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Effects of titanium addition on structural, mechanical, tribological, and corrosion properties of Al-25Zn-3Cu and Al-25Zn-3Cu-3Si alloys

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Transactions of Nonferrous Metals Society of China 2020年第2期30卷 303-317页

作者： ali Pa?a HEK?MO?LU merve ?ali? Mechanical Engineering Department Engineering Faculty Recep Tayyip Erdo?an University

To investigate the effect of grain refinement on the material properties of recently developed Al-25 Zn-3 Cu based alloys,Al-25 Zn-3 Cu,Al-25 Zn-3 Cu-0.01 Ti,Al-25 Zn-3 Cu-3 Si and Al-25 Zn-3 Cu-3 Si-0.01 Ti alloys were produced by permanent mold casting *** of the alloys were examined by *** and mechanical properties of the alloys were determined by Brinell method and tensile tests,*** characteristics of the alloys were investigated by a ball-on-disc type test *** properties of the alloys were examined by an electrochemical corrosion experimental *** was observed that microstructure of the ternary A1-25 Zn-3 Cu alloy consisted ofα,α+ηandθ(Al2Cu)*** was also observed that the addition of 3 wt.%Si to A1-25Zn-3Cu alloy resulted in the formation of silicon particles in its *** addition of 0.01 wt.%Ti to the Al-25Zn-3Cu and Al-25 Zn-3 Cu-3 Si alloys caused a decrement in grain size by approximately 20%and 39%and an increment in hardness from HRB 130 to 137 and from HRB 141 to 156,*** strengths of these alloys increased from 278 to 297 MPa and from 320 to 336 MPa while their tensile strengths increased from 317 to 340 MPa and from 334 to 352 *** resistance of the alloys increased,but corrosion resistance decreased with titanium addition.

关键词： Al-Zn-Cu alloy as-cast microstructure characterization corrosion fracture friction and wear characteristics mechanical properties

Development of a functional chocolate using gamma-amino butyric acid producer Lacticaseibacillus rhamnosus NRRL B-442

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Food Bioscience 2022年第3期47卷 700-706页

作者： merve Ozer Burcu Ozturk ali Adnan Hayaloglu Sebnem Tellioglu Harsa İzmir Institute of Technology Faculty of EngineeringDepartment of Food EngineeringGulbahçe Campus35430UrlaİzmirTurkey İnönü University Faculty of EngineeringDepartment of Food Engineering44280MalatyaTurkey

The human microbiota is influenced by the immune and nervous systems of the ***-aminobutyric acid (GABA) is known as bioactive compound and it has important physiological functions,such as anti-hypertensive and antidepressant *** acid bacteria (LAB),especially Lactobacillus species are known as the most important GABA producers because of the food-grade *** purpose of this study is to develop a functional chocolate using microencapsulated GABA producer Lacticaseibacillus rhamnosus NRRL B-442 strain for patients having an anxiety ***-in-oil emulsion technique was conducted for microencapsulation using whey-pullulan *** and free *** cell counts were 6.75 and 7.20 log CFU/g in chocolates,respectively,at the end of 60 *** simulated in vitro digestion analysis,survival rate of microencapsulated bacteria in chocolate samples was found at higher percentage (87%) than free bacteria (75%).Furthermore,microencapsulated *** did not affect the physical,chemical,and sensory properties of ***,*** with the highest GABA producing capability may provide insight for an anxiety disorder patient,since this strain has been thought as having a therapeutic effect.A new functional food model was developed for “GutBrain Axis” phenomena since the chocolate could be accepted as a good carrier for GABA producer bacteria.

关键词： Microencapsulation Anxiety disorder Functional food Simulated digestion

Naringin attenuates oxidative stress,inflammation,apoptosis,and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第5期12卷 223-232页

作者： Volkan Gelen Serkan Yıldırım EminŞengül aliÇınar FikretÇelebi merve Küçükkalem Melahat Gök Department of Physiology Faculty of Veterinary MedicineKafkas UniversityKarsTurkey Department of Pathology Faculty of Veterinary MedicineAtatürk UniversityErzurumTurkey Department of Physiology Faculty of Veterinary MedicineAtatürk UniversityErzurumTurkey

Objective:To explore the possible effects of naringin on acrylamide-induced nephrotoxicity in ***:Sprague-Dawley rats weighing 200-250 g were randomly divided into five *** control group was given intragastric(i.g.)saline(1 mL)for 10 *** acrylamide group was given *** in saline(38.27 mg/kg titrated to 1 mL)for 10 *** treatment groups were administered with naringin in saline(50 and 100 mg/kg,respectively)for 10 d and given ***(38.27 mg/kg)1 h after naringin *** naringin group was given ***(100 mg/kg)alone for 10 *** day 11,intracardiac blood samples were obtained from the rats when they were under anesthesia,after which they were *** and creatinine concentrations of blood serum samples were analyzed with an ***-linked immunosorbent assay was used to quantify malondialdehyde,superoxide dismutase,glutathione,glutathione peroxidase,catalase,tumor necrosis factor-α,nuclear factor-κB,interleukin(IL)-33,IL-6,IL-1β,cyclooxygenase-2,kidney injury molecule-1,mitogen-activated protein kinase-1,and caspase-3 in kidney *** tissues were also evaluated by histopathological and immunohistochemical examinations for 8-OHdG and ***:Naringin attenuated acrylamide-induced nephrotoxicity by significantly decreasing serum urea and creatinine *** increased superoxide dismutase,glutathione,glutathione peroxidase,and catalase activities and decreased malondialdehyde levels in kidney *** addition,naringin reduced the levels of inflammatory and apoptotic parameters in kidney *** histopathological assay showed that acrylamide caused histopathological changes and DNA damage,which were ameliorated by ***:Naringin attenuated inflammation,apoptosis,oxidative stress,and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats.

关键词： Acrylamide Nephrotoxicity Apoptosis Inflammation Naringin Oxidative stress Oxidative DNA damage

Design and fabrication of a vigorous“cavitation-on-a-chip”device with a multiple microchannel configuration

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Microsystems & Nanoengineering 2021年第3期7卷 149-161页

作者： Farzad Rokhsar Talabazar Mohammad Jafarpour merve Zuvin Hongjian Chen Moein Talebian Gevari Luis Guillermo Villanueva Dmitry Grishenkov ali Koşar Morteza Ghorbani Faculty of Engineering and Natural Science Sabanci UniversityTuzlaIstanbulTurkey Sabanci University Nanotechnology Research and Application Center TuzlaIstanbulTurkey Advanced NEMS Laboratory École Polytechnique Fédérale de Lausanne(EPFL)CH-1015LausanneSwitzerland Department of Biomedical Engineering and Health Systems KTH Royal Institute of TechnologySE-14157StockholmSweden Division of Solid State Electronics Department of Electrical EngineeringTheÅngström LaboratoryUppsala UniversityUppsalaSweden Center of Excellence for Functional Surfaces and Interfaces for Nano-Diagnostics(EFSUN) Sabanci UniversityOrhanliTuzlaIstanbulTurkey

Hydrodynamic cavitation is one of the major phase change phenomena and occurs with a sudden decrease in the local static pressure within a *** the emergence of microelectromechanical systems(MEMS),high-speed microfluidic devices have attracted considerable attention and been implemented in many fields,including cavitation *** this study,a new generation of‘cavitation-on-a-chip’devices with eight parallel structured microchannels is *** new device is designed with the motivation of decreasing the upstream pressure(input energy)required for facile hydrodynamic cavitation *** and a poly(vinyl alcohol)(PVA)microbubble(MB)suspension are used as the working *** results show that the cavitation inception upstream pressure can be reduced with the proposed device in comparison with previous studies with a single flow restrictive ***,using PVA MBs further results in a reduction in the upstream pressure required for cavitation *** this new device,different cavitating flow patterns with various intensities can be observed at a constant cavitation number and fixed upstream pressure within the same ***,cavitating flows intensify faster in the proposed device for both water and the water–PVA MB suspension in comparison to previous *** to these features,this next-generation‘cavitation-on-a-chip’device has a high potential for implementation in applications involving microfluidic/organ-on-a-chip devices,such as integrated drug release and tissue engineering.

关键词： cavitation bubble faster

Clinical characteristics and outcomes of nosocomial COVID-19 in Turkey:A retrospective multicenter study

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Asian Pacific Journal of Tropical Medicine 2023年第8期16卷 347-353页

作者： Süleyman Yıldırım Celalettin Yılmaz Gülru Polat Serap Argun Baris İlknur Başyiğit İlknur Kaya Ceyda Anar Mihriban Bozkurt HüsnüBaykal Hulya Dirol Gamzenur Ozbey Emine Ozsari Emel Cireli ali KadriÇırak Dursun Tatar Mine Gayaf Selen Karaoglanoglu Yener Aydin Atilla Eroglu Yıldız Olçar Berna Botan Yıldırım Bengül Gürsoy Deniz Demir Yılmaz Elif Yelda Ozgun Niksarlioglu Ramazan Eren Ayşegül Tomruk Erdem Müge Meltem Tor Fusun Fakili MustafaÇolak merve Erçelik ali Tabaru Özlem Ediboglu Intensive Care Unit Dr.Suat Seren Chest Disease and Surgery Training and Research HospitalUniversity of Health Sciences TurkeyİzmirTurkey Department of Pulmonology Dr.Suat Seren Chest Disease and Surgery Training and Research HospitalUniversity of Health Sciences TurkeyİzmirTurkey Department of Pulmonary Medicine School of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonology Kütahya Health Sciences UniversityKütahyaTurkey Department of Pulmonology Atatürk Training and Research Hospitalİzmir KatipÇelebi UniversityİzmirTurkey Department of Pulmonology Ankara Atatürk Sanatory Training and Research HospitalUniversity of Health SciencesAnkaraTurkey Department of Pulmonology Faculty of MedicineAkdeniz UniversityAntalyaTurkey Department of Pulmonology Bolu Abantİzzet Baysal University Training and Research HospitalBoluTurkey Department of Pulmonology Ordu University Training and Research HospitalOrduTurkey Department of Thoracic Surgery Medical FacultyErzurumAtaturk UniversityTurkey Department of Infectious Disease and Clinical Microbiology Kastamonu Training and Research HospitalKastamonuTurkey Department of Pulmonology Başkent University Hospital KonyaKonyaTurkey Department of Pulmonology İstanbul SancaktepeŞehit Prof.Dr.İlhan Varank Training and Research HospitalİstanbulTurkey Department of Chest Diseases Yedikule Chest Diseases and Thoracic Surgery Training and Research HospitalHealth Science UniversityİstanbulTurkey Department of Pulmonology Faculty of MedicineZonguldak Bülent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine GaziantepFaculty of MedicineŞahinbey Research HospitalGaziantep UniversityTurkey Department of Pulmonology BalıkesirHealth Practice and Research HospitalBalıkesir UniversityTurkey Department of Pulmonology Afyonkarahisar Dinar State HospitalAfyonTurkey Department of Pulmonology Söke Fehime Faik Kocagöz State HospitalAydınTurkey

Objective:To identify the clinical characteristics and outcomes of hospital-acquired SARS-CoV-2 infection during the vaccination period nationwide in ***:COVID-19 patients followed in the pandemic services across Turkey between January 1,2021,and March 31,2022 were investigated *** COVID-19 was defined as a patient neither diagnosed with COVID-19 nor suspected COVID-19 at the hospital admission and was confirmed COVID-19≥5 days after hospital *** primary outcome of this study was in-hospital mortality;demographic features and vaccination status was compared between survivors and ***:During the study period,15573 COVID-19 patients were followed in 18 centers and 543(3.5%)patients were nosocomial *** patients with nosocomial COVID-19(80.4%)were transferred from medical wards.162(29.8%)of the patients with nosocomial COVID-19 admitted to the intensive care unit due to disease severity and 138(25.4%)of the patients died during hospital *** age(≥65 years)and number of comorbid diseases(≥2)was found to be associated with mortality in nosocomial COVID-19(OR 1.74,95%CI 1.11-2.74 and OR 1.60,95%CI 1.02-2.56,respectively).Vaccination was associated with survival in nosocomial COVID-19(OR 0.25,95%CI 0.16-0.38).Conclusions:Patients with nosocomial COVID-19 had increased admission to intensive care units and higher mortality *** can decrease the in-hospital mortality rate.

关键词： COVID-19 Nosocomial infection Vaccination Intensive care unit

Post-discharge mortality in the first wave of COVID-19 in Turkey

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 479-484页

作者： Fusun Fakili Pelin Duru Cetinkaya Oya Baydar Serap Argun Baris Nurdan Kokturk Seval Kul Oguz Karcioglu Pinar Aysert Yildiz Ilim Irmak Yonca Sekibag Emel Azak Sait Mulamahmutoglu Caglar Cuhadaroglu Bugra Kerget Burcu Baran Ketencioglu Hasan Selcuk Ozger Gulcihan Ozkan Zeynep Ture merve Ercelik Tansu Ulukavak Ciftci Ozlem alici Esra Nurlu Temel Ozlem Ataoglu Neslihan Kose Muge Meltem Tor Gulsah Gunluoglu Sedat Altin Onder Ozturk Pinar Yildiz Gulhan Ilknur Basyigit Hasim Boyaci I Kivilcim Oguzulgen Sermin Borekci Bilun Gemicioglu Ismail Hanta Hacer Kuzu Okur Gulseren Sagcan Metin Akgun ali Fuat Kalyoncu Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalFaculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Halil Sivgin Cubuk State HospitalAnkaraTurkey Department of Infectious Disease Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Pulmonary Medicine Cerrahpasa Faculty of MedicineIstanbul University−CerrahpasaIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineAtaturk UniversityErzurumTurkey Department of Pulmonary Medicine Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Maslak Acibadem HospitalIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Infectious Disease Faculty of MedicineTurkiye Gazetesi Private HospitalIstanbulTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine Universi

Objective:To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society(TTD)-TURCOVID ***:In this retrospective cohort study,we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study,and 1112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the *** causes of death after COVID-19 discharge were ***:The mean age of the patients was(51.07±16.93)years,with 57.6%male *** the cohort group,89.1%of COVID-19 treatment locations were hospital wards,3.6%were intensive care units(ICUs),and 7.2%were community *** the longterm follow-up,the in-hospital mortality rate was 3.6%(95%CI 2.6-4.8),the post-discharge mortality rate was 2.8%(95%CI 1.9-3.9),and the total mortality was 6.3%(95%CI 5.0-7.8).After discharge,63.3%of mortality overall occurred during the first six *** rates in post-discharge follow-ups were 12.7%(95%CI 8.0-30.6)in cancer patients,10.8%(95%CI 6.3-22.9)in chronic obstructive pulmonary disease patients,11.1%(95%CI 4.4-22.7)in heart failure patients,7.8(95%CI 3.8-14.3)in atherosclerotic heart disease patients,and 2.3%(95%CI 0.8-5.6)in diabetes mellitus *** smokers/ex-smokers,the all-mortality rates were higher than in ***:This multicenter study showed that patients over 65 years of age,males,former/active smoker,ICU stay,lung,heart disease,and malignancy should be followed up for at least the first six months after discharge due to COVID-19.

关键词： COVID-19 Post-discharge Mortality Comorbidity