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Imprinting at the KBTBD6 locus involves species-specific m ternal methylation and monoallelic expression in livestock animals

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Journal of Animal Science and Biotechnology 2024年第1期15卷 127-145页

作者： Jinsoo Ahn In-Sul Hwang mi-ryung park Seongsoo Hwang Kichoon Lee Department of Animal Sciences The Ohio State UniversityColumbusOH 43210USA Animal Biotechnology Division Rural Development AdministrationNational Institute of Animal ScienceJeonbuk 55365Republic of Korea Columbia Center for Translational Immunology Columbia University Irving Medical CenterColumbia UniversityNew YorkNY 10032USA Animal Welfare Research Team National Institute of Animal ScienceRDA1500Kongjwipatjwi‑roJeollabuk‑do 55365Republic of Korea

Background The primary differentially methylated regions(DMRs) which are maternally hypermethylated serve as imprinting control regions(ICRs) that drive monoallelic gene expression, and these ICRs have been investigated due to their implications in mammalian development. Although a subset of genes has been identified as imprinted, in-depth comparative approach needs to be developed for identification of species-specific imprinted genes. Here, we examined DNA methylation status and allelic expression at the KBTBD6 locus across species and tissues and explored potential mechanisms of *** Using whole-genome bisulfite sequencing and RNA-sequencing on parthenogenetic and normal porcine embryos, we identified a maternally hypermethylated DMR between the embryos at the KBTBD6 promoter Cp G island and paternal monoallelic expression of KBTBD6. Also, in analyzed domesticated mammals but not in humans, non-human primates and mice, the KBTBD6 promoter Cp G islands were methylated in oocytes and/or allelically methyl-ated in tissues, and monoallelic KBTBD6 expression was observed, indicating livestock-specific imprinting. Further analysis revealed that these Cp G islands were embedded within transcripts in porcine and bovine oocytes which coexisted with an active transcription mark and DNA methylation, implying the presence of transcription-dependent *** In this study, our comparative approach revealed an imprinted expression of the KBTBD6 gene in domesticated mammals, but not in humans, non-human primates, and mice which implicates species-specific evolution of genomic imprinting.

关键词： Differentially methylated region Domesticated mammal Imprinting KBTBD6 Parthenogenetic

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Low-molecular-weight fucoidan inhibits the proliferation of melanoma via Bcl-2 phosphorylation and PTEN/AKT pathway

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Oncology Research 2024年第2期32卷 273-282页

作者： miNJI park CHULHWAN BANG WON-SOO YUN YUN-mi JEONG T&R Biofab Co. Ltd.Seongnam-si13487Korea Department of Dermatology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul02706Korea Department of Mechanical Engineering Tech University of KoreaSi-heung City15073Korea

Fucoidan,a sulfate polysaccharide obtained from brown seaweed,has various bioactive properties,including anti-inflammatory,anti-cancer,anti-viral,anti-oxidant,anti-coagulant,anti-thrombotic,anti-angiogenic,and anti-Helicobacter pylori ***,the effects of low-molecular-weight fucoidan(LMW-F)on melanoma cell lines and three dimensional(3D)cell culture models are not well *** study aimed to investigate the effects of LMW-F on A375 human melanoma cells and cryopreserved biospecimens derived from patients with advanced *** wave was used to fragment fucoidan derived from Fucus vesiculosus into smaller *** and live/dead assays showed that LMW-F inhibited cell proliferation in both A375 cells and patientderived melanoma explants in a 3D-printed collagen *** PTEN/AKT pathway was found to be involved in the anti-melanoma effects of *** blot analysis revealed that LMW-F reduced the phosphorylation of Bcl-2 at Thr 56,which was associated with the prevention of anti-apoptotic activity of cancer *** findings suggested that LMW-F could enhance anti-melanoma chemotherapy and improve the outcomes of patients with melanoma resistance.

关键词： Low-molecular-weight fucoidan Melanoma Patient-derived melanoma explants in a 3D-printed collagen scaffold Anti-melanoma effect PTEN-AKT-Bcl-2 network

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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of parkinson's disease:a systematic review and meta-analysis

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Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： Jong mi park Masoud Rahmati Sang Chul Lee Jae Il Shin Yong Wook Kim Department and Research Institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease *** cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of parkinson’s *** stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of *** performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a parkinson’s disease animal *** searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,*** study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control *** use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 parkinson’s disease model animals were included in the *** with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational *** the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a

关键词： animal animal experimentation mesenchymal stem cells models parkinson’s disease stem cell transplantation

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Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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Nano-micro Letters 2024年第12期16卷 468-514页

作者： Jung Hwan park Srinivas Pattipaka Geon-Tae Hwang minok park Yu mi Woo Young Bin Kim Han Eol Lee Chang Kyu Jeong Tiandong Zhang Yuho min Kwi-Il park Keon Jae Lee Jungho Ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61Daehak-RoGumiGyeongbuk 39177Republic of Korea Department of Materials Science and Engineering Pukyong National University45Yongso-RoNam-GuBusan 48513Republic of Korea Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Division of Advanced Materials Engineering Jeonbuk National UniversityJeonju 54896JeonbukRepublic of Korea School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080People’s Republic of China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080People’s Republic of China Department of Materials Science and Metallurgical Engineering Kyungpook National University80 Daehak-RoBuk-GuDaegu 41566Republic of Korea School of Materials Science and Engineering Yeungnam UniversityDaehak-RoGyeongsan-Si 38541Gyeongsangbuk-doRepublic of Korea

This review provides a comprehensive overview of the progress in light-material interactions(Lmis),focusing on lasers and flash lights for energy conversion and storage *** discuss intricate Lmi parameters such as light sources,interaction time,and fluence to elucidate their importance in material *** addition,this study covers various light-induced photothermal and photochemical processes ranging from melting,crystallization,and ablation to doping and synthesis,which are essential for developing energy materials and ***,we present extensive energy conversion and storage applications demonstrated by Lmi technologies,including energy harvesters,sensors,capacitors,and *** the several challenges associated with Lmis,such as complex mechanisms,and high-degrees of freedom,we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

关键词： Light Light-material interaction Nanomaterials Energy conversion and storage devices

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Omni-functional simultaneous interfacial treatment for enhancing stability and outgassing suppression of lithium-ion batteries

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Journal of Energy Chemistry 2024年第7期94卷 677-687页

作者： Youbean Lee Chanjoo park Kyoungmin min Kwangjin park Department of Mechanical Engineering Gachon UniversityGyeonggi-do 13120Republic of Korea Department of Battery Engineering Gachon UniversityGyeonggi-do 13120Republic of Korea School of Mechanical Engineering Soongsil UniversitySeoul 06978Republic of Korea

Ni-rich layered oxides in lithium-ion batteries have problems with gas generation and electrochemical performance reduction due to residual lithium's reaction on the surface with the *** address this issue,in this study,the Acid solvent evaporation(AsE)method has been proposed as a potential method to remove residual lithium while promoting the formation of a new LiNO_(3)-derived coating layer on the cathode *** reduction of residual lithium using the ASE method and the construction of a LiNO_(3)-derived coating layer suppresses gas evolution caused by the side effects of the electrolyte,improves electrochemical performance,and improves thermal stability by facilitating the smooth movement of lithium ***,the structural stability and resistance change due to the LiNO_(3)-derived coating layer effects is guaranteed through cycling and DCIR of the pouch *** a result,compared to Pristine,the capacity retention of coin cells increased by 8%after 100 cycles,and pouch cells increased by 25%after 160 *** addition,after cycling the pouch cell,CO_(2) gas has significantly reduced by about 30%compared to Pristine using gas *** ASE method effectively forms a robust LiNO_(3)-derived coating layer on the cathode active material,which helps minimize electrolyte reactivity,suppress ,CO_(2) emissions,enhance surface structure stability,improve thermal stability,and improveoverallbatteryperformance.

关键词： Lithium-ion batteries Ni-rich NCM Acid solvent evaporation LiNO_(3)-derived coating Gasevolution

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Non-interleaved chiral metasurfaces and neural networks enhance the spatial resolution of polarimetry

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Light(Science & Applications) 2024年第3期13卷 396-398页

作者： Jaewon Jang minsu park Yeonsang park Department of Physics Chungnam National UniversityDaejeon 34134Korea Institute of Quantum Systems Chungnam National UniversityDaejeon 34134Korea

Non-interleaved chiral metasurfaces for high-spatial-resolution polarimetry are proposed and ***,a convolutional neural network is incorporated to analyze interferometric images with the polarization state of light,an... 详细信息

关键词： parameters chiral resolution

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Iso-propagation vortices:a breakthrough in optical communication technology

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Advanced Photonics 2024年第3期6卷 13-15页

作者： Cherry park Junsuk Rho Pohang University of Science and Technology(POSTECH) Department of Mechanical EngineeringPohangRepublic of Korea Pohang University of Science and Technology(POSTECH) Department of Chemical EngineeringPohangRepublic of Korea Pohang University of Science and Technology(POSTECH) Department of Electrical EngineeringPohangRepublic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics PohangRepublic of Korea

The rapid advance of optical communication technology requires improvements in data transmission capacity and *** methods of increasing the transmission capacity such as polarization,wavelength,and spatial mode division multiplexing have shown significant promise,while spatial mode division multiplexing(SDM)offers a new approach through the use of orthogonal spatial modes as distinct communication channels.

关键词： communication optical polarization

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Electrochemically Deposited CZTSSe Thin Films for Monolithic Perovskite Tandem Solar Cells with Efficiencies Over 17%

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Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： Sun Kyung Hwang Ik Jae park Se Won Seo Jae Hyun park So Jeong park Jin Young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control

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An Investigation on Open-RAN Specifications:Use Cases,Security Threats,Requirements,Discussions

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 13-41页

作者： Heejae park Tri-HaiNguyen Laihyuk park Department of Computer Science and Engineering Seoul National University of Science and TechnologySeoul01811Republic of Korea Faculty of Information Technology School of TechnologyVan Lang UniversityHo Chi Minh City70000Vietnam

The emergence of various technologies such as terahertz communications,Reconfigurable Intelligent Surfaces(RIS),and AI-powered communication services will burden network operators with rising infrastructure ***,the Open Radio Access Network(O-RAN)has been introduced as a solution for growing financial and operational burdens in Beyond 5G(B5G)and 6G networks.O-RAN promotes openness and intelligence to overcome the limitations of traditional *** disaggregating conventional Base Band Units(BBUs)into O-RAN Distributed Units(O-DU)and O-RAN Centralized Units(O-CU),O-RAN offers greater flexibility for upgrades and network ***,this openness introduces new security challenges compared to traditional *** existing studies overlook these security requirements of the O-RAN *** gain deeper insights into the O-RAN system and security,this paper first provides an overview of the general O-RAN architecture and its diverse use cases relevant to B5G and 6G *** then delve into specifications of O-RAN security threats and requirements,aiming to mitigate security vulnerabilities *** providing a comprehensive understanding of O-RAN architecture,use cases,and security considerations,thisworkserves as a valuable resource for future research in O-RAN and its security.

关键词： O-RAN architecture use cases security issues security requirements security discussions

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Environmentally adaptive reshaping of plant photomorphogenesis by karrikin and strigolactone signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 865-882页

作者： Young-Joon park Bo Eun Nam Chung-Mo park Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea Departmentof Biological Sciences Seoul National UniversitySeoul 08826Korea Department of Chemistry Seoul National UniversitySeoul 08826Korea

Coordinated morphogenic adaptation of growing plants is critical for their survival and propagation under fluctuating *** morphogenic responses to light and warm temperatures,termed photomorphogenesis and thermomorphogenesis,respectively,have been extensively studied in recent *** photomorphogenesis,plants actively reshape their growth and developmental patterns to cope with changes in light ***,photomorphogenesis is closely associated with diverse growth hormonal ***,accumulating evidence indicates that light-directed morphogenesis is profoundly affected by two recently identified phytochemicals,karrikins(KARs)and strigolactones(SLs).KARs and SLs are structurally related butenolides acting as signaling molecules during a variety of developmental steps,including seed *** receptors and signaling mediators have been identified,and associated working mechanisms have been explored using gene-deficient mutants in various plant *** particular interest is that the KAR and SL signaling pathways play important roles in environmental responses,among which their linkages with photomorphogenesis are most comprehensively studied during seedling *** this review,we focus on how the phytochemical and light signals converge on the optimization of morphogenic *** also discuss molecular mechanisms underlying the signaling crosstalks with an aim of developing potential ways to improve crop productivity under climate changes.

关键词： karrikins morphogenic adaptation photomorphogenesis seedling establishment strigolactones

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