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Oximes： Unrecognized Chameleons in Genera and specialized Plant Metabolism

Molecular Plant 2018年第1期11卷 95-117页

作者： mette s rensen Elizabeth H.J. Neilson Birger Lindberg Moiler Plant Biochemistry Laboratory Department of Plant and Environmental Sciences University of Copenhagen Thorvaldsensvej 40 Frederiksberg C Copenhagen Denmark VILLUM Center for Plant Plasticity University of Copenhagen Thorvaldsensvej 40 Frederiksberg C Copenhagen Denmark Center for synthetic Biology University of Copenhagen Thorvaldsensvej 40 Frederiksberg C Copenhagen Denmark

Oximes （R1R2C=NOH） are nitrogen-containing chemical constituents that are formed in species representing all kingdoms of life. In plants, oximes are positioned at important metabolic bifurcation points between general and specialized metabolism. The majority of plant oximes are amino acid-derived metabolites formed by the action of a cytochrome P450 from the CYP79 family. Auxin, cyanogenic glucosides, glucosinolates, and a number of other bioactive specialized metabolites including volatiles are produced from oximes. Oximes with the E configuration have high biological activity compared with Z-oximes. Oximes or their derivatives have been demonstrated or proposed to play roles in growth regulation, plant defense, pollinator attraction, and plant communication with the surrounding environment. In addition, oxime-derived products may serve as quenchers of reactive oxygen species and storage compounds for reduced nitrogen that may be released on demand by the activation of endogenous turnover pathways. As highly bioactive molecules, chemically synthesized oximes have found versatile uses in many sectors of society, especially in the agro- and medical sectors. This review provides an update on the structural diversity, occurrence, and biosynthesis of oximes in plants and discusses their role as key players in plant general and specialized metabolism.

关键词： structural diversity CYP79 auxin cyanogenic glucosides volatile organic compounds E-oxime Z-oxime

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长期交通噪声暴露与糖尿病发生率:一项队列研究

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环境与职业医学 2013年第5期30卷 349-349页

作者： mette s rensen Zorana J.Andersen Rikke *** Thomas Becker Anne Tj nneland Kim Overvad Ole Raaschou-Nielsen

[背景]正常城市水平的道路交通噪声会导致紧张和睡眠障碍。过多的紧张激素和睡眠质量及持续时间的下降均可能增加患2型糖尿病的风险。[目的]研究长期暴露于住宅道路交通噪声是否与糖尿病风险增加有关联。[方法]以人口为基础的丹麦饮食... 详细信息

[背景]正常城市水平的道路交通噪声会导致紧张和睡眠障碍。过多的紧张激素和睡眠质量及持续时间的下降均可能增加患2型糖尿病的风险。[目的]研究长期暴露于住宅道路交通噪声是否与糖尿病风险增加有关联。[方法]以人口为基础的丹麦饮食、癌症与健康队列研究于1993--1997午纳入57053名50～64岁的参加者。从入组到2006年期间，从全国糖尿病登记系统中确定有3869例发生糖尿病，平均随访时间为9．6年。通过国家登记册，确定这些患者在1988年至2006年间的现有及既往居住地址，并且对所有住址的道路交通噪声进行评估。

关键词：空气污染队列糖尿病流行病学交通噪声

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User Driven Innovation in the Building Process

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Tsinghua science and Technology 2008年第S1期13卷 248-254页

作者： Per Christiansson Kistian Birch sφrensen mette Rφdtness mette Abrahamsen Lars Ostenfeld Riemnann Morten Alsdorf Aalborg University Department of Civil Engineering Rambφll A/s Arkitema A/s

During the late years there has been an ever-increasing focus on the possibilities to change the building process to raise quality on the final building products as well as the activities of actors involved in the building process. One reason for this interest is the new opportunities evolving due to introduction of advanced information and communication technology (ICT). The paper focuses on creative changes of the building process powered by user driven innovation activities. An overview of existing user driven innovation methodologies is given as well experiences from the ongoing Virtual Innovation in Construction (VIC) project. One important driving force for change is the opportunity for users to develop and articulate real needs concerning for example different functionalities of a building and its parts, but also on artifacts supporting the actual needs capture and requirements formulation during building design. A general methodological framework and meta ontology for Virtual Innovation in Construction is presented as well as findings from implementation of the method.

关键词： innovation user driven needs requirements creative design construction system development

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Compensating active power imbalances in power system with large-scale wind power penetration

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Journal of Modern Power systems and Clean Energy 2016年第2期4卷 229-237页

作者： Abdul BAsIT Anca D.HANsEN Mufit ALTIN Poul E.sØrensen mette GAMsT Department of Wind Energy Technical University of DenmarkFrederiksborgvej 3994000 RoskildeDenmark sino-Danish Center for Education and Research Niels JensensVej 28000 AarhusDenmark Energinet.dk Tonne Kjærsvej 657000 FredericiaDenmark

Large-scale wind power penetration can affect the supply continuity in the power *** is a matter of high priority to investigate,as more regulating reserves and specified control strategies for generation control are required in the future power system with even more high wind power *** paper evaluates the impact of large-scale wind power integration on future power *** active power balance control methodology is used for compensating the power imbalances between the demand and the generation in real time,caused by wind power forecast *** methodology for the balance power control of future power systems with large-scale wind power integration is described and exemplified considering the generation and power exchange capacities in2020 for Danish power system.

关键词： Wind power plant simBa Centralized or decentralized combined heat and power plant Automatic generation control

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Application of heat shock protein expression for detecting natural adaptation and exposure to stress in natural populations

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Current Zoology 2010年第6期56卷 703-713页

作者： Jesper Givskov sφrensen National Environmental Research Institute Aarhus UniversityDepartment of Terrestrial Ecology

Heat-shock proteins （HsPs） play an undisputed role for maintaining cellular functioning under environmental challenges and protein denaturing conditions. Compelling evidence points to an evolutionary important role of HsPs and a strict evolutionary control of these proteins as a balance between benefits and costs. While there is a great potential for using HsP expression for detecting natural adaptation and exposure to stress in natural populations, some obstacles and key issues await investigation. From an ecological perspective these key issues needs to be resolved in order to fully appreciate the complex responses and adaptations to stress and to increase our understanding of HsPs and other molecular chaperones for stress adaptation and potential use as biomarkers. Here, the current knowledge and understanding of HsPs is reviewed and a number of key issues including the interpretation of elevated HsP levels, the complications of extrapolating between laboratory and field conditions, the effects of choice of traits and methodology and the larger intra-and extracellular networks of interactions that HsPs participate in are discussed [Current Zoology 56 （6）： 703-713, 2010].

关键词： Biomarker Hsp Molecular chaperone Thermal adaptation Thermal stress

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The 21st International Geological Congress, Norden 1960

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Episodes 2007年第2期30卷 125-130页

作者： Henning sφrensen

The 21st International Geological Congress （IGC） was held in Copenhagen, Denmark in 1960, but was organised jointly by the five Nordic countries. It attracted 2,386 geoscientists and 948 accompanying members and was up till then the largest scientific congress held in Copenhagen. It also had more members than any previous IGC. The paper presents an overview of the practical arrangements, the lecture sessions, and the excursions, and evaluates the outcome of the Congress. The meeting took place at the threshold of the formulation of the plate-tectonic concept, which, however, was hardly discernible in the Congress Prigs. The 430 oral presentations and 407 printed papers nevertheless supplied new information in many fields of geology, examples of which are mentioned in the present paper.

关键词：国际会议地质会议地理科学北欧国家

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Plasma metabolomic profiles and immune responses of piglets after weaning and challenge with ***

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Journal of Animal science and Biotechnology 2014年第3期5卷 291-298页

作者： sugiharto sugiharto mette s Hedemann Charlotte Lauridsen Department of Animal science Faculty of Science and TechnologyAarhus University Faculty of Animal science and Agriculture Diponegoro UniversitySemarang Central Java 50275Indonesia

Background： The processes of weaning and exposure to pathogenic bacteria induce stress responses, which may alter the metabolism. In this study, we investigated the changes in plasma metabolites and immune responses in piglets in response to the stress induced by weaning and Escherichia coli challenge. Results： Fecal dry matter decreased （P = 0.003） and nearly half （44.4%） the piglets developed diarrhea on day 2 and 3 postweaning. The concentration of plasma immunoglobulin A was higher （P 〈 0.001） on day 11 postweaning than on day 0 or 4 postweaning. The levels of white blood cells increased continuously （P〈 0.001） from day 0 to day 11 postweaning. Differences in the percentages of neutrophils （P = 0.029） and lymphocytes （P = 0.022） were seen, but the neutrophil/lymphocyte ratio did not differ in the period after weaning. A clear separation of the metabolomic profile data for day 0 and day 4 postweaning was observed with a principal components analysis （PCA） scores plot, and the data for day 11 were located between those for day 0 and day 4 postweaning. The plasma levels of proline, taurine, and carnitine were higher, whereas those of betaine, creatine, L-arginine and acetylcarnitine were lower on day 4 postweaning than on day 0. Levels of lysophosphatidylcholine and phosphatidylcholine were either higher or lower after weaning, depending on the chain lengths or characters of these metabolites. Conclusions： Our results show a clear separation in the plasma metabolomic profiles of piglets that corresponded to the fecal responses to stress on the piglets induced by weaning or exposure to a pathogen （E. coli）. These plasma metabolite profiles suggest that the challenges induced proinflammatory responses in the piglets, resulting in postweaning diarrhea, which was associated with higher concentrations of IgA in the plasma.

关键词： E. coil F18 Immunity Metabolite Piglet Weaning

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miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia-an exploratory study

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Translational Neurodegeneration 2016年第1期5卷 40-51页

作者： sofie sølvsten sørensen Ann-Britt Nygaard Thomas Christensen Department of Neurology Copenhagen University HospitalNordsjællands HospitalDyrehavevej 293400 HillerødDenmark Department of Clinical Biochemistry Copenhagen University HospitalNordsjællands HospitalDyrehavevej 293400 HillerødDenmark

Background:MicroRNAs(miRNAs)are small non-coding RNA molecules that function as posttranscriptional regulators of gene *** of miRNAs in cerebrospinal fluid(CsF)and blood have just started gaining attention as a novel diagnostic tool for various neurological *** purpose of this exploratory investigation was to analyze the expression of miRNAs in CsF and blood of patients with Alzheimer’s disease(AD)and other neurodegenerative disorders in order to identify potential miRNA biomarker candidates able to separate AD from other types of ***:CsF was collected by lumbar puncture performed on 10 patients diagnosed with AD and 10 patients diagnosed with either vascular dementia,frontotemporal dementia or dementia with Lewy *** samples were taken immediately *** RNA was extracted from cell free fractions of CsF and plasma,and a screening for 372 known miRNA sequences was carried out by real time quantitative polymerase chain reactions(miRCURY LNA™Universal RT miRNA PCR,Polyadenylation and cDNA synthesis kit,Exiqon).Results:Fifty-two miRNAs were detected in CsF in at least nine out of ten patients in both *** these,two miRNAs(let-7i-5p and miR-15a-5p)were found significantly up-regulated and one miRNA(miR-29c-3p)was found significantly down-regulated in patients with AD compared to *** hundred and sixty-eight miRNAs were frequently detected in the blood,among which miR-590-5p and miR-142-5p were significantly up-regulated and miR-194-5p was significantly down-regulated in AD patients compared to ***:Detection of miRNA expression profiles in blood and in particular CsF of patients diagnosed with different types of dementia is feasible and it seems that several expressional differences between AD and other dementia types do exist when measured in a clinically relevant *** this explorative pilot study,the deregulated miRNAs in CsF of AD patients may be associated with relevant targ

关键词： Alzheimer’s disease Dementia Neurodegenerative disease miRNA expression Diagnostic biomarker Cerebrospinal fluid Blood

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Changes in various metabolic parameters in blood and milk during experimental Escherichia coli mastitis for primiparous Holstein dairy cows during early lactation

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Journal of Animal science and Biotechnology 2015年第1期6卷 37-46页

作者： Kasey M Moyes Torben Larsen Peter s?rensen Klaus L Ingvartsen Department of Animal and Avian sciences University of Maryland142 Animal Sciences BuildingMD 20742-231120910 College ParkMDUSA Department of Animal science Faculty of Science and TechnologyAarhus University

Background： The objective of this study was to characterize the changes in various metabolic parameters in blood and milk during IMI challenge with Escherichia coli （E. coh. for dairy cows during early lactation. Thirty, healthy primiparous Holstein cows were infused （h = 0） with -20-40 cfu of live E. coil into one front mammary quarter at -4-6 wk in lactation. Daily feed intake and milk yield were recorded. At -12, 0, 3, 6, 12, 18, 24, 36, 48, 60, 72, 96, 108, 120, 132, 144, 156, 168, 180 and 192 h relative to challenge rectal temperatures were recorded and quarter foremilk was collected for analysis of shedding of E. coil Composite milk samples were collected at -180, -132, -84, -36, -12, 12, 24, 36, 48, 60, 72, 84, 96, 132 and 180 h relative to challenge （h=0） and analyzed for lactate dehydrogenase （LDH）, somatic cell count, fat, protein, lactose, citrate, beta-hydroxybutyrate （BHBA）, free glucose （fglu）, and glucose-6-phosphate （G6P）. Blood was collected at -12, 0, 3, 6, 12, 18, 24, 36, 60, 72, 84, 132 and 180 h relative to challenge and analyzed for plasma non-esterified fatty acids （NEFA）, BHBA and glucose concentration. A generalized linear mixed model was used to determine the effect of IMI challenge on metabolic responses of cows during early lactation. Results： By 12 h, E. coli was recovered from challenged quarters and shedding continued through 72 h. Rectal temperature peaked by 12 h post-challenge and returned to pre-challenge values by 36 h post-IMI challenge. Daily feed intake and milk yield decreased （P 〈0.05） by 1 and 2 d, respectively, after mastitis challenge. Plasma BHBA decreased （12 h, P 〈0.05） from 0.96± 1.1 at 0 h to 0.57±0.64 mmol/L by ]8 h whereas concentration of plasma NEFA （78 h） and glucose （24 h） were significantly greater, 11 and 27%, respectively, after challenge. In milk fglu, lactose, citrate, fat and protein yield were lower whereas yield of BHBA and G6P were higher after challenge when compared to pre-challenge values. Conclusion

关键词： Cow Early lactation Escherichia coli Metabolism

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Application of the health risk assessment of acetochlor in the development of water quality criteria

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Journal of Environmental sciences 2021年第12期33卷 48-54页

作者： Wei An Chenhui sang Kristian Marienlund Jensen Peter Borgen sørensen Bin Zhang Min Yang Key Laboratory of Drinking Water science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China sino-Danish College University of Chinese Academy of SciencesBeijing 100190China Department of Bioscience Aarhus UniversityVejlsovej 25PO BOX 314SilkeborgDenmark University of Chinese Academy of sciences Beijing 100049China Department of Mathematical sciences Tsinghua UniversityBeijing 100084China

Acetochlor is a widely used herbicide in agricultural production. studies have shown that acetochlor has obvious environmental hormone effects, and long-term exposure may pose a threat to human health. To quantify the hazards of acetochlor in drinking water, a health risk assessment of acetochlor was conducted in major cities of China based on the data of acetochlor residue concentrations in drinking water. The approach of the species sensitivity Distributions(ssD) method is used to extrapolate from animal testing data to reflect worst case human toxicity. Results show that hazard quotients related to acetochlor residues in drinking water for different age groups range from 1.94 × 10-4 to 6.13 × 10-4, so, there are no indication of human risk. Compared to the total estimated hazard quotient from oral intake of acetochlor, the chronic exposure imputed to acetochlor residues in drinking water in China accounts for 0.4%. This paper recommends 0.02 mg/L to be the maximum acetochlor residue concentration level in drinking water and source water criteria.

关键词： Acetochlor Drinking water source water Contribution rate species sensitivity distributions(ssD)

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