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Genesis of the Nuri Cu-W-Mo Deposit,Tibet,China:Constraints from in situ Trace Elements and Sr Isotopic Analysis of Scheelite

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 117-131页

作者： WANG Yiyun WU Zhishan CHEN Wenqing DU Qing’an TANG Liwei SHI Hongzhao MA Guotao ZHANG Zhi LIANG Wei WU Bo miao hengyi Chengdu Center China Geological Survey(Geoscience Innovation Center of Southwest China)Chengdu 610081China The Second Geological Institute of China’s Metallurgical Geology Bureau Fuzhou 351111China

The Nuri deposit is the only Cu-W-Mo polymetallic deposit with large-scale WO3 resources in the eastern section of the Gangdese metallogenic belt,Tibet,***,the genetic type of this deposit has been controversial since its *** on a study of the geological characteristics of the deposit,this study presents mineralization stages,focusing on the oxide stage and the quartz-sulfide stage where scheelite is mainly formed,referred to as Sch-A and Sch-B,*** LA-ICP-MS trace element and Sr isotope analyses,the origin,evolutionary process of the oreforming fluid and genesis of the ore deposit are *** Electron Microscope-Cathodoluminescence(SEMCL)observations reveal that Sch-A consists of three generations,with dark gray homogenous Sch-A1 being replaced by relatively lighter and homogeneous Sch-A2 and Sch-A3,with Sch-A2 displaying a gray CL image color with vague and uneven growth bands and Sch-A3 has a light gray CL image color with hardly any growth *** contrast,Sch-B exhibits a‘core-rim’structure,with the core part(Sch-B1)being dark gray and displaying a uniform growth band,while the rim part(Sch-B2)is light gray and *** normalized distribution pattern of rare earth elements in scheelite and Sr isotope data suggest that the early ore-forming fluid in the Nuri deposit originated from granodiorite porphyry and,later on,some country rock material was mixed in,due to strong water-rock *** the O-H isotope data further indicates that the ore-forming fluid in the Nuri deposit originated from magmatic-hydrothermal sources,with contributions from metamorphic water caused by water-rock interaction during the mineralization process,as well as later meteoric *** intense water-rock interaction likely played a crucial role in the precipitation of scheelite,leading to varying Eu anomalies in different generations of scheelite from the oxide stage to the quartz-sulfide stage,while also causing a

关键词： trace elements in situ Sr isotopes tungsten mineralization Gangdese metallogenic belt Tibet

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong miao Michael S.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu miao Yu Yuhang Song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan miao Li Zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

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西藏努日铜多金属矿南矿段地质特征及短波红外光谱的勘查应用

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地质与勘探 2024年第5期60卷 932-943页

作者：汤立伟王艺云陈文庆陈斌吴志山缪恒毅吴波陈龙照中国冶金地质总局第二地质勘查院福建福州350108 中国地质调查局成都地质调查中心四川成都610081 中国冶金地质总局二局福建福州350100

西藏努日斑岩-矽卡岩型矿床作为冈底斯成矿带上发现的唯一具有Cu-W-Mo矿化组合的大型矿床,带上找矿潜力较大,成果丰硕。随着区带成矿理论和矿区研究程度的深入,亟需使用新的方法和技术手段来满足区内深部找矿的需要。本次研究利用短波... 详细信息

西藏努日斑岩-矽卡岩型矿床作为冈底斯成矿带上发现的唯一具有Cu-W-Mo矿化组合的大型矿床,带上找矿潜力较大,成果丰硕。随着区带成矿理论和矿区研究程度的深入,亟需使用新的方法和技术手段来满足区内深部找矿的需要。本次研究利用短波红外光谱技术SWIR(Short wave infrared),对努日铜多金属矿床南矿段中典型蚀变矿物进行研究,根据其矿床地质特征、蚀变矿物组合、分带特征以及光谱分析结果,总结了矿区典型蚀变矿物短波红外光谱特征值分布规律,进而确定其勘查标志。研究认为白云母的吸收峰位值Pos2200>2208 nm、伊利石的吸收峰位值Pos2200>2203 nm、绿泥石的吸收峰位值Pos2250>2249 nm的大量或连续出现,可以作为努日矿区矽卡岩型铜多金属矿床有效的蚀变矿物勘查指标;在此基础上,综合努日南矿段地质特征分析、蚀变矿物分布规律分析,对矿区深部斑岩型铜矿进行成矿预测,认为南矿段45线东侧深部的石英闪长(玢)岩具有斑岩型铜矿找矿的潜力,为矿区下一步的找矿提供了方向与思路。

关键词：短波红外光谱蚀变矿物铜多金属努日南矿段冈底斯成矿带

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Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng Li Meifeng Cai Shengjun miao Yuan Li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang Feng miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： miao Zhou Xiongbin Luo Hang Li Shan Guo Zhuang Tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

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西藏努日Cu-W-Mo矿床白钨矿原位微量元素、Sr同位素特征及其指示意义

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沉积与特提斯地质 2024年第4期44卷 723-739页

作者：吴志山汤立伟巴桑元旦陈文庆陈斌杜庆安侯海峰缪恒毅中国冶金地质总局第二地质勘查院福建福州350108 西藏自治区土地矿权交易和资源储量评审中心西藏拉萨850000 中国冶金地质总局二局福建福州350108

西藏努日Cu-W-Mo矿床是目前冈底斯成矿带上发现的唯一具有Cu-W-Mo矿化组合的大型矿床。然而,自该矿床上世纪发现以来,关于其成因类型,一直存在较大的争议。本次研究根据矿床地质特征对矿床成矿阶段进行了精确的划分,并以氧化物阶段和石... 详细信息

西藏努日Cu-W-Mo矿床是目前冈底斯成矿带上发现的唯一具有Cu-W-Mo矿化组合的大型矿床。然而,自该矿床上世纪发现以来,关于其成因类型,一直存在较大的争议。本次研究根据矿床地质特征对矿床成矿阶段进行了精确的划分,并以氧化物阶段和石英-硫化物阶段的白钨矿(Sch-A和Sch-B)为研究对象,通过LA-ICP-MS微量元素和Sr同位素测试分析,对矿床成矿流体来源、演化过程及成因进行深入探讨。扫描电镜-阴极发光(SEM-CL)图像显示,白钨矿Sch-A具有两个世代,暗色均质Sch-A1被浅色均质Sch-A2不规则交代;而白钨矿Sch-B具有“核-边”结构,核部Sch-B1呈深灰色、具有均匀生长环带,边部为浅灰色、均质的Sch-B2。白钨矿Sch-A的稀土元素球粒陨石标准化分布特征和Sr同位素数据指示,成矿流体早期来源于花岗闪长斑岩,后期因强烈的水-岩反应而有围岩物质混入,而成矿流体与围岩发生的强烈水-岩反应也是白钨矿大量沉淀的重要机制。其高Mo和低Sr含量的特征,也符合岩浆-热液型矿床中白钨矿的特点。因此,综合努日矿床地质特征,白钨矿微量元素、Sr同位素地球化学特征及其对成矿流体来源、演化过程及矿床成因的指示,认为努日矿床属于斑岩-夕卡岩型矿床。

关键词：原位微量元素原位Sr同位素斑岩-夕卡岩型矿床努日冈底斯成矿带

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基于3D艺术仿真建模的旋耕机产品设计

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农机化研究 2025年第3期47卷 192-196页

作者：王淼河南工业职业技术学院河南南阳473000

通过基于三维艺术的旋耕机产品设计,探究如何优化农业机械的设计和生产。首先,分析了三维艺术特点,以及将其应用在旋耕机产品设计的优势;接着,介绍了旋耕机核心零部件结构的设计,并基于三维艺术完成了旋耕机的3D外观模型设计。基于Solid... 详细信息

通过基于三维艺术的旋耕机产品设计,探究如何优化农业机械的设计和生产。首先,分析了三维艺术特点,以及将其应用在旋耕机产品设计的优势;接着,介绍了旋耕机核心零部件结构的设计,并基于三维艺术完成了旋耕机的3D外观模型设计。基于SolidWorks的旋耕机动力学仿真结果表明:传动齿轮接触力和刀辊反作用力满足设计需求,整个机器稳定性良好。

关键词：旋耕机三维艺术 SolidWorks 动力学

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