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Transplantation of human adipose tissue-derived stem cells for repair of injured spiral ganglion neurons in deaf guinea pigs

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Neural Regeneration Research 2016年第6期11卷 994-1000页

作者： Sujeong Jang Hyong-Ho cho Song-Hee Kim kyung-Hwa Lee Yong-Bum cho Jong-Seong Park Han-Seong Jeong Department of Physiology Chonnam National University Medical School Department of Otolaryngology Chonnam National University Medical School Department of Pathology Chonnam National University Medical School

Excessive noise, ototoxic drugs, infections, autoimmune diseases, and aging can cause loss of spiral ganglion neurons, leading to permanent sensorineural hearing loss in mammals. Stem cells have been confirmed to be able to differentiate into spiral ganglion neurons. Little has been reported on adipose tissue-derived stem cells（ADSCs） for repair of injured spiral ganglion neurons. In this study, we hypothesized that transplantation of neural induced-human ADSCs（NI-h ADSCs） can repair the injured spiral ganglion neurons in guinea pigs with neomycin-induced sensorineural hearing loss. NI-h ADSCs were induced with culture medium containing basic fibroblast growth factor and forskolin and then injected to the injured cochleae. Guinea pigs that received injection of Hanks＇ balanced salt solution into the cochleae were used as controls. Hematoxylin-eosin staining showed that at 8 weeks after cell transplantation, the number of surviving spiral ganglion neurons in the cell transplantation group was significantly increased than that in the control group. Also at 8 weeks after cell transplantation, immunohistochemical staining showed that a greater number of NI-h ADSCs in the spiral ganglions were detected in the cell transplantation group than in the control group, and these NI-h ADSCs expressed neuronal markers neurofilament protein and microtubule-associated protein 2. Within 8 weeks after cell transplantation, the guinea pigs in the cell transplantation group had a gradually decreased auditory brainstem response threshold, while those in the control group had almost no response to 80 d B of clicks or pure tone burst. These findings suggest that a large amount of NI-h ADSCs migrated to the spiral ganglions, survived for a period of time, repaired the injured spiral ganglion cells, and thereby contributed to the recovery of sensorineural hearing loss in guinea pigs.

关键词： guinea ganglion repair hearing adipose injured brainstem auditory neuronal cochlear

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Beneficial Effect of Berberis amurensis Rupr. on Penile Erection

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Chinese Journal of Integrative Medicine 2018年第6期24卷 448-454页

作者： Rui Tan Yun Jung Lee kyung Woo cho Dae Gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang CardioRenal Syndrome Research Center Wonkwang University Brain Korea 21 Plus Team Professional Graduate School of Oriental MedicineWonkwang University

Objective： To investigate whether the methanol extract of Berberis amurensis Rupr. （BAR） augments penile erection using in vitro and in vivo experiments. Methods： The ex vivo study used corpus cavemosum strips prepared from adult male New Zealand White rabbits. In in vivo studies for intracavernous pressure （ICP）, blood pressure, mean arterial pressure （MAP）, and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats. Results： Preconstricted with phenylephrine （PE） in isolated endothelium- intact rabbit corus cavernosum, BAR relaxed penile smooth muscle in a dose-dependent manner, which was inhibited by pretreatment with NG-nitro-L-arginine methyl ester （L-NAME）, a nitric oxide synthase inhibitor, and 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-l-one, a soluble guanylyl cclase inhibitor. BAR significantly relaxed penile smooth muscles dose-dependently in ex vivo, and this was inhibited by pretreatment with L-NAME 1H-[1,2,4]- oxadiazole-[4,3-α ]-quinoxalin-l-one. BAR-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium （TEA, P〈0.01）, a nonselective K＋ channel blocker, 4-aminopyridine （4-AP, P〈0.01）, a voltage-dependent K＋ channel blocker, and charybdotoxin （P〈0.01）, a large and intermediate conductance Ca2. sensitive-K＋ channel blocker, respectively. BAR induced an increase in peak ICP, ICP/MAP ratio and area under the curve dose dependently. Conclusion： BAR augments penile erection via the nitric oxide/cyclic guanosine monophosphate system and Ca2. sensitive-K＋（BK＋ and IK＋） channels in the corpus cavemosum.

关键词： penile erection Berberis amurensis Rupr. nitric oxide cyclic guanosine monophosphate K+ channel

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DNA-Binding Domain of AtTRB2 Reveals Unique Features of a Single Myb Histone Protein Family that Binds to Both Arabidopsis- and Human-Type Telomeric DNA Sequences

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Molecular Plant 2012年第6期5卷 1406-1408页

作者： Won kyung Lee Ji-Hye Yun Weontae Lee Myeon Haeng cho Department of Systems Biology College of Life Science and Biotechnology Yonsei University Seoul 120–749 Korea Department of Biochemistry College of Life Science and Biotechnology Yonsei University Seoul 120–749 Korea

Dear Editor, Telomeres are specific protein-DNA complexes that pro- tect the ends of eukaryotic chromosomes from fusion and degradation and are maintained by a specialized mecha- nism exerted by telomerase and telomere-binding proteins. Mammalian telomeres contain TTAGGG and are associated with a six-protein （e.g. TRF1, TRF2, TIN2, RAP1, POT1, and TPP1） complex called shelterin （de Lange, 2005）, which was involved in telomere homeostasis. Similarly to mammalian telomeres, telomeres in most plants are maintained by tel- omerase and telomere-associated proteins （e.g. AtTBP1, AtTRP1, AtTRB1, POT1, POT2, KU70, and KU80） and consist of tandem arrays of TTTAGGG. Among telomere-associated proteins in Arabidopsis thaliana, AtTRB proteins belong to the SMH （Single-Myb-Histone）-Iike family, in which proteins are composed of an N-terminal Myb domain, a central his- tone Hl-like globular domain, and a C-terminal coiled-coil region.

关键词： DNA结合结构域端粒结合蛋白组蛋白拟南芥 DNA序列 Arabidopsis 结合型家族

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In vitro antibacterial activity and major bioactive components of Cinnamomum verum essential oils against cariogenic bacteria,Streptococcus mutans and Streptococcus sobrinus

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 308-314页

作者： Okhee choi Su kyung cho Junheon Kim Chung Gyoo Park Jinwoo Kim Division of Applied Life Science (BK21 Plus) Gyeongsang National University Institute of Agriculture & Life Science Gyeongsang National University

Objective:To evaluate the antibacterial activity of Cinnamomum verum(***) from32 different essential oils against cariogenic bacteria,Streptococcus mutans(***)and Streptococcus sobrinus(***).Methods:The antibacterial activities of each essential oil were individually investigated against *** and *** essential oil of *** was selected for further evaluation against *** and *** chromatography mass spectrometry was used to determine the major constituents of *** essential *** addition,the minimum inhibitory concentration(miC) and minimum bactericidal concentration of the most effective constituent was ***:The essential oil from *** exhibited the greatest antibacterial *** chromatography mass spectrometry analysis revealed that the major components of *** essential oil were cinnamaldehyde(56.3%),cinnamyl acetate(7.1%) and bphellandrene(6.3%).The miC of cinnamaldehyde was measured using broth dilution *** miC of cinnamaldehyde was 0.02%(v/v) against both bacterial strains *** minimum bactericidal concentration of cinnamaldehyde against *** and *** were 0.2% and 0.1%(v/v),***:The essential oil of *** and its major component cinnamaldehyde possessed considerable in vitro antibacterial activities against cariogenic bacteria,*** and *** *** results showed that the essential oil of *** and its bioactive component,cinnamaldehyde,have potential for application as natural agents for the prevention and treatment of dental caries.

关键词： Streptococcus mutans Streptococcus sobrinus Cariogenic bacteria Essential oil Antibacterial activity Cinnamaldehyde

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Anti-inflammatory Effects of Sanguisorbae Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in mice

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Chinese Journal of Integrative Medicine 2020年第9期26卷 688-693页

作者： Suzy Jo Junghyun Ryu Hanna Kim miyoung Kim mi Heon Ryu Hyungwoo Kim Su-ln cho School of Korean Medicine Pusan National UniversityPusan(626-870)Republic of Korea School of Dentistry Pusan National UniversityPusan(626-870)Republic of Korea

Objective:To investigate the anti-inflammatory effects of Sanguisorbae Radix on contact dermatitis(CD).Methods:mice were sensitized by painting 30μL of 1-fluoro-2,4-dinitrofluorobenzene(DNFB)onto each ear for 3 *** days later,mice were challenged by painting with 50μL of DNFB onto the shaved dorsum every 2 *** Radix methanol extract(MESR)was applied onto the shaved dorsum every 2 *** effects of MESR on skin thickness,skin weights,histopathological changes,skin lesions and cytokine production in DNFB-induced CD mice were investigated,as well as its effects on body weights and spleen/body weight ***:Topical application of MESR effectively inhibited enlargement of skin thickness and weight(P<0.05).MESR treatment also inhibited hyperplasia,spongiosis and immune cell infiltration induced by DNFB in inflamed tissues and improved lesions on dorsum skin in CD ***,treatment with MESR suppressed the increase in the levels of tumor necrosis factor α(TNF-α,P<0.01)and interferonγ(IFN-γ,P<0.05),***,MESR had no effect on body weight gain or spleen/body weight ***:These data suggest that MESR acts as an anti-inflammatory agent that decreases the production of TNF-α and IFN-γ,resulting in reductions of skin lesions and histopathological changes in inflamed skin tissues.

关键词： Sanguisorba officinalis skin diseases herbal Chinese materia medica

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Structurally engineered colloidal quantum dot phosphor using TiO_(2) photonic crystal backbone

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Light(Science & Applications) 2022年第11期11卷 2782-2789页

作者： Hansol Lee Tae-Yun Lee Yeonsang Park kyung-Sang cho Young-Geun Rho Hyuck choo Heonsu Jeon Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center Seoul National UniversitySeoul 08826Republic of Korea Department of Physics Chungnam National UniversityDaejeon 34134Republic of Korea Institute of Quantum Systems Chungnam National UniversityDaejeon 34134Republic of Korea Samsung Advanced Institute of Technology Suwon 16678Republic of Korea Institute of Applied Physics Seoul National UniversitySeoul 08826Republic of Korea

Photonic crystal(PhC)phosphor,in which the phosphor material is periodically modulated for an enhancement in color-conversion efficiency via resonant absorption of excitation photons,is a paradigm-shifting structural phosphor ***-dimensional(2D)square-lattice PhC phosphor is currently considered the most advanced platform because of not only its high efficiency,but also its immunity to excitation *** the present study,two major modifications are made to further improve the performance of the 2D PhC phosphor:increasing the refractive index contrast and planarizing the *** index contrast is improved by replacing the PhC backbone material with TiO_(2)whereas the surface planarization is achieved by removing excessive colloidal quantum dots from the *** comparison with the reference phosphor,the upgraded PhC phosphor exhibits~59 times enhanced absorption(in simulations)and~7 times enhanced emission(in experiments),both of which are unprecedentedly *** results not only brighten the viability and applicability of the PhC phosphor but also spur the phosphor development through structural engineering of phosphor materials.

关键词： immunity phosphor backbone

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FET-based nanobiosensors for the detection of smell and taste

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Science China(Life Sciences) 2020年第8期63卷 1159-1167页

作者： Dongseok Moon Yeon kyung Cha So-ong Kim Seongyeon cho Hwi Jin Ko Tai Hyun Park School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea

Various nanobiosensors composed of biomaterials and nanomaterials have been developed,due to their demonstrated advantage of showing high *** various biomaterials for biological recognition elements of the nanobiosensor,sensory receptors,such as olfactory and taste receptors,are promising biomaterials for developing nanobiosensors,because of their high selectivity to target ***-effect transistors(FET)with nanomaterials such as carbon nanotube(CNT),graphene,and conducting polymer nanotube(CPNT),can be combined with the biomaterials to enhance the sensitivity of ***,many efforts have been made to develop nanobiosensors using biomaterials,such as olfactory receptors and taste receptors for detecting various smells and *** review focuses on the biomaterials and nanomaterials used in nanobiosensor systems and studies of various types of nanobiosensor platforms that utilize olfactory receptors and taste receptors which could be applied to a wide range of industrial fields,including the food and beverage industry,environmental monitoring,the biomedical field,and anti-terrorism.

关键词： nanobiosensor olfactory receptor taste receptor field-effect transistor(FET)

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Fish bone migration to the urinary bladder after rectosigmoid colon perforation

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World Journal of Gastroenterology 2014年第22期20卷 7075-7078页

作者： min-kyung cho Moon-Soo Lee Hyun-Young Han Seung Hyo Woo Department of Surgery Eulji University HospitalDaejeon 302-799South Korea Department of Radiology Eulji University HospitalDaejeon 302-799South Korea Department of Urology Eulji University HospitalDaejeon 302-799South Korea

Fish bones are the most common foreign objects leading to bowel *** cases are confined to the extraluminal space without penetration of an adjacent ***,abscess formation due to the perforation of the rectosigmoid colon by a fish bone can lead to the penetration of the urinary bladder and may subsequently cause the fish bone to migrate into the urinary *** the presented case,a 42-yearold female was admitted for lower abdominal *** computed tomography(CT)demonstrated a 5cm pelvic abscess containing a thin and curvilinear foreign *** conservative management,the patient was *** 1 mo,the subject developed a mechanical *** had to be delayed due to her *** of the foreign body to the urinary bladder was shown on additional CT.A Yellowish fish bone 3.5 cm in size was removed through intraoperative *** patient was discharged 8 d after the operation without any unexpected event.

关键词： Fish bone Rectosigmoid colon perforation Urinary bladder Foreign body ingestion Foreign body induced bowel perforation

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Efficacy of a Community-Based Trauma Recovery Program after a Fire Disaster

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International Journal of Mental Health Promotion 2022年第1期24卷 85-94页

作者： Yun-Jung choi mi-Ra Won Dong-Hee cho Red Cross College of Nursing Chung-Ang UniversitySeoulKorea Department of Nursing Daewon University CollegeJecheonKorea

As industries develop,fire disasters and their associated damage are *** the mental health of victims is imperative because this is an essential issue for community recovery after a *** study was conducted to determine the efficacy of a program implemented by a community mental health center based on the investigation of the victims’depression and post-traumatic stress disorder(PTSD)levels immediately after the disaster and at one-year *** a result,victims’depression and PTSD recovered over time,and more changes were *** particular,the high-risk group for PTSD showed a high program participation rate,and there was significant recovery over time compared with the group without *** on these results,community mental health programs are an effective way to increase community mental health after *** the future,community-based recovery programs after disasters should be expanded,and administrative support for them should be developed.

关键词： Fire disaster victims post-traumatic stress disorder depression community mental health services

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Oxygen vacancy engineering for tuning the catalytic activity of LaCoO_(3) perovskite

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Journal of Rare Earths 2024年第3期42卷 506-514,I0003页

作者： Jeong Hyun cho minjae Kim Inchan Yang kyung Tae Park Chang Houn Rhee Hai Woong Park Ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju-gunJeollabuk-do 55324Republic of Korea Iron&Steel Process Engineering Research Group POSCOPohang 37859Republic of Korea Hydrogen Research Center Research Institute of Industrial Science&Technology(RIST)Pohang 37673Republic of Korea

Herein, we attempted to engineer oxygen vacancies on the surface of LaCoO_(3) perovskite through simple post-treatments(acid or reductive thermal treatments). Acid treatment induces oxygen vacancies through the selective etching of the La cations, whereas thermal treatment in a reducing atmosphere generates oxygen vacancies by directly removing lattice oxygen. The characterization results confirm that the number of surface oxygen vacancies, which are crucial in various catalytic oxidation reactions,considerably increases in the LaCoO_(3) catalysts treated with acid or reducing gas. Acid treatment enriches the oxygen vacancies while maintaining the structure of the LaCoO_(3) catalysts, which can not be achieved through reductive thermal treatment. Therefore, the acid treatment is considered a promising technique for oxygen vacancy engineering of perovskite catalysts for tuning their catalytic activities. Furthermore,the catalytic activities of the posttreated LaCoO_(3) catalysts for CO oxidation were evaluated and are noted to be considerably better than those of the pristine LaCoO_(3) catalyst due to their abundant oxygen vacancies. Consequently, we conclude that the oxygen vacancies of perovskite catalysts can be effectively engineered via two simple methods and play a significant role in CO oxidation.

关键词： LaCoO_(3)perovskite Acid treatment Reductive thermal treatment Oxygen vacancy CO oxidation Rare earths

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