in the Tano Basin: A Coastal West African perspective

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International Journal of Geosciences 2024年第2期15卷 137-161页

作者： michael k. Appiah Sylvester k. Danuor Striggner Bedu-Addo Alfred k. Bienibuor Department of physics Kwame Nkrumah University of Science and Technology (KNUST) Kumasi Ghana Department of Chemical Sciences University of Energy and Natural Resources Sunyani Ghana

This study examines the turbidite dynamics and hydrocarbon reservoir formation in Ghana’s Tano Basin, which is located in coastal West Africa. Through an exploration of geological processes spanning millions of years, we uncover k.y factors shap.ng hydrocarbon accumulation, including source rock.richness, temperature, pressure, and geological structures. The research offers valuable insights applicable to exploration, management, and sustainable resource exploitation in coastal West Africa. It facilitates the identification of exploration targets with higher hydrocarbon potential, enables the anticipation of reservoir potential within the Tano Basin, and assists in tailoring exploration and management strategies to specific geological conditions of the Tano Basin. Analysis of fluvial channels sheds light on their impact on landscape formation and hydrocarbon exploration. The investigation into turbidite systems unveils intricate interactions involving tectonics, sea-level fluctuations, and sedimentation patterns, influencing the development of reservoirs. An understanding of sediment transport and depositional settings is essential for efficient reservoir management. Geomorphological features, such as channels, submarine canyons, and distinct channel types, are essential in this situation. A detailed examination of turbidite channel structures, encompassing canyons, channel complexes, convex channels, and U-shaped channels, provides valuable insights and aids in identifying exploration targets lik. basal lag, channel levees, and lobes. These findings underscore the enduring significance of turbidite systems as conduits for sediment transport, contributing to enhanced reservoir management and efficient hydrocarbon production. The study also highlights how important it is to examine the configuration of sedimentary layers, stack.ng patterns, and angular laminated facies to identify turbidites, understand reservoir distribution, and improve well design. The dynamic nat

关键词： Reservoir Characterization Tano Basin Seismic Data Hydrocarbon potential Channels Turbidites