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Endocrine stress response of Eastern Fence Lizards in fire-disturbed landscapes

Current Zoology 2019年第6期65卷 643-650页

作者： michael g.iacchetta K.Nichole MALONER C.M.gIENgER Department of Biology and Center of Excellence for Field Biology Austin Peay State University ClarksvilleTNUSA Department of Forestry and Natural Resources Purdue UniversityWest LafayetteINUSA Department of Pathology Microbiologyand ImmunologyVanderbilt University Medical Center NashvilleTNUSA

Landscape disturbances can alter habitat structure and resource availability,often inducing physiological responses by organisms to cope with the changing *** the endocrine stress response through measurement of glucocorticoids has become an increasingly common method for determining how organisms physiologically respond to challenges imposed by their *** tested the hypothesis that Eastern Fence Lizards cope with fire disturbance effects by modulating their secretion of corticosterone(CORT).We measured the baseline and stress-induced plasma CORT of male Eastern Fence Lizards in a chronosequence of fire-altered habitats(recently burned,recovering from burn,and unburned).Although habitat use by lizards differed among burn treatments,including differences in use of canopy cover,leaf litter,and vegetation composition,we did not detect a significant effect of fire-induced habitat alteration on plasma CORT concentration or on body *** addition,we found no effect of blood draw treatment(baseline or stress-induced),body temperature,body condition,or time taken to collect blood samples on concentration of plasma *** intensity burns,which are typical of prescribed fire,may not be a sufficient stressor to alter CORT secretion in Eastern Fence Lizards(at least during the breeding season).Instead,lizards may avoid allostatic overload using behavioral responses and by selecting microsites within their environment that permit thermoregulatory opportunities necessary for optimal performance and energy assimilation.

关键词： endocrine response fire ecology habitat alteration prescribed fire reptile Sceloporus undulatus

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Like a g6-nal:transcriptional control of g-protein coupled receptors during oligodendroglial development

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Neural Regeneration Research 2025年第7期20卷 2001-2002页

作者： Tim Aberle michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for gpr37(Schmidt et al.,2024),a g-protein coupled receptor(gPCR)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

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NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno michael K.E.Schafer Sudena Wang michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal g-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

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NONUNIQUENESS AND SINgULAR RADIAL SOLUTIONS OF SYSTEMS OF CONSERVATION LAWS

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Acta Mathematica Scientia 2012年第1期32卷 367-379页

作者： michael g.Hilgers Business and Information Technology Department Missouri University of S & T

The case of a radial initial state for a family of hyperbolic systems of con- servation laws with several spatial dimensions is considered. It will be shown that the singularity at the origin introduces multiple solut... 详细信息

关键词： conservation laws singular solutions nonuniqueness

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Statistical variability and fragility assessment of ballistic perforation of steel plates for 7.62 mm AP ammunition

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Defence Technology（防务技术） 2020年第3期16卷 503-513页

作者： Mark g.Stewart michael DNetherton Centre for Infrastructure Performance and Reliability The University of NewcastleNew South Wales2038Australia

The paper describes field test results of 7.62×51 mm M61 AP(armour piercing) ammunition fired into mild steel targets at an outdoor *** targets varied from 10 mm to 32 mm in *** tests recorded penetration depth,probability of perforation(i.e.,complete penetration),muzzle and impact velocities,bullet mass,and plate yield strength and *** measured penetration depth exhibited a variability of approximately±12%.The paper then compared ballistic test results with predictive models of steel penetration depth and thickness to prevent *** parameters were derived for muzzle and impact velocity,bullet mass,plate thickness,plate hardness,and model error.A Monte-Carlo probabilistic analysis was then developed to estimate the probability of plate perforation of 7.62 mm M61 AP ammunition for a range of impact velocities,and for mild steels,and High Hardness Armour(HHA) *** perforation fragility analysis considered the random variability of impact velocity,bullet mass,plate thickness,plate hardness,and model *** a probabilistic analysis allows for reliability-based design,where,for example,the plate thickness with 95% reliability(*** 1 in 20 shots will penetrate the wall) can be estimated knowing the probabilistic distribution of ***,it was found that the plate thickness to ensure a low 5% probability of perforation needs to be 11-15% thicker than required to have a 50/50 chance of perforation for mild steel *** would need to be 20-30% thicker if probability of perforation is reduced to zero.

关键词： Ballistics Probability Statistics Steel plates Armour steel Ammunition Experimental Perforation

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Review:Partial discharge diagnostics in wind turbine insulation

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第6期12卷 515-522页

作者： michael g.DANIKAS Athanasios KARLIS Power Systems Lab Department of Electrical and Computer Engineering Democritus University of Thrace Electrical Machines Lab Department of Electrical and Computer Engineering Democritus University of Thrace

The purpose of this paper is to review work undertaken on partial discharges and their influence on the insulation of wind turbines. No matter whether partial discharges can be considered as the main cause of deterioration of the insulation material, the initial cause of failure or not but an indication of the material degradation, there is no doubt that they are intimately linked to the aging of machine insulation. Material degradation can be detected by non-destructive techniques (e.g., partial discharge measurements, change of tan δ) or by destructive techniques, such as by cutting small pieces of the insulating material and by putting them under the scrutiny of the scanning electron microscope (SEM). Wind generators are a modern subject of research, especially in view of the growing demands of electric energy worldwide and the problems facing the environment all over the globe. Wind turbines are a novel field of research regarding partial discharge diagnostics since they are subjected to a variety of aging factors, which are different from conventional turbines. In this respect, particular attention should be paid to the multi-factor stressing of insulation and their consequences on the partial discharges.

关键词： Partial discharges Rotating machine insulation Wind turbines

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How might epigenetics contribute to ecological speciation？

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Current Zoology 2013年第5期59卷 686-696页

作者： gilbert SMITH michael g. RITCHIE Department of Ecology and Evolutionary Biology University of California Irvine California USA School of Biology University of St Andrews St Andews Fife KY16 9TH Scotland UK

Speciation research has seen a renewed interest in ecological speciation, which emphasises divergent ecological se- lection leading to the evolution of reproductive isolation. Selection from divergent ecologies means that phenotypic plasticity can play an important role in ecological speciation. Phenotypic plasticity involves the induction of phenotypes over the lifetime of an organism and emerging evidence suggests that epigenetic marks such as cytosine and protein （histone） modifications might regu- late such environmental induction. Epigenetic marks play a wide role in a variety of processes including development, sex dif- ferentiation and allocation, sexual conflict, regulation of transposable elements and phenotypic plasticity. Here we describe recent studies that investigate epigenetic mechanisms in a variety of contexts. There is mounting evidence for environmentally induced epigenetic variation and for the stable inheritance of epigenetic marks between generations. Thus, epigenetically-based pheno- typic plasticity may play a role in adaptation and ecological speciation. However, there is less evidence for the inheritance of in- duced epigenetic variation across multiple generations in animals. Currently few studies of ecological speciation incorporate the potential for the involvement of epigenetically-based induction of phenotypes, and we argue that this is an important omission [Current Zoology 59 （5）： 686-696, 2013 ].

关键词： Ecological speciation Adaptation Reproductive isolation Phenotypic plasticity Epigenetic mechanisms

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Absorbed fractions and dose factors for a model of the mouse skeleton

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Nuclear Science and Techniques 2016年第1期27卷 71-74页

作者： Yan-Ling Yi michael g.Stabin Institute of Radiation Medicine Fudan University Department of Radiology and Radiological Sciences Vanderbilt University

A general model for skeletal dosimetry in mice is presented. geometrical constructs were made for four general regions in the mouse skeleton, and dose factors for90 Sr and90Y were calculated using the MCNP Monte Carlo transport code. Then, an overall skeletal dose factor for the whole skeleton was derived based on the individual values and the fraction of the total skeleton that they were assumed to represent. The whole skeleton average values were 1.56 9 10-11gy/dis for90 Sr and 1.74 9 10-11gy/dis for90 Y.

关键词：骨骼模型剂量吸收部位小鼠一般模型几何构造程序计算蒙特卡罗

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Whole-mine subsidence over tabular deposits and related seismicity

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International Journal of Mining Science and Technology 2017年第1期27卷 171-177页

作者： Pariseau William g. McCarterr michael K. Department of Mining Engineering University of UtahSalt Lake CityUTUSA

The challenge of estimating mine-wide subsidence and linkages to seismicity over tabular deposits is addressed by a special finite element technique(dual node–dual mesh). Subsidence and mine-induced seismicity begins near the face when caving occurs and propagates to the surface as extraction reaches a critical extent. Thus, the challenge is to obtain details at the face at the meter scale and also at the surface over the whole mine at the kilometer scale. Interactions between old and new sections of a mine are automatically taken into account with this technique. The finite element method is well established technology based on fundamentals of physical laws, kinematics and material laws. With this technique, no empirical ‘‘scaling" or fitting computer output by input data ‘‘adjustment" to mine measurements is necessary. Capability is demonstrated for doing practical whole-mine subsidence analysis from first principles. Mine-induced seismicity is shown to correlate well with face advance and element failure.

关键词： Whole mine subsidence Multi-scale Finite element analysis Mine induced seismicity

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Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats

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Acta Pharmacologica Sinica 2005年第5期26卷 546-550页

作者： michael g IRWIN Tak-ming WONg Department of Anesthesiology Department of Physiology the University of Hong Kong Hong Kong China

Aim:To examine whether the protective effect of remifentanil preconditioning（RPC）on postischemic hearts is mediated by protein kinase（PKC）activation incomparison with ischemic preconditioning（IPC）.Methods:Male Sprague-Dawleyrats were anesthetized and their chests were *** experiment was per-formed with chelerythrine（CHE,2mg/kg）,gF109203X（0.05 mg/kg）protein kinaseC（PKC）inhibitors administered before RPC(remifentanil 6μ***-1·min-1×3 cycle)orIPC,*** size（IS）,as a percentage of the area at risk（AAR）,wasdetermined by triphenyltetrazolium ***:In groups subjected to IPCand RPC the IS/AAR were significantly reduced（IS/AAR from 52.7%±5.5% to12.9%±3.4%,PgF,both PKC inhibitors,administered 5 min before RPC or IPC completelyabolished the cardioprotective effect of RPC（IS/AAR:CHE+RPC 51.2%±5.0%,gF+RPC 53.6%±6.1%,P>0.05 vs CON）or IPC（CHE+IPC 53.7%±4.3%,gF+IPC54.1%±6.2%,P>0.05 vs CON）.The difference was not significant in any of thehemodynamic parameters between control and treatment groups during ischemiaand ***:Remifentanil confers myocardial protection againstischemic injury through a mechanism that is similar to IPC and involves PKCactivation.

关键词： remifentanil myocardial ischemia preconditioning myocardial reperfusion injury protein kinase C chelerythrine gF109203X

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