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Ever-changing endoscopic treatment for early gastric cancer:Yesterday-today-tomorrow

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World Journal of Gastroenterology 2014年第37期20卷 13273-13283页

作者： mi-Young Kim Jun-Hyung cho Joo Young cho Digestive Disease Center Soonchunhyang University Hospital

Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer(EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection(ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis(LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of EGC with high risk of LNM. This review covers the development and challenges of endoscopic treatment for EGC. Moreover, a new microscopic imaging and endoscopic techniques for precise endoscopic diagnosis and minimally invasive treatment of EGC are introduced.

关键词： Endoscopic resection Early gastric cancer Confocal laser endomicroscopy Sentinel node navigation Hybrid natural orifice transluminal endoscopic surgery

Antifi brotic effects of green tea on in vitro and in vivo models of liver fibrosis

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World Journal of Gastroenterology 2009年第41期15卷 5200-5205页

作者： Hye kyung Kim Taik-Hoon Yang Hong-Yon cho Department of Food and Biotechnology Hanseo University Seosan Chungnam 356-706 South Korea Department of Food and Bio-technology College of Science and Technology Korea University Jochiwon Chungnam 339-700 South Korea

AIM: To examine the protective effect of green tea extract (GT) on hepatic fi brosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced ***: HSC-T6, a rat hepatic stellate cell line, was used as an in vitro assay system. Cell proliferation, collagen content, and type 1 collagen expression were examined in activated HSC-T6 cells. Collagen was determined by estimating the hydroxyproline content. In rats with DMN-induced hepatic fi brosis, serum aspartate aminotransferase and alanine aminotransferase concentrations, liver hydroxyproline and lipid peroxides were determined. Pathologic changes were examined by hematoxylin & eosin ***: GT administration prevented the development of hepatic fibrosis in the rat model of DMN-induced liver fi brosis. These results were confi rmed both by liver histology and by quantitative measurement of hepatic hydroxyproline content, a marker of liver collagen deposition. Accordingly, inhibition of proliferation, reduced collagen deposition, and type 1 collagen expression were observed in activated HSC-T6 cells following GT treatment. These results imply that GT reduced the proliferation of activated HSC and down regulated the collagen content and expression of collagen type 1, thereby ameliorating hepatic ***: This study demonstrates that greentea administration can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic f ibrosis.

关键词： Dimethylnitrosamine Green tea extract HSC-T6 cell Liver fibrosis Rat model Type 1 collagen

Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

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Nano-micro Letters 2020年第4期12卷 14-28页

作者： mi Hyeon cho Yan Li Pui‑Chi Lo Hyeri Lee Yongdoo choi Division of Translational Science Research InstituteNational Cancer Center323 Ilsan‑roGoyangGyeonggi 10408Republic of Korea Department of Biomedical Sciences City University of Hong KongTat Chee AvenueKowloonHong KongChina

In this study, a fucoidan-based theranostic nanogel(CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve acti-vatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy(PDT) to induce the com-plete death of cancer cells. A CFN-gel has nanomolar a nity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention e ect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar a nity for the vascular endothelial growth factor, it also provides a significant anti-tumor e ect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high e cacy and specificity.

关键词： Fucoidan Theranostic nanogel P-selectin Activatable Anti-angiogenic

Efficacy of haptic sutured in-the-bag intraocular lens for intraocular lens-capsule complex stability:a comparison of three insertion methods

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1468-1475页

作者： Yang kyung cho Andrew Thomson Balamurali K Ambati Department of Ophthalmology College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Pacific Clear Vision Institute EugeneOregon 97403-1299USA University of Oregon EugeneOregon 97403-1299USA

·AIM:To evaluate the efficacy and stability of haptic sutured in-the-bag intraocular lens(IOL)in eyes with zonular instability.·METHODS:A total 60 eyes of 60 patients were included in this retrospective cohort *** stability in three groups[haptic sutured IOL in the bag,IOL in the bag insertion with haptics oriented toward areas of zonulysis,IOL with capsular tension ring(CTR)in the bag insertion]were compared according to the IOL insertion *** evaluate the IOL stability,the changes of anterior chamber depth(ACD),refraction,contraction of anterior continuous curvilinear capsulotomy(CCC)area,and tilt of IOL were compared.·RESULTS:There was no significant difference in change of ACD(-0.04±0.01 mm in group of haptic sutured IOL,-0.07±0.01 mm in group of CTR insertion)and refraction(0.05±0.05 D in group of haptic sutured IOL,0.37±015 D in group of CTR insertion)between the group of haptic sutured IOL in the bag and CTR insertion *** in comparison of CCC contraction and IOL tilt,CTR insertion group showed less contraction(1.00%±0.52%)and less IOL tilt(2.66°±0.11°)than the group of haptic sutured IOL in the bag(6.32%±1.36%,3.47°±0.11°,respectively).The CTR insertion group showed the least CCC contraction and the least tilt.·CONCLUSION:In eyes with zonular instability,the method of haptic sutured IOL in-the-bag shows comparable stability in ACD and refraction in comparison with IOL with CTR in the bag *** method of IOL only in-thebag insertion shows the largest contraction of CCC and the largest tilt of IOL.

关键词： zonular instability capsular tension ring haptic sutured in the bag

A critical regulation of Th2 cell responses by RORa in allergic asthma

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Science China(Life Sciences) 2021年第8期64卷 1326-1335页

作者： Jeong-Eun Lee Garam cho minkyoung cho Daehong Kim mi-Ock Lee Yeonseok Chung Laboratory of Immune Regulation Research Institute of Pharmaceutical SciencesCollege of PharmacySeoul National UniversitySeoul 08826Republic of Korea BK21 Plus Program College of PharmacySeoul National UniversitySeoul 08826Republic of Korea

Allergic asthma is a chronic inflammatory disease of the lung and the airway,which is characterized by aberrant type 2 immune responses to otherwise unharmful *** the central role of Th2 cells and type 2 cytokines in the pathogenesis of allergic asthma is well documented,the regulation and plasticity of Th2 cells remain incompletely *** using an animal model of allergic asthma in IL-4-reporter mice,we found that Th2 cells in the lung expressed higher levels of Rora than those in the lymph nodes,and that treatment with an RORa agonist SRI 078 resulted in diminished Th2 cell responses in *** determine the T cell-intrinsic role of RORa in allergic asthma in vivo,we established T cell-specific RORa-deficient^(f/f)fyf(Cd4creRora^(f/f))*** intranasal allergen challenges,Cd4creRora^(f/f)mice exhibited a significantly increased Th2 cells in the lungs and the airway and showed an enhanced eosinophilic inflammation compared to littermate control *** with Foxp3^(YFP-cre)Rora^(f/f)mice and CD^(8+)T cell depletion showed that the increased Th2 cell responses in the Cd4creRora^(f/f)mice were independent of Treg cells and CD^(8+)T *** findings demonstrate a critical regulatory role of RORa in Th2 cells,which suggest that RORa agonists could be effective for the treatment of allergic diseases.

关键词： Th2 allergic critical

Simulation of Solid Particle Interactions Including Segregated Lamination by Using MPS Method

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Computer Modeling in Engineering & Sciences 2018年第7期116卷 11-29页

作者： kyung Sung Kim Moo-Hyun Kim Hakun Jang Hee Chen cho Tongmyong University BusanRepublic of Korea Texas A&M University College StationTXU.S.A mississippi State University MSU.S.A

A new MPS(Moving Particle Semi-implicit)method is developed to simulate the behaviors and interactions of multiple fine solid particles as a *** fluid particles are affected by viscosity,so solid particles are affected by *** solid particle dynamics for landslides,dumping,and gravity sorting *** can be difficult to simulate using conventional MPS methods,are modeled in this paper using the developed multi-solid-particle MPS method that benefits from drawing comparisons with the corresponding fluid particle *** present MPS results for dumping solid particles are verified against the corresponding DEM(Discrete Element Method)*** shape and angle of repose for solid particles are shown to be highly dependent on the friction coefficient between *** peculiar phenomenon of segregated lamination(gravity sorting)among grains of different densities has been successfully reproduced using the multi-solid-particle MPS *** quality is found to be dependent on the densities and frictional coefficients of the constituent *** behavior of heterogeneous mixtures of multiple solid and liquid particles are also compared and *** newly developed tool offers a window into the physical dynamics of sedimentology that the broader geoscience community might benefit from.

关键词： Fine solid particle MPS(Moving Particle Semi-implicit) friction force land sliding dumping segregated lamination heterogeneous multiple particles gravity sorting

Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner

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Cellular & Molecular Immunology 2017年第11期14卷 895-908页

作者： kyung-Ah cho Jun-Kyu Lee Yu-Hee Kim minhwa Park So-Youn Woo kyung-Ha Ryu Department of microbiology School of MedicineEwha Womans UniversitySeoul 07985Republic of Korea Department of Pediatrics School of MedicineEwha Womans UniversitySeoul 07985Republic of Korea

Effector B cells are central contributors to the development of autoimmune disease by activating autoreactive T cells,producing pro-inflammatory cytokines and organizing ectopic lymphoid ***,IL-10-producing regulatory B(Breg)cells have pivotal roles in maintaining immunological tolerance and restraining excessive inflammation in autoinflammatory ***,regulating the equilibrium between antibody-producing effector B cells and Breg cells is critical for the treatment of autoimmune *** this study,we investigated the effect of human palatine tonsil-derived mesenchymal stem cells(T-MSCs)on estradiol(E2)-induced B-cell responses in vivo and in *** of T-MSC into E2-treated mice alleviated B-cell-mediated immune responses and increased the population of IL-10-producing Breg cells.T-MSCs regulated the B-cell populations by producing Epstein–Barr virus(EBV)-induced 3(EBI3),one of the two subunits of IL-35 that is the well-known inducer of Breg *** demonstrate a critical role of EBI3(IL-35)in vitro by depleting EBI3 in T-MSCs and by adding exogenous IL-35 to the culture *** together,our data suggest that IL-35-secreting MSCs may become an attractive therapeutic to treat B-cell-mediated autoimmune diseases via expanding Breg cells.

关键词： autoimmune disease B cells IL-35 mesenchymal stem cells

Prediction of gas pulsation of an industrial compressor

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Journal of Central South University 2013年第10期20卷 2735-2740页

作者： Heuicheol Kim mi-Gyung cho Jaehong Park Cheolho Bai Jaesool Shim School of Mechanical Engineering Yeungnam University Department of Media Engineering Tongmyong University MEMS-Bio Team Korea National NanoFab Center 305 806 Korea

The measurement and prediction of gas pulsations are performed along the discharge pipeline of a reciprocating compressor for a refrigerator. A regression based experimental model of the one-dimensional acoustic field is developed. First, the conventional method for gas pulsation measurement and prediction, which separates the incident and reflected wave of acoustic waves traveling in the frequency domain, is discussed. Then, regression based on our proposed simple model, which is able to predict gas pulsation compared to the conventional method, is introduced for the analysis of a reciprocating compressor(The conventional method requires the value of sound speed in the piping line for the reciprocating compressor). A numerical prediction is made for the regression method. Three power spectrum values along the discharge pipeline are used for analysis, and two values are used for verification. Our results are in a good agreement with the conventional method.

关键词： gas pulsation reciprocating compressor discharging piping line regression model

High-index-contrast photonic structures:a versatile platform for photon manipulation

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Light(Science & Applications) 2022年第11期11卷 2617-2632页

作者： Young-Bin Kim Jin-Woo cho Yun-Jo Lee Dukkyu Bae Sun-kyung Kim Department of Applied Physics Kyung Hee UniversityYonginGyeonggido 17104Republic of Korea Hexa Solution Co. LtdSuwonGyeonggi-do 16229Republic of Korea

In optics,the refractive index of a material and its spatial distribution determine the characteristics of light ***,exploring both low-and high-index materials/structures is an important consideration in this *** cavities,which are defined as low-index bases,exhibit a variety of unusual or even unexplored optical characteristics and are used in numerous functionalities including diffraction gratings,localised optical antennas and low-loss *** this report,we discuss the fabrication of hollow cavities of various sizes(O.2-5μm in diameter)that are supported by conformal dielectric/metal shells,as well as their specific applications in the ultraviolet(photodetectors),visible(light-emitting diodes,solar cells and metalenses),near-infrared(thermophotovoltaics)and mid-infrared(radiative coolers)*** findings demonstrate that hollow cavities tailored to specific spectra and applications can serve as versatile optical platforms to address the limitations of current optoelectronic ***,hollow cavity embedded structures are highly elastic and can minimise the thermal stress caused by high *** such,future applications will likely include high-temperature devices such as thermophotovoltaics and concentrator photovoltaics.

关键词： versatile index ultraviolet