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Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease

Translational Neurodegeneration 2022年第1期11卷 547-565页

作者： Dongmei Chen Guihua Lan Ruomeng Li Yingxue Mei Xindong Shui Xi Gu Long Wang Tao zhang Chen-Ling Gan Yongfang Xia Li Hu Yuan Tian mi zhang Tae Ho Lee Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases Institute for Translational MedicineSchool of Basic Medical SciencesFujian Medical UniversityFuzhou 350122FujianChina Department of Pathology Longyan First Hospital Affiliated to Fujian Medical UniversityLongyan 364000FujianChina.

Background:Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of Alzheimer’s disease(AD).Melatonin has been shown to prevent tau hyperphosphorylation in cellular and animal ***,the molecular mechanisms by which melatonin attenuates tau hyperphosphorylation and tau-related pathologies are not fully ***:Immunofluorescence,immunoblotting analysis and thioflavin-S staining were employed to examine the effects of early and late treatment of melatonin on tau-related pathology in hTau mice,in which nonmutated human tau is overexpressed on a mouse tau knockout ***-throughput microRNA(miRNA)sequencing,quantitative RT-PCR,luciferase reporter assay and immunoblotting analysis were performed to determine the molecular ***:We found that both early and late treatment of melatonin efficiently decreased the phosphorylation of soluble and insoluble tau at sites related to ***,melatonin significantly reduced the number of neurofibrillary tangles(NFTs)and attenuated neuronal loss in the cortex and ***,using miRNA microarray analysis,we found that miR-504-3p expression was upregulated by melatonin in the hTau *** administration of miR-504-3p mimics dramatically decreased tau phosphorylation by targeting p39,an activator of the well-known tau kinase cyclin-dependent kinase 5(CDK5).Compared with miR-504-3p mimics alone,co-treatment with miR-504-3p mimics and p39 failed to reduce tau ***:Our results suggest for the first time that melatonin alleviates tau-related pathologies through upregulation of miR-504-3p expression by targeting the p39/CDK5 axis and provide novel insights into AD treatment strategies.

关键词： Alzheimer’s disease Melatonin miR-504-3p p39 Tau

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Transcriptome analysis reveal key genes potentially related to high fiber strength in a Gossypium Mustelinum introgression line IL9

Transcriptome analysis reveal key genes potentially related ...

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2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： Qi Chen mi zhang Baohua Wang School of life science Nantong University

Cotton（Gossypium L.） is one of the most important crops in the world, with the innovation of modern textile technology and the general increase of consumers’ demand, higher requirements on cotton fiber quality are necessary in China, and it is urgent for us to improve the quality of cotton fiber. In this research, a pair of near-isogenic lines, namely a Gossypium mustelinum introgression line（IL9） and a G. hirsutum line PD94042 were developed through backcross breeding. PD94042 is the recurrent parent, whereas IL9 is an introgression line with segments introgressed from a wild tetroploid cotton G. mustelinum, which is characterized by high fiber strength and long fiber length. In order to identify candidate genes related to fiber quality traits, we conducted fiber transcriptome analysis with PD94042 and IL9 at two development periods of 17 dpa and 21 dpa. The scatter diagram was used for DEGs in four kinds of samples. Gene Ontology（GO） enrichment analysis of the annotated DEGs showed that these DEGs are rich in two main biological processes（cellular process and metabolic process） and two main molecular functions（binding and catalytic activity）. KEGG pathway analysis showed that these DEGs are mainly enriched in metabolic pathways and biosynthesis of secondary metabolites. A total of 46 DEGs were chosen for the candidate genes by comparing PD94042 and IL9 because of the specialty of the materials, and the results of qRT-PCR analysis for 12 selected DEGs were consistent with that of transcriptome analysis.

关键词： Gossypium mustelinum introgression lines fiber quality traits key genes transcriptome analysis

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FuzzerAPP:Android应用程序组件通信鲁棒性测试

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计算机研究与发展 2017年第2期54卷 338-347页

作者：张密杨力张俊伟西安电子科技大学网络与信息安全学院西安710071

针对Android应用程序的安全性问题,提出一种基于模糊测试方法的组件通信鲁棒性测试方案.首先构造测试集和测试用例,随后将测试用例发送给目标应用程序并收集测试数据,最后对测试数据进行分析.依据测试方案设计并实现了模糊测试工具Fuzze... 详细信息

针对Android应用程序的安全性问题,提出一种基于模糊测试方法的组件通信鲁棒性测试方案.首先构造测试集和测试用例,随后将测试用例发送给目标应用程序并收集测试数据,最后对测试数据进行分析.依据测试方案设计并实现了模糊测试工具FuzzerAPP,进而对常用应用程序进行鲁棒性测试.通过对测试数据的分析,发现发送特殊Intent可以导致应用程序的崩溃,甚至引发系统服务的级联崩溃.此外,发现测试集中多款应用程序存在测试模块暴露的问题,可能会导致隐私泄露、拒绝服务等严重安全问题.最后,通过与其他工具的对比,表明测试方法的有效性和测试工具的实用性.

关键词：安卓组件通信模糊测试鲁棒性测试模块暴露

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中国翻译研究走出去之探讨——Target主编Dirk Delabastita教授访谈录

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外语教学理论与实践 2016年第2期 91-94,F0004页

作者：张汨北京航空航天大学鲁汶大学

Dirk Delabastita(德克·德拉巴斯蒂塔)是比利时那慕尔大学教授和国际著名翻译期刊Target(《目标》)的主编,他主要从事幽默语、双关语和莎士比亚翻译研究等,而作为《目标》期刊主编,他对翻译研究方面文章审稿和发表等也拥有丰富的经验... 详细信息

Dirk Delabastita(德克·德拉巴斯蒂塔)是比利时那慕尔大学教授和国际著名翻译期刊Target(《目标》)的主编,他主要从事幽默语、双关语和莎士比亚翻译研究等,而作为《目标》期刊主编,他对翻译研究方面文章审稿和发表等也拥有丰富的经验。本访谈中他向笔者介绍了《目标》期刊的历史渊源、投稿要注意的方面、审稿和发表流程,同时对中国翻译研究如何更好地走向国际舞台提出了自己的见解;笔者希望该访谈的内容能够使国内学仁对翻译学国际期刊有更深入的了解,同时对中国翻译研究的走出去起到相应的推动作用。

关键词： Target期刊翻译研究走出去方法途径

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考古学期刊的h指数分析——基于CSSCI(1998-2007年度)数据

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西南民族大学学报（人文社会科学版） 2009年第5期30卷 74-77页

作者：张宓南京大学信息管理系

本文基于CSSCI中1998-2007年度的引文数据,计算各类中文考古学期刊的h指数,并将其排名分别与被引篇次排名和影响因子排名进行对比分析,还对Hirsch核心从年份分布及高质量论文方面进行分析。

关键词： h指数期刊评价考古学学术期刊

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Patterns and driving factors of WUE and NUE in natural forest ecosystems along the North-South Transect of Eastern China

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Journal of Geographical Sciences 2011年第4期21卷 651-665页

作者： SHENG Wenping REN Shujie YU Guirui FANG Huajun JIANG Chunming zhang mi Key Laboratory of Ecosystem Network Observation and Modeling Synthesis Research Center of Chinese Ecosystem Research Network Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China Graduate University of Chinese Academy of Sciences Beijing 100094 China Institute of Applied Ecology CAS Shenyang 110016 China

From July 2008 to August 2008, 72 leaf samples from 22 species and 81 soil samples in the nine natural forest ecosystems were collected, from north to south along the North-South Transect of Eastern China （NSTEC）. Based on these samples, we studied the geographical distribution patterns of vegetable water use efficiency （WUE） and nitrogen use efficiency （NUE）, and analyzed their relationship with environmental factors. The vegetable WUE and NUE were calculated through the measurement of foliar δ 13C and C/N of predominant species, respectively. The results showed：（1） vegetable WUE, ranging from 2.13 to 28.67 mg C g-1 H2O, increased linearly from south to north in the representative forest ecosystems along the NSTEC, while vegetable NUE showed an opposite trend, increasing from north to south, ranging from 12.92 to 29.60 g C g-1 N. （2） Vegetable WUE and NUE were dominantly driven by climate and significantly affected by soil nutrient factors. Based on multiple stepwise regression analysis, mean annual temperature, soil phosphorus concentration, and soil nitrogen concentration were responding for 75.5% of the variations of WUE （p0.001）. While, mean annual precipitation and soil phosphorus concentration could explain 65.7% of the change in vegetable NUE （p0.001）. Moreover, vegetable WUE and NUE would also be seriously influenced by atmospheric nitrogen deposition in nitrogen saturated ecosystems. （3） There was a significant trade-off relationship between vegetable WUE and NUE in the typical forest ecosystems along the NSTEC （p0.001）, indicating a balanced strategy for vegetation in resource utilization in natural forest ecosystems along the NSTEC. This study suggests that global change would impact the resource use efficiency of forest ecosystems. However, vegetation could adapt to those changes by increasing the use efficiency of shortage resource while decreasing the relatively ample one. But extreme impacts, such as heavy nitrogen deposition, would break this trade

关键词： water use efficiency (WUE) nitrogen use efficiency (NUE) δ 13C C/N North-South Transect of Eastern China (NSTEC)

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Construction of a Talent Cultivation Mode for Traditional Chinese Medicine Nursing Inheritance

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Journal of Integrative Nursing 2019年第3期1卷 132-137页

作者： Ye LI Jing LIU Ling TANG Chun-Mei zhang mi zhang Otolaryngology Head and Neck SurgeryPeking University First HospitalBeijing100034China Outpatient Department Beijing University of Chinese Medicine Third Affiliated HospitalBeijing10029China Department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijing 100078China

Objective:To explore and build traditional Chinese medicine(TCM)nursing inheritance on the talent training scheme,the foundation for cultivating outstanding talents of TCM nursing ***:The modified Delphi method was used for conducting two rounds of consultation with 15 TCM nursing experts to formulate training ***:The questionnaire recovery rates of two rounds of expert enquiry were 100.00%,with high experts enthusiasm,experts coefficients were 0.83 and 0.81,*** coordination coefficient were 0.26 and 0.30,respectively(P<0.01).After two rounds of expert consultation,the TCM nursing inheritance talent training scheme was finally formed,including 3 first-level indicators,7 second-level indicators and 24 third-level ***:Construction of talent cultivating program of TCM nursing inheritance is scientific and feasible,with a certain reference value.

关键词： Traditional Chinese medicine nursing Inheritance Talent cultivation

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Development of rheometer for semi-solid high-melting point alloys

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China Foundry 2005年第4期2卷 268-274页

作者： LIU Wen XING Shu-min zhang Lin zhang mi-lian zhang Hai-ying Beijing Jiaotong University Beijing 100044 P. R. China Zhengzhou Vocation Technical College Zhengzhou 450121 Henan P.R. China

A rheometer for semi-solid high-melting point alloys was developed based on the principle of a double-bucket rheometer, with which the solidifying of semi-solid high-melting point alloy melt could be effectively controlled by the control of temperature and the outer force-field; and different microstructures have also been obtained. This rheometer can be used to investigate the rheological behavior under different conditions by changing the Theological parameters. By way of full-duplex communication between the computer and each sensor, automatic control of the test equipment and real- time measurement of rheological parameters were realized. Finally, the influencing factors on torque are also quantitatively analyzed .

关键词： rheometer rheological behavior high-melting alloys semi-solid

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高温高压作用下致密砂岩三轴压缩试验

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石油与天然气地质 2017年第6期38卷 1172-1179页

作者：邓辉张咪邓通海张茜成都理工大学地质灾害防治与地质环境保护国家重点实验室四川成都610059 成都理工大学环境与土木工程学院四川成都610059

为探究温度和围压对四川盆地新场气田须家河组二段致密石英砂岩力学性质和破坏方式的影响,利用MTS815电液伺服控制刚性试验机还原其地下深部高温高压的地质环境进行常规三轴压缩试验。结果表明,温度一定时,试样的三轴抗压强度和弹性模... 详细信息

为探究温度和围压对四川盆地新场气田须家河组二段致密石英砂岩力学性质和破坏方式的影响,利用MTS815电液伺服控制刚性试验机还原其地下深部高温高压的地质环境进行常规三轴压缩试验。结果表明,温度一定时,试样的三轴抗压强度和弹性模量平均值均随围压增大而增大;围压一定时,随试验温度升高,60℃之前,致密石英砂岩试样的粘聚力呈二次非线性减小,内摩擦角、三轴抗压强度及弹性模量呈非线性增加;60℃之后,各参数变化趋势则与之前相反。60℃是温度-围压共同作用条件下试样力学性质变化的温度节点。在0~100 MPa围压范围、15~150℃温度范围内,致密砂岩试样变形破坏类型取决于温度和围压,围压对岩石强度的影响程度大于温度。按试样破坏过程和破坏方式,可将应力-应变曲线大致分为5种类型,破坏方式包含拉张破坏、剪切破坏、剪胀破坏和拉张-剪切破坏。

关键词：围压变形破坏类型常规三轴压缩试验致密石英砂岩新场气田四川盆地

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Natural products against HIV latency

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Acupuncture and Herbal Medicine 2021年第1期1卷 10-21页

作者： Kouharu Otsuki mi zhang Wei Li Faculty of Pharmaceutical Sciences Toho UniversityMiyama 2-2-1FunabashiChibaJapan

Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic ***,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to ***,the development of new treatment methods aimed at a complete cure for HIV is *** leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir *** LRAs can be obtained from natural resources,including plants and marine *** this review,we provide an overview of natural products used to eliminate HIV latency.

关键词： Diterpenoid Human immunodeficiency virus Human immunodeficiency virus latency Shock and kill Thymelaeaceae

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