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BiCuSeO as state-of-the-art thermoelectric materials for energy conversion:from thin films to bulks

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Rare Metals 2018年第4期37卷 259-273页

作者： Rui Liu Xing Tan Yao-Chun Liu Guang-Kun Ren Jin-le Lan Zhi-Fang Zhou Ce-Wen Nan Yuan-Hua Lin State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology

BiCuSeO-based thermoelectric material has attracted great attention as state-of-the-art thermoelectric materials since it was first reported in 2010. In this review, we update the studies on the BiCuSeO thin films first. Then, we focus on the most recent progress of multiple approaches that enhance the thermoelectric performance including advanced synthesized technologies, notable mechanisms for higher power factor （optimizing carrier concentration, carrier mobility, Seebeck coefficient） and doping effects predicted by calculation. And finally, aiming at further enhancing the performance of these materials and ultimately commercial application, we give a brief discussion on the urgent issues to which should be paid close attention.

关键词： BiCuSeO State-of-the-art thermoelectricmaterials Thin films Bulks

支气管封堵试验在早产儿重度支气管肺发育不良伴严重肺叶气肿中的应用1例

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中国当代儿科杂志 2024年第6期26卷 659-664页

作者：刘辉娟关瑞莲秦欣王怀贞张高龙李建斌马力李乐鹿连伟孙轶张华岩广州医科大学附属妇女儿童医疗中心新生儿中心广东广州510623 广州医科大学附属妇女儿童医疗中心麻醉科广东广州510623 广州医科大学附属妇女儿童医疗中心心脏中心广东广州510623 广州医科大学附属妇女儿童医疗中心胸外科广东广州510623 广州医科大学附属妇女儿童医疗中心影像科广东广州510623 美国费城儿童医院-宾夕法尼亚大学佩雷尔曼医学院宾夕法尼亚州费城19104

重度支气管肺发育不良(bronchopulmonary dysplasia,BPD)的患儿可合并严重肺叶气肿造成通气障碍,临床管理非常困难,少数患儿需要切除过度气肿的肺叶才能改善通气。但是这些患儿在术前很难评估肺叶切除后剩余的肺叶是否能够提供足够的通... 详细信息

重度支气管肺发育不良(bronchopulmonary dysplasia,BPD)的患儿可合并严重肺叶气肿造成通气障碍,临床管理非常困难,少数患儿需要切除过度气肿的肺叶才能改善通气。但是这些患儿在术前很难评估肺叶切除后剩余的肺叶是否能够提供足够的通气,且术前准备及术中/术后管理也都具有很大的挑战性。该文报道1例重度BPD伴重度右上叶气肿的患儿通过多学科紧密协作,在纤维支气管镜引导下行支气管封堵试验,评估右上肺叶切除手术的安全性及有效性后,安全行右上肺叶切除术的治疗过程,以帮助同行了解支气管封堵术在重度BPD伴严重肺叶气肿患儿评估肺叶切除安全性及有效性中的应用。重度BPD患儿已经存在严重肺发育不良及肺损伤,肺叶切除应被视为非常规治疗手段,不应随意进行。支气管封堵试验对于重度BPD合并肺气肿患儿可以是术前评估肺叶切除风险和获益的有效手段,但技术难度大,需在经验丰富的多学科团队紧密协作下完成。

关键词：支气管封堵支气管肺发育不良肺气肿肺叶切除术婴儿

MEMS inductor fabrication and emerging applications in power electronics and neurotechnologies

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Microsystems & Nanoengineering 2021年第4期7卷 1-22页

作者： Hoa Thanh le Rubaiyet I.Haque Ziwei Ouyang Seung Woo lee Shelley I.Fried Ding Zhao Min Qiu Anpan Han The Rowland Institute at Harvard Harvard UniversityCambridgeMAUSA Department of Mechanical Engineering Technical University of DenmarkLyngbyDenmark Department of Electrical Engineering Technical University of DenmarkLyngbyDenmark Department of Neurosurgery Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Boston VA Healthcare System BostonMAUSA Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhouChina Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhouChina

MEMS inductors are used in a wide range of applications in micro-and nanotechnology,including RF MEMS,sensors,power electronics,and *** technologies set the boundary conditions for inductor design and their electrical and mechanical *** review provides a comprehensive overview of state-of-the-art MEMS technologies for inductor fabrication,presents recent advances in 3D additive fabrication technologies,and discusses the challenges and opportunities of MEMS inductors for two emerging applications,namely,integrated power electronics and *** the four top-down MEMS fabrication approaches,3D surface micromachining and through-substrate-via(TSV)fabrication technology have been intensively studied to fabricate 3D inductors such as solenoid and toroid in-substrate TSV *** 3D inductors are preferred for their high-quality factor,high power density,and low parasitic capacitance,in-substrate TSV inductors offer an additional unique advantage for 3D system integration and efficient thermal *** features make in-substrate TSV inductors promising to achieve the ultimate goal of monolithically integrated power *** another perspective,3D bottom-up additive techniques such as ice lithography have great potential for fabricating inductors with geometries and specifications that are very challenging to achieve with established MEMS ***,we discuss inspiring and emerging research opportunities for MEMS inductors.

关键词： inductor power lithography

贵州省核桃叶斑病病原菌鉴定、生物学特性及防治药剂筛选

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南方农业学报 2024年第7期55卷 2126-2136页

作者：敖显禧欧阳浩杨文佳樊瑞冬吕周乐吴朝明陈孝玉龙贵阳学院生物与环境工程学院/贵州省高等学校外来入侵生物监测与防控重点实验室贵州贵阳550005 贵州大学农学院/生命科学学院贵州贵阳550025

【目的】明确贵州省核桃叶斑病的病原菌分类地位及生物学特性,筛选有效的杀菌剂,为核桃叶斑病的田间防治提供理论参考。【方法】以采集自贵州省毕节市赫章县核桃种植基地的核桃叶斑病病叶为材料,采用组织分离法分离纯化病原菌,利用柯赫... 详细信息

【目的】明确贵州省核桃叶斑病的病原菌分类地位及生物学特性,筛选有效的杀菌剂,为核桃叶斑病的田间防治提供理论参考。【方法】以采集自贵州省毕节市赫章县核桃种植基地的核桃叶斑病病叶为材料,采用组织分离法分离纯化病原菌,利用柯赫氏法则对病原菌进行致病性测定,对病原菌的ITS、β-tubulin和TEF1-α基因序列进行扩增,结合形态学特征及多基因序列联合分析对病原菌进行分类鉴定,采用单因子变量法测定病原菌的生物学特性,采用室内毒力测定评估17种常用杀菌剂对病原菌的抑制效果。【结果】从贵州省赫章县核桃病叶样品中共分离得到18株菌株,选取代表性菌株C5进行形态学和致病性测定。致病性测定结果显示,菌株C5为核桃叶斑病的致病菌,该菌的形态特征与木贼镰刀菌(Fusarium equiseti)相似,且多基因联合聚类分析显示与*** yl-1聚为一支。菌株C5生长最适温度为20~25℃、最适光周期为18 h∶6 h(光照∶黑暗),可利用多种碳源和氮源,最佳碳源为蔗糖、最佳氮源为牛肉膏;湿度为70%时分生孢子的萌发率最高。17种供试杀菌剂中,45%咪鲜胺ME、30%唑醚·戊唑醇SC、0.15%四霉素AS、40%腈菌唑SC、10%苯醚甲环唑WG和1%申嗪霉素SC对菌株C5菌丝生长的抑制效果较好,其抑制中浓度(EC50)分别为0.0006、0.0016、0.0046、0.0062、0.0084和0.0097μg/mL。【结论】贵州省毕节市赫章县核桃种植区核桃叶斑病的病原菌为木贼镰刀菌,首选45%咪鲜胺ME或0.15%四霉素AS防治该病害,30%唑醚·戊唑醇SC、40%腈菌唑SC、10%苯醚甲环唑WG和1%申嗪霉素SC可作为备选防治药剂。

关键词：核桃叶斑病木贼镰刀菌生物学特性药剂筛选贵州省

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Activation of Defense Response Pathways by OGs and Fig22 Elicitors in Arabidopsis Seedlings

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Molecular Plant 2008年第3期1卷 423-445页

作者： Carine Denoux Roberta Galletti Nicole Mammarella Suresh Gopalan Danièle Werck Giulia De Lorenzo Simone Ferrari Frederick M. Ausubel Julia Dewdney Department of Genetics Harvard Medical School and Department of Molecular Biology Massachusetts General Hospital 185 Cambridge St Simches 7700Boston MA 02114 USA Institut de Biologie Moleculaire des Plantes CNRS Universite Louis Pasteur. Strasbourg France Dipartimento di Biologia Vegetale University di Roma 'La Sapienza' Piazzale Aldo Moro 5 00185 Rome. Italy

We carried out transcriptional profiling analysis in 10-d-old Arabidopsis thaliana seedlings treated with oligogalacturonides （OGs）, oligosaccharides derived from the plant cell wall, or the bacterial flagellin peptide Fig22, general elicitors of the basal defense response in plants. Although detected by different receptors, both OGs and Fig22 trigger a fast and transient response that is both similar and comprehensive, and characterized by activation of early stages of multiple defense signaling pathways, particularly JA-associated processes. However, the response to Fig22 is stronger in both the number of genes differentially expressed and the amplitude of change. The magnitude of induction of individual genes is in both cases dose-dependent, but, even at very high concentrations, OGs do not induce a response that is as comprehensive as that seen with Fig22. While high doses of either microbe-associated molecular pattern （MAMP） elicit a late response that includes activation of senescence processes, SA-dependent secretory pathway genes and PR1 expres- sion are substantially induced only by Fig22. These results suggest a lower threshold for activation of early responses than for sustained or SA-mediated late defenses. Expression patterns of amino-cyclopropane-carboxylate synthase genes also implicate ethylene biosynthesis in regulation of the late innate immune response.

关键词： Fig22 唇形科种子活化作用

From Farming to Engineering： The Microbiota and Allergic Diseases

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Engineering 2017年第1期3卷 98-109页

作者： Dominique Angèle Vuitton Jean-Charles Dalphin University Bourgogne Franche-Comte Besancon 25030 France Anergology Network of Franche-Comte Besancon 25030 France

The steady increase of lgE-dependent allergic diseases after the Second World War is a unique phenomenon in the history of humankind. Numerous cross-sectional studies, comprehensive longitudinal cohort studies of children living in various types of environment, and mechanistic experimental studies have pointed to the disappearance of ＂protective factors＂ related to major changes in lifestyle and environment. A common unifying concept is that of the immunoregulatory role of the gut microbiota. This review focuses on the protection against allergic disorders that is provided by the farming environment and by exposure to microbial diversity. It also questions whether and how microbial bioengineering will be able in the future to restore an interplay that was beneficial to the proper immunological development of children in the past and that was irreversibly disrupted by changes in lifestyle. The protective ＂farming environment＂ includes independent and additional influences： contact with animals, stay in barns/stables, and consumption of unprocessed milk and milk products, by mothers during pregnancy and by children in early life. More than the overall quanti- ty of microbes, the biodiversity of the farm microbial environment appears to be crucial for this protection, as does the biodiversity of the gut microbiota that it may provide. Use of conventional probiotics, especially various species or strains of Lactobacillus and Bifidobacterium, has not fulfilled the expectations of allergists and pediatricians to prevent allergy. Among the specific organisms present in cowsheds that could be used for prevention, Acinetobacter （A.） lwoffii F78, Lactococcus （ L.） lactis G121, and Staphylococcus （S.） sciuri W620 seem to be the most promising, based on experimental studies in mouse models of allergic respiratory diseases. However, the development of a new generation of probiotics based on very productive research on the farming environment faces several obstacles that cannot b

关键词： Allergy Farming Microbial biodiversity Immune regulation Microbiota Translational research

Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3

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Gastroenterology Report 2021年第1期9卷 59-70,I0002页

作者： Ke-Wang Luo Jun Xia Bao-Hui Cheng Han-Chao Gao Li-Wu Fu Xin-le Luo Key Laboratory People’s Hospital of LonghuaShenzhenGuangdongP.R.China Key Laboratory of Medical Programming Technology Shenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongP.R.China Shenzhen Key Laboratory of ENT Longgang ENT Hospital and Institute of ENTShenzhenGuangdongP.R.China Department of Nephrology Shenzhen Longhua District Central HospitalAffiliated Central Hospital of Shenzhen Longhua DistrictGuangdong Medical UniversityShenzhenGuangdongP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China

Background Green tea is a popular beverage worldwide and epigallocatechin-3-gallate(EGCG)is the most bioactive polyphenol in green *** study aims to investigate the anti-proliferation and anti-migration effects of EGCG against colorectal-cancer SW480,SW620,and LS411N cells,and elucidate the underlying *** The in vitro anti-proliferation and anti-migration effects of EGCG against colon-cancer cells were evaluated using MTT,scratch-wound-healing,and transwell-migration *** effects of EGCG on apoptosis were assessed by Annexin V-FITC/PI double staining and JC-1 ***,Western blotting was employed to detect the protein-expression level and elucidate the underlying ***-time qPCR and dual-luciferase reporter assay were adopted to determine the mRNA level and promoter *** Our results demonstrated that treatment with EGCG resulted in significant inhibition of cell proliferation by the induction of *** also inhibited SW480 cell migration in a dose-dependent manner as assessed by wound-healing and transwell-migration *** blot confirmed that EGCG induced apoptosis by the activation of Caspase-3 and *** addition,both STAT3 and phosphorylated STAT3(p-STAT3)were downregulated significantly by EGCG in three selected colorectal-cancer cell *** treatment also resulted in a significant decrease in Bcl-2,MCL-1,and Vimentin,and an increase in *** STAT3 was inhibited,EGCG showed no obvious effect on cell proliferation and *** investigation by luciferase-reporter-activity assay showed that EGCG suppressed the promoter activity of STAT3 and downregulated the transcription of *** Our study presents evidence on the anti-proliferation and anti-migration effects of EGCG against colorectalcancer SW480,SW620,and LS411N cells by downregulating the expression of STAT3 and suggests that EGCG could be an effective and natural supplement for colon-cancer treatment.

关键词： EGCG colon cancer STAT3 SW480 SW620 LS411N

不同标本类型在非小细胞肺癌基因检测中的应用及意义

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西部医学 2024年第4期36卷 512-517页

作者：朱启淦孟加榕魁国菊张小红黄江宾禹乐联勤保障部队第九〇九医院•厦门大学附属东南医院病理科福建漳州363000

目的研究分析不同标本类型在非小细胞肺癌(NSCLC)患者的驱动基因检出率,并分析表皮生长因子受体(EGFR)、间变性淋巴瘤激酶(ALK)、C-ros原癌基因1-受体酪氨酸激酶(ROS1)、Kristen鼠肉瘤病毒原癌基因同源体(KRAS)、鼠类肉瘤滤过性毒菌致... 详细信息

目的研究分析不同标本类型在非小细胞肺癌(NSCLC)患者的驱动基因检出率,并分析表皮生长因子受体(EGFR)、间变性淋巴瘤激酶(ALK)、C-ros原癌基因1-受体酪氨酸激酶(ROS1)、Kristen鼠肉瘤病毒原癌基因同源体(KRAS)、鼠类肉瘤滤过性毒菌致癌基因同源体B(BRAF)等驱动基因异常情况及与临床病理特征关系。方法收集2021年1月—2021年12月我院病理科明确诊断为NSCLC样本180例,包括手术切除标本25例,肺活检标本80例,恶性胸腔积液细胞蜡块标本29例,转移病灶标本46例,采用扩增阻滞突变系统(ARMS)法检测驱动基因突变状态。结果5种驱动基因的总突变率为53.33%(96/180),驱动基因突变可在不同标本类型中检出,不同标本间突变率比较差异无统计学意义(P>0.05)。EGFR基因突变率40.56%(73/180),性别及组织类型突变率比较差异有统计学意义(P0.05);KRAS基因突变率6.11%(11/180),其中性别类型突变率比较差异有统计学意义(P0.05);ALK融合基因突变率4.44/%(8/180),年龄、性别及组织类型突变率比较差异无统计学意义(P>0.05);BRAF基因突变率1.11%(2/180),ROS1融合基因突变率1.11%(2/180)。结论不同标本类型均可检出驱动基因,增加了临床基因检测的取样途径。NSCLC患者EGFR基因突变率明显高于其他驱动基因,EGFR基因突变与患者性别及组织类型有差异,KRAS基因突变与患者性别有差异;ALK、ROS1、BRAF基因突变率较低,但指导NSCLC治疗有重要意义。多基因联合检测可一次获取更多驱动基因突变信息,能够更快、更全面地指导临床治疗。

关键词：扩增阻滞突变系统非小细胞肺癌驱动基因基因突变

AIR-GAP-BASED RF COAXIAL TSV AND ITS CHARACTERISTIC ANALYSIS

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Journal of Electronics(China) 2013年第6期30卷 587-598页

作者： Yu le Sun Jiabin Zhang Chunhong Wang Zhaoxin Zhang Chao Yang Haigang Institute of Electronics Chinese Academy of Sciences University of Chinese Academy of Sciences

Many 3D IC applications such as MEMS and RF systems require Through-Silicon Via （TSV） with operations for high-speed vertical communication. In this paper, we introduce a novel air-gap coaxial TSV that is suiTab, for such RF applications. Firstly, the detailed fabrication process is described to explain how to acquire such a structure. Then, an Resistor Inductance Conductance Capacitance （RLGC） model is developed to profile the transverse electromagnetic field effect of the proposed air-gap TSV. The model is further verified by a 3D field solver program through the S-parameter comparison. With reference to the numerically simulated results, this analytical model delivers a maximum deviation of less than 6%0, on the conditions of varying diameters, outer to inner radius ratios, and SU-8 central angles, etc. Taking advantages of scalability of the model, a number of air-gap-based TSV designs are simulated, providing 1.6-4.0 times higher bandwidth than the con- ventional coaxial TSVs and leading to an efficient high frequency vertical RF interconnection solution for 3D ICs.

关键词： Through-Silicon Via (TSV) Three dimensional Integrated Circuits (3D IC) Air-gap Coaxial Radio Frequency-Interconnect (RF-I)