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Immuno-Histochemical Profile of Breast Cancers at the General Hospital of Douala-Cameroon

Open Journal of Obstetrics and Gynecology 2023年第8期13卷 1377-1388页

作者： Ekono Michel Roger Guy Ngaha Yaneu Junie Neng Humphry Tatah messakop yannick Azoumbou Mefant Thérèse Ze Ngbwa Mimi Flore Essome Henri Essola Basile Engbang Jean-Paul Tchente Nguefack Charlotte Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Obstetrics and Gynecology Ebolowa Regional Hospital Ebolowa Cameroon Faculty of Health Sciences University of Buea Buea Cameroon

Introduction: The aim of the study was to describe the immunohistochemical aspects of breast cancers at Douala General Hospital, Cameroon. Methodology: This was a descriptive study with retrospective data collection, conducted from January 1st 2010 and December 31st 2019. It was focused on histologically proven breast cancers followed up at Douala General Hospital. Results: We collected 285 cases of breast cancer, all female, representing an annual frequency of 28.5 cases. The mean age of the patients was 48 ± 13 years. The most frequent histological form was infiltrating ductal carcinoma (83.9%), with grade II predominating (38.6%). Immunohistochemical analyses were performed on 89 patients (31.23%). The triple-negative subtype was the most common class (35.95%), followed by Luminal A (32.60);Human Epidermal Receptor 2-class and Luminal B tumors were observed at a frequency of 13.48% each. Treatment consisted mainly of surgery (78.60%) combined with chemotherapy (65.97%) and/or radiotherapy (63.16%). Hormonal treatment was used in only 10.18% of patients. Targeted therapy was exceptional (4%). Conclusion: Triple-negative phenotype is the most common. However, potentially hormone-sensitive tumors account for almost half of all patients, who are relatively young. Individualized treatments are rare. It is important to systematize these analyses for all breast cancers, with a view to appropriate management in our environment.

关键词： Breast Cancer Immunohistochemistry Douala General Hospital of Cameroon

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