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Numerical modeling of blast-induced rock fragmentation in deep mining with 3D and 2D FEM method approaches

Journal of Rock Mechanics and Geotechnical Engineering 2024年第11期16卷 4532-4553页

作者： michał Kucewicz Mazurkiewicz Łukasz Paweł Baranowski Jerzy Małachowski Krzysztof Fuławka Piotr Mertuszka Marcin Szumny Military University of Technology Faculty of Mechanical EngineeringInstitute of Mechanics and Computational Engineering2 Gen.S.Kaliskiego Street00-908WarsawPoland KGHM CUPRUM ltd. Research and Development Center2-8 Sikorskiego Street53-659WrocławPoland

To optimize the excavation of rock using underground blasting techniques,a reliable and simplified approach for modeling rock fragmentation is *** paper presents a multistep experimentalnumerical methodology for simplifying the three-dimensional(3D)to two-dimensional(2D)quasiplane-strain problem and reducing computational costs by more than ***,in situ tests were conducted involving single-hole and free-face blasting of a dolomite rock mass in a 1050-m-deep *** results were validated by laser *** craters were then compared with four analytical models to calculate the radius of the crushing ***,a full 3D model for single-hole blasting was prepared and validated by simulating the crack length and the radius of the crushing *** on the stable crack propagation zones observed in the 3D model and experiments,a 2D model was *** properties of the high explosive(HE)were slightly reduced to match the shape and number of radial cracks and crushing zone radius between the 3D and 2D *** final methodology was used to reproduce various cut-hole blasting scenarios and observe the effects of residual cracks in the rock mass on further *** presence of preexisting cracks was found to be crucial for fragmentation,particularly when the borehole was situated near a free rock ***,an optimization study was performed to determine the possibility of losing rock continuity at different positions within the well in relation to the free rock face.

关键词： Dolomite rock Two-dimensional(2D)rock modeling Rock fragmentation Cut-hole blasting

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New perspectives on World Heritage management in the GCC legislation

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Built Heritage 2022年第1期6卷 30-41页

作者： michat Marcin Wosinski Principal Archaeology and Cultural Heritage Specialis JacobsCracowPoland

New legislative acts on heritage protection have been published in several Arab Countries in the last *** this is a positive trend in general,what remains to be seen is the factual impact of the new legislation on the pressing issues of heritage management,including the holistic and integrated approaches,monitoring,enforcement and *** paper compares the new legislative solutions from Gulf Arab Countries to the older ones and determines whether the new trends have potential of improving the heritage management *** findings of this paper are intended to increase the awareness of the still-marginal issue of heritage management in the heritage legislation of Arab region and promote the successful measures among the countries with outdated statutory heritage protection.

关键词： Heritage management Heritage law Antiquities law Arab States GCC

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Pressure and Temperature Conditions Recorded by the Beni-Bousera Ultramafic Body and the Overlying lower-crustal Rocks(Rif,Morocco)

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地学前缘 2009年第S1期16卷 203-204页

作者： El Atrassi Fatima Fabrice Brunet Vincent Bonneau Christian chopin Mohamed Bouybaouene Gilles Chazot laurent Jolivet laboratoire de Geologie ENS-CNRS UMR-8538Paris(France)Departement des Sciences de la Terre Faculte des Sciences BP 1014 laboratoire de Geologie Département des Sciences de la Terre Faculté des Sciences BP 1014 UMR-6538 Domaines OcéaniquesUniversité de Bretagne Occidentale laboratoire de Tectonique

The Beni Bousera massif(Rifean belt,northern Morocco)is predominantly composed of spinel lherzolite with subordinate garnet pyroxenite and garnet peridotite *** formed an antiformal dome which was overlain by graphite-sillimanite-garnet gneisses(kinzigites)equilibrated at around 1 GPa and 750℃.Within these kinzigites,kyanite-bearing basic granulites record somewhat higher PT conditions of around 1.6-2.0 GPa and 760-820℃.Garnet clinopyroxenite(either graphite-bearing or graphi-

关键词： garnet exsolution periodotite pyrox-enite UHP conditions Beni Bousera Rif

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The Problem of Overloaded Vehicles in Poland

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Journal of Civil Engineering and Architecture 2022年第12期16卷 611-618页

作者： michałKarkowski Road and Bridge Research Institute Poland

The international and national forecasts road transport development is optimistic,and they should promote implementations of innovations in road *** producers of heavy vehicles and their users aim to increase total vehicle weights and axle *** organizations:the Joint Transport Research Committee(JTRC)and the Forum of National Highway Research laboratories(FEHRl)study the influence of increased loads on road infrastructure and define the directions of innovative solutions for trucks and the road *** number of registered vehicles has been growing in *** reliable part of heavy vehicles is overloaded and they cause considerable damage to roads and influence traffic *** degradation of roads results from unacceptable axle loads and the total mass of heavy *** is necessary to introduce the weigh-in-motion system in Poland for pre-selective weighing of *** system will measure axle loads,number of axles,vehicle length and calculate its mass without *** the identification of vehicles,the intelligent system ISKIP may be used,developed by the Road and Bridge Research *** weigh-in-motion system is under implementation in Poland.

关键词： road transport infrastructure traffic safety

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From trees to fleas: masting indirectly affects flea abundance on a rodent host

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Integrative Zoology 2023年第3期18卷 440-452页

作者： Ivan BAlÁŽ michałBOGDZIEWICZ Sylwia DZIEMIAN-ZWOlAK Carlotta lO PRESTI Aleksandra WRÓBEl Milena ZDUNIAK RafałZWOlAK Faculty of Natural Sciences and Informatics Constantine the Philosopher University in NitraNitraSlovakia Department of Systematic Zoology Adam Mickiewicz University in Pozna´nPozna´nPoland INRAE LESSEMUniversity Grenoble AlpesSaint-Martind’HèresFrance University of Catania CataniaItaly Department of Zoology Pozna´n University of Life SciencesPozna´nPoland

Mast seeding causes strongﬂuctuations in populations of forest ***,this phenomenon can be used as a natural experiment to examine how variation in host abundance affects parasite *** investigatedﬂeas infesting yellow-necked mice in beech forest after 2 mast and 2 non-mast *** tested 2 mutually exclusive scenarios:(1)as predicted by classical models of density-dependent transmission,an increase in host density will cause an increase in ectoparasite abundance(deﬁned as the number of parasites per host),versus(2)an increase in host density will cause a decline inﬂea abundance(“dilution,”which is thought to occur when parasite population growth is slower than that of the host).In addition,we assessed whether masting alters the relationship between host traits(sex and body mass)andﬂea *** found a hump-shaped relationship between host andﬂea ***,the most basic predictions are too simple to describe ectoparasite dynamics in this *** addition,masting modiﬁed seasonal dynamics ofﬂea abundance,but did not affect the relationship between host traits andﬂea abundance(individuals with the highest body mass hosted the mostﬂeas;after controlling for body mass,parasite abundance did not vary between sexes).Our results demonstrate that pulses of tree reproduction can indirectly,through changes in host densities,drive patterns of ectoparasite infestation.

关键词： Apodemusﬂavicollis Fagus sylvatica indirect effects pulsed resources Siphonaptera

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Effects of combined cannabidiol(CBD)and hops(Humulus lupulus)terpene extract treatment on RAW 264.7 macrophage viability and inflammatory markers

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Natural Products and Bioprospecting 2023年第1期13卷 554-567页

作者： Inga Dammann Claudia Keil Iris Hardewig Elżbieta Skrzydlewska michałBiernacki Hajo Haase Sanity Group GmbH Jägerstraße 28-3110117 BerlinGermany Department of Food Chemistry and Toxicology Technische Universität BerlinStraße Des 17.Juni 13510623 BerlinGermany Department of Analytical Chemistry Medical University of BialystokA.Mickiewicza 2D15-222 BialystokPoland

This study investigates the potential of cannabidiol(CBD),one major cannabinoid of the plant Cannabis sativa,alone and in combination with a terpene-enriched extract from Humulus lupulus(“Hops 1”),on the lPS-response of RAW 264.7 macrophages as an established in vitro model of *** the present study,we could support earlier findings of the anti-inflammatory potential of CBD,which showed a dose-dependent[0-5μM]reduction in nitric oxide and tumor necrosis factor-alpha(TNF-α)released by lPS-stimulated RAW 264.7 ***,we observed an additive anti-inflammatory effect after combined CBD[5μM]and hops extract[40μg/ml]*** combination of CBD and Hops 1 showed effects in lPS-stimulated RAW 264.7 cells superior to the single sub-stance treatments and akin to the control ***,cellular CBD uptake increased dose-depend-ently in the presence of terpenes from Hops 1 *** anti-inflammatory effect of CBD and its cellular uptake positively correlated with terpene concentration,as indicated by comparison with a hemp extract containing both CBD and *** findings may contribute to the postulations for the so-called“entourage effect”between cannabinoids and terpenes and support the potential of CBD combined with phytomolecules from a non-cannabi-noid source,such as hops,for the treatment of inflammatory diseases.

关键词： CBD Terpenes Cannabinoids Entourage effect Inflammation

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An ultra-wideband circularly polarized microstrip patch antenna loaded with split-ring resonator

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Optoelectronics letters 2025年

作者： WANG Shike XIA Dan lü lianrong QIN Juan WANG Meng REN Haiping School of Integrated Circuit Science and Engineering， Tianjin University of Technology

In this paper， the effect of a single-opening split-ring resonator （SRR） structure on the performance of ultra-wideband （UWB） microstrip patch antenna （MPA） is studied. Here a UWB MPA based on partial grounding is proposed， and the SRR structure is utilized to optimize other characteristics of the low-profile microstrip antenna while ensuring the bandwidth and gain remain unchanged. The proposed metamaterial structure， consisting of a 2 × 2 array of SRR， is loaded on the reverse side of the substrate. The volume of the proposed antenna is 61.6×67.6×1.5mm3. According to simulation and experimental results， the proposed microstrip antenna loaded with 2×2 SRRs performs better than that without SRR structure. It produces an operating band of 1.62 GHz-8 GHz while achieving circular polarization characteristics with an axial ratio （AR） bandwidth of 3.92 GHz-4.57 GHz. In addition， the performance of the proposed antenna is superior to relevant works of literature The antenna can be widely utilized in wireless communication systems.

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Decade of optimizing therapy with direct-acting antiviral drugs and the changing profile of patients with chronic hepatitis C

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World Journal of Gastroenterology 2023年第6期29卷 949-966页

作者： michałBrzdęk Dorota Zarębska-michaluk Federica Invernizzi Marta Cilla Krystyna Dobrowolska Robert Flisiak Collegium Medicum Jan Kochanowski UniversityKielce 25-516Poland of Infectious Diseases Jan Kochanowski UniversityKielce 25-516Poland Center for liver Disease Division of Internal Medicine and HepatologyIRCCS Ospedale San RaffaeleMilan 20-132Italy Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-540Poland

Chronic infection with the hepatitis C virus(HCV)remains a major health problem affecting approximately 58 million people *** the era of interferon(IFN)-based regimens,patients particularly infected with genotypes 1 and 4 achieved a low response *** implementation of direct-acting antivirals changed the landscape of HCV *** increase in effectiveness provided us with the hope of eliminating HCV as a significant public threat by *** the following years,there was an observed improvement in the treatment of HCV with genotype-specific regimens and highly effective pangenotypic options that are the most recent stage of the *** optimization of therapy was accompanied by changes in the patient profile from the beginning of the IFN-free era over *** treated with antiviral therapies were younger in successive periods,less burdened with comorbidities and comedications,more frequently treatment-naïve and had less advanced liver *** the IFN-free era,specific subpopulations such as patients with HCV/HIV coinfection,those with a history of previous treatment,patients with renal impairment or with cirrhosis had lower chances for a virologic ***,these populations should no longer be considered difficult to *** the high effectiveness of HCV therapy,there is a small percentage of patients with treatment ***,they can be effectively retreated with pangenotypic rescue regimens.

关键词： Hepatitis C virus Interferon Direct-acting antiviral Epidemiology Chronic hepatitis C

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Saccharomyces cerevisiae prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HlA-B27 transgenic rats

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World Journal of Gastroenterology 2023年第5期29卷 851-866页

作者： Caroline Valibouze Silvia Speca Caroline Dubuquoy Florian Mourey lena M'Ba lucil Schneider Marie Titecat Benoît Foligné michaël Genin Christel Neut Philippe Zerbib Pierre Desreumaux Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France U1286-INFINITE-Institute for Translational Research in Inflammation Univ.LilleInsermCHU LilleLille 59000France Intestinal Biotech Development Lille 59045France Department of Research and Applications Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France UlR 2694-METRICS:Évaluation des Technologies de Santéet des Pratiques Médicales University of LilleLille University HospitalLille 59000France Department of Hepato-Gastroenterology Lille University HospitalLille 59037France

BACKGROUND Postoperative recurrence(POR)after ileocecal resection(ICR)affects most Crohn's disease patients within 3-5 years after ***-invasive Escherichia coli(AIEC)typified by the lF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease *** cerevisiae CNCM I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elimination from the *** To evaluate the efficacy of CNCM I-3856 in preventing POR induced by lF82 in an HlA-B27 transgenic(TgB27)rat *** Sixty-four rats[strain F344,38 TgB27,26 control non-Tg(nTg)]underwent an ICR at the 12th wk(W12)of life and were sacrificed at the 18th wk(W18)of ***27 rats were challenged daily with oral administration of lF82(109 colony forming units(CFUs)/day(d),n=8),PBS(n=5),CNCM I-3856(109 CFUs/d,n=7)or a combination of lF82 and CNCM I-3856(n=18).nTg rats receiving lF82(n=5),PBS(n=5),CNCM I-3856(n=7)or CNCM I-3856 and lF82(n=9)under the same conditions were used as *** was analyzed using macroscopic(from 0 to 4)and histologic(from 0 to 6)*** lF82 quantifications were performed weekly for each *** lF82 and inflammatory/regulatory cytokines were quantified in biopsies at W12 and *** are expressed as the median with the interquartile *** nTg animals did not develop POR.A total of 7/8(87%)of the TgB27 rats receiving lF82 alone had POR(macroscopic score≥2),which was significantly prevented by CNCM I-3856 administration[6/18(33%)TgB27 rats,P=0.01].Macroscopic lesions were located 2 cm above the anastomosis in the TgB27 rats receiving lF82 alone and consisted of ulcerations with a score of 3.5(2-4).Seven out of 18 TgB27 rats(39%)receiving CNCM I-3856 and lF82 had no macroscopic *** to untreated TgB27 animals receiving lF82 alone,coadministration of CNCM I-3856 and lF82 significantly red

关键词： Crohn's disease Recurrence Escherichia coli Probiotic Saccharomyces cerevisiae Colorectal surgery

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal Michele l Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

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