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Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region:a systematic review and meta-analysis

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Infectious Diseases of Poverty 2018年第1期7卷 427-439页

作者： Jennifer a.steele Carsten H.Richter Pierre Echaubard Parichat Saenna Virginia Stout Paiboon Sithithaworn Bruce A.Wilcox Department of Infectious Disease and Global Health Tufts UniversityCummings School of Veterinary MedicineNorth GraftonMAUSA Global Health Asia Integrative Education and Research ProgrammeFaculty of Public HealthFaculty of Public Health StudiesBangkokThailand Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunmingChina Department of Biology Laurentian UniversityGreater SudburyONCanada Department of Science Education Khon Kaen UniversityFaculty of EducationKhon KaenThailand Department of Parasitology Khon Kaen UniversityFaculty of MedicineKhon KaenThailand

Background:Cholangiocarcinoma(CCA)is a fatal bile duct cancer associated with infection by the liver fluke,Opisthorchis viverrini,in the lower Mekong *** public health interventions have focused on reducing exposure to ***,but incidence of CCA in the region remains *** this may indicate the inefficacy of public health interventions due to complex social and cultural factors,it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of *** systematic review aims to provide a comprehensive analysis of described risk factors for CCA in addition to *** to guide future integrative *** body:We searched five international and seven Thai research databases to identify studies relevant to risk factors for CCA in the lower Mekong *** studies were assessed for risk of bias and quality in terms of study design,population,CCA diagnostic methods,and statistical *** final 18 included studies reported numerous risk factors which were grouped into behaviors,socioeconomics,diet,genetics,gender,immune response,other infections,and treatment for *** risk factors were reported by two or more studies and were assessed with random effects models during *** meta-analysis indicates that the combination of alcohol and smoking(OR=11.1,95%CI:5.63-21.92,P<0.0001)is most significantly associated with increased risk for CCA and is an even greater risk factor than *** *** analysis also suggests that family history of cancer,consumption of raw cyprinoid fish,consumption of high nitrate foods,and praziquantel treatment are associated with significantly increased *** risk factors may have complex relationships with the host,parasite,or pathogenesis of CCA,and many of these risk factors were found to interact with each other in one or more ***:Our findings suggest that a complex variety of risk factors in ad

关键词： Cholangiocarcinoma Risk factors Opisthorchis viverrini Mekong Southeast Asia Thailand Public health

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Syringoid eccrine carcinoma of the eyelid presenting as cicatricial entropion

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 912-913页

作者： Manjool M.Shah Eric a.steele Kevin P.White David J.Wilson Department of Ophthalmology Casey Eye InstituteOregon Health&Science University Portland Veteran's Affairs Medical Center Department of Dermatology Oregon Health&Science University

Dear Sir,My name is Manjool ***,from the Casey Eye Institute at Oregon Health&Science University in Portland,Oregon,USA.I wish to write to you with regards to an interesting presentation of a rare eyelid malignancy.A 41-year old Caucasian female was referred to the oculoplastic service by her comprehensive ophthalmologist

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Phase Transitions and Anion Exchange in All-Inorganic Halide Perovskites

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Accounts of Materials Research 2020年第1期1卷 3-15页

作者： Julian a.steele Minliang Lai Ye Zhang Zhenni Lin Johan Hofkens Maarten B.J.Roeffaers Peidong Yang cMACS Department of Microbial and Molecular SystemsKU Leuven3001 LeuvenBelgium Department of Chemistry University of CaliforniaBerkeleyCalifornia 94720United States Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720United States Department of Materials Science and Engineering University of CaliforniaBerkeleyCalifornia 94720United States Department of Chemistry KU Leuven3001 HeverleeBelgium Max Plank Institute for Polymer Research Mainz D-55128Germany Kavli Energy Nano Science Institute BerkeleyCalifornia 94720United States

CONSPECTUS:A new generation of semiconducting materials based on metal halide perovskites has recently been launched into the scientific spotlight,exhibiting outstanding optoelectronic properties and providing promise for the development of efficient optical *** a vivid example,solar cells made from these materials have quickly reached conversion efficiencies exceeding 25%,now on par with well-established technologies,like *** widespread success is due,in part,to a unique ability to retain high-quality optoelectronic performance while being easily solutionprocessed into thin *** feature is what defines them as a brand-new class of optoelectronic materials,with the ability to compete with traditional semiconductors requiring higher processing costs,like the III−Vs or II−***,the interesting photophysics of metal halide perovskites come with a catch;their soft ionic lattice promotes complex thermal-induced phase transitions and a high capacity for postsynthetic compositional changes,e.g.,halide anion *** dynamic behavior has ultimately made understanding several important structure−property relationships ambiguous and obstructed a clear path toward commercialization due to inherent phase *** aim in this Account is to highlight the fundamental aspects of metal halide perovskites that dictate a stable crystal structure and enable efficient anion exchange,through the lens of thermodynamic preference and phase formation *** the allinorganic CsPbI3‑xBrx system as a suitable case study,we focus on several ways in which its thermodynamically unstable perovskite structure can be maintained at room temperature and elucidate the restructuring pathways taken during *** addition,we will discuss the origin and mechanisms of postsynthetic anion exchange in CsPbX3(X=I,Br,Cl)perovskites,with emphasis made toward direct visualization using in situ optical microspectroscopy and arriving at quantitative resu

关键词： properties. perovskite halide

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Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1980-1995页

作者： Koki Nishihara Clothilde Villot Lautaro Cangiano Le Luo Guan michael steele Department of Animal Biosciences Animal Science and NutritionUniversity of GuelphGuelphON N1G 1Y2Canada Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada Lallemand SAS Blagnac F‑31702France Department of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Faculty of Land and Food Systems The University of British ColumbiaVancouverBC V6T 1Z4Canada Present Address:Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada

Background As Holstein calves are susceptible to gastrointestinal disorders during the first week of life,understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal *** probiotics in early life may contribute to host intestinal health by facilitating beneficial bacteria colonization and developing intestinal immune *** objective of this study was to characterize the impact of early life yeast supplementation and growth on colon mucosa-attached bacteria and host immune *** Twenty Holstein bull calves received no supplementation(CON)or Saccharomyces cerevisiae boulardii(SCB)from birth to 5 d of *** tissue biopsies were taken within 2 h of life(D0)before the first colostrum feeding and 3 h after the morning feeding at d 5 of age(D5)to analyze mucosa-attached bacteria and colon *** sequencing showed that there was no difference inαandβdiversity of mucosa-attached bacteria between day and treatment,but bacteria related to diarrhea were more abundant in the colon mucosa on D0 compared to *** addition,q PCR indicated that the absolute abundance of Escherichia coli(***)decreased in the colon mucosa on D5 compared to D0;however,that of Bifidobacterium,Lactobacillus,and Faecalibacterium prausnitzii,which could competitively exclude ***,increased in the colon mucosa on D5 compared to ***-sequencing showed that there were no differentially expressed genes between CON and SCB,but suggested that pathways related to viral infection such as“Interferon Signaling”were activated in the colon mucosa of D5 compared to *** Growth affected mucosa-attached bacteria and host immune function in the colon mucosa during the first 5 d of life in dairy calves independently of SCB *** early life,opportunistic pathogens may decrease due to intestinal environmental changes by beneficial bacteria and/or host immune *** activation

关键词： Colon biopsy Dairy calves RNA-sequencing Saccharomyces cerevisiae boulardii 16S rRNA amplicon-sequencing

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Pre-treatment platelet counts as a prognostic and predictive factor in stage Ⅱ and Ⅲ rectal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2017年第1期9卷 42-49页

作者： Morgan steele Ioannis A Voutsadakis Clinical Trials Unit Sault Area Hospital Division of Medical Oncology Department of Internal Medicine Sault Area Hospital Division of Clinical Sciences Northern Ontario School of Medicine

AIM To investigate if pre-treatment platelet counts could provide prognostic information in patients with rectal adenocarcinoma that received neo-adjuvant treatment. METHODS Platelet number on diagnosis of stage II and III rectal cancer was evaluated in 51 patients receiving neoadjuvant treatment and for whom there were complete follow-up data on progression and survival, as well as pathologic outcome at the time of surgery. Pathologic responses on the surgical specimen of patients with lower platelet counts(150-300 × 10~9/L) were compared with these of patients with higher platelet counts(> 300 × 10~9/L) by the χ~2 test. Overall and progression free survival Kaplan-Meier curves of the two groups were constructed and compared with the Log-Rank *** A significant difference was present between the two groups in regards to pathologic response with patients with lower platelet counts being more likely to exhibit a good or complete response to neo-adjuvant treatment than patients with higher platelet counts(P = 0.015). Among other factors evaluated, there was also a significant difference between the carcinoembryonic antigen(CEA) at presentation of patients that exhibited a good or complete response and those that had no response or a minimal to moderate response. Patients with a good or complete response were more likely to present with a CEA of less than 5 μg/L(P = 0.00066). There was no significant difference in overall and progression free survival between the two platelet count groups(Log-Rank tests P = 0.42 and P = 0.35, respectively).CONCLUSION In this retrospective analysis of stage II and III rectal cancer patients, platelet counts at the time of diagnosis had prognostic value for neo-adjuvant treatment pathologic response. Pre-treatment CEA also held prognostic value in regards to treatment effect.

关键词： Rectal cancer Platelets Prognosis Treatment response neo-adjuvant Chemoradiation

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Rapid conversion of cellulose to 5-hydroxymethylfurfural using single and combined metal chloride catalysts in ionic liquid

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燃料化学学报 2013年第2期41卷 214-222页

作者： Hussein Abou-Yousef El Barbary Hassan Philip steele Department of Forest Products Mississippi State University Cellulose & Paper Department National Research CenterDokkiCairoEgypt

Direct conversion of cellulose into 5-hydroxymethylfurfural(HMF) was performed by using single or combined metal chloride catalysts in 1-ethyl-3-methylimidazolium chloride(Cl) ionic *** study demonstrated formation of 2-furyl hydroxymethyl ketone(FHMK),and furfural(FF) simultaneously with the formation of *** reaction parameters were addressed to optimize yields of furan derivatives produced from cellulose by varying reaction temperature,time,and the type of metal chloride *** reaction by using FeCl3 resulted in 59.9% total yield of furan derivatives(HMF,FHMK,and FF) from ***3 was the most effective catalyst for selective conversion of cellulose into HMF(35.6%) with less concentrations of FHMK,and *** the yields of furans produced from cellulose could be achieved via reactions catalyzed by different combinations of two metal *** optimization was carried out to produce total furans yield 75.9% by using FeCl3/CuCl2 ***3/CuCl2 was the most selective combination to convert cellulose into HMF(39.9%) with total yield(63.8%) of furans produced from the *** temperature and time of the catalytic reaction played an important role in cellulose conversion,and the yields of *** the reaction temperature could enhance the cellulose conversion and HMF yield for short reaction time intervals(5~20 min).

关键词：化学动力学燃料化学理论 EMIM HMF

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Salivary leptin concentrations in Bruneian secondary school children

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 335-337页

作者： Adi Idris Ahmed Gharib Khamis Nur Basirah Ghazali michael steele David Koh Nik Ani Tuah PAPRSB Institute of Health Sciences Universiti Brunei Darussalam Faculty of Science Universiti Brunei Darussalam Saw Swee Hock School of Public Health National University of Singapore

Objective:To investigate the association between leptin levels and body mass index in Bruneian secondary school ***:The body mass index of Bruneian secondary school students(aged 11–18years) was determined before collecting their saliva using the passive drool *** leptin concentration was determined by ***:Correlation and partial correlation(controlled for age) analyses showed no significant differences between the levels of salivary leptin of normal weight and overweight ***:No significant increase in the salivary leptin concentration was observed in overweight compared with normal weight Bruneian secondary school students.

关键词： Obesity Saliva Leptin Brunei Adolescents Body mass index

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Evolving screening and surveillance techniques for Barrett's esophagus

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World Journal of Gastroenterology 2019年第17期25卷 2045-2057页

作者： David steele Kondal Kyanam Kabir Baig Shajan Peter Basil Hirschowitz Endoscopic Centre of Endoscopic Excellence Division of Gastroenterology and HepatologyUniversity of Alabama at Birmingham

Barrett's esophagus(BE) is a change in the esophageal lining and is known to be the major precursor lesion for most cases of esophageal adenocarcinoma(EAC).Despite an understanding of its association with BE for many years and the falling incidence rates of squamous cell carcinoma of the esophagus, the incidence for EAC continues to rise exponentially. In association with this rising incidence, if the delay in diagnosis of EAC occurs after the onset of symptoms,then the mortality at 5 years is greater than 80%. Appropriate diagnosis and surveillance strategies are therefore vital for BE. Multiple novel optical technologies and other advanced approaches are being utilized to assist in making screening and surveillance more cost effective. We review the current guidelines and evolving techniques that are currently being evaluated.

关键词： Barrett’s esophagus Screening Surveillance New techniques Endoscopy Imaging Radiofrequency ablation Narrow band imaging

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Neurosurgical treatment for addiction: lessons from an untold story in China and a path forward

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National Science Review 2020年第3期7卷 702-712页

作者： Shuo Ma Chencheng Zhang Ti-fei Yuan Douglas steele Valerie Voon Bomin Sun Department of Functional Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine Co-innovation Center of Neuroregeneration Nantong University Division of Imaging Science and Technology Medical School University of Dundee Department of Psychiatry University of Cambridge

Addiction is a major public-health crisis associated with significant disability and mortality. Although various pharmacological and behavioral treatments are currently available, the clinical efficacy of these treatments is limited. Given this situation, there is a growing interest in finding an effective neurosurgical treatment for addiction. First, we discuss the use of ablative surgery in treating addiction. We focus on the rise and fall of nucleus accumbens ablation for addiction in China. Subsequently, we review recent studies that have explored the efficacy and safety of deep-brain-stimulation treatment for addiction. We conclude that neurosurgical procedures, particularly deep-brain stimulation, have a potentially valuable role in the management of otherwise intractable addictive disorders. Larger well-controlled clinical trials, however, are needed to assess clinical efficacy and safety. We end by discussing several key issues involved in this clinical field and identifying some areas of progress.

关键词： drug addiction psychosurgery ablative surgery deep-brain stimulation medical ethics

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Could titin have a role in strain-induced injuries？

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Journal of Sport and Health Science 2017年第2期6卷 143-144页

作者： Craig Perrin Kazunori Nosaka James steele School of Sport Health and Social SciencesSouthampton Solent University Ringgold Standard InstitutionSouthamptonS014 OYNUK School of Exercise and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia

It has been known for some time that strain injuries occur through the excessive lengthening of a muscle.^(1–3)However,the precise mechanism for strain injury remains elusive and has been the subject of recent debate in the Journal of Sport and Health Science,^(4–9)but it seems sensible to consider mechanisms at the level of the muscle *** was previously believed that damage was the result of non-uniform stretching of

关键词：肌联蛋白损伤机制应变诱导肌肉纤维最佳长度肌原纤维最大变形力曲线

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