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Recombinant tissue plasminogen activator plus heparin compared with heparin alone for patients with acute submassive pulmonary embolism: one-year outcome

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Journal of Geriatric Cardiology 2013年第4期10卷 323-329页

作者： Yu-hong mi Ying Liang Yan-Hui Lu Ya-min Li Wen-Xu Liu Wang Qian Emergency Intensive Care Unit in Respiration Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Ultrasound Cardiography Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Nuclear Medicine Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

OBJECTIVE: To evaluate the long-term effects of thrombolysis on patients with submassive pulmonary embolism (PE)。 METHODS: Data of 136 patients with acute submassive PE and low risk of bleeding were prospectively collected from January 2005 to October 2011 in a single medical center。 Patients received recombinant tissue plasminogen activator (r-tPA) plus low molecular weight heparin (LMWH, TT group, n = 79) or LMWH alone (AT group, n = 57), depending on treating physician's recommendation and patient's preference。 Echocardiography was performed at admission, 24 h, 6 and 12 months to evaluate right ventricular function。 Computed tomography pulmonary angiography (CTPA) and lung perfusion scan were performed on admission, at 7 days, 6 and 12 months to evaluate clot burden。 RESULTS: Seventy-nine patients received r-tPA plus LMWH (TT group) while 57 received LMWH alone (AT group)。 The baseline characteristics and risk factors did not differ between the two groups。 Respiratory rate, heart rate, and systolic blood pressure improved within two hours in both groups。 Systolic pulmonary arterial pressure and tricuspid regurgitation improved to a greater extent in the TT group at 24 h, and at 12 months (P milar in both groups (2.5% in TT vs。 1.8% in AT)。 The rates of minor hemorrhages were 6.3% in TT group and 1.8% in AT group (P < 0.05)。 In submassive PE patient who has low risk of bleeding, thrombolysis plus anticoagulation can lead to greater improvement of right ventricular dysfunction and clot burden reduction as compared to anticoagulation therapy alone。

关键词： Anticoagulation Bleeding Pulmonary embolism Right ventricle dysfunction Thrombolysis

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Size and temperature effects on band gaps in periodic fluid-filled micropipes

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Applied Mathematics and Mechanics(English Edition) 2021年第9期42卷 1219-1232页

作者： Jun hong Zhuangzhuang HE Gongye ZHANG Changwen mi Jiangsu Key Laboratory of Engineering Mechanics School of Civil EngineeringSoutheast UniversityNanjing 210096China

A new model is proposed for determining the band gaps of flexural wave propagation in periodic fluid-filled micropipes with circular and square thin-wall cross-sectional shapes, which incorporates temperature, microstructure, and surface energy effects. The band gaps depend on the thin-wall cross-sectional shape, the microstructure and surface elastic material constants, the pipe wall thickness, the unit cell length, the volume fraction, the fluid velocity in the pipe, the temperature change,and the thermal expansion coefficient. A systematic parametric study is conducted to quantitatively illustrate these factors. The numerical results show that the band gap frequencies of the current non-classical model with both circular and square thin-wall cross-sectional shapes are always higher than those of the classical model. In addition,the band gap size and frequency decrease with the increase of the unit cell length according to all the cases. Moreover, the large band gaps can be obtained by tailoring these factors.

关键词： band gap couple stress surface energy size effect conveying fluid thermal load

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DICE:An Effective Query Result Cache for Distributed Storage Systems

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Journal of Computer Science & Technology 2010年第5期25卷 933-944页

作者： Jun-Ki min Member, A CM mi-Young Lee School of Computer Science and Engineering Korea University of Technology and Education Byeongcheon-myeon Cheonan Chungnam 330-708 Korea Cloud Computing Research Department Electronics and Telecommunications Research Institute (ETRI) Daejeon 305-700 Korea

Due to the proliferation of Internet and Intranet,the distributed storage systems have received a lot of attention. These systems span a large number of machines and store huge amount of data for a lot of *** the distributed storage systems,a row can be directly accessed using a row *** concentrate on a problem of efficient processing of queries whose predicate is on a column but not a row *** this paper,we present a cache management technique,called DICE which maintains query results of range queries to support the next range *** accelerate the search time of the cached query results,we use modified Interval Ski *** addition,we devise a novel cache replacement policy since DICE maintains an interval rather than a data *** our cache replacement policy considers the properties of intervals,our proposed technique is more efficient than traditional buffer replacement *** experimental result demonstrates the efficiency of our proposed technique.

关键词： distributed system range query query caching Interval Skip List cache replacement

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An effective method to generate controllable levels of ROS for the enhancement of HUVEC proliferation using a chlorin e6-immobilized PET film as a photo-functional biomaterial

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Regenerative Biomaterials 2021年第2期8卷 94-103页

作者： Seung Hee hong min-Ah Koo mi Hee Lee Gyeung mi Seon Ye Jin Park HaKyeong Jeong Dohyun Kim Jong-Chul Park Cellbiocontrol Laboratory Department of Medical Engineering Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 Project Department of Medical Device Engineering and Management Yonsei UniversityCollege of MedicineSeoul 03722Republic of Korea

Reactive oxygen species(ROS)are byproducts of cellular metabolism;they play a significant role as secondary messengers in cell *** cells,high concentrations of ROS induce apoptosis,senescence,and contact inhibition,while low concentrations of ROS result in angiogenesis,proliferation,and cytoskeleton ***,controlling ROS generation is an important factor in cell *** designed a chlorin e6(Ce6)-immobilized polyethylene terephthalate(PET)film(Ce6-PET)to produce extracellular ROS under red-light *** application of Ce6-PET films can regulate the generation of ROS by altering the intensity of light-emitting diode *** confirmed that the Ce6-PET film could effectively promote cell growth under irradiation at 500 μW/cm^(2) for 30 min in human umbilical vein endothelial *** also found that the Ce6-PET film is more efficient in generating ROS than a Ce6-incorporated polyurethane film under the same ***6-PET fabrication shows promise for improving the localized delivery of extracellular ROS and regulating ROS formation through the optimization of irradiation intensity.

关键词： reactive oxygen species chlorin e6 dopamine covalent bond HUVEC proliferation

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Synthesis of Al-doped ZnO Nanorods via microemulsion Method and Their Application as a CO Gas Sensor

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Journal of Materials Science & Technology 2015年第6期31卷 639-644页

作者： Sang Kyoo Lim Seong Hui hong Sung-Ho Hwang Won mi Choi Soonhyun Kim Hyunwoong Park min Gi Jeong Division of Nano & Bio Technology Daegu Gyeongbuk Institute of Science and Technology(DGIST) School of Energy Engineering Kyungpook National University Department of Advanced Organic Materials Engineering Yeungnam University

Aluminum doped ZnO(AZO) nanorods were synthesized by microemulsion method with different types of *** phase and the morphology of the above nanorods were investigated by scanning electron microscopy(SEM) and X-ray diffraction(XRD).SEM observations showed that the ZnO nanorods had diameters around about 50—200 nm and lengths up to several *** CO gas sensing properties of the AZO nanorods were tested at operating temperatures of 200,300,350 and 400 ℃.It was found that AZO nanorods based sensor exhibited the highest sensitivity to CO at 350℃.

关键词： Zinc oxide Nanorod microemulsion Aluminum CO and g

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye Xue-Zhi Zhang Jian-Xiang Liu hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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Influence of group B streptococcus and vaginal cleanliness on the vaginal microbiome of pregnant women

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World Journal of Clinical Cases 2022年第34期10卷 12578-12586页

作者： Qi Liao Xiao-Fen Zhang Xin mi Feng Jin hong-min Sun Qing-Xuan Wang Department of Obstetrics and Gynecology Shunyi Maternal and Children’s Hospital of Beijing Children’s HospitalBeijing 101300China Department of Genetics and Reproductive Medicine Shunyi Maternal and Children’s Hospital of Beijing Children’s HospitalBeijing 101300China

BACKGROUND The vaginal microbiome plays a critical role in the health of pregnant women and their *** B Streptococcus(GBS)and vaginal cleanliness significantly affect the vaginal microecosystem and are closely associated with vaginal *** To explore the effects of GBS status and vaginal cleanliness on vaginal *** We collected 160 vaginal swabs from pregnant women and divided them into the following four groups based on GBS status and vaginal cleanliness:GBS-positive+vaginal cleanliness I–II degree,GBS-negative+vaginal cleanliness I–II degree,GBS-positive+vaginal cleanliness III–IV degree,and GBS-negative+vaginal cleanliness III–IV *** were subjected to 16S rRNA gene amplicon *** Alpha diversity analysis showed that the Shannon index did not significantly differ between the four *** identified significant variation in taxa abundance between the GBS-positive and GBS-negative groups and between the vaginal cleanliness I–II degree and III–IV degree *** coordinate analysis and non-metric multidimensional scaling analysis further confirmed the microbial diversity of the four ***,the linear discriminant analysis demonstrated that Lactobacillus jensenii and Actinobacteria were strongly associated with GBS-positive status,and Lactobacillus iners,Lactobacillaceae,Lactobacillus,Lactobacillales,Bacilli and Firmicutes were closely correlated with GBS-negative *** GBS status and vaginal cleanliness significantly affect vaginal microbiome differences in pregnant *** findings provide instructional information for clinical antibiotic treatment in pregnant women with different GBS statuses and vaginal cleanliness degrees.

关键词： Vaginal microbiome Pregnant women 16S rRNA gene amplicon sequencing Group B Streptococcus Vaginal cleanliness

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Successful cardiopulmonary resuscitation combined with thrombolysis for massive pulmonary embolism during peri-cardiac arrest

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World Journal of Emergency Medicine 2022年第6期13卷 495-499页

作者： Mei-ning Li Yan-hui Lu Ya-min Li Hai-yun Wang Yu-hong mi Emergency and Critical Care Center Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vascular DiseaseBeijing 100029China

Dear editor,Pulmonary thromboembolism(PTE)has become the third most lethal type of thrombotic disease in the world.[1]Thrombolysis has been advised for high-risk PTE patients,however due to its unique pathophysiology,which differs from other atherosclerotic diseases,this can still be a challenge for PTE patients.[2]We reported two cases with a high-risk of PTE that had the onset of or progressed to cardiac arrest(CA)during hospitalization and were successfully managed with cardiopulmonary resuscitation(CPR)combined with thrombolytic therapy.

关键词： resuscitation cardiac embolism

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Influence of Silver Contents on the Tribological Properties of Ni-Based Self-Lubricating Coatings by Atmospheric Plasma Spraying

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Acta Metallurgica Sinica(English Letters) 2017年第8期30卷 801-808页

作者： Bo Li Jun-hong Jia Yi-min Gao hong-Jian Guo min-min Han Wen-Zhen Wang State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences State Key Laboratory for Mechanical Behaviour of Materials School of Materials Science and Engineering Xi'an Jiaotong University

The NiCrAlY-Mo-Ag composite coatings were prepared by atmospheric plasma spraying. The tribological properties of the composite coatings were investigated from 25 to 900 ℃ in details. The tribo-layer formed on the worn surface of the composite coatings and influenced the tribological properties at different temperatures. The addition of silver could effectively decrease the friction coefficient and wear rate of the coatings at the wide range of temperature. The rubbing process could form the nickel molybdate and promote the formation of silver molybdate within the worn surfaces at high temperature. The synergistic lubricating effects of nickel molybdate and silver molybdate are attributed to the improvement of the tribological properties of coatings at high temperature.

关键词： Plasma spraying Tribologicai properties Synergistic lubricating High temperature

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久坐与社区老年人下肢肌力:跌倒恐惧与年龄的中介和调节作用

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中国组织工程研究 2025年第17期29卷 3566-3571页

作者：洪金涛王晶晶李岩松王晨弭守玲上海体育科学研究所(上海市反兴奋剂中心) 上海市200030 青岛大学体育学院山东省青岛市266071 复旦大学附属中山医院心内科上海市心血管病研究所上海市200032 国家放射与治疗临床医学研究中心上海市200032 心脏病全国重点实验室上海市200032 国家卫生健康委缺血性心脏病重点实验室上海市200032 中国医学科学院病毒性心脏病重点实验室上海市200032

背景:人体老龄化进程中,下肢肌肉力量会随着年龄的增长呈现显著的生理性下降,久坐、跌倒恐惧、年龄与下肢肌力之间可能存在一定关联,但它们之间的影响路径与效应关系尚不明确。目的:探究社区老年人久坐和下肢肌肉力量之间的关系,并探讨... 详细信息

背景:人体老龄化进程中,下肢肌肉力量会随着年龄的增长呈现显著的生理性下降,久坐、跌倒恐惧、年龄与下肢肌力之间可能存在一定关联,但它们之间的影响路径与效应关系尚不明确。目的:探究社区老年人久坐和下肢肌肉力量之间的关系,并探讨跌倒恐惧和年龄在上述两者关系中的作用。方法:共招募331名60岁及以上的上海市社区老年人。采用问卷调查法收集基本信息、人口学资料等;采用国际身体活动问卷-短卷评估久坐时间,采用30 s坐站测试测量下肢肌力,采用中文版国际跌倒效能量表测评跌倒恐惧。对数据进行描述统计、相关分析、基于回归的路径分析和中介效应检验。结果与结论:最终以318名老年人[78.9%为女性,平均年龄(67.8±5.5)岁]的有效数据纳入分析,其中久坐时间≥3 h的185名,<3 h的133名。①久坐和跌倒恐惧呈正相关关系(P<0.01),下肢肌力和久坐(P<0.01)、跌倒恐惧(P<0.001)均呈负相关关系。②久坐显著负向预测下肢肌力(β=-0.125,P<0.05),久坐显著正向预测跌倒恐惧(β=0.182,P<0.01);跌倒恐惧显著负向预测下肢肌力(β=-0.293,P<0.001)。③跌倒恐惧在久坐和下肢肌力之间起中介作用(β=-0.053,95%CI:-0.100至-0.018)。④久坐对跌倒恐惧的预测效应具有统计学意义(β=0.164,P<0.01),这说明年龄调节了久坐对跌倒恐惧的影响。

关键词：老年群体老龄化肌肉萎缩肌肉力量久坐跌倒恐惧中介效应调节作用

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