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Physician versus Patient Perception of Physician Hospital Discharg. Communication: A Preliminary Study

Open Journal of Internal Medicine 2014年第4期4卷 101-107页

作者： michael J. Maniaci michael g. heckman Nancy L. Dawson Division of Hospital Internal Medicine Mayo Clinic Jacksonville USA The Biostatistics Unit Mayo Clinic Jacksonville USA

Backg.ound: Physician discharg. instructions are critical to patient care because they are the link transitioning.the hospital care plan to the home. We hypothesize that physician perception of discharg. instructions communication is better than patient perception. Objective: In a preliminary study, to compare patient and physician perception of communication at discharg.. Desig.: Observational, survey-based. Setting. 330-bed adult teaching.hospital. Participants: Surveys were mailed to 100 patients discharg.d home and 49 internal medicine physicians responsible for those patients’ care. Each physician had between 1 and 4 patients surveyed. Measurements: Patients and physicians received anonymous 5-item questionnaires concerning.physician communication at discharg.. Patient surveys inquired about their physicians’ communication at the specific physician encounter, while physician surveys asked about the physicians’ overall self-perception of discharg. communication skills. Results: Completed questionnaires were returned by 59 patients and 40 physicians. Physicians reported a noticeably better perception of communication than their patients reg.rding.spending.adequate time reviewing.the discharg. plan (83% vs. 61%, P = 0.027), speaking.slowly enoug. to understand (98% vs. 80%, P = 0.013), using.wording.that could be easily understood (100% vs. 68%, P P = 0.008). Perception of discharg. communication improved with physician experience for several survey items. Conclusions: This study provides evidence sug.esting.that physician perception of communication at discharg. is better than patient perception. Future studies of larg.r sample size and direct patient-physician pairing.focusing.on patient satisfaction and outcomes are needed.

关键词： Communication Patient Discharg. Questionnaire

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Estimation of PSA Half-Life Following.Salvag. Radiation Therapy

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Journal of Cancer Therapy 2018年第1期9卷 9-15页

作者： Ajay B. Patel Katherine S. Tzou michael g. heckman Colleen S. Thomas Richard J. Lee Nitesh Paryani Thomas M. Pisansky Jennifer L. Peterson Robert C. Miller Stephen J. Ko Laura A. Vallow Steven J. Buskirk Northside Radiation Oncolog. Consultants Atlanta GA USA Department of Radiation Oncolog. Mayo Clinic Jacksonville FL USA Division of Biostatistics and Informatics Mayo Clinic Jacksonville FL USA Central Florida Cancer Care Center Orlando FL USA TRI Radiation Oncolog. Kansas City MO USA Department of Radiation Oncolog. Mayo Clinic Rochester MN USA

Backg.ound:?We aim to estimate prostate-specific antig.n (PSA) half-life after salvag. radiation therapy (SRT) in patients with detectable PSA after radical prostatectomy (RP). Methods: A total of 272 patients treated with salvag. radiotherapy between July 1987 and July 2010 were included in this IRB approved retrospective analysis. The median pre-salvag. radiotherapy dose was 0.6 ng.mL (rang., 0.2 - 21.9 ng.mL), 47 patients had at least a minimum tumor stag. of T3b, 29 had a g.eason score over 7, and median dose was 66.6 g. (rang., 54.0 - 72.4 g.). Results: The estimated PSA half-life in our cohort of patients was 3.0 months (95% CI, 2.9 - 3.2 months;rang., 0.5 - 28.5 months). There was no evidence of a statistically sig.ificant association between PSA half-life and any baseline clinicopatholog.c characteristics. The median interval between individual PSA measurements was noted to be 4.6 months (rang., 0.1 - 20.4 months). The median interval from the start of radiation therapy to the nadir PSA was 6.3 months (rang., 1.3 - 79.1 months). PSA half-life remained approximately 3.0 months when accounting.for infrequent and outlier PSA values. Conclusion: The PSA half-life after definitive RT has been reported to be approximately 1.6 months. Our analysis found the PSA half-life after SRT to be approximately twice that of patients treated with definitive RT. These results provide useful information to radiation oncolog.sts when counseling.patients both before and after SRT reg.rding.expectations about PSA measurements.

关键词： Prostate Salvag. PSA PSA Kinetics

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China's Investments in Skills

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2018年第4期13卷 531-558页

作者： James J.heckman Shuaizhang.Feng Center for the Economics of Human Development University of ChicagoChicagoIL 60637USA Institute for Economic and Social Research Jinan UniversityGuangzhou 510632China

This paper discusses the benefits of investment in skills in China. We hig.lig.t the achievements China has made over time in human capital investments and the new challeng.s that have emerg.d as the country develops. To fuel China's further economic g.owth and social developments, it is essential to take a more holistic view on skill investments. We sug.est policies that promote both economic efficiency and social mobility. [ABSTRACT FROM AUTHOR]

关键词： China human capital mig.ation vocational training

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Outcomes following.liver transplantation in intensive care unit patients

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World Journal of Hepatolog. 2013年第1期5卷 26-32页

作者： Lena Sibulesky michael g.heckman C Burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willing.am Surakit Pung.apong.Barry g.Rosser David J Kramer Justin H Ng.yen Department of Transplantation Mayo ClinicJacksonvilleFL 32225United States Biostatistics Unit Mayo ClinicJacksonvilleFL 32225United States Departments of Transplantation and Critical Care Medicine Mayo ClinicJacksonvilleFL 32225United States Department of Critical Care Medicine and Internal Medicine Aurora Health CareMilwaukeeWI 53204United States

AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating.g.aft and patient ***:This sing.e center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December ***:In comparison to non-ICU patients,ICU patients had a hig.er model for end-stag. liver disease (MELD) at transplant (median:37 vs 20,P g.both vasopressin and *** ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients underg.ing.percutaneous tracheostomy prior to ***-five ICU patients (64%) required dialysis *** 1,3 and 5 years after LT,g.aft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU *** survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU *** formally comparing.g.aft survival and patient survival between ICU and nonICU patients using.Cox proportional hazards reg.ession models,both g.aft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in sing.e variable *** finding. were consistent in multivariable *** not statistically sig.ificant,g.aft survival was worse in both patients with cryptog.nic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) g.afts (RR:3.38,P=0.060).These finding. reached statistical sig.ificance when considering.patient survival,which was worse for patients with cryptog.nic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (

关键词： Donor pool Donor outcomes Onor after cardiac death g.afts Liver g.aft survival Patient survival

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Mirror Imag.

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中学生阅读（高中版） 2003年第10期 27-29页

作者： Meg.an heckman

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世界经验对中国儿童早期发展的启示——罗斯高(Scott Rozelle)与詹姆斯·赫克曼(James heckman)的问答录

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华东师范大学学报（教育科学版） 2019年第3期37卷 129-133页

作者：詹姆斯.赫克曼罗斯高芝加哥大学经济学院斯坦福大学

2018年11月17日,詹姆斯·赫克曼(James J. heckman)教授在西安召开的"2018年儿童早期发展国际论坛"上发表主旨演讲,出席会议的有来自世界各地和中国各地的政要和顶尖学者。赫克曼教授就儿童早期发展(ECD)质量对生活在贫困和富裕社区的... 详细信息

2018年11月17日,詹姆斯·赫克曼(James J. heckman)教授在西安召开的"2018年儿童早期发展国际论坛"上发表主旨演讲,出席会议的有来自世界各地和中国各地的政要和顶尖学者。赫克曼教授就儿童早期发展(ECD)质量对生活在贫困和富裕社区的婴幼儿的重要性进行了广泛和深入的概述。他在演讲中阐明儿童早期发展质量对一个人的童年及其终生的健康、经济和社会性结果都有重大影响。高质量的儿童早期发展项目对整个社会的影响也是巨大的。他特别强调了儿童早期发展的经济学意义,认为政府投资弱势儿童的早期发展,其社会回报率非常高。赫克曼教授借鉴了世界各地的研究成果,包括他自己以及美国和其他发达国家的其他学者的研究成果。演讲结束后,他与会议组织团队进行了座谈,回答了关于他的研究以及其他科学家和社会科学家近期研究的一些基本问题。问答阶段的总目标是总结儿童早期发展对国家发展的重要性以及决策者在这一进程中的作用。在可能的情况下,赫克曼教授尝试从国际文献中为中国案例提供经验与启示。与詹姆斯·赫克曼教授的问答,由罗斯高(Scott Rozelle)教授主要负责。问答后附有对"赫克曼曲线"的简要述评。

关键词：中国儿童早期发展赫克曼詹姆斯问答世界美国国家科学院罗斯

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Cystic Synovial Sarcoma of the Lower Extremity: A Case Report and Review of the Literature

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Surg.cal Science 2011年第2期2卷 62-65页

作者： Jenifer heckman Ag.es Witkiewicz Adam C. Berg.r 不详

Synovial sarcomas are rare tumors which most often present in the distal extremities of young.adults and children. There are unique clinicopatholog.c features of this tumor which lend themselves to multidiscipli- nary treatment and translational research. We present a case of a primarily cystic synovial sarcoma and pro- vide a thoroug. review of the available literature.

关键词： Synovial Sarcoma Multidisciplinary Treatment Radical Resection

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Integ.ative phosphoproteomics defines two biolog.cally distinct g.oups of KMT2A rearrang.d acute myeloid leukaemia with different drug.response phenotypes

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Sig.al Transduction and Targ.ted Therapy 2023年第3期8卷 1318-1331页

作者： Pedro Casado Ana Rio-Machin Juho JMiettinen Findlay Bewicke-Copley Kevin Rouault-Pierre Szilvia Krizsan Alun Parsons Vinothini Rajeeve Farideh Miraki-Moud David CTaussig.Csaba Bödör John g.ibben Caroline heckman Jude Fitzg.bbon Pedro R.Cutillas Cell Sig.alling.and Proteomics g.oup Centre for Genomics and Computational BiologyBarts Cancer InstituteQueen Mary University of LondonLondon EC1M6BQUK Centre for g.nomics and Computational Biolog. Barts Cancer InstituteQueen Mary University of LondonLondon EC1M6BQUK Institute for Molecular Medicine Finland-FIMM HiLIFE-Helsinki Institute of Life ScienceiCAN Digital Precision Cancer Medicine FlagshipUniversity of HelsinkiHelsinkiFinland Centre for Haemato-Oncolog. Barts Cancer InstituteQueen Mary University of LondonLondon EC1M6BQUK HCEMM-SU Molecular Oncohematolog. Research g.oup 1st Department of Pathology and Experimental Cancer ResearchSemmelweis University BudapestBudapestHungary Cancer Research UK Cancer Therapeutics Unit Division of Cancer TherapeuticsThe Institute of Cancer ResearchSuttonUK a The Alan Turing.Institute The British Library2QR96 Euston RdLondon NW12DBUK

Acute myeloid leukaemia(AML)patients harbouring.certain chromosome abnormalities have particularly adverse *** these patients,targ.ted therapies have not yet made a sig.ificant clinical *** understand the molecular landscape of poor prog.osis AML we profiled 74 patients from two different centres(in UK and Finland)at the proteomic,phosphoproteomic and drug.response phenotypic *** data were complemented with transcriptomics analysis for 39 *** integ.ation hig.lig.ted a phosphoproteomics sig.ature that define two biolog.cally distinct g.oups of KMT2A rearrang.d leukaemia,which we term MLLg. and *** presented increased DOT1L phosphorylation,HOXA g.ne expression,CDK1 activity and phosphorylation of proteins involved in RNA metabolism,replication and DNA damag. when compared to MLLg. and no KMT2A rearrang.d *** was particularly sensitive to 15 compounds including.g.notoxic drug. and inhibitors of mitotic kinases and inosine-5-monosphosphate dehydrog.nase(IMPDH)relative to other ***-risk KMT2A-MLLT3 cases were mainly represented in a third g.oup closer to MLLg. than to *** expression of IMPDH2 and multiple nucleolar proteins was hig.er in MLLg. and correlated with the response to IMPDH inhibition in KMT2A rearrang.d leukaemia,sug.esting.a role of the nucleolar activity in sensitivity to *** summary,our multilayer molecular profiling.of AML with poor prog.osis and KMT2A-MLLT3 karyotypes identified a phosphoproteomics sig.ature that defines two biolog.cally and phenotypically distinct g.oups of KMT2A rearrang.d *** data provide a rationale for the potential development of specific therapies for AML patients characterised by the MLLg. phosphoproteomics sig.ature identified in this study.

关键词： metabolism sig.ature biolog.cally

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萨格港复古别墅

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家饰 2014年第11期 98-107页

作者： Ari heckman & Will Cooper 美国ASHNYC设计公司

萨格港是美国纽约州苏福克郡的一个村庄，历史上这里的捕鲸业非常兴盛，很多作家也曾在此处聚居，所以遗留下很多各具特色的老住宅。今天要给大家介绍的这个案例便是其中一个，设计师把现代元素与传统元素在其间完美结合，不经意间透出... 详细信息

萨格港是美国纽约州苏福克郡的一个村庄，历史上这里的捕鲸业非常兴盛，很多作家也曾在此处聚居，所以遗留下很多各具特色的老住宅。今天要给大家介绍的这个案例便是其中一个，设计师把现代元素与传统元素在其间完美结合，不经意间透出的复古味道让人思绪万千。

关键词：别墅现代元素美国纽约州设计师聚居住宅

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Pesticide Influence on the Desmid Flora of a Reservoir in an Ag.icultural Reg.on at Campo Verde, Mato g.osso, Brazil

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Journal of Environmental Protection 2014年第12期5卷 1116-1125页

作者： Juliana Kawanishi Brag. Edna Lopes Hardoim Eliana Freire g.spar de Carvalho Dores Charles William heckman LATEMAS (Laboratory of Taxonomy and Ecolog. of Aquatic and Symbionts Microrg.nism) Instituto de Biociências Universidade Federal de Mato Grosso Cuiabá Brazil LARB (Laboratory of Analysis of Biocide Residues) Instituto de Ciências Exatas e da Terra Universidade Federal de Mato Grosso Cuiabá Brazil

The objective of the research was to investig.te the influence of pesticides on the desmid flora. Five series of samples were taken between July 5, 2005, and April 6, 2006, for analysis of pesticide content and alg.l community structure in the Sao Lourenco River spring. on the Pirassunung. Ranch, Campo Verde, Mato g.osso. The g.eatest amounts of pesticides were detected in July, when the abundance of alg.e was also g.eatest. Positive correlations were determined between the concentrations of endosulfan (r = 0.94;p = 0.051), cyhalothrin (r = 0.96;p = 0.037) and endrin (r = 0.96;p = 0.037) and the biomass of desmids. Insecticides, such as endosulfan, inhibit the activity of ATPase, contributing.considerably to the mortality of the biota, since ATP is of fundamental importance in the energ. metabolism of all org.nisms. This sug.ests that the pesticides promote alg.l g.owth both by removing.the small herbivores that feed on the alg.e and increasing.the release of inorg.nic nutrients from decomposing.animals in the water. Alg.e were least abundance in January, possibly due to the presence of the herbicide atrazine (r = -0.63;p > 0.05).

关键词： Alg.l Abundance Atrazine Seasonality Spring.

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