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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Tadpole Shrimps-A General Review of the little Known Crustaceans of Ephemeral Waterbodies

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Research in Ecology 2021年第2期3卷 18-24页

作者： michałRogacki Adam Brysiewicz Institute of Technology and life Sciences FalentyRaszynPoland

In time of global climate changes,astatic inland water reservoirs that contribute to water retention and alleviation of adverse effects of periodic river floods,are getting more and more ***,periodically drying off water reservoirs are also rich hubs of *** especially connected to such ecosystems are primitive but unique crustaceans called tadpole shrimps(order Notostraca).Those animals seem to have universal significance-both ecological and *** their primitive morphology and small size,they can radically affect the nature of their habitats,sometimes even helping us fight with noxious ***,due to progressing global warming,intensification in agriculture,and urbanisation,habitats of notostracans are disappearing ***,because of their rare occurences and taxonomic difficulties,tadpole shrimps have been insufficiently ***,protection of these crustaceans is inseparably connected with conservation of once numerous,periodically drying reservoirs as tadpole shrimps are referred as keystone species of such ***,the aim of this review article is to sum up and disseminate current state of knowledge about Notostraca by a general overview of available international *** might help to engage more scientists into research and conservation of these little known,yet interesting crustaceans and their unique habitats.

关键词： Notostraca Branchiopoda Nature maintenance Astatic water reservoirs Hydrobiology

Synthesis of Heterocyclic Ring Systems Using Organometallic Reagents

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复旦学报（自然科学版） 2005年第5期44卷 699-700页

作者： Sameer Agarwal Jan Knll micha P. Krahl Hans-Joachim Knlker Institut für Organische Chemie Technische Universitt Dresden Bergstrasse 66 01069 Dresden GermanyInstitut für Organische Chemie Technische Universitt Dresden Bergstrasse 66 01069 Dresden GermanyInstitut für Organische Chemie Technische Universitt Dresden Bergstrasse 66 01069 Dresden GermanyInstitut für Organische Chemie Technische Universitt Dresden Bergstrasse 66 01069 Dresden Germany

We developed novel synthetic routes to heterocyclic ring systems by using transition metal-mediated or -catalyzed reactions. A lewis acid-promoted addition of the propargyl Grignard reagent 2 to the Schiff base 1 followed by a silvermediated oxidative cyclization of the homopropargylamine 3 provided the aryl-substituted pyrrole 4. Combined with a chemoselective hydrogenation of the pyrrole ring, this method has been applied to the total synthesis of the biologically active fused indolizidine alkaloids ( ± )-harmicine and ( ± )-crispine A[1]. See Fig. 1.

关键词：生物碱咔唑杂环有机金属反应物氧化特性钯吡咯

Radioprotectors from pyrodextrins

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Chinese Science Bulletin 2010年第31期55卷 3556-3561页

作者： michalSKI Oskar BIDZINSKA Ewa BOROWSKI micha DYREK Krystyna OlKO Pawe STOlARCZYK liliana SWAKON Jan TOMASIK Piotr WENDA ElZbieta Department of Chemistry and Physics University of Agriculture in Krakow Faculty of Chemistry Jagiellonian University Institute of Nuclear Physics of the Polish Academy of Sciences

Cornstarch heated in the range of 230-280°C depolymerized into pyrodextrins characterized by two-component EPR signals of relatively stable free *** thermally generated radicals could serve as efficient scavengers for free radicals generated from pyrodextrins with the 200 Gy dose of γ-*** most efficient traps/scavengers were produced from cornstarch at 250-280°*** data indicated incorporation of the OH groups to the *** groups most probably originated from the OH· radicals formed by the radiolysis of *** spectra provided evidence for trapping free radicals generated by γ-irradiation and for their subsequent annihilation on contact with *** affected radical processes occurring in pyrodextrins caused by γ-irradiation.

关键词：自由基清除剂玉米淀粉生产 EPR谱信号特征相对稳定双组分拾荒者数据表

辊弯成形下塑性应变对挤压态6063T66铝合金型材疲劳性能的影响

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Transactions of Nonferrous Metals Society of China 2023年第11期33卷 3282-3294页

作者： Tomasz TOMASZEWSKI michał STOPEl Andrzej SKIBICKI Jan SEYDA Tomasz PIĄTKOWSKI Faculty of Mechanical Engineering Bydgoszcz University of Science and TechnologyBydgoszczPoland

分析从辊弯成形型材区和预应变材料取样的材料的拉伸塑性应变。利用概率Weibull累积分布(P-S-N曲线)近似高周疲劳的实验数据。利用lS-Dyna程序和实验数据对辊弯成形进行数值模拟,建立疲劳寿命预测模型。材料的循环行为表明,随着静态失... 详细信息

分析从辊弯成形型材区和预应变材料取样的材料的拉伸塑性应变。利用概率Weibull累积分布(P-S-N曲线)近似高周疲劳的实验数据。利用lS-Dyna程序和实验数据对辊弯成形进行数值模拟,建立疲劳寿命预测模型。材料的循环行为表明,随着静态失效水平的增加,疲劳寿命分布减小。断裂表面的断口形貌分析表明,由于晶界附近的位错积累,拉伸预应变的晶间裂纹水平增加。所提模型预测结果与概率散射带具有良好的相关性(误差低于10%)。

关键词： 6063铝合金预应变高周疲劳 P-S-N曲线 Weibull分布

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Dolomite fracture modeling using the Johnson-Holmquist concrete material model:Parameter determination and validation

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第2期13卷 335-350页

作者： michal Kucewicz Pawel Baranowski Jerzy Maachowski Faculty of Mechanical Engineering Institute of Mechanics and Computational EngineeringMilitary University of Technology2 Gen.S.Kaliskiego StreetWarsaw00-908Poland

In this paper,the Johnson-Holmquist concrete(JHC)constitutive model is adopted for modeling and simulating the fracture of dolomite.A detailed step-by-step procedure for determining all required parameters,based on a series of experiments under quasi-static and dynamic regimes,is *** rate coefficients,failure surfaces,equations of state and damage/failure constants are acquired based on the experimental data and finite element *** JHC model with the obtained parameters for dolomite is subsequently validated using quasi-static uniaxial and triaxial compression tests as well as dynamic split Hopkinson pressure bar(SHPB)*** influence of mesh size is also *** shows that the simulated fracture behavior and waveform data are in good agreement with the experimental data for all tests under both quasi-static and dynamic loading *** studies will implement the validated JHC model in small-and large-scale blasting simulations.

关键词： Johnson-Holmquist concrete(JHC)model Rock modeling Dolomite Constitutive modeling Split Hopkinson pressure bar(SHPB) Fracture Triaxial compression

Analysis of the Signal of Singing Using the Vibrato Parameter in the Context of Choir Singers

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Journal of Electronic Science and Technology 2013年第4期11卷 417-423页

作者： Edward Pórolniczak micha Kramarczyk the West Pomeranian University of Technology

Evaluation of quality of singing is an issue subjectively realized by the experts. This paper presents the results of the analysis of the vibrato parameter in the singing. The well-known fact is the existence of vibrato of sufficient quality in the voices of professional singers. The authors focus here on the choral voices to assess the quality of their singing from the point of view of the vibrato parameter. The method presented here is developed to evaluate the vibrato while singing under conditions close to the real ones. The study was carried out on the recordings of the members of an academic choir. As a result of tests it was found that not all singers present the same quality of vibrato in terms of deviation of vibrato confidence （STDCV）.

关键词： Quality of singing signal analysis,singing voice vibrato.

EO-1 Hyperion数据的预处理、特征提取和岩性填图研究(英文)

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中国图象图形学报 2007年第6期12卷 981-990页

作者：张显峰 PAZNER micha 北京大学遥感与GIS研究所北京100871 加拿大西安大略大学

EO-1 Hyperion传感器是第一个可以获取可见光与近红外以及短波红外波长范围光谱信息的星载高光谱传感器。本文以美国最早的金矿采矿区之一,加利福尼亚州东南巧克力山的Rainbow金矿区作为研究案例,探讨了Hyperion数据的预处理方法,专题... 详细信息

EO-1 Hyperion传感器是第一个可以获取可见光与近红外以及短波红外波长范围光谱信息的星载高光谱传感器。本文以美国最早的金矿采矿区之一,加利福尼亚州东南巧克力山的Rainbow金矿区作为研究案例,探讨了Hyperion数据的预处理方法,专题信息提取与填图,评估了Hyperion高光谱数据在识别与金矿有关的岩性类型的应用价值。结果表明,本文所提出的Hyperion数据预处理方法是有效的,MNF方法能有效用于Hyperion数据维数的降低和数据冗余的去除以及分类特征的提取。最大似然分类器能够有效地从Hyperion高光谱数据中提取与金矿相关的重要岩体信息,所得到的岩性单元与地质图上对应的岩性分布具有很好的一致性。岩体分类的总精度为86%。该研究表明,Hyperion高光谱数据能够很好识别有细微光谱差别的岩性,因而在地质学研究与找矿领域有着良好的应用前景。

关键词： EO-1 Hyperion 岩性填图垂直条带噪声特征提取

Influence of lead and Cadmium Concentration on the Accumulation Capacity of Panicum maximum

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Open Journal of Soil Science 2022年第10期12卷 490-502页

作者： Aman Messou Pétémanagnan Jean-Marie Ouattara Franck michaël Zahui lacina Coulibaly laboratory of Environment and Aquatic Biology Department of Sciences and Environment Management Nangui Abrogoua University Abidjan C&ocirc te d’Ivoire Department of Agronomic Forestry and Environmental Engineering University of Man Man C&ocirc te d’Ivoire

The restoration of soils polluted by trace metals (Pb and Cd) by phytoremediation is an innovative and ecologically sustainable solution. The objective of the study was to develop a process of phytoaccumulation of trace metals (Pb and Cd) in soils with the species Panicum maximum. For this purpose, 30 buckets containing soil were used. These included six (06) buckets per dose of soil contamination by Pb and Cd (3 mg/kg and 9 mg/kg of Cd and 100 mg/kg and 300 mg/kg of Pb) and six (6) buckets containing uncontaminated soil (control). During a period of 90 days of experimentation, the concentrations of trace metals in the plant biomass and in the soils were measured. Also, the bioaccumulation (BF) and translocation (TF) factors, the mass of Pb and Cd taken up by the plant were determined. The results showed that the biomass produced was negatively influenced by increasing Pb and Cd concentration. The concentrations of Pb and Cd accumulated by P. maximum varied in the aboveground biomass from 6.48 ± 0.55 to 18.09 ± 0.71 mg/kg (Pb100);from 10.93 ± 0.38 to 23.04 ± 0.79 mg/kg (Pb300);from 0.91 ± 0.02 to 1.50 ± 0.03 mg/kg (Cd3);and from 3.05 ± 0.08 to 5.43 ± 0.09 mg/kg (Cd9) from day 30 to day 90. However, in the root biomass, trace metals (Pb and Cd) ranged from 8.09 ± 0.58 to 22.57 ± 0.86 mg/kg (Pb100);from 29.45 ± 0.49 to 62.35 ± 0.82 mg/kg (Pb300);from 0.66 ± 0.01 to 1.11 ± 0.07 mg/kg (Cd3);and from 2.22 ± 0.08 to 3, 97 ± 0.09 mg/kg (Cd9), from day 30 to day 90. Pb was concentrated in the root biomass and Cd in the aboveground biomass. Bioaccumulation factor values ranged from 0.26 ± 0.02 to 0.99 ± 0.04 (Pb100);from 0.21 ± 0.04 to 0.50 ± 0.06 (Pb300);from 0.83 ± 0.09 to 1.72 ± 0.18 (Cd3);and from 0.70 ± 0.08 to 1.54 ± 0.18 (Cd9). High concentrations of Pb and Cd show a negative effect on the accumulation potential of P. maximum.

关键词： Phytoaccumulation Panicum maximum lead Cadmium