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Rural congestive heart failure mortality among US elderly, 1999-2013: Identifying counties with promising outcomes and opportunities for implementation research

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Family Medicine and Community Health 2015年第2期3卷 27-38页

作者： Maria C.Mejia de Grubb Robert S.Levine Barbara Kilbourne Baqar A.Husaini Tyler Skelton Lisa Gittner michael a.langston George E.Rust Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Department of Sociology Tennessee State UniversityNashvilleTennesseeUSA Center for PreventionResearch Tennessee State University College of AgricultureNashvilleTennesseeUSA Department of Political Science Texas Tech UniversityLubbockTXUSA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTennesseeUSA Department of Family Medicine National Center for Primary CareMorehouse School of MedicineAtlantaGeorgiaUSA

Objective:Describe modern trends in congestive heart failure(CHF)among elderly(>65 years of age)in the United States,to identify potentially successful rural *** CHF mortality using multiple-(MCOD)versus underlying-(UCOD)cause of death ***:*** for Disease Control and Prevention mortality files(WONDER internet site).Results:Using MCOD data,overall mortality rates/100,000 population(and 95%confidence intervals)for CHF among persons>65 years of age(1999-2013)were 482.0(481.2-482.8)for large central and large fringe metropolitan(LCLF)counties,549.6(548.6-550.7)in small and medium metropolitan(SM)counties,and 652.6(650.9-654.0)in micropolitan and non-core,non-metropolitan(MNCNM)*** positive deviance NCNM counties(collectively including 198,581 residents>65 years of age)had an overall CHF rate of 300.9(275.0-326.9)in *** was significantly lower than the LCLF rate for 2013(482.0[481.2-482.8]),and rep-resented a reduction of 47%since *** CHF occurrence as estimated with MCOD was 3.4-fold higher than that obtained with ***:These data illustrate underestimation of CHF by UCOD data and the importance of correct death *** CHF mortality rates are higher than urban rates,but some positive deviance counties demonstrate that this is not *** research is needed to understand the relative contribution of research innovation,medical care,and public health to rural-urban disparities and the relative success of positive deviance counties.

关键词： Congestive heart failure elderly mortality rural

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STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses

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National Science Review 2024年第7期11卷 189-204页

作者： Taokun Luo Xiaomin Jiang Yingjie Fan Eric Yuan Jinhong Li langston Tillman Wenbin Lin Department of Chemistry University of Chicago Department of Radiation and Cellular Oncology and the Ludwig Center for Metastasis Research University of Chicago

Radiotherapy is widely used for cancer treatment, but its clinical utility is limited by radioresistance and its inability to target metastases. Nanoscale metal-organic frameworks(MOFs) have shown promise as high-Z nanoradiosensitizers to enhance radiotherapy and induce immunostimulatory regulation of the tumor microenvironment. We hypothesized that MOFs could deliver small-molecule therapeutics to synergize with radiotherapy for enhanced antitumor efficacy. Herein, we develop a robust nanoradiosensitizer,GA-MOF, by conjugating a STING agonist, 2,3-cyclic guanosine monophosphate–adenosine monophosphate(GA), on MOFs for synergistic radiosensitization and STING activation. GA-MOF demonstrated strong anticancer efficacy by forming immune-cell-rich nodules(artificial leukocytoid structures) and transforming them into immunostimulatory hotspots with radiotherapy. Further combination with an immune checkpoint blockade suppressed distant tumors through systemic immune activation. Our work not only demonstrates the potent radiosensitization of GA-MOF, but also provides detailed mechanisms regarding MOF distribution, immune regulatory pathways and long-term immune effects.

关键词： metal-organic framework radiosensitization STING agonist artificial leukocytoid structures immune hotspots immunotherapy nanomedicine

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Donald ***’s art and science of waveforms

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Earthquake Science 2022年第1期35卷 3-5页

作者： Charles a.langston Center for Earthquake Research and Information University of MemphisMemphisTN 38152USA

I arrived at the Caltech Seismo Lab early in May *** faculty and graduate students had the run of an old mansion(Donnelly Lab)that was slightly tattered around the edges but conducive to both all-night work sessions and goofing off since it still had well-kept grounds that included a tennis *** of the graduate students occupied the large dining room on the first floor and we hunted out our advisors,when needed,by trying their offices around the rest of the house,checking out the tennis courts,or visiting the coffee pot in the basement.

关键词： floor slightly graduate

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Synchronization of Radar Observations with Multi-Scale Storm Tracking

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Advances in Atmospheric Sciences 2009年第1期26卷 78-86页

作者：杨洪平 Jian ZHANG Carrie langston Wuhan Institute of Heavy Rain China Meteorological Administration Wuhan 430074 Cooperative Institute for Mesoscale Meteorological Studies The University of Oklahoma and NOAA/OAR National Severe Storms Laboratory Norman O.K. U.S.A

The 3-D radar reflectivity data has become increasingly important for use in data assimilation towards convective scale numerical weather prediction as well as next generation precipitation estimation. Typically, reflectivity data from multiple radars are objectively analyzed and mosaiced onto a regional 3-D Cartesian grid prior to being assimilated into the models. One multi-radar observations is the synchronization of all of the scientific issues associated with the mosaic of the observations. Since radar data is usually rapidly updated （-every 5-10 min）, it is common in current multi-radar mosaic techniques to combine multiple radar＇ observations within a time window by assunfing that the storms are steady within the window. The assumption holds well for slow evolving precipitation systems, but for fast evolving convective storms, this assumption may be violated and the mosaic of radar observations at different times may result in inaccurate storm structure depictions. This study investigates the impact of synchronization on storm structures in multiple radar data analyses using a multi-scale storm tracking algorithm.

关键词： synchronization radar multi-scale storm tracking

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Vibration induced flow in hoppers:DEM 2D polygon model

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Particuology 2008年第6期6卷 455-466页

作者： Feras Y. Fraige Paul A. langston Andrew J. Matchett John Dodds Faculty of Mining and Environmental Engineering Al-Hussein Bin Talal University Jordan Chemical and Environmental Engineering Nottingham University University Park Chemical Engineering University of Teesside Centre RAPSODEE Ecole Des Mines

A two-dimensional discrete element model （DEM） simulation of cohesive polygonal particles has been developed to assess the benefit of point source vibration to induce flow in wedge-shaped hoppers. The particle-particle interaction model used is based on a multi-contact principle. The first part of the study investigated particle discharge under gravity without vibration to determine the critical orifice size （Bc） to just sustain flow as a function of particle shape. It is shown that polygonal-shaped particles need a larger orifice than circular particles. It is also shown that Bc decreases as the number of particle vertices increases. Addition of circular particles promotes flow of polygons in a linear manner. The second part of the study showed that vibration could enhance flow, effectively reducing Bc. The model demonstrated the importance of vibrator location （height）, consistent with previous continuum model results, and vibration amplitude in enhancing flow.

关键词： Bulk solids Vibration DEM Hoppers Materials handling Polygon

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Spatial distribution and structure of benthic polychaete communities of Essaouira intertidal rocky shores(Atlantic coast of Morocco)

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Journal of Oceanology and Limnology 2020年第1期38卷 143-155页

作者： CHOUIKH Nor-eddine GILLET Patrick langston WJ CHEGGOUR Mohamed MAAROUF Abdelmalek MOUABAD Abdelfattah Laboratory“Aliments Environnement et santé”Faculty of Sciences and TechnicsB.P.549Cadi Ayyad UniversityMarrakech 40000Morocco Mer Molécules Santé Department of Biology EnvironmentFaculty of Sciences UCOAngers 49008France Marine Biological Association the LaboratoryCitadel HillPlymouth PL12PBUnited Kingdom Department of Biology Ecole Normale SupérieureB.P.2400Cadi Ayyad UniversityMarrakech 40000Morocco

Polychaetes are one of the most important groups ofmacrobenthic organisms in coastal and marine environments,in terms of diversity and abundance,and play an important role in the functioning of *** study aims to describe the structure and spatial distribution ofpolychaete communities along Essaouira's rocky shoreline(Atlantic coast of Morocco)in relation to the major environmental variables such as granulometry,salinity,temperature,pH,and intertidal *** sites from these intertidal rocky shores were sampled using a quadrat method during the summer 2016.A total of 4435 individuals belonging to 34 taxa were *** the families,Sabellaridae(24%)and Nereididae(23%)were ranked first in terms of abundance of *** alveolata(24%)and Perinereis cultrifera(13%)were the dominant ***(H')values varied from 2.28 to ***'s index(J')varied between 0.62 and *** was essentially due to the low dominance of few *** analysis was used to characterise Essaouira's rocky shores on the basis of benthic polychaete *** analysis confirmed the presence of three distinct *** to canonical correspondence analysis,the structure and distribution of faunal assemblages of benthic polychaetes was mainly related to topographical complexity,water temperature,hydrodynamic conditions and *** conclude that these rocky shores show typically high benthic polychaete diversity compared to the taxonomic list of other rocky *** addition,these results constitute a baseline data for the development of a sustainable network for long-term monitoring of benthic polychaete community changes due to ecological factor influences and anthropogenic activity impacts.

关键词： polychaetes taxonomic diversity Essaouira rocky shore faunal assemblage

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Socioeconomic, environmental, and geographic factors and US lung cancer mortality, 1999-2009

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Family Medicine and Community Health 2017年第1期5卷 3-12页

作者： Maria C.Mejia de Grubb Barbara Kilbourne Katy Kilbourne michael langston Lisa Gittner Roger J.Zoorob Robert Levine Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Sociology Department Tennessee State UniversityNashvilleTNUSA Department of Family and Community Medicine Meharry Medical CollegeNashvilleTNUSA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTNUSA Department of Political Science Texas Tech University College of Arts and SciencesLubbockTXUSA

Background:The American Cancer Society estimates that about 25%of all US cancer deaths will be due to lung cancer-more than from cancers of the colon,breast,and prostate ***:We ascertained county-level age-adjusted and age-specific death rates and 95%confidence intervals from the Centers for Disease Control and Prevention Compressed Mortality *** regression analyses were used to estimate the strength and direction of relationships between county poverty,smoking,fine particulate matter(PM2.5)air pollution,and US Census divisions and race-and sex-specific lung cancer ***:Poverty,smoking,and particulate matter air pollution were positively and signifi-cantly related to lung cancer deaths among white men,but of these,only poverty and smoking were significantly associated with lung cancer deaths among white *** in the South Atlantic,East South Central,and West South Central US Census divisions at the time of death was significantly associated with lung cancer deaths for both white men and white *** with white men,poverty and smoking were associated with lung cancer deaths among black men,but of these,only adult smoking had a statistically significant association among black ***:The results support the need for further research,particularly in high-risk areas,to better differentiate factors specific to race and sex and to understand the impact of local risk factors.

关键词： Lung cancer mortality geographic risk factors environmental hot spot

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Alleviating forest degradation in the Lancang-Mekong Region requires closing management—measurement gaps

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Journal of Forestry Research 2020年第6期31卷 2033-2051页

作者： Julia Brewer James Douglas langston Kalifi Ferretti-Gallon John LInnes Shuyu Xin Hongbo Zhai Guangyu Wang Faculty of Forestry University of British Columbia2424 Main MallVancouverBCCanada APFNet Secretariat 6th FloorBaoneng Center Building A12 Futong DongdajieChaoyang DistrictBeijing 100102P.R.China

Deforestation and forest degradation are having profound negative impacts on social-ecological systems in the emerging economies across the ***,interest in restoring and rehabilitating degraded forests has been *** paper explores current issues related to addressing forest degradation in the Lancang-Mekong Region(LMR)of Southeast Asia through a review of the use of criteria and indicators for forest degradation and *** degradation must be understood in the context of its underlying drivers,which are numerous and *** these underlying drivers of degradation requires diagnosing the entwined political,social,economic,and environmental systems that aff ect *** are the relevant scales to diagnose and intervene for improved *** to restore or rehabilitate forests should be process-driven,focused on the underlying social,ecological and political processes that degrade *** should also include negotiation among all actors infl uencing and competing for natural resource claims in forest *** and indicators for forest landscape restoration should therefore help to improve the governance of forest *** and indicators provide measures of the biophysical outcomes of degradation,in addition to processes,but these should be adapted to changing contexts and emerging challenges,and should rectify any pre-existing fl awed *** activities should synthesize,integrate,and build upon the rich history of pre-existing restoration guidelines,but should be adaptable in order to be applied eff ectively in the contexts of local *** project is facilitating a dialogue around the use of criteria and indicators to help solve the degradation challenge in the *** will trial the use of the criteria and indicators generated through this research in the LMR to learn what works and what doesn’*** will provide an opportunity t

关键词： Forest rehabilitation Forest restoration Forest landscape restoration Sustainable forest management Criteria and indicators

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Early Autumn

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大学英语 1988年第4期 23-25页

作者： langston Hughes 陈许

简介:《初秋》是一篇小小说.作者仅用一千余字,便以素描笔法,描写出一对昔日的情人若干年后重逢的情景,突出表现了女主人公的怀旧心理。读来不禁使人想起了一句西方谚语:草率结婚后悔多.

关键词： bus Early Autumn

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Research methods laboratory manual for psychology 2nd ed.

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2005年

作者： langston William

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