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Acta Pharmacologica Sinica 2007年第6期28卷 901-907页

作者： Myung-hyun YIM Jang-woo SHIN Jin-young SON Se-mi OH Seung-hyun HAN Jung-hyo cho chong-kwan cho Hwa-seung YOO Yeon-weol LEE Chang-gue SON East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea

Aim:To investigate the immunoregulatory functions of water extracts of Hericiumerinaceum （WEHE） focusing on natural killer （NK） cell-based anticancer ***:Mouse splenocytes or purely isolated NK ceils were stimulated with1-100 mg/L WEHE for 24 h followed by co-culture with51Cr-labled Yac-1 cells for4 h,then NK cell-derived cytolytic activity was measured using a *** antibodies against mouse interleukin-12 （IL-12） were addedinto the WEHE-stimulated splenocytes,thereafter,cytotoxicity was measured toexamine the involvement of ***-PCR and ELISA analyses were performed toconfirm the induction of transcription and the translation of IL-12 and interferon-gamma （IFN-gamma） in the WEHE-treated ***:WEHE enhancedthe cytolytic activity of total splenocytes towards Yac-1 ceils in a ***,this activation was not observed when the NK cells isolatedfrom the splenocytes were treated with ***,the treatment withantibodies against IL-12 abolished the effect of WEHE on splenocyte-derivedcytolytic ***-PCR and ELISA analyses showed the induction of IL-12 andIFN-gamma in the WEHE-treated ***:WEHE indirectlyactivates the cytolytic ability of NK cells via the induction of IL-12 in totalsplenocytes,and possibly via other immuno-mediators or cellular components.

关键词： Hericium erinaceum NK cells interleukin-12

3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration

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Bioactive Materials 2023年第1期19卷 611-625页

作者： Suhun Chae Uijung Yong Wonbin Park Yoo-mi choi In-Ho Jeon Homan Kang Jinah Jang Hak Soo choi Dong-Woo cho Department of Mechanical Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea EDmicBio Inc. 111 Hoegi-roDongdaemun-guSeoul 02445South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul03722South Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital&Harvard Medical School14913th StreetBostonMA02114USA Department of Convergence IT Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea Department of Orthopaedic Surgery Asan Medical CenterCollege of MedicineUniversity of Ulsan86 Asanbyeongwon-gilSongpa-guSeoul05505South Korea

Owing to the prevalence of rotator cuff(RC)injuries and suboptimal healing outcome,rapid and functional regeneration of the tendon-bone interface(TBI)after RC repair continues to be a major clinical *** the essential role of the RC in shoulder movement,the engineering of biomimetic multi-tissue constructs presents an opportunity for complex TBI reconstruction after RC ***,we propose a gradient cell-laden multi-tissue construct combined with compositional gradient TBI-specific bioinks via 3D cell-printing *** vitro studies demonstrated the capability of a gradient scaffold system in zone-specific inducibility and multi-tissue formation mimicking *** regenerative performance of the gradient scaffold on RC regeneration was determined using a rat RC repair *** particular,we adopted nondestructive,consecutive,and tissue-targeted near-infrared fluorescence imaging to visualize the direct anatomical change and the intricate RC regeneration progression in real time in ***,the 3D cell-printed implant promotes effective restoration of shoulder locomotion function and accelerates TBI healing in *** summary,this study identifies the therapeutic contribution of cell-printed constructs towards functional RC regeneration,demonstrating the translational potential of biomimetic gradient constructs for the clinical repair of multi-tissue interfaces.

关键词： 3D cell-printing Tissue-specific bioink Gradient tissue scaffolds Near-infrared fluorophores Rotator cuff repair

Repeat hepatic resection in patients with colorectal liver metastases

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World Journal of Gastroenterology 2015年第7期21卷 2124-2130页

作者： Huisong Lee Seong Ho choi Yong Beom cho Seong Hyeon Yun Hee Cheol Kim Woo Yong Lee Jin Seok Heo Dong Wook choi kyung Uk Jung Ho-kyung Chun Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

AIM:To investigate the survival outcomes of secondaryhepatectomy for recurrent colorectal liver metastases(CRLM).METHODS:From October 1994 to December 2009,patients with CRLM who underwent surgical treatment with curative intent were *** were divided into two groups:patients who underwent primary hepatectomy(Group 1)and those who underwent secondary hepatectomy for recurrent CRLM(Group 2).RESULTS:Survival and prognostic factors were analyzed.A total of 461 patients were included:406patients in Group 1 and 55 patients in Group *** a median 39-mo(range,3-195 mo)follow-up,there was a significant difference between Groups 1 and 2in terms of disease-free survival(P=0.029)although there was no significant difference in overall survival(P=0.206).Secondary hepatectomy was less effective in patients with multiple recurrent CRLM than primary hepatectomy for initial CRLM(P=0.008).Multiple CRLM and radiofrequency ablation therapy were poor prognostic factors of secondary hepatectomy in multivariate Cox regression analysis(P=0.006,P=0.004,respectively).CONCLUSION:Secondary hepatectomy for single recurrent CRLM is as effective as primary surgical treatment for single recurrent ***,secondary hepatectomy for multiple recurrent CRLM is less effective than that for single recurrent CRLM.

关键词： Colorectal neoplasm Metastasis Recurrence Hepatect

Eosinophilic gastroenteritis presenting as small bowel obstruction: A case report and review of the literature

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World Journal of Gastroenterology 2007年第11期13卷 1758-1760页

作者： min Young Yun Young Up cho In Suh Park Sun Keun choi Sei Joong Kim Seok Hwan Shin kyung Rae Kim Department of Surgery College of Medicine Inha University Incheon Korea Department of Pathology College of Medicine Inha University Incheon Korea

Eosinophilic gastroenteritis is a rare disease of unknown etiology. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract. Recently, the authors experienced a case of eosinophilic gastroenteritis presenting as small bowel obstruction. A 51-year old woman was admitted to our hospital complaining of abdominal pain and vomiting. Physical examination revealed a distended abdomen with diffuse tenderness. Complete blood count showed mild leukocytosis without eosinophilia. Computed tomography confirmed a dilatation of the small intestine with ascites. An emergency laparotomy was performed for a diagnosis of peritonitis due to intestinal obstruction. Segmental resection of the ileum and end to end anastomosis were performed. Histologically, there was a dense infiltration of eosinophils throughout the entire thickness of ileal wall and eosinophilic enteritis was diagnosed. The patient recovered well, and was free from gastrointestinal symptoms at the time when we reported her disease.

关键词： Eosinophilic gastroenteritis Small bowel obstruction Eosinophilic infiltration

Tonsil-derived stem cells as a new source of adult stem cells

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World Journal of Stem Cells 2019年第8期11卷 506-518页

作者： kyung-Ah cho Hyun Jung Lee Hansaem Jeong miri Kim Soo Yeon Jung Hae Sang Park kyung-Ha Ryu Seung Jin Lee Byeongmoon Jeong Hyukjin Lee Han Su Kim Department of microbiology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 South Korea College of Pharmacy Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul 03760 South Korea Department of Otorhinolaryngology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Otorhinolaryngology College of Medicine Hallym University Chuncheon 24252 South Korea Department of Pediatrics College of Medicine Ewha Womans University Seoul 07985 South Korea

Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, TSCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.

关键词： Stem cell Tonsil-derived stem cell Differentiation Endoderm Mesoderm Ectoderm Cell therapy

Gelfoam embolization for distal, medium vessel injury during mechanical thrombectomy in acute stroke: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5668-5674页

作者： Ji Yun Kang kyung Sik Yi Sang-Hoon Cha Chi-Hoon choi Yook Kim Jisun Lee Bum Sang cho Department of Radiology Chungbuk National University HospitalCheongju 28644South Korea College of Medicine and Medical Research Institute Chungbuk National UniversityCheongju 28644South Korea

BACKGROUND Arterial perforation has inevitably increased as endovascular treatments have become more common for intracranial large vessel occlusions,and even distal,medium vessel occlusions.A distal,medium vessel has a tortuous course and thinner wall compared to large arteries,making it more susceptible to ***,we review the treatment strategies for arterial perforation during mechanical thrombectomy,and we report the case of a patient treated with gelfoam *** SUMMARY A 63-year-old woman presented to the emergency department with sudden neurologic symptoms of right hemiparesis and global *** initial National Institutes of Health Stroke Scale score was *** tomography(CT)and CT angiography revealed hyperacute infarction and emergent arterial occlusion of the left middle cerebral artery M2-3 *** endovascular mechanical thrombectomy,arterial rupture *** patient’s vital signs were stable,but delayed angiography showed persistent active ***,selective embolization of the injured artery was performed using *** left vertebral and internal carotid angiography was performed to confirm hemostasis.A localized subarachnoid hemorrhage(SAH)was confirmed on a follow-up CT scan.A repeated CT scan after 12 d showed resolution of the SAH,and rebleeding did not *** Rescue embolization with gelfoam could be considered an additional option in distal,medium vessel perforation.

关键词： Gelfoam Embolization Acute ischemic stroke Mechanical thrombectomy Arterial perforation Case report

Fiber-based quantum-dot pulse oximetry for wearable health monitoring with high wavelength selectivity and photoplethysmogram sensitivity

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npj Flexible Electronics 2023年第1期7卷 413-424页

作者： Ho Seung Lee Byeongju Noh Seong Uk Kong Yong Ha Hwang Ha-Eun cho Yongmin Jeon kyung Cheol choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Biomedical Engineering Gachon UniversitySeongnamRepublic of Korea

Increasing demand for real-time healthcare monitoring is leading to advances in thin and flexible optoelectronic device-based wearable pulse *** previous studies have used OLEDs for this purpose,but did not consider the side effects of broad full-width half-maximum(FWHM)characteristics and single *** this study,we performed SpO_(2)measurement using a fiber-based quantum-dot pulse oximetry(FQPO)system capable of mass production with a transferable encapsulation technique,and a narrow FWHM of about 30 *** on analyses we determined that uniform angular narrow FWHM-based light sources are important for accurate SpO_(2)measurements through multi-layer structures and human skin *** FQPO was shown to have improved photoplethysmogram(PPG)signal sensitivity with no waveguide-mode noise signal,as is typically generated when using a single substrate(30–50%).We successfully demonstrate improved SpO_(2)measurement accuracy as well as all-in-one clothing-type pulse oximetry with FQPO.

关键词： pulse waveguide quantum

Bacteriophage cocktail supplementation improves growth performance,gut microbiome and production traits in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1339-1350页

作者： Santi Devi Upadhaya Je min Ahn Jae Hyoung cho Jin Young Kim Dae kyung Kang Sung Woo Kim Hyeun Bum Kim In Ho Kim Department of Animal Resource and Science Dankook UniversityNo.29 AnseodongCheonanChoongnam 31116South Korea Department of Animal Science North Carolina State University116 Polk HallBox 7621120 W Broughton DrRaleighNC 27695USA

Background:Effective antibiotic alternatives are urgently needed in the poultry industry to control disease *** therapy mainly utilizes lytic phages to kill their respective bacterial hosts and can be an attractive solution to combating the emergence of antibiotic resistance in ***:Five hundred and four,one-day-old broilers(Ross 308)were allotted to 1 of 4 treatment groups in a completely randomized *** consisted of CON(basal diet),PC(CON+0.025%Avilamax®),BP 0.05(CON+0.05%bacteriophage),and BP 0.10(CON+0.10%bacteriophage).Results:A significant linear effect on body weight gain(BWG)was observed during days 1–7,days 22–35,and cumulatively in bacteriophage(BP)supplemented *** BWG tended to be higher(P=0.08)and the feed intake(FI)was increased(P=0.017)in the PC group over CON group.A greater(P=0.016)BWG and trends in increased FI(P=0.06)were observed in the experiment in birds fed PC than CON *** the genus level,the relative abundance of Lactobacillus was decreased in PC(65.28%),while it was similar in BP 0.05 and BP 0.10(90.65%,86.72%)compared to CON(90.19%).At the species level,the relative abundance of Lactobacillus salivarus was higher in BP 0.05(40.15%)and BP 0.10(38.58%)compared to the CON(20.04%)and PC(18.05%).A linear reduction in the weight of bursa of Fabricius(P=0.022)and spleen(P=0.052)was observed in birds fed graded level of BP and an increase(P=0.059)in the weight of gizzard was observed in birds fed PC over BP *** and quadratic responses were observed in redness of breast muscle color in birds fed graded level of ***:The inclusion of the 0.05%and 0.1%BP cocktail linearly improved broiler weight during the first 7 days,22–35 days and cumulatively,whereas 0.05%BP addition was sufficient for supporting immune organs,bursa and spleen as well as enhancing gut microbiome,indicating the efficacy of 0.05%BP as a substitute antibiotic growth promoter in broiler diets.

关键词： Bacteriophage Broiler chickens Gut microbiome Performance

Anemia after gastrectomy for early gastric cancer:Long-term follow-up observational study

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World Journal of Gastroenterology 2012年第42期18卷 6114-6119页

作者： Chul-Hyun Lim Sang Woo Kim Won Chul Kim Jin Soo Kim Yu kyung cho Jae Myung Park In Seok Lee Myung-Gyu choi Kyo-Young Song Hae Myung Jeon cho-Hyun Park Department of Internal Medicine The Catholic University of Korea College of MedicineSeoul 137-701South Korea Department of Surgery The Catholic University of Korea College of MedicineSeoul 137-701South Korea

AIM:To identify the incidence and etiology of anemia after gastrectomy in patients with long-term follow-up after gastrectomy for early gastric ***:The medical records of those patients with early gastric adenocarcinoma who underwent curative gastrectomy between January 2006 and October 2007 were *** with anemia in the preoperative workup,cancer recurrence,undergoing systemic chemotherapy,with other medical conditions that can cause anemia,or treated during follow up with red cell transfusions or supplements for anemia were *** was defined by World Health Organization criteria(Hb min B 12 mia was defined as anemia with concomitant iron *** from vitamin B 12 deficiency was defined as megaloblastic anemia(mean cell volume > 100 fL) with vitamin B 12 *** profile of anemia over 48 mo of follow-up was ***:One hundred sixty-one patients with gastrectomy for early gastric cancer were *** incidence of anemia was 24.5% at 3 mo after surgery and increased up to 37.1% at 48 mo after *** incidence of iron deficiency anemia increased during the follow up and became the major cause of anemia at 48 mo after *** of chronic disease and megaloblastic anemia were *** incidence of anemia in female patients was significantly higher than in male patients at 12(40.0% vs 22.0%,P = 0.033),24(45.0% vs 25.0%,P = 0.023),36(55.0% vs 28.0%,P = 0.004),and 48 mo(52.0% vs 31.0%,P = 0.022) after *** with total gastrectomy showed significantly higher incidence of anemia than patients with subtotal gastrectomy at 48 mo after surgery(60.7% vs 31.3%,P = 0.008).The incidence of iron deficiency was significantly higher in female patients than in male patients at 6(35.4% vs 13.3%,P = 0.002),12(45.8% vs 16.8%,P

关键词： Gastrectomy Stomach neoplasms Anemia Iron deficiency Vitamin B 12 deficiency

Successful endoscopic submucosal dissection of a giant polyp in a 21-month-old female

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World Journal of Gastroenterology 2014年第1期20卷 323-325页

作者： Eun-Young Jung Soon-Ok choi Kwang Bum cho Eun Soo Kim kyung Sik Park Jin-Bok Hwang Department of Pediatric Surgery Division of Gastroenterology and HepatologyKeimyung University School of MedicineDaegu 700-712South Korea Department of Internal Medicine Division of Gastroenterology and HepatologyKeimyung University School of MedicineDaegu 700-712South Korea Division of Gastroenterology and Hepatology Department of PediatricsKeimyung University School of MedicineDaegu 700-712South Korea

Endoscopic submucosal dissection(ESD)is now recognized as the preferred treatment modality for gastrointestinal epithelial lesions.A 21-month-old female was admitted with a giant hyperplastic polyp causing a gastric outlet *** ESD was performed with *** post-procedural course was uneventful without a bleeding *** further study of the feasibility of ESD in early children is necessary,ESD could be applied to avoid laparotomy even in young children.

关键词： Obstruction Endoscopic submucosal dissection Infant Hyperplastic polyp