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Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease

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World Journal of gastroenterology 2024年第10期30卷 1393-1404页

作者： mi.g-hui Zeng qi-Yu Shi Liang Xu Yu-qiang mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of gastroenterology Cangzhou People’s HospitalCangzhou 061000Hebei ProvinceChina Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Tianjin Research Institute of Liver Diseases Tianjin 300192China

BACKgROUND Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,affecting about 1/4th of the global population and causing a huge global economic *** date,no drugs have been approved for the treatment of NAFLD,making the correction of unhealthy lifestyles the principle method of *** patients with poor adherence to lifestyle correction and attempting to improve their adherence are therefore very *** To develop and validate a scale that can rapidly assess the adherence of patients with NAFLD to lifestyle *** The Exercise and Diet Adherence Scale(EDAS)was designed based on com-pilation using the Delphi method,and its reliability was subsequently *** and laboratory indicators were measured,and patients completed the EDAS questionnaire at baseline and after 6 *** efficacy of the EDAS was evaluated in the initial ***,the efficacy of the EDAS was internally verified in a validation *** The EDAS consisted of 33 items in six dimensions,with a total of 165 *** EDAS score correlated significantly with daily number of exercise and daily reduction in calorie intake(Pght loss.A total score of 116 was excellent in predicting adherence to daily reduction in calorie intake(>500 kacl/d),(sensitivity/specificity was 100.0%/75.8%),while patients score below 97 could nearly rule out the possibility of daily exercise(sensitivity/specificity was 89.5%/44.4%).Total EDAS scores≥116,97-115,andgood,average,and poor adherence,respectively,to diet and exercise *** The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.

关键词： Fatty liver Lifestyle intervention Behavioral change Patient adherence Compliance

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Boundary points, minimal L^(2) integrals and concavity property Ⅱ: Weakly pseudoconvex Kähler manifolds

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Science China Mathematics 2024年第7期67卷 1665-1718页

作者： qi’an guan Zhitong mi Zheng Yuan School of Mathematical Sciences Peking UniversityBeijing100871China School of Mathematics and Statistics Beijing Jiaotong UniversityBeijing100044China Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100190China

In this paper, we consider minimal L^(2) integrals on the sublevel sets of plurisubharmonic functions on weakly pseudoconvex K?hler manifolds with Lebesgue measurable gain related to modules at boundary points of the sublevel sets, and establish a concavity property of the minimal L^(2) integrals. As applications, we present a necessary condition for the concavity degenerating to linearity, a concavity property related to modules at inner points of the sublevel sets, an optimal support function related to modules, a strong openness property of modules and a twisted version, and an effectiveness result of the strong openness property of modules.

关键词： minimal L^(2)integrals plurisubharmonic functions boundary points weakly pseudoconvex K?hler manifold

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Retinitis pigmentosa and stem cell therapy

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1363-1369页

作者： Xin-Ya qi Chen-hui mi De-Rui Cao Xie-Qun Chen Peng Zhang School of Medicine Department of Life Sciences and MedicineNorthwest UniversityXi’an 710069Shaanxi ProvinceChina The Third Hospital of Xi’an Affiliated Hospital of Northwest UniversityXi’an 710021Shaanxi ProvinceChina

Retinitis pigmentosa(RP)is a group of genetic disorders characterized by progressive degeneration of photoreceptors and retinal pigment epithelium(RPE)*** main clinical manifestations include night blindness and progressive loss of peripheral vision,making it a prevalent debilitating eye disease that significantly impacts patients’quality of *** exhibits significant phenotypic and genetic *** instance,numerous abnormal genes are implicated in RP,resulting in varying clinical presentations,disease progression rates,and pathological characteristics among different ***,gene therapy for RP poses challenges due to these ***,stem cells have garnered considerable attention in the field of RPE therapy since both RPE cells and photoreceptors can be derived from stem *** recent years,a large number of animal experiments and clinical trials based on stem cell transplantation attempts,especially cord blood mesenchymal stem cell(MSC)transplantation and bone marrow-derived MSC transplantation,have confirmed that stem cell therapy can effectively and safely improve the outer retinal function of the RP-affected ***,stem cell therapy also has certain limitations,such as the fact that RP patients may involve multiple types of retinal cytopathia,which brings great challenges to stem cell transplantation therapy,and further research is needed to solve various problems faced by this approach in the *** comprehensive analysis of the etiology and histopathological changes associated with RP,this study substantiates the efficacy and safety of stem cell therapy based on rigorous animal experimentation and clinical trials,while also highlighting the existing limitations that warrant further investigation.

关键词： retinitis pigmentosa photoreceptor stem cell therapy

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Boundary Points,minimal L^(2)Integrals and Concavity PropertyⅢ—Linearity on Riemann Surfaces and Fibrations over Open Riemann Surfaces

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2091-2152页

作者： qi An gUAN Zhi Tong mi Zheng YUAN School of Mathematical Sciences Peking UniversityBeijing 100871P.R.China School of Mathematics and Statistics Beijing Jiaotong UniversityBeijing 100044P.R.China Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190P.R.China

In this article,we consider a modified version of minimal L^(2) integrals on sublevel sets of plurisubharmonic functions related to modules at boundary points,and obtain a concavity property of the modified *** applications,we give characterizations for the concavity degenerating to linearity on open Riemann surfaces and on fibrations over open Riemann surfaces.

关键词： minimal L^(2)integrals plurisubharmonic functions boundary points weakly pseudoconvex Kähler manifold

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Ultracycles consisting of macrocycles

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Chinese Chemical Letters 2024年第5期35卷 183-188页

作者： Wen-hui mi Teng-Yu Huang Yu-Fei Ao Xu-Dong Wang qi-qiang Wang De-Xian Wang Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Presented here is a one-pot strategy starting from rationally designed macrocyclic precursors for the diverse construction of sophisticated *** type and amount of the base were found to significantly influence the macrocyclization *** use of 4.0 *** resulted in ultracycles of both types A and B while the presence of CsF larger than 6.0 *** only type B *** of anion template increased the total yields and affected the distribution of the *** ultracycles can accommodate large organic dicarboxylates anions via multiple anion-πand hydrogen bonds,and show selectivity to the size-matched heptanedioate(C7^(2−)).Based on all possible species and relevant equilibrium constants as well as material and charge balances,a numerical iterative algorithm was developed and applied to fit the association constants of B2H with dicarboxylates from glutarate(C5^(2−))to octanedioate(C8^(2−)),which gave association constants up to 10^(3) L/mol.

关键词： Ultracycles Diversity-oriented synthesis Anion recognition Anion-πinteraction

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Strain-tuned electronic and valley-related properties in Janus monolayers of SWSiX_(2)(X=N,P,As)

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Chinese Physics B 2024年第9期33卷 487-492页

作者： Yunxi qi Jun Zhao hui Zeng New Energy Technology Engineering Laboratory of Jiangsu Province&School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China School of microelectronics Nanjing University of Science and TechnologyNanjing 210094China

Exploring novel two-dimensional(2D)valleytronic materials has an essential impact on the design of spintronic and valleytronic *** first principles calculation results reveal that the Janus SWSiX_(2)(X=N,P,As)monolayer has excellent dynamical and thermal *** to strong spin–orbit coupling(SOC),the SWSiX_(2)monolayer exhibits a valence band spin splitting of up to 0.49 eV,making it promising 2D semiconductor for valleytronic *** opposite Berry curvatures and optical selection rules lead to the coexistence of valley and spin Hall effects in the SWSiX2 ***,the optical transition energies can be remarkably modulated by the in-plane *** tensile(compressive)in-plane strains can achieve spin flipping in the SWSiN2 monolayer,and induce both SWSiP_(2)and SWSiAs_(2)monolayers transit from semiconductor to *** research provides new 2D semiconductor candidates for designing high-performance valleytronic devices.

关键词： first-principles calculations two-dimensional valleytronic spintronic

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Unsupervised Multi-Expert Learning Model for Underwater Image Enhancement

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 708-722页

作者： Hongmin Liu qi Zhang Yufan Hu hui Zeng Bin Fan the School of Intelligence Science and Technology and the Institute of Artificial Intelligence University of Science and Technology BeijingBeijing 100083China the School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing 100083China IEEE

Underwater image enhancement aims to restore a clean appearance and thus improves the quality of underwater degraded *** methods feed the whole image directly into the model for ***,they ignored that the R,g and B channels of underwater degraded images present varied degrees of degradation,due to the selective absorption for the *** address this issue,we propose an unsupervised multi-expert learning model by considering the enhancement of each color ***,an unsupervised architecture based on generative adversarial network is employed to alleviate the need for paired underwater *** on this,we design a generator,including a multi-expert encoder,a feature fusion module and a feature fusion-guided decoder,to generate the clear underwater ***,a multi-expert discriminator is proposed to verify the authenticity of the R,g and B channels,*** addition,content perceptual loss and edge loss are introduced into the loss function to further improve the content and details of the enhanced *** experiments on public datasets demonstrate that our method achieves more pleasing results in vision *** metrics(PSNR,SSIM,UIQM and UCIQE) evaluated on our enhanced images have been improved obviously.

关键词： Multi-expert learning underwater image enhancement unsupervised learning

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Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： Bing-Bing Liu Yi-hui Liu You-Bin Zhang Zhen-guo qi guo-hui qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

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mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death

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Chinese Chemical Letters 2024年第5期35卷 338-343页

作者： Kun-Heng Li Hong-Yang Zhao Dan-Dan Wang mi.g-hui qi Zi-Jian Xu Jia-mi Li Zhi-Li Zhang Shi-Wen Huang Key Laboratory of Biomedical Polymers of ministry of Education Department of ChemistryWuhan UniversityWuhan 430072China

AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)*** date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emission(AIE)molecules have been developed and have evoked massive ICD in ***,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to elicit ***-based nanomicelles,which maintain a stable micellar structure,can prevent defects of AIE molecules in photodynamic therapy(PDT)***,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.

关键词： Aggregation induced emission Photodynamic therapy Immunogenic cell death Reactive oxygen species Nanophotosensitizer mitochondria

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Role of polarization evolution in the hysteresis effect of Pb-based antiferroelecrtics

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Chinese Chemical Letters 2024年第4期35卷 516-519页

作者： Botao gao He qi hui Liu Jun Chen Beijing Advanced Innovation Center for Materials genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201899China Hainan University Haikou 570228China

The electric field-induced irreversible domain wall motion results in a ferroelectric(FE) hysteresis. In antiferroelectrics(AFEs), the irreversible phase transition is the main reason for the hysteresis effects, which plays an important role in energy storage performance. Compared to the well-demonstrated FE hysteresis,the structural mechanism of the hysteresis in AFE is not well understood. In this work, the underlying correlation between structure and the hysteresis effect is unveiled in Pb(Zr,Sn,Ti)O_(3) AFE system by using in-situ electrical biasing synchrotron X-ray diffraction. It is found that the AFE with a canting dipole configuration, which shows a continuous polarization rotation under the electric field, tends to have a small hysteresis effect. It presents a negligible phase transition, a small axis ratio, and electric field-induced lattice changing, small domain switching. All these features together lead to a slim hysteresis loop and a high energy storage efficiency. These results offer a deep insight into the structure-hysteresis relationship of AFEs and are helpful for the design of energy storage material.

关键词： Antiferroelectric Hysteresis effect Structure refinement Perovskite In situ synchrotron radiation

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