检索结果-南通市图书馆

Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 513-528页

作者： miao chu Guangdong CHEN Kai CHEN Pengfei ZHU Zhen WANG Zhonglai QIAN Huaqiang TAO Yaozeng XU Dechun GENG Department of Orthopedics the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Orthopedics Yixing People’s HospitalYixing 214200China Department of Orthopedics Hai’an People’s HospitalHai’an 226600China Department of Orthopedics Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedicineSuzhou 215028China

Osteoarthritis(OA)is a chronic progressive osteoarthropathy in the *** activation plays a crucial role in the occurrence of subchondral bone loss in early ***,the specific mechanism of osteoclast differentiation in OA remains *** our study,gene expression profiles related to OA disease progression and osteoclast activation were screened from the Gene Expression Omnibus(GEO)***2R and Funrich analysis tools were employed to find differentially expressed genes(DEGs).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses demonstrated that chemical carcinogenesis,reactive oxygen species(ROS),and response to oxidative stress were mainly involved in osteoclast differentiation in OA subchondral ***,fourteen DEGs that are associated with oxidative stress were *** first ranked differential gene,heme oxygenase 1(HMOX1),was selected for further *** results showed that osteoclast activation in the pathogenesis of OA subchondral bone is accompanied by the downregulation of *** was revealed to inhibit osteoclastogenesis by targeting HMOX1 and upregulating the expression of antioxidant protein in ***,carnosol was found to alleviate the severity of OA by inhibiting the activation of subchondral osteoclasts in *** research indicated that the activation of osteoclasts due to subchondral bone redox dysplasia may serve as a significant pathway for the advancement of *** HMOX1 in subchondral osteoclasts may offer novel insights for the treatment of early OA.

关键词： Osteoclast Oxidative stress Osteoarthritis(OA) Heme oxygenase 1(HMOX1) Carnosol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

儿童家具仿生设计研究

引用

玩具世界 2024年第3期 155-157页

作者：王亚凡初苗西安工业大学

文章旨在探讨如何通过仿生设计理念改进儿童家具的外观、功能等，以提升其吸引力、舒适性和安全性。仿生设计要求对自然界中生物的形态、结构和功能进行观察和分析，结合儿童的审美需求和行为特点进行设计。文章分析了仿生设计的概念、... 详细信息

文章旨在探讨如何通过仿生设计理念改进儿童家具的外观、功能等，以提升其吸引力、舒适性和安全性。仿生设计要求对自然界中生物的形态、结构和功能进行观察和分析，结合儿童的审美需求和行为特点进行设计。文章分析了仿生设计的概念、特点，并提出一系列儿童家具仿生设计策略，具体从色彩仿生、材料仿生、形状仿生和功能仿生等方面展开。旨在为儿童家具设计提供新的思路和方法，促进儿童成长环境的改善。

关键词：儿童家具仿生设计设计策略

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于ITO的Co-ZnO电极的制备及对邻苯二酚的检测评价

引用

现代化工 2024年第3期44卷 206-211,217页

作者：马寅杨意吴青华缪楚宇武莹李宇春长沙理工大学化学化工学院湖南长沙410000

采用分布电沉积法在ITO导电玻璃表面制备Co-ZnO电极传感器,并将其用于邻苯二酚的分析检测。利用SEM、EDS和XRD对制备的Co-ZnO电极进行表面形貌、元素组成和晶体结构分析,并利用循环伏安法和计时电流法对其进行电化学分析。结果表明,Co-... 详细信息

采用分布电沉积法在ITO导电玻璃表面制备Co-ZnO电极传感器,并将其用于邻苯二酚的分析检测。利用SEM、EDS和XRD对制备的Co-ZnO电极进行表面形貌、元素组成和晶体结构分析,并利用循环伏安法和计时电流法对其进行电化学分析。结果表明,Co-ZnO电极对邻苯二酚具有非常明显的电催化活性,通过测试分析得到其线性范围为0.01~10 mmol/L、灵敏度为1429.67 mA/(mM·cm^(2))、检出限为0.87μmol/L。通过干扰试验可知,Co-ZnO电极对其有良好的选择性,且电极的重现性良好。

关键词：邻苯二酚 ITO导电玻璃 Co-ZnO电极电沉积

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relationship between Sleep Quality and Cognitive Function in Patients with Mild-to-Moderate Parkinson＇s Disease

引用

Chinese Medical Journal 2018年第8期131卷 994-996页

作者： Hui-miao Liu miao chu Na Li Sai Zhang Yong-Zhi Zhang Ping Gu Department of Neurology The First Hospital of Hebei Medical University Shijiazhuang Hebei 050031 China Department of Ophthalmology The First Hospital of Hebei Medical University Shijiazhuang Hebei 050031 China

To the Editor： Parkinson＇s disease （PD） is a common degenerative disease of the central nervous systern （CNS） in middle-aged and elderly people. PD is characterized by resting tremor, myotonia, bradykinesia, abnormal posture, and gait. The incident of PD increases with age. In addition to motor symptoms, nonmotor symptoms have raised additional concerns in recent years. Cognitive impairment is very common in PD patients. It is estimated that the incidence of PD mild cognitive impairment （PD-MCI） is 20 50%, which is present at the initial visit in some patients and a great number of patients with PD-MCI eventually develop PD with dementia （PDD）.

关键词： BEHAVIOR DISORDER IMPAIRMENT

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A review of CFD simulation in pressure driven membrane with fouling model and anti-fouling strategy

引用

Frontiers of Environmental Science & Engineering 2024年第8期18卷 1-29页

作者： Shiyong miao Jiaying Ma Xuefei Zhou Yalei Zhang Huaqiang chu State Key Laboratory of Pollution Control and Resource Reuse Tongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Tongji UniversityShanghai 200092China

Pressure-driven membrane filtration systems are widely utilized in wastewater treatment,desalination,and water reclamation and have received extensive attention from *** fluid dynamics(CFD)offers a convenient approach for conducting mechanistic studies of flow and mass transfer characteristics in pressure-driven *** a signature phenomenon in membrane systems,the concentration polarization that accompanies the permeation process is a key factor in membrane performance degradation and membrane fouling *** fouling models(scaling,biofouling and colloidal particle fouling)based on CFD theory have been constructed,and considerable research has been *** representative antifouling strategies with special simulation methods,including patterned membranes,vibration membranes,rotation membranes,and pulsatile flows,have also been *** studies should focus on refining fouling models while considering local hydrodynamic characteristics;experimental observation tools focusing on the internal structure of inhomogeneous fouling layers;techno-economic model of antifouling strategies such as vibrational,rotational and pulsatile flows;and unfavorable hydraulic phenomena induced by rapidly changing flows in simulations.

关键词： Computational fluid dynamics Membrane Fouling model Concentration polarization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health risk assessment of trace metal(loid)s in agricultural soils based on Monte Carlo simulation coupled with positive matrix factorization model in Chongqing, southwest China

引用

Journal of Mountain Science 2024年第1期21卷 100-112页

作者： MA Jie chu Lijuan SUN Jing WANG Shenglan GE miao DENG Li Chongqing Ecological and Environmental Monitoring Center Chongqing 401147China Key Laboratory of Organic Pollutants in Environmental Chemical Behavior and Ecological Toxicology of Chongqing Chongqing 401147China Department of Pediatrics Chongqing Health Center for Women and ChildrenChongqing 401147China Department of Pediatrics Women and Children’s Hospital of Chongqing Medical UniversityChongqing 401147China

This study aimed to investigate the pollution characteristics, source apportionment, and health risks associated with trace metal(loid)s(TMs) in the major agricultural producing areas in Chongqing, China. We analyzed the source apportionment and assessed the health risk of TMs in agricultural soils by using positive matrix factorization(PMF) model and health risk assessment(HRA) model based on Monte Carlo simulation. Meanwhile, we combined PMF and HRA models to explore the health risks of TMs in agricultural soils by different pollution sources to determine the priority control factors. Results showed that the average contents of cadmium(Cd), arsenic (As), lead(Pb), chromium(Cr), copper(Cu), nickel(Ni), and zinc(Zn) in the soil were found to be 0.26, 5.93, 27.14, 61.32, 23.81, 32.45, and 78.65 mg/kg, respectively. Spatial analysis and source apportionment analysis revealed that urban and industrial sources, agricultural sources, and natural sources accounted for 33.0%, 27.7%, and 39.3% of TM accumulation in the soil, respectively. In the HRA model based on Monte Carlo simulation, noncarcinogenic risks were deemed negligible(hazard index <1), the carcinogenic risks were at acceptable level(10^(-6)

关键词： Monte Carlo simulation Health risk assessment Trace metal(loid)s Positive matrix factorization Agricultural soils

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synergy of sodium doping and nitrogen defects in carbon nitride for promoted photocatalytic synthesis of hydrogen peroxide

引用

Chinese Chemical Letters 2024年第8期35卷 324-329页

作者： Fabrice Nelly Habarugira Ducheng Yao Wei miao Chengcheng chu Zhong Chen Shun Mao College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource ReuseTongji UniversityShanghai 200092China Baowu Water Technology Co. Ltd.Research InstituteShanghai 201999China

Photocatalytic synthesis of hydrogen peroxide has gradually become a promising method for in-situ pro-duction of hydrogen peroxide,which relies on sustainable solar ***,the commonly used photocatalyst,i.e.,carbon nitride(CN),still suffers from the drawbacks of narrow light absorption range and fast charge ***,we report a facile method to introduce nitrogen defects into carbon nitride together with sodium *** adjusting the ratio of sodium dicyandiamide,the band gap of carbon nitride can be controlled,while the carrier separation and transfer ability of carbon nitride is *** modified CN with sodium doping and nitrogen defect(SD-CN)demonstrates outstanding H_(2)O_(2)pro-duction performance(H_(2)O_(2)yield rate of 297.2μmol L^(−1)h^(−1))under visible light irradiation,which is approximately 9.8 times higher than that of pristine *** work deepens the understanding of the coordinated effect of structural defect and element doping of carbon nitride on the photocatalytic H_(2)O_(2)production performance,and provides new insight into the design of photocatalytic system for efficient production of H_(2)O_(2).

关键词： Photocatalysis H_(2)O_(2)evolution Sodium doping Nitrogen defect Metal-free catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tau truncation in the pathogenesis of Alzheimer's disease:a narrative review

引用

Neural Regeneration Research 2024年第6期19卷 1221-1232页

作者： Dandan chu Xingyue Yang Jing Wang Yan Zhou Jin-Hua Gu Jin miao Feng Wu Fei Liu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsCoinnovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Department of Biochemistry and Molecular Biology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Clinical Pharmacy Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong UniversityNantongJiangsu ProvinceChina Laboratory of Animal Center Nantong UniversityNantongJiangsu ProvinceChina Department of Neurochemistry Inge Grundke-Iqbal Research FloorNew York State Institute for Basic Research in Developmental DisabilitiesStaten IslandNYUSA

Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau *** studies suggest that dysregulation of the microtubuleassociated protein Tau,especially specific proteolysis,could be a driving force for Alzheimer's disease *** physiologically promotes the assembly and stabilization of microtubules,whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers,resulting in them gaining prion-like *** addition,Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent *** review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments,investigates the role of specific truncations in physiological and pathological states of Alzheimer's disease,and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer's disease.

关键词： Alzheimer's disease cleavage site diagnosis marker neurofibrillary tangles phosphorylation Tau Tau aggregation therapy truncation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Si-miao-Yong-An Decoction alleviates thromboangiitis obliterans by regulating miR-548j-5p/IL-17A signaling pathway

引用

Chinese Journal of Natural Medicines 2024年第6期22卷 541-553页

作者： chu chu SUN Shangwen ZHANG Zhen WU Qi LI Haoyang LIANG Gang miao Xiuming JIANG Haiqiang GAO Yan ZHANG Yunhong WANG Bin LI Xia Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China National Key Laboratory for Innovation and Transformation of Luobing Theory The Key Laboratory of Cardiovascular Remod-eling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan 250012China School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJinan 271016China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014China International Business School Tianjin Foreign Studies UniversityTianjin 300204China Institute of Pharmaceutical Research Shandong University of Traditional Chinese MedicineJinan 250355China

Thromboangiitis obliterans(TAO)is a rare,chronic,progressive,and segmental inflammatory disease characterized by a high rate of amputation,significantly compromising the quality of life of ***-miao-Yong-An decoction(SMYA),a tradition-al prescription,exhibits anti-inflammatory,anti-thrombotic,and various other pharmacological ***,it was fully proved to be effective for TAO therapy,but the specific therapeutic effect of SMYA on TAO has been ***,deep unveiling the mechanism of SMYA in TAO for identifying clinical therapeutic targets is extremely *** this study,we observed elev-ated levels of IL-17A in the peripheral blood mononuclear cells(PBMCs)of TAO patients,whereas the expression of miR-548j-5p was significantly decreased.A negative correlation between the levels of miR-548j-5p and IL-17A was also *** vitro ex-periments showed that overexpression of miR-548j-5p led to a decrease in IL-17A levels,whereas downregulation of miR-548j-5p showed the opposite *** a dual luciferase assay,we confirmed that miR-548j-5p directly targets ***,serum containing SMYA effectively decreased IL-17A levels by increasing the expression of *** importantly,the results of in vivo tests indicated that SMYA mitigated the development of TAO by inhibiting IL-17A through the upregulation of miR-548j-5p in vascular *** conclusion,SMYA significantly enhances the expression of miR-548j-5p,thereby reducing the levels of the target gene IL-17A and alleviating *** research not only identifies novel targets and pathways for the clinical diagnosis and treatment of TAO but also advances the innovation in traditional Chinese medicine through the elucidation of the SMYA/miR-548j-5p/IL-17A regulatory axis in the pathogenesis of TAO.

关键词： Thromboangiitis obliterans IL-17A Inflammation miR-548j-5p Si-miao-Yong-An Decoction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

引用

Current Medical Science 2024年第2期44卷 333-345页

作者： Jun-li ZHAO Lin ZHAO Qiu-nan ZHAN miao LIU Ting ZHANG Wen-wen chu Department of Nephrology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghai 201318China Orthopedic Department Guangming Traditional Chinese Medicine Hospital of Pudong New AreaShanghai 201399China

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to ***:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of *** and Masson staining were performed to evaluate the extent of *** therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function ***-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%*** were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 ***:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to *** RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD *** found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD *** with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious f

关键词： peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelialmesenchymal transition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：