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Fast and Accurate Thoracic SPECT Image Reconstruction

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 881-904页

作者： Afef Houimli Issam ben mhamed Bechir Letaief Dorra ben-Sellem University of Tunis El Manar Higher Institute of Medical Technologies of TunisResearch Laboratory in Biophysics and Medical Technologies LR13ES07Tunis1006Tunisia University of Tunis Higher National School of Engineers of TunisSignal Image and Energy Management Laboratory:LR13 ES03 SIMEENSITMontfleury1008Tunisia Faculty of Medicine of Tunis University of Tunis El ManarTunis1007Tunisia Nuclear Medicine Department Salah AZAIEZ InstituteTunis1006Tunisia

In Single-Photon Emission Computed Tomography(SPECT),the reconstructed image has insufficient contrast,poor resolution and inaccurate volume of the tumor size due to physical degradation ***,nonstationary filtering of the projection or the slice is one of the strategies for correcting the resolution and therefore improving the quality of the reconstructed SPECT *** paper presents a new 3D algorithm that enhances the quality of reconstructed thoracic SPECT images and reduces the noise level with the best degree of *** suggested algorithm is composed of three *** first one consists of denoising the acquired projections using the benefits of the complementary properties of both the Curvelet transformand theWavelet transforms to provide the best noise *** second step is a simultaneous reconstruction of the axial slices using the 3D Ordered Subset Expectation Maximization(OSEM)*** last step is post-processing of the reconstructed axial slices using one of the newest anisotropic diffusion models named Partial Differential Equation(PDE).The method is tested on two digital phantoms and clinical bone SPECT images.A comparative study with four algorithms reviewed on state of the art proves the significance of the proposed *** simulated data,experimental results show that the plot profile of the proposed model keeps close to the original one compared to the other ***,it presents a notable gain in terms of contrast to noise ratio(CNR)and execution *** proposed model shows better results in the computation of contrast metric with a value of 0.68±7.2 and the highest signal to noise ratio(SNR)with a value of 78.56±6.4 in real *** experimental results prove that the proposed algorithm is more accurate and robust in reconstructing SPECT images than the other *** could be considered a valuable candidate to correct the resolution of bone in the SPECT images.

关键词： SPECT image resolution correction thoracic SPECT images wavelet transform curvelet transforms 3D-OSEM PDE

Modeling and Analysis of Low Frequency Noise in Ion-Field-Effect Transistors Sensors

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Modeling and Numerical Simulation of Material Science 2014年第3期4卷 119-127页

作者： Jihen Chermiti Sawsen Azzouzi Mounir ben Ali mhamed Trabelsi Abdelhamid Errachid Higher Institute of Applied Sciences and Technology of Sousse University of Sousse Sousse Tunisia Higher Institute of Applied Sciences and Technology of Sousse University of Sousse Sousse Tunisia Laborory Materials Molecules and Applications University of Carthage IPEST Tunis Tunisia Institute of Analytical Sciences of Lyon Université Claude Bernard Lyon 1 Lyon France

Ions Sensitive Field Effect Transistors (ISFETs) are becoming the platform sensors for important chemical and biomedical applications. However, the accuracy of ISFET output measurement is greatly affected by the presences of low-frequency noise, drift and slow response of the device. This requires more safety in measured results and the tools of analysis. In this paper, we present fundamental limits on the sensitivity of ISFETs micro-sensors, arising from intrinsic and extrinsic noise sources. We developed an algorithm in MATLAB in order to model the frequency analysis of the 1/f noise in ISFET sensor using Hooge theory. We have shown that the 1/f noise of the ISFETs sensors is due to both the electrochemical system (pH solution) and the MOS component (canal size, insulator thickness). The temperature effect on the ISFET noise and the signal conditioning are also performed.

关键词： Top-Spice Modeling Ion Sensitive Field Effect Transistor Low-Frequency Noise

Extranodal Tuberculosis of Head and Neck: A Series of 29 Cases

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Journal of Tuberculosis Research 2019年第3期7卷 148-158页

作者： Sameh Mezri Ghassen Chebbi Manel Chebbi Sabrine Maamouri Rania ben mhamed Khemaies Akkari ENT Department Military Hospital of Tunis Tunis Tunisia

Background: Despite a re-increase in the incidence of tuberculosis, extranodal location on head and neck remains rare. Clinical symptomatology is non-specific and even data from paraclinical explorations often pose the problem of differential diagnosis with tumor pathology. Methods: We report a series of 29 cases of extranodal tuberculosis collected over a period of 32 years [1986-2018] in ENT department of the military hospital of Tunis. Results: Rhinosinusopharyngeal involvement was predominant (45%) followed by glandular involvement (14%). Diagnosis was histopathological in most cases. Concomitant pulmonary tuberculosis was detected in two cases and spinal lumbar in one case. Treatment was medical in all cases. Conclusion: Clinical presentation of extranodal tuberculosis is various and non-specific. Neoplastic pathology is the main differential diagnosis. However, diagnosis should be systematically raised in endemic countries. Treatment is essentially medical.

关键词： Tuberculosis ENT Extranodal

Predictive Factors of Multiple Hospitalizations for Acute Exacerbations of COPD

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Open Journal of Respiratory Diseases 2019年第3期9卷 61-74页

作者： Ahmed ben Saad Nesrine Fahem Asma Migaou Saousen Cheikh mhamed Samah Joobeur Naceur Rouatbi Pulmonology Department Fattouma Bourguiba Teaching Hospital Monastir Tunisia

Background: Multiple hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with considerable morbidity and mortality. Objectives: To identify predictive factors of multiples hospitalizations for AECOPD. Methods: This is a retrospective single center study of consecutive patients with COPD hospitalized at the Department of Respiratory Medicine between January 1990 and December 2015. We calculated for each patient the mean number of hospitalizations for AECOPD/year (H/y). We distinguished 2 groups (G) of patients. G1: <2 H/y and G2: ≥2 H/y. Predictors of multiple admissions identified by univariate analysis were included in the multivariate analysis. Results: The study included 1167 COPD patients (mean age 67 ± 10 years, 97% males). Three hundred six (26%) COPD patients had a mean number of hospitalizations per year ≥ 2. Multivariate logistic regression analysis demonstrated that an mMRC ≥ 2 (Odd ratio [OR] 1.8, 95% confidence interval [CI] 1.08 - 2.99, p = 0.022), a low PaO2 (PaO2 OR 0.97, 95% CI 0.95 - 0.99, p = 0.007) and frequent exacerbations (OR 2.95, 95% CI 2.56 - 3.39, p < 0.001) are independent factors associated with multiple admissions for AECOPD. Conclusions: An mMRC ≥ 2, a low PaO2 and frequent exacerbations are independently associated with multiple hospitalizations for AECOPD. The identification of these high risk COPD patients will be helpful in the decision of intervention strategies.

关键词： COPD Hospitalization COPD Exacerbation Risk Factors Hospital Readmission

Infrathyroidian hydatid cyst: Diagnostic difficulties and therapeutic management, a case report

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World Journal of Otorhinolaryngology 2015年第2期5卷 78-81页

作者： Ali Mardassi Nabil Mathlouthi Hajer Mbarek Chiraz Halouani Sameh Mezri Cyrine Zgolli Ghassen Chebbi Rania ben mhamed Khemaies Akkari Sonia benzarti Ear Nose and Throat Department of the Military Hospital

Hydatidosis is a cosmopolitan anthropozoonose common to humans and many mammals. The cervical localization is rare even in endemic countries. We report a case of cervical hydatidosis located in the infra-thyroidian region. The diagnosis was suspected on clinical and radiological examinations(Ultrasonography, computed tomography-scan). The surgical removal of the cyst was difficult because of the inflammatory tissue around the mass. The confirmation of the diagnosis was obtained by the histopathological examination. During the followup, a local recurrence of the disease was diagnosed after 9 mo treated successfully by surgery.

关键词： Hydatidosis Anthropozoonose Cervical localization Ultrasonography Surgery Histopathology

Nasopharyngeal carcinoma: Long term follow-up of 83 patients

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World Journal of Otorhinolaryngology 2015年第2期5卷 65-70页

作者： Ali Mardassi Nabil Mathlouthi Nawel Hlila Chiraz Halouani Sameh Mezri Cyrine Zgolli Ghassen Chebbi Rania ben mhamed Khemaies Akkari Sonia benzarti ENT Department Military Hospital of Tunis

AIM: To analyzes the clinical, paraclinical, therapeutical and evolutive features of nasopharyngeal carcinoma(NPC).METHODS: All the patients treated for a nasopharyngeal carcinoma between 2000 and 2013 in the Ear-NoseThroat Department of the Military Hospital of Tunis, Tunisia were collected in this study. Eighty-three patients signed a written consent prior to study enrollment. The gender ratio(M/W) was 6.5 with a median age of 49 years(range 16-85). The median follow up time was 37 mo(18 to 108 mo). The evolution, during and after the end of therapy, was assessed on clinical biological and radiological exams. Different parameters were analyzed and compared to other series: complications of chemo and radiotherapy, recurrence of the disease, metastasis and overall survival ***: Of the 83 patients of our study, 15% had T1 tumors, 20% had T2, 23% had T3 and 41% had T4 disease. At the time of diagnosis, 14% of the patients had a cranial nerve deficit. Only 12 patients had exclusive radiotherapy and the remaining of our patients had concomitant radio chemotherapy. Iatrogenic complications were diagnosed in 53% of the cases: radioepithelitis(28%), radiodermatitis(9%), xerostomia(17%), osteoradionecrosis(3%), cerebral radionecrosis(1%) and a pancytopenia(17%). The follow-up period varied from 18 to 108 mo(average: 37 mo). During the first six months after treatment, a persistence of the disease was found in 11% of patients, while a recurrence of the cancer was diagnosed in 6% and distant metastasis developed in 14% of the patients. Fifteen patients needed remedial chemotherapy for a relapse or metastasis and five had palliative chemotherapy for very advanced cases. We report 3 cases of death during the follow-up. CONCLUSION: Despite its excellent radio-chemotherapy response, and general good prognosis, a careful follow-up of patients with NPC is necessary to detect and manage any iatrogenic complication, locoregional recurrence or metastasis of the disease.

关键词： Nasopharyngeal carcinoma Cranial nerve Radiotherapy Chemotherapy Metastasis

Synchronous carcinoma of head and neck: 2 cases report

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World Journal of Otorhinolaryngology 2015年第2期5卷 74-77页

作者： Ali Mardassi Nabil Mathlouthi Nawel Hlila Chiraz Halouani Sameh Mezri Cyrine Zgolli Ghassen Chebbi Rania ben mhamed Khemaies Akkari Sonia benzarti Ear Nose and Throat Department the Military Hospital Tunis

Multiple primary cancers are becoming an increasingly frequent situation and are often the source of many diagnostic and therapeutic difficulties. We report the case of two patients diagnosed with head and neck synchronous carcinomas. The first case is a 33-yearold man with a history of a keratinizing squamous cell carcinoma of the eye lid and who was operated 4 mo later from a mucoepidermoid carcinoma of thesubmandibular salivary gland. The second case is a 71-year-old woman who underwent a total parotidectomy for a mucoepidermod carcinoma of the left parotid gland and who consulted 2 mo later for epistaxis. The explorations concluded to a squamous cell carcinoma of the nasopharynx. The patient had a complementary radiotherapy. No local neither distant recurrence of the two tumors has been detected after a follow-up of 36 mo in the first case and 24 mo in the second one.

关键词： Carcinoma Submandibular gland Parotid gland Nasopharynx Radiotherapy

Complicated sinusitis in children:18 cases report

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World Journal of Otorhinolaryngology 2015年第1期5卷 30-36页

作者： Ali Mardassi Nabil Mathlouthi Hajer Mbarek Chiraz Halouani Sameh Mezri Cyrine Zgolli Ghassen Chebbi Rania ben mhamed Khemaies Akkari Sonia benzarti ENT Department Military Hospital

AIM: To precise the clinical characteristics of rhinosinusitis in pediatric population, their complications and therapeutic ***: All infants younger than 15 years adm-itted to the Ear, Nose and Throat Department of the Military Hospital of Tunis, Tunisia for a complicated rhinosinusitis between 2006 and 2013 were evaluated. Data related to patients and the disease were collected and analyzed: past medical history, complaints, clinical examination, radiologic findings, therapeutic management and evolution. RESULTS: Eighteen cases were identified with a mean age of 5.1 years(5 mo to 13 years)(SD ± 3.1). A male preponderance was noted in 72% of the cases. Rhinorrhea and fever were the most common presenting symptoms. Radiological explorations(computed tomography-scan ± magnetic resonance imaging) have been practiced for all of our patients. Orbital involvement was found in 77% of the cases associated with meningitis in 2 cases. Antibiotherapy was prescribed to all our patients. Surgical procedures were performed in 8 cases: endoscopic sinus surgery and/or external drainage of orbital abscess. After an average follow-up period of 2.5 years, 3 of our patients were lost. The ophthalmic sequelae noted in 3 cases(16%) were permanent and caused important functional and social problems. A favourable outcome has been noted in the rest of our patients. CONCLUSION: Rhinosinusitis can be extremely severe in children requiring urgent radiological imaging and aggressive treatment to avoid orbital and intracranial complications.

关键词： Rhinosinusitis Children Imaging Orbit Meningitis Antibiotherapy Surgery