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Outcome predictors for severely brain-injured patients directly admitted or transferred from emergency departments to a trauma center

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World Journal of Emergency Medicine 2020年第2期11卷 120-121页

作者： Ryne Jenkins Nicholas a.morris Bryce Haac Richard Van Besien Deborah MStein Neeraj Badjatia Amir Medic Gaurika Mester Quincy K.Tran Program in Trauma The R Adams Cowley Shock Trauma CenterUniversity of Maryland School of MedicineBaltimoreMDUSA Section of Neurocritical Care and Emergency Neurology Department of NeurologyUniversity of Maryland School of MedicineBaltimoreMDUSA University of Maryland School of Medicine BaltimoreMDUSA University of Maryland at College Park College ParkMDUSA Department of Emergency Medicine University of Maryland School of MedicineBaltimoreMDUSA

Dear editor,After sustaining severe traumatic brain injury(TBI),patients frequently require invasive mechanical ventilation(MV).However,up to 26%of patients require tracheostomy due to failure to wean from the ventilator.[1]The decision of when to perform tracheostomy is important as it balances the risk between avoiding prolonged MV and avoiding risk of *** predictors for tracheostomy,i.e.,clinical factors when patients first present to an Emergency Department after trauma or when patient fi rst arrive at a regional trauma center,can help clinicians’medical decision-making process.

关键词： patients admitted trauma

Raman spectroscopy monitors adverse bone sequelae of cancer radiotherapy

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Chinese Chemical Letters 2015年第4期26卷 401-406页

作者： Bo Gong michael D.morris Department of Chemistry College of LiteratureScience and the ArtsUniversity of Michigan

Raman spectroscopy provides information on bone chemical composition and structure via widely used metrics including mineral to matrix ratio, mineral crystallinity and carbonate content, collagen cross- linking ratio and depolarization ratios. These metrics are correlated with bone material properties, such as hardness, plasticity and Young＇s modulus. We review application of Raman spectroscopy to two important irradiated animal models： the mouse tibia, a model for damage to cortical bone sites including the rib （breast cancer） and to healthy tissue adjacent to extremity sarcomas, and the rat mandible, a model for radiation damage in head and neck cancer radiotherapy. Longitudinal studies of irradiated mouse tibia demonstrate that radiation-induced matrix abnormalities can persist even 26 weeks post- radiation. Polarized Raman spectroscopy shows formation of more ordered orientation of both mineral and collagen. At 8 weeks post-radiation, irradiated rat hemimandible exhibits transient hyperminer- alization, increased collagen cross-linking and decreased depolarization ratios of mineral and collagen. A standard radioprotectant, amifostine, mitigates rat mandible radiation damage, with none remaining detectable 18 weeks post-radiation. Already a powerful tool to monitor radiation damage, Raman spectroscopy may be important in development of new radiotherapy protocols and radioprotective agents. Further in vfvo studies of radiation effects on the rodent models are underway, as are development of methodologies for eventual use in human subjects.

关键词： BoneRaman spectroscopyCancer radiotherapy

Redox regulation of the immune response

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Cellular & Molecular Immunology 2022年第10期19卷 1079-1101页

作者： Gerwyn morris Maria Gevezova Victoria Sarafian michael Maes Deakin University IMPACT-the Institute for Mental and Physical Health and Clinical TranslationSchool of MedicineBarwon HealthGeelongVICAustralia Department of Medical Biology Medical University-PlovdivPlovdivBulgaria Research Institute at Medical University-Plovdiv PlovdivBulgaria Department of Psychiatry Faculty of MedicineKing Chulalongkorn Memorial HospitalBangkokThailand Department of Psychiatry Medical University of PlovdivPlovdivBulgaria

The immune-inflammatory response is associated with increased nitro-oxidative *** aim of this mechanistic review is to examine:(a)the role of redox-sensitive transcription factors and enzymes,ROS/RNS production,and the activity of cellular antioxidants in the activation and performance of macrophages,dendritic cells,neutrophils,T-cells,B-cells,and natural killer cells;(b)the involvement of high-density lipoprotein(HDL),apolipoprotein A1(ApoA1),paraoxonase-1(PON1),and oxidized phospholipids in regulating the immune response;and(c)the detrimental effects of hypernitrosylation and chronic nitro-oxidative stress on the immune *** redox changes during immune-inflammatory responses are orchestrated by the actions of nuclear factor-κB,HIF1α,the mechanistic target of rapamycin,the phosphatidylinositol 3-kinase/protein kinase B signaling pathway,mitogen-activated protein kinases,5'AMP-activated protein kinase,and peroxisome proliferator-activated *** performance and survival of individual immune cells is under redox control and depends on intracellular and extracellular levels of ROS/*** are heavily influenced by cellular antioxidants including the glutathione and thioredoxin systems,nuclear factor erythroid 2-related factor 2,and the HDL/ApoA1/PON1 *** nitro-oxidative stress and hypernitrosylation inhibit the activity of those antioxidant systems,the tricarboxylic acid cycle,mitochondrial functions,and the metabolism of immune *** conclusion,redox-associated mechanisms modulate metabolic reprogramming of immune cells,macrophage and T helper cell polarization,phagocytosis,production of pro-versus anti-inflammatory cytokines,immune training and tolerance,chemotaxis,pathogen sensing,antiviral and antibacterial effects,Toll-like receptor activity,and endotoxin tolerance.

关键词： Oxidative and nitrosative stress Immune response Inflammation Antioxidants Physiological stres

A case of phenibut withdrawal and treatment with baclofen

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World Journal of Emergency Medicine 2023年第4期14卷 338-340页

作者： michael morris James Espinosa Alan Lucerna Robin Lahr Department of Emergency Medicine Rowan University SOM/Jefferson StratfordNJ 08084USA Emergency Medicine Residency Program Director Rowan University SOM/Jefferson StratfordNJ 08084USA

Phenibut(β-phenyl-γ-aminobutyric acid)is a psychoactive gamma-aminobutyric acid(GABA)analog marketed online as a nutritional and nootropic(cognition enhancing)*** consumption poses a high risk of potential *** from phenibut mimics benzodiazepine and alcohol withdrawal and can be dangerous.A number of approaches have been described for phenibut withdrawal,including protocols that include baclofen,but for inpatient and outpatient *** we describe a 30-year-old male who presented to an emergency department(ED)with insomnia,anxiety and palpitations after he stopped taking phenibut.

关键词： treatment withdrawal alcohol

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基于专利引文分析的时间线技术

现代图书情报技术 2008年第6期 51-55页

作者：孙涛涛 Steven a.morris 黄亚明中国科学院国家科学图书馆北京100190 中国科学院研究生院北京100049 Baker Hughes/INTEQ HoustonTexasUSA 中国医科大学信息管理与信息系统(医学) 沈阳110001

在对专利引文可视化技术现状进行分析的基础上,将基于引文分析的时间线技术运用到专利文献的可视化分析。详细阐述该技术的理论依据、设计思想,并用美国专利数据库中的DVD激光头专利进行技术应用,证明该技术能揭示专利文献中的技术热点... 详细信息

在对专利引文可视化技术现状进行分析的基础上,将基于引文分析的时间线技术运用到专利文献的可视化分析。详细阐述该技术的理论依据、设计思想,并用美国专利数据库中的DVD激光头专利进行技术应用,证明该技术能揭示专利文献中的技术热点及其发展演变,并挖掘关键技术。

关键词：专利引文分析时间线技术热点

Results of selective decontamination with oral neomycin and metronidazole for major colorectal surgery in Australia:A cohort study

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 72-78页

作者： James Wei Tatt Toh Devansh Shah Henry Wang Charlotte Kwik Joseph Do Woong Choi Chelsie Leonie Beinke Paul morris Eleni Baird-Gunning Geoffrey Peter Collins Fiona Gavegan Karen Shedden Toufic El-Khoury Nimalan Pathma-Nathan Kerry Hitos Department of Colorectal Surgery Westmead HospitalWestmeadNew South WalesAustralia The University of Sydney Westmead HospitalWestmeadNew South WalesAustralia Western Sydney University New South WalesAustralia University of Notre Dame New South WalesAustralia Westmead Research Centre for Evaluation of Surgical Outcomes Westmead HospitalSydneyAustralia

Objective The role of selective decontamination with oral antibiotics(OABs)and mechanical bowel preparation(MBP)prior to elective colorectal surgery is still widely *** objective of this study was to compare the outcomes of selective decontamination with neomycin,metronidazole and MBP compared to those of decontamination with MBP alone or with no *** Selective decontamination with neomycin and metronidazole combined with bowel preparation was introduced prior to elective colorectal surgery as part of an enhanced recovery after surgery program at Westmead Hospital,a major Australian tertiary referral hospital,between June 2017 and January *** between short-term outcomes of OAB+MBP and MBP/no preparation were made using prospectively collected data on length of stay(LOS),readmission,mortality within 30 days,anastomotic leakage(AL),surgical site infection(SSI),urinary tract infection,deep venous thrombosis and/or pulmonary embolism,pneumonia,and ***-up was limited to hospital stays and subsequent presentations within the health district within thirty days of *** Mann-Whitney U test was used to analyse continuous data,and the chi-square test was used for categorical *** and multivariate regression modelling was performed to identify risk factors associated with an increased likelihood of SSI and *** Patients with oral neomycin and metronidazole combined with bowel preparation had reduced superficial SSI(2.7%vs.7.6%,p=0.043)and overall complications(32.7%vs.44.6%,p=0.020),particularly Clavien-Dindo 1 complications(7.3%vs.16.5%,p=0.009).However,the differences in AL(2.7%vs.4.5%,p=0.369)and organ/space SSI(1.3%vs.3.7%,p=0.327)were not statistically *** median LOS(6 d vs.6 d,p=0.370)was not different between the *** Selective decontamination with neomycin and metronidazole reduces the risk of SSIs and overall *** was a trend to toward a lower AL,but this differ

关键词： Neomycin Metronidazole Colorectal surgery Anastomotic leakage Surgical site infection

THE WORLDWIDE IMPACT OF CHINA'S MODERNIZATION

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Beijing Review 2024年第31期67卷 22-22页

作者： David morris the Center for China and Globalization

Each generation deals with big changes,but today's world is experiencing a perfect storm of seismic disruptions in the balance of power,a technological transformation,and a climate *** is central to each of these,and ... 详细信息

关键词： storm seismic climate

Why China Will Lead The World With EVs

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Beijing Review 2024年第10期67卷 23-23页

作者： David morris Center for China and Globalization

Abattle is underway to determine which country will lead in the transition to zero-emission *** electric vehicle(EV)sector is expected to be a major pillar of the new green ***,Germany,where the petrolguzzling car was... 详细信息

关键词： World sector leader

Development of a facile block copolymer method for creating hard mask patterns integrated into semiconductor manufacturing

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Nano Research 2016年第10期9卷 3116-3128页

作者： Tandra Ghoshal Matthew T. Shaw Justin D. Holmes michael A. morris Department of Chemistry and Tyndall National Institute University College Cork Cork Ireland AMBER Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin Ireland Intel Ireland Ltd. Collinstown Industrial Estate Co. Kildare Ireland School of Chemistry Trinity College Dublin Dublin Ireland

Our goal is to develop a facile process to create patterns of inorganic oxides and metals on a substrate that can act as hard masks. These materials should have high etch contrast （compared to silicon） and so allow high-aspect-ratio, high- fidelity pattern transfer whilst being readily integrable in modem semiconductor fabrication （FAB friendly）. Here, we show that ultra-small-dimension hard masks can be used to develop large areas of densely packed vertically and horizontally orientated Si nanowire arrays. The inorganic and metal hard masks （Ni, NiO, and ZnO） of different morphologies and dimensions were formed using microphase- separated polystyrene-b-poly（ethylene oxide）（PS-b-PEO） block copolymer （BCP） thin films by varying the BCP molecular weight, annealing temperature, and annealing solvent（s）. The self-assembled polymer patterns were solvent-processed, and metal ions were included into chosen domains via a selective inclusion method. Inorganic oxide nanopatterns were subsequently developed using standard techniques. High-resolution transmission electron microscopy studies show that high-aspect-ratio pattern transfer could be affected by standard plasma etch techniques. The masking ability of the different materials was compared in order to create the highest quality uniform and smooth sidewall profiles of the Si nanowire arrays. Notably good performance of the metal mask was seen, and this could impact the use of these materials at small dimensions where conventional methods are severely limited.

关键词： block copolymer self-assembly hard mask silicon nanowires