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Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events

Stroke & Vascular Neurology 2024年第2期9卷 108-125,I0001-I0005页

作者： miao Lin Liubing hu Si Shen Jiyue Liu Yanyan Liu Yixian Xu Honglin Chen Kazuo Sugimoto Jianshuang Li Ikuo Kamitsukasa Takaki Hiwasa Hao Wang Anding Xu Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouChina Department of Anesthesiology The First Affiliated HospitalJinan UniversityGuangzhouChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhouChina Department of Radiology Medical Imaging CenterThe First Affiliated HospitalJinan UniversityGuangzhouChina Department of Biochemistry and Genetics Graduate School of MedicineChiba UniversityChibaJapan Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Department of Neurology Chiba Rosai HospitalChibaJapan Department of Neurology Chibaken Saiseikai Narashino HospitalChibaJapan Department of Neurological Surgery Graduate School of MedicineChiba UniversityChibaJapan

Background Atherosclerosis(AS)and tumours are the leading causes of death worldwide and share common risk factors,detection methods and molecular ***,searching for serum markers shared by AS and tumours is beneficial to the early diagnosis of *** The sera of 23 patients with AS-related transient ischaemic attack were screened by serological identification of antigens through recombinant cDNA expression cloning(SEREX),and cDNA clones were *** function enrichment analysis was performed on cDNA clones to identify their biological pathways and determine whether they were related to AS or ***,gene–gene and protein–protein interactions were performed and AS-associated markers would be *** expression of AS biomarkers in human normal organs and pan-cancer tumour tissues were ***,immune infiltration level and tumour mutation burden of various immune cells were *** curves analysis could show the expression of AS markers in *** AS-related sera were screened by SEREX,and 83 cDNA clones with high homology were *** functional enrichment analysis,it was found that their functions were closely related to AS and tumour *** multiple biological information interaction screening and the external cohort validating,poly(A)binding protein cytoplasmic 1(PABPC1)was found to be a potential AS *** assess whether PABPC1 was related to pan-cancer,its expression in different tumour pathological stages and ages was *** AS-associated proteins were closely related to cancer immune infiltration,we investigated and found that PABPC1 had the same role in ***,analysis of Kaplan-Meier survival curves revealed that high PABPC1 expression in pan-cancer was associated with high risk of *** Through the findings of SEREX and bioinformatics pan-cancer analysis,we concluded that PABPC1 might serve as a potential biomarker for the

关键词： diagnosis cancer organs

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miR-98-5p靶向HIF1AN对LPS诱导的支气管上皮细胞凋亡及炎症因子的影响

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中国免疫学杂志 2023年第1期39卷 55-58,64页

作者：蒋刚健胡淼胡东坡漯河市中心医院检验科漯河462000 新乡医学院三全学院临床生物化学与仪器教研室新乡453003 商丘医学高等专科学校医学检验技术教研室商丘476100

目的:探讨miR-98-5p对LPS诱导的支气管上皮细胞凋亡、炎症因子的影响及对HIF1AN的调控作用。方法:体外培养人支气管上皮细胞16-HBE,LPS刺激细胞建立细胞损伤模型(LPS组),分别将miR-NC、miR-98-5p mimics、si-NC、si-HIF1AN、pcDNA-NC、p... 详细信息

目的:探讨miR-98-5p对LPS诱导的支气管上皮细胞凋亡、炎症因子的影响及对HIF1AN的调控作用。方法:体外培养人支气管上皮细胞16-HBE,LPS刺激细胞建立细胞损伤模型(LPS组),分别将miR-NC、miR-98-5p mimics、si-NC、si-HIF1AN、pcDNA-NC、pcDNA-HIF1AN、miR-98-5p mimics与pcDNA-NC、miR-98-5p mimics与pcDNA-HIF1AN转染至16-HBE细胞后进行LPS处理(miR-NC+LPS组、miR-98-5p+LPS组、si-NC+LPS组、si-HIF1AN+LPS组、pcDNA-NC+LPS组、pcDNAHIF1AN+LPS组、miR-98-5p+pcDNA-NC+LPS组、miR-98-5p+pcDNA-HIF1AN+LPS组);qRT-PCR与Western blot分别检测miR-98-5p、HIF1AN表达;流式细胞术检测细胞凋亡率;ELISA检测TNF-α、IL-6、IL-1α水平;双荧光素酶报告实验检测miR-98-5p、HIF1AN的靶向关系;Western blot检测Cleaved-caspase-3、HIF1AN、BNIP3蛋白表达。结果:转染miR-98-5p mimics或si-HIF1AN可明显降低LPS诱导的16-HBE细胞凋亡率、Cleaved-caspase-3蛋白表达及TNF-α、IL-6、IL-1α水平(P<0.05);双荧光素酶报告实验证实miR-98-5p可靶向结合HIF1AN;共转染miR-98-5p mimics与pcDNA-HIF1AN可明显提高细胞凋亡率、Cleaved-caspase-3、BNIP3蛋白表达及TNF-α、IL-6、IL-1α水平(P<0.05)。结论:miR-98-5p过表达可通过下调HIF1AN表达抑制LPS诱导的支气管上皮细胞凋亡及炎症因子释放进而减轻细胞损伤。

关键词： miR-98-5p HIF1AN 脂多糖支气管上皮细胞凋亡炎症

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Investigation of mechanical and electrical characteristics of selfsensing pneumatic torsional actuators

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Science China(Technological Sciences) 2024年第1期67卷 130-142页

作者： XIAO Wei hu DeAn hu GuoLiang XIAO Yihua Key Laboratory of Conveyance and Equipment Ministry of EducationEast China Jiaotong UniversityNanchang 330013China Key Laboratory of Advanced Design and Simulation Techniques for Special Equipment Ministry of EducationHunan UniversityChangsha 410082China

Soft pneumatic actuators are one of the most promising actuation for soft robots,and great achievements have been *** it remains challenging to endow sensing capabilities to pneumatic actuators,especially for the sensing ability originating directly from the actuator ***,a self-sensing pneumatic torsional actuator(SPTA)is designed based on the electromagnetic induction effect and magnetically responsive *** SPTA can generate feedback voltage and current with the deformation,in which the sensing function comes from its inherent *** investigate the mechanical and electrical characteristics,an experimental platform and a finite element model are established,*** find that the torsion angle and output torque increase in nonlinear with the actuating *** maximum torsion angle is 66.35°,which is 84.34%of that for the actuator fabricated by pure *** maximum output torque(24.9 N mm)improves by 23.19%compared with the actuator made by pure *** regards the electrical characteristics,the maximum feedback voltage and current are 2.90μV and 29.50 nA when the SPTA is actuated by a pressure of−40 *** also demonstrate that the relationship between the torsion angle and the magnetic flux change is approximately ***,the number of turns of wires,magnetic powders contents,and magnetic direction on the feedback voltage and current are *** show that the feedback voltage and current can be enhanced by increasing the number of turns and magnetic powders *** envision that the SPTA would be promising for soft robots to realize their accuracy control and intelligentization.

关键词： pneumatic torsional actuators self-sensing feedback voltage finite element modeling soft robots

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Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

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Green Energy & Environment 2024年第6期9卷 1016-1026页

作者： Xing Fu Yexin hu Ping hu hui Li Shuguang Xu Liangfang Zhu Changwei hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan610064China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan611137China

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in ***,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical *** bimolecular reaction pathways to build up soluble humins are *** is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' *** successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble *** show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

关键词： Carbohydrates 5-hydroxymethylfurfural Reaction network Soluble humins Tautomer

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BBO晶体四倍频全固态小功率紫外激光器

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强激光与粒子束 2009年第2期21卷 203-207页

作者：胡淼葛剑虹陈军刘崇杭州电子科技大学通信工程学院杭州310018 浙江大学现代光学仪器国家重点实验室杭州310027

利用KTP晶体和BBO晶体,进行了激光二极管泵浦的Nd:YVO4声光调Q激光脉冲四倍频实验。在不同绿光功率入射时,获得光束的束腰半径和紫外转换效率的依赖关系:当绿光功率为1.10 W,束腰半径为12.4μm时,得到了210 mW的准连续266 nm紫外脉冲输... 详细信息

利用KTP晶体和BBO晶体,进行了激光二极管泵浦的Nd:YVO4声光调Q激光脉冲四倍频实验。在不同绿光功率入射时,获得光束的束腰半径和紫外转换效率的依赖关系:当绿光功率为1.10 W,束腰半径为12.4μm时,得到了210 mW的准连续266 nm紫外脉冲输出,四倍频转换效率为19.1%。实验还对紫外远场光斑分别在o光振动面和e光振动面内进行分析,指出了BBO晶体在该两平面内不同的倍频接受角是造成椭圆形紫外光斑和主光斑附近明暗条纹的主要原因。

关键词： BBO晶体优化束腰半径相位匹配接受角

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巴黎郊区化进程中教育资源配置策略探析

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比较教育研究 2014年第7期36卷 46-50页

作者：胡淼刘双佳北京师范大学国际与比较教育研究院北京师范大学体育与运动学院北京100875

郊区化是人口、就业岗位和服务业从大城市中心城区向郊区迁移的分散化过程,是城市化进程中的一个阶段。作为典型的大都市,巴黎于20世纪后期开始了郊区化进程。巴黎市政府在推进城市格局改造的同时,积极调整基础教育资源配置,采取的举措... 详细信息

郊区化是人口、就业岗位和服务业从大城市中心城区向郊区迁移的分散化过程,是城市化进程中的一个阶段。作为典型的大都市,巴黎于20世纪后期开始了郊区化进程。巴黎市政府在推进城市格局改造的同时,积极调整基础教育资源配置,采取的举措包括:重新规划学校布局,保障学校布局与人口分布相适应;建立"教育优先区",对教育薄弱的郊区及新城给予政策倾斜;促进区域间教师流动,保证师资均衡配置。期冀巴黎的经验为我国正在郊区化进程中的大城市推进教育均衡提供有益的借鉴。

关键词：郊区化基础教育教育资源配置法国教育

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超高密度光存储研究进展

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中国激光 2024年第11期51卷 410-424页

作者：阮昊胡巧赵苗中国科学院上海光学精密机械研究所光芯片集成研发中心上海201800 中国科学院大学北京100049

当前,全球数据量正处在爆发式增长阶段,为光存储领域带来了巨大的发展机遇。受光学衍射极限的制约,传统光存储技术的密度难以满足海量数据的存储需求。为了提升光存储密度,人们开发了三维空间、偏振、波长等多维信息复用技术,同时,随着... 详细信息

当前,全球数据量正处在爆发式增长阶段,为光存储领域带来了巨大的发展机遇。受光学衍射极限的制约,传统光存储技术的密度难以满足海量数据的存储需求。为了提升光存储密度,人们开发了三维空间、偏振、波长等多维信息复用技术,同时,随着纳米技术的发展,现已突破衍射极限实现超分辨纳米信息存储。本文介绍了超高密度光存储领域的发展现状,总结了多维信息复用技术和超分辨光存储技术的代表性研究成果,梳理了不同技术方案可提升存储密度的理论极限。此外,本文还介绍了本课题组基于双光束超分辨光存储技术实现单盘拍比特(Pb)存储量级的最新研究进展,并展望了超高密度光存储面向大数据应用的挑战和发展趋势。

关键词：光数据存储超高密度多维信息复用超分辨光存储技术

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褪黑素处理对采后猕猴桃果实后熟衰老的影响

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食品科学 2018年第19期39卷 226-232页

作者：胡苗李佳颖饶景萍西北农林科技大学园艺学院陕西杨凌712100

采后‘华优’猕猴桃(Actinidia Chinensis ‘huayou’)果实经0(对照)、0.05、0.10、0.20、0.50 mmol/L褪黑素分别浸泡10 min后,置于(0.0±0.5)℃、相对湿度90%~95%的低温条件下贮藏90 d。结果表明:0.10 mmol/L褪黑素处理较其他浓度处理... 详细信息

采后‘华优’猕猴桃(Actinidia Chinensis ‘huayou’)果实经0(对照)、0.05、0.10、0.20、0.50 mmol/L褪黑素分别浸泡10 min后,置于(0.0±0.5)℃、相对湿度90%~95%的低温条件下贮藏90 d。结果表明:0.10 mmol/L褪黑素处理较其他浓度处理更明显地延缓了猕猴桃果实硬度和色泽L*值的下降,有效地降低了呼吸速率和乙烯释放速率,且在贮藏结束后保持了较低的质量损失率和腐烂率。与对照相比,0.10 mmol/L褪黑素处理降低了淀粉酶活力,延缓了淀粉质量分数的下降,维持了较高的超氧化物歧化酶、抗坏血酸过氧化物酶和谷胱甘肽还原酶活力,提高了过氧化氢酶活力峰值,显著提高了抗坏血酸和谷胱甘肽的含量。这表明0.10 mmol/L褪黑素处理能在低温贮藏条件下延缓猕猴桃果实的后熟衰老进程。

关键词：褪黑素后熟衰老低温贮藏猕猴桃

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NON-ENVIRONMENTAL PULLUTION CONTROL OF PEANUT SCAB SPHACELOMA ARAHIDICOLA BIT. ET JENK

NON-ENVIRONMENTAL PULLUTION CONTROL OF PEANUT SCAB SPHACELOM...

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The ⅩⅤth International Plant Protection Congress

作者： hu miao and Zhu You-gen Plant Protection Station Ganyu County 222100 Jiangsu Province China

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Effect of CO_(2) Opposing Multiple Jets on Thermoacoustic Instability and NO_(x) Emissions in a Lean-Premixed Model Combustor

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Journal of Thermal Science 2024年第1期33卷 207-221页

作者： ZHOU Hao hu Liubin Institute for Thermal Power Engineering State Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China

This paper experimentally studied the effect of CO_(2) opposing multiple jets on the thermoacoustic instability and NO_(x) emissions in a lean-premixed model *** feasibility was verified from three variables:the CO_(2) jet flow rate,hole numbers,and hole diameters of the *** indicate that the control effect of thermoacoustic instability and NO_x emissions show a reverse trend with the increase of open area ratio on the whole,and the optimal jet flow rate range is 1-4 L/min with CO_(2) opposing multiple *** this flow rate range,the amplitude and frequency of the dynamic pressure and heat release signals CH~* basically decrease as the CO_(2) flow rate increases,which avoids high-frequency and high-amplitude thermoacoustic *** amplitude-damped ratio of dynamic pressure and CH*can reach as high as 98.75% and 93.64% with an optimal open area ratio of 3.72%.NO_(x) emissions also decrease as the jet flow rate increases,and the maximum suppression ratio can reach 68.14%.Besides,the flame shape changes from a steep inverted "V" to a more flat "M",and the flame length will become shorter with CO_(2) opposing multiple *** research achieved the synchronous control of thermoacoustic instability and NO_(x) emissions,which could be a design reference for constructing a safer and cleaner combustor.

关键词： thermoacoustic instability lean-premixed model combustor CO_(2)opposing multiple jets open area ratio NO_(x)emissions

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