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A highly stable polymolybdate-based metal-organic framework as an anode material for lithium ion battery

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A highly stable polymolybdate-based metal-organic framework ...

Insights into spinal muscular atrophy from molecular biomarkers

中国化学会第七届全国结构化学学术会议

作者： Qing Huang Tao Wei mi zhang Long-zhang Dong Ya-Qian Lan School of Chemistry and Materials Science Nanjing Normal University

Anovelpolyoxometalate(POM)-basedmetal-organicframework(MOF),[ε PMoMoO(OH)Zn][TPT]·2TPT(Zn-ε-keggin-TPT,TPT=tris-(4-pyridyl)triazine),consists ofπ-πstacking supported two-dimensional(2D)layers,whose Zn-ε-keggin fragments and TPT ligands act as nodes and linkers,*** compound exhibits excellent stability in air

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Pyrrole-imidazole polyamides induce the tumor cells apoptosis by targeting c-kit gene

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Pyrrole-imidazole polyamides induce the tumor cells apoptosi...

重庆主城区三峡水域优势藻类的演替及其增殖行为研究

第十一届全国化学生物学学术会议

作者： mi zhang Jing Liang Ling Xu Qian zhang Xuqiong Xiong Yanling Wu Wen zhang Lab of Chemical Biology and Molecular Drug Design College of Pharmaceutical ScienceZhejiang University of Technology Institute of Drug Development & Chemical Biology Zhejiang University of Technology Lab of Molecular Immunology Virus Inspection DepartmentZhejiang Provincial Center for Disease Control and Prevention

Pyrrole-imidazole Polyamide（PIP）[1-2] can specifically bind in the minor-groove of DNA, which has been demonstrated in a variety of biological applications, including anti-cancer activity, regulation of gene expression and translation. c-kit is one of the type III receptor tyrosine kinase（RTK） family members and plays an important role in tumor growth, proliferation, differentiation and cell apoptosis, but its mutations and overexpression cause dysfunction leading to tumors. In this study, we design six kinds of PIP to inhibit c-kit gene expression. Finally, the experimental results by EMSA, CD, RTCA, Western blot, RT-PCR, flow cytometry show that PIP 5 has optimal intracellular and extracellular effect. Hence PIP can achieve therapeutic effects by inhibiting c-kit expression.

关键词： Pyrrole-imidazole Polyamides c-kit gene Target therapy

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环境科学 2008年第7期29卷 1838-1843页

作者：刘信安张密芳重庆大学化学化工学院重庆400044

通过在三峡水系中重庆主城段的长江与嘉陵江现场布点、采样和分析自然水体中的藻类,在实验室内分别模拟氮磷比、光照和流速对嘉陵江水体中藻类生长的影响,发现在不同TN/TP和光照强度的静水环境中蓝藻和绿藻生长迅速,硅藻消亡很快,其它... 详细信息

通过在三峡水系中重庆主城段的长江与嘉陵江现场布点、采样和分析自然水体中的藻类,在实验室内分别模拟氮磷比、光照和流速对嘉陵江水体中藻类生长的影响,发现在不同TN/TP和光照强度的静水环境中蓝藻和绿藻生长迅速,硅藻消亡很快,其它藻类变化不大,总藻细胞密度最大可达107个/L以上;而在0.03 m/s左右的缓流下总藻细胞增长最明显,但密度也只能达到106个/L,硅藻比例提高,当流速进一步加快,蓝藻和绿藻比例降低.显然,优势藻类随水文情势发生演替.总藻密度分别与TN/TP、流速拟合的可决系数R2均在0.93以上,与光照强度的拟合效果次之.自然状态下两江的现场水样分析还表明:嘉陵江总藻密度大于长江,硅藻占绝对优势,其次为绿藻和蓝藻,与实验室测试结果相符.

关键词：三峡库区藻类水华实验模拟藻类生长

中国政治话语译介效果的译者期待与读者反馈双重检验研究——以《习近平谈治国理政》核心概念“自我革命”英译修订为例

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外语研究 2024年第4期41卷 82-87页

作者：张汨张威北京外国语大学英语学院北京100089

新形势下,中国政治话语的对外翻译成为战略重点,对相关核心概念的目标读者开展调查能够为提升国际传播效能提供参考。本文以《习近平谈治国理政》核心概念“自我革命”及其英译修订版本为考察对象,通过译者口述阐释修订期待并基于母语... 详细信息

新形势下,中国政治话语的对外翻译成为战略重点,对相关核心概念的目标读者开展调查能够为提升国际传播效能提供参考。本文以《习近平谈治国理政》核心概念“自我革命”及其英译修订版本为考察对象,通过译者口述阐释修订期待并基于母语读者调查验证修订效果。研究发现,该核心概念英译修订接受效果与译者期待相匹配。基于调查结果,本文从接受者和传播者两方面总结了借鉴受众反馈和明晰规范译法对中国政治话语国际传播的双重启示。

关键词：《习近平谈治国理政》核心概念翻译修订译者期待读者反馈

Preparation of Mg-Li-La alloys by electrolysis in molten salt

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Transactions of Nonferrous Metals Society of China 2012年第1期22卷 16-22页

作者： zhang mi-lin CAO Peng HAN Wei YAN Yong-de CHEN Li-jun Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China

An electrochemical method was used to prepare Mg-Li-La alloys in a molten LiCl-KCl-KF-MgCl2 containing La2O3 at 943 K. The results showed preparation of Mg-Li-La alloys by electrolysis is feasible. The Mg-Li-La alloys were analyzed by means of X-ray diffraction （XRD）, optical micrograph （OM） and scanning electron microscopy （SEM）. XRD analysis indicates that α＋Mg17La2, α＋β＋Mg17La2 and β＋LaMg3 Mg-Li-La alloys with different lithium and lanthanum contents were obtained via galvanostatic electrolysis. The microstructures of typical α＋Mg17La2 and β＋LaMg3 phases of Mg-Li-La alloys were characterized by optical microscopy （OM） and scanning electron microscopy （SEM）. The analysis of energy dispersive spectrometry （EDS） shows that the element of Mg distributes homogeneously in the Mg-Li-La alloy and the element of La mostly exists at grain boundaries to restrain the grain growth rate due to the larger ionic radius and lower electronegativity compared with Mg.

关键词： Mg-Li-La alloys La2O3 electrolysis microstructure

Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS:a multicenter randomized controlled trial

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2164-2171页

作者： Lifeng Wang Zheng zhang Ruonan Xu Xicheng Wang Zhanjun Shu Xiejie Chen Siyu Wang Jiaye Liu Yuanyuan Li Li Wang mi zhang Wei Yang Ying Wang Huihuang Huang Bo Tu Zhiwei Liang Linghua Li Jingxin Li Yuying Hou ming Shi Fu-Sheng Wang Treatment and Research Center for Infectious Diseases Fifth Medical Center of Chinese PLA General HospitalBeijingChina lnstitute of Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third Peopled HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Yunnan Provincial Hospital of Infectious Diseases KunmingChina Xinjiang Uygur Autonomous Regional the Sixth People's Hospital UrumqiChina Guangzhou Eighth Peopled Hospital Guangzhou Medical UniversityGuangzhouChina NHC Key Laboratory of Enteric Pathogenic microbiology Jiangsu Provincial Center for Disease Control and PreventionNanjingChina

We examined the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC)infusion for immune nonresponder(INR)patients with chronic HIV-1 infection,who represent an unmet medical need even in the era of efficient antiretroviral therapy(ART).Seventy-two INR patients with HIV were enrolled in this phase II randomized,double-blinded,multicenter,placebo-controlled,dose-determination trial(NCT01213186)from May 2013 to March *** were assigned to receive high-dose(1.5 x 106/kg body weight)or low-dose(0.5 x 106/kg body weight)hUC-MSC,or *** clinical and immunological parameters were monitored during the 96-week follow-up *** found that hUC-MSC treatment was safe and *** with baseline,there was a statistical increase in CD4+T counts in the high-dose(P<0.001)and low-dose(P<0.001)groups after 48-week treatment,but no change was observed in the control ***-Meier analysis revealed a higher cumulative probability of achieving an immunological response in the low-dose group compared with the control group(95.8%vs.70.8%,P=0.00A).However,no significant changes in CD4/CD84-T counts and CD4/CD8 ratios were observed among the three *** summary,hUC-MSC treatment is ***,the therapeutic efficacy of hUC-MSC treatment to improve the immune reconstitution in INR patients still needs to be further investigated in a large cohort study.

关键词： CD4/CD8 transfusion randomized

SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants

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Virologica Sinica 2024年第1期39卷 173-176页

作者： Fan Shen Chun Liang Cui-Xian Yang Ying Lu An-Qi Li Ying Duan mi zhang c Ren-Rong Tian a Xing-Qi Dong Yong-Tang Zheng Wei Pang Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming650223China University of Chinese Academy of Sciences Beijing100049China Yunnan Provincial Infectious Disease Hospital Kunming650399China Department of Pathogen Biology and Immunology Faculty of Basic Medical ScienceKunming Medical UniversityKunming650500China

Dear Editor,COVID-19 inactivated vaccines have been extensively administered ***,the majority of the Chinese population has experiencedbreakthrough infections from SARS-CoV-2 ancestral,Delta or Omicronvariants over the past three years,particularly during the wave of Omicron BA.5 and BA.7 variants at the end of 2022(Zhu et al.,2023).Subsequently,new Omicron variants,such as BQ.1,BQ.1.1,XBB,XBB.1/XBB.1.9,and XBB.1.5/XBB.1.9.1,are emerging in China(Yueetal.,2023;Zhu et al.,2023).Therefore,it is an urgentneed and a publichealth imperative to assess the extent of the immunoprotection established in this population.

关键词： breakthrough neutral Omi

基于Citespace Ⅲ的国内近10年民族地区乡村旅游发展研究的可视化分析

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中国农业资源与区划 2017年第8期38卷 230-236页

作者：卢世菊张咪中南民族大学管理学院

近年来,基于民族地区独特的旅游资源优势,我国民族地区乡村旅游呈风起云涌之势,引起了众多学者的关注。[目的]为了推动民族地区乡村旅游在理论和实践中有进一步的发展,[方法]采用CitespaceⅢ引文可视化分析软件,从研究机构、研究作者、... 详细信息

近年来,基于民族地区独特的旅游资源优势,我国民族地区乡村旅游呈风起云涌之势,引起了众多学者的关注。[目的]为了推动民族地区乡村旅游在理论和实践中有进一步的发展,[方法]采用CitespaceⅢ引文可视化分析软件,从研究机构、研究作者、研究主题、研究前沿等方面对我国民族地区乡村旅游发展研究状况进行文献计量分析。[结果]研究机构多为西部旅游院校,以西南民族地区为主要研究区域;研究作者之间交流合作较少,缺乏权威著作;研究内容主要集中在新农村建设、乡村旅游的可持续发展、民族文化的开发保护以及乡村旅游开发等几个方面;研究前沿主要体现在研究内容的深度化和研究视角的多元化等方面。[结论]在今后的研究工作中,加强区域之间、学者之间的交流与合作,深入贯彻全域旅游发展,立足微观层面,解决实际问题。通过分析总结希望能够对民族地区乡村旅游发展的实践推进和理论研究提供有益的参考和借鉴。

关键词：民族地区乡村旅游研究综述新农村建设可持续发展