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Association between Polymorphisms of SNPs Located at the 3’-Untranslated Region of SET8 and Codon 72 of the TP53 with Breast Cancer among Cameroonian Women

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Journal of Biosciences and Medicines 2020年第11期8卷 23-45页

作者： Arnol Auvaker Zébazé Tiofack Elvis A. Ofon Esther Dina Bell Chancelin M. Kamla Roger Tchamfong Smiths Lueong Gustave simo Molecular Parasitology & Entomology Unit Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Medical Oncology Direction of the Bonassama District Hospital Douala Cameroon Faculty of Medicine and Pharmaceutical Science University of Douala Douala Cameroon St. Joseph Clinic Cancer Center Yaounde Cameroon German Cancer Research Center Essen Germany

In sub-Saharan Africa, breast cancer (BC) constitutes a serious public health problem and the genetic basis of its development is remaining poorly understood. Although the SNPs at codon 72 of TP53 (rs1042522) and at the UTR of SET8 (rs16917496) have both been associated with BC development among Asian and European women, no published data has been reported within African population. We herein report on the impact of these polymorphisms on the risk of BC among Cameroonian women. Blood samples were collected from 111 breast cancer patients and 224 controls. DNA was extracted from each sample and PCR-RFLP was used to investigate the polymorphisms at SNPs rs1042522 of TP53 and rs16917496 of SET8. Association studies were performed according to ethno-linguistic groups and menopausal status. The minor allele “T” of SET8 gene revealed a protective effect in premenopausal women (OR, 0.327;95% CI 0.125 - 0.852) while the CT genotype of SET8 was associated with increased risk of BC (OR, 2.93;95% CI, 1.1 - 7.8). The minor “G” allele of TP53 gene was significantly associated (OR, 2.533;95% CI, 1.455 - 4.408) with increased disease risk in premenopausal women while the CG genotype was significantly associated (OR, 0.39;95% CI, 0.23 - 0.69) with decreased risk of BC. A synergistic genetic interaction at both loci for CC genotype of SET8 and CG genotype of TP53 was associated (OR, 0.46;95% CI, 0.24 - 0.91) with reduced disease risk. No significant association between polymorphisms at the SET8 and TP53 loci and clinical pathologic features of BC was observed. This study suggests significant associations between the SNPs located at the 3’-UTR of SET8 and codon 72 of the TP53 with the risk of breast cancer development among premenopausal women. There is an interaction between TP53 and SET8 genes.

关键词： SNPs TP53 SET8 Breast Cancer Women Cameroon

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Seroprevalence of <i>Brucella</i>Antibodies and Risk Factors Associated with Human Brucellosis in High-Risk Occupational Groups of the Noun Division in the West Region of Cameroon

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Journal of Biosciences and Medicines 2021年第3期9卷 105-123页

作者： Rolin Mitterran Ndefo Kamga Barberine Silatsa Assongo Eugenie Melaine Kemta Magang Amadou Fouapon Moussa Salihou Jules-Roger Kuiate Gustave simo Molecular Parasitology & Entomology Unit Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Divisional Delegation of Livestock Fisheries and Animal Industries Noun Cameroon Laboratory of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Sciences University of Dschang Dschang Cameroon

Brucellosis is an anthropozoonotic disease with an important public health impact. Although the transmission of Brucella from animals to humans can occur in different epidemiological settings of sub-Saharan African countries, little data has been published on human brucellosis. This study aimed to detect Brucella antibodies and the risk factors associated to brucellosis among high-risk occupational groups of people in the Noun Division of Cameroon. For this study, a structured questionnaire was used to assess risk factors associated with human brucellosis. Thereafter, blood samples were collected from high-risk occupational groups of people in four villages. Plasma was extracted from each sample and Brucella antibodies were detected using Rose Bengal Plate Test (RBPT) and indirect Enzyme-Linked Immunosorbent Assay (i-ELISA). Of the 273 participants enrolled, the overall seroprevalence of Brucella antibodies was 12.45% with RBPT and 10.26% with i-ELISA test. This seroprevalence was significantly (P = 0.04;X2 = 9.73) higher among livestock herdsmen (15.8%), slaughterhouse workers (9.8%), butchers (4.8%), participants having no educational level (14.3%) and those experiencing above 5 years of risky activity (15%). Raw milk consumption (OR: 4.8;P = 0.001), no formal education (OR: 6.4;P = 0.03) and assistance of animal during parturition (OR: 7.2;P Brucella infections. The detection of Brucella antibodies indicates the risk of human brucellosis in some groups of people of the Noun division. Consuming unpasteurized milk, participating in parturition and lacking knowledge on brucellosis appeared as risk factors associated with human brucellosis in western Cameroon. It raises the need of developing and implementing control measures for human and animal brucellosis.

关键词： Brucellosis Risk Factors High-Risk Occupational Groups Cameroon

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An In-Depth Analysis of the Causes of Road Accidents in Developing Countries: Case Study of Douala-Dschang Highway in Cameroon

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Journal of Transportation Technologies 2021年第3期11卷 455-470页

作者： simon Armand Zogo Tsala merlin Zacharie Ayissi Gerald Azeh Pierre Anicet Noah Fabien Betene Ebanda Louis Max Ayina Ohandja Department of Civil Engineering Advanced Teachers Technical Training College of Ebolowa University of Yaoundé I Yaoundé Cameroon Laboratory of Mechanics University of Douala Douala Cameroon Ministry of Transport Kupe Muanenguba Divisional Delegation Bangem Cameroon National Advanced School of Engineering Yaoundé University of Yaoundé I Yaoundé Cameroon

This paper is aimed at identifying the risk factors that mainly contribute to reckless driving and other related causes of road accidents along the Douala-Dschang highway of Cameroon. The research work started with the collection of accident reports for 2018 and 2019 from security officials in charge of road safety and the police stations of the different localities included in the sample of the study. Three hundred and eighty-two (382) road accidents reports were collected and analyzed using the 2020 version logit regression model of XLSTAT. From these analyses, it appears that, of the 382 accidents recorded during this period, six factors were identified and classified as follows: causes of accidents related to speed and carelessness, location of the accident, type of vehicle at fault, day the accident occurred, time of the accident and the age of drivers involved. These results could contribute to reduce the gravity of accidents along the Douala-Dschang highway and develop other policies in the program for road safety. In addition, this study can as much as possible equally contribute to reorienting road construction trends and development techniques in our environment.

关键词： Road Safety Traffic Road Accidents Douala-Dschang Highway Logistic Regression Model

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用于核试验监测的大气法

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地震科技情报 1996年第4期 22-23页

作者： simo.,DJ 赵宇彤

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电梯导向系统的摩擦及其能耗测量

电梯导向系统的摩擦及其能耗测量

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第十三届全国实验力学学术会议

作者：钱磊史熙 simo Makimattila 上海交通大学机械与动力工程学院

随着电梯保有量的增多,电梯作为重要的建筑能耗损耗源之一,其能效越来越引起人们的关注。而由于偏载引起的电梯导向系统的摩擦能耗又是电梯机械能耗中的重要部分。因此,对实际电梯导向系统的摩擦及其能耗进行实验测量对于分析电梯的能...

随着电梯保有量的增多,电梯作为重要的建筑能耗损耗源之一,其能效越来越引起人们的关注。而由于偏载引起的电梯导向系统的摩擦能耗又是电梯机械能耗中的重要部分。因此,对实际电梯导向系统的摩擦及其能耗进行实验测量对于分析电梯的能耗构成及改进能效具有积极的意义。本文针对实际的曳引式电梯系统,提出一种电梯导向系统摩擦及能耗测量的间接测量方法,并对实际电梯系统的摩擦及能耗进行了测量和分析,实验数据证实了测量方法的可行性。实验结果表明电梯在起停以及上行和下行过程中的摩擦能耗存在较大差异。

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Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance:Results of a Pilot Study

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Infectious Microbes & Diseases 2022年第1期4卷 26-33页

作者： merlin Moni Thushara Madathil Dipu T.Sathyapalan Veena Menon Georg Gutjahr Fabia Edathadathil Deepthi Sureshkumar Preetha Prasanna Soumya Jose Roshni Jerome Ajai Krishnan Indulekha C.L.Pillai Geetha Kumar Bipin Nair Victor Nizet Aveek Jayant Department of Medicine Division of Infectious DiseasesAmrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia Department of Cardiac Anaesthesiology Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia Clinical Virology Laboratory Amrita Institute of Medical SciencesAmrita Vishwa VidyapeethamKochiKeralaIndia Center for Research in Analytics and Technologies for Education(CREATE) Amrita Vishwa VidyapeethamAmritapuriKollamKeralaIndia Department of Infection Control and Epidemiology Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia School of Medicine Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia School of Biotechnology Amrita Vishwa VidyapeethamAmritapuriKollamKeralaIndia Skaggs School of Pharmacy and Pharmaceutical Sciences University of CaliforniaSan DiegoLa JollaCaliforniaUSA Department of Pediatrics University of CaliforniaSan DiegoLa JollaCaliforniaUSA

Hypoxic patients with coronavirus disease 2019(COVID-19)are at high risk of adverse *** nitric oxide(iNO)has shown anti-viral and immunomodulatory effects in ***,in vivo evidence of efficacy in hypoxic COVID-19 is *** open label feasibility study was conducted at a single referral center in South India and evaluated the effectiveness of repurposed iNO in improving clinical outcomes in COVID-19 and its correlation with viral *** recruited hypoxemic COVID-19 patients and allocated them into treatment(iNO)and control groups(1:1).Viral clearance on day 5 favored the treatment group(100%vs 72%,P<0.01).The speed of viral clearance as adjudged by normalized longitudinal cycle threshold(Ct)values was positively impacted in the treatment *** proportion of patients who attained clinical improvement,defined as a≥2-point change on the World Health Organization ordinal scale,was higher in the iNO cohort(n=11,79%)as compared to the control group(n=4,36%)(odds ratio 6.42,95%confidence interval 1.09–37.73,P=0.032).The proportion of patients progressing to mechanical ventilation in the control group(4/11)was significantly higher than in the treatment group(0/14).The all-cause 28-day mortality was significantly different among the study arms,with 36%(4/11)of the patients dying in the control group while none died in the treatment *** numbers needed to treat to prevent an additional poor outcome of death was estimated to be *** study demonstrates the putative role of repurposed iNO in hypoxemic COVID-19 patients and calls for extended validation.

关键词： nitric oxide COVID-19 antiviral activity WHO ordinal scale

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Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity

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Cancer Drug Resistance 2023年第4期6卷 709-728页

作者： Hannah Zaryouh Ines De Pauw Hasan Baysal Joran Melis Valentin Van den Bossche Christophe Hermans Ho Wa Lau Hide Lambrechts Celine merlin Cyril Corbet Marc Peeters Jan Baptist Vermorken Jorrit De Waele Filip Lardon An Wouters Center for Oncological Research(CORE) Integrated Personalized&Precision Oncology Network(IPPON)University of AntwerpCampus Drie EikenAntwerp 2610Belgium Pole of Pharmacology and Therapeutics(FATH) Institut de Recherche Experimentale et Clinique(IREC)UCLouvainBrussels B-1200Belgium institut Roi Albert Il Department of Medical OncologyCliniques Universitaires Saint-LucBrussels B-1200Belgium Department of Medical Oncology Antwerp University HospitalEdegem 2650Belgium

Aim:Acquired resistance to the targeted agent cetuximab poses a significant challenge in finding effective anti-cancer treatments for head and neck squamous cell carcinoma(HNSCC).To accurately study novel combination treatments,suitable preclinical mouse models for cetuximab resistance are key yet currently *** study aimed to optimize an acquired cetuximab-resistant mouse model,with preservation of the innate immunity,ensuring intact antibody-dependent cellular cytotoxicity(ADCC)***:Cetuximab-sensitive and acquired-resistant HNSCC cell lines,generated in vitro,were subcutaneously engrafted in Rag2 knock-out(KO),BALB/c Nude and CB17 Scid mice with/without Matrigel or *** tumor growth was established,mice were intraperitoneally injected twice a week with cetuximab for a maximum of 3 *** addition,immunohistochemistry was used to evaluate the tumor and its ***:Despite several adjustments in cell number,cell lines and the addition of Matrigel,Rag2 KO and BALB/C Nude mice proved to be unsuitable for xenografting our HNSCC cell *** tumor growth of resistant SC263-R cells could be induced in CB17 Scid ***,these cells had lost their resistance phenotype in *** revealed a high infiltration of macrophages in cetuximab-treated SC263-R ***-S and FaDu-R cells successfully engrafted into CB17 Scid mice and maintained their sensitivity/resistance to ***:We have established in vivo HNSCC mouse models with intact ADCC functionality for cetuximab resistance and sensitivity using the FaDu-R and FaDu-S cell lines,*** models serve as valuable tools for investigating cetuximab resistance mechanisms and exploring novel drug combination strategies.

关键词： HNSCC cetuximab resistance xenograft mouse model immunodeficient mice

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Elaboration and Characterization of a Plaster Reinforced with Fibers from the Stem of Cola lepidota for Industrial Applications

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World Journal of Engineering and Technology 2022年第4期10卷 824-842页

作者： Zogo Tsala simon Armand Noah Pierre Marcel Anicet Ayissi Zacharie merlin Betene Ebanda Fabien Nkenne Youmba Judide Kenmogne Fabien Atangana Ateba Department of Civil Engineering ENSET University of Ebolowa Ebolowa Cameroon Department of Mechanical Engineering ENSET University of Douala Douala Cameroon Laboratory of Mechanics University of Douala Cameroon Douala Cameroon Laboratory of Energy Materials Modelisation and Method University of Douala Douala Cameroon Department of Civil Engineering ENSET University of Douala Douala Cameroon

Current environmental and eco-design issues require the use of environmentally friendly materials. These make up a large share of the building materials market. Natural fibers are already used in various types of materials, such as plastics, concrete and lime-based products. They exhibit different attributes like the right combination of mechanical, thermal and acoustic properties, allowing these types of materials to be used for different applications. The main disadvantage associated with plaster is its fragility, especially under mechanical stress. Therefore, it becomes interesting to study different methods that could improve the mechanical properties of plaster. The addition of fibers to the plaster to obtain a composite material is already recognized as a means of improving the behavior of the product, in particular after the rupture of the matrix. The aim of this work was to study the effects of the addition of natural fibers from the stem of Cola lepidota (CL), on the physical properties and the mechanical behavior of the composite matrix. This study highlights the effects of fiber size and volume fraction. It has been shown that the mass of composites decreases as the percentage and length of fibers increases. The mechanical properties of composite materials are also discussed. Even at low addition rates, CL stem fibers achieved slightly higher values of flexural properties.

关键词： Cola lepidota Vegetable Fiber Plaster Composite Retting Characterization

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Caesarean Section in African Setting: Current Situation, Problematic and Qualitative Approaches at Laquintinie Hospital (Douala, Cameroon)

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Open Journal of Obstetrics and Gynecology 2019年第10期9卷 1392-1406页

作者： Essome Henri Mve Koh Valere Engbang Jean Paul Boten merlin Essiben Felix Tocki Toutou Grace Foumane Pascal Mboudou Emile Telesphore Laquintinie Hospital of Douala Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon University Teaching Hospital Yaoundé Yaoundé Cameroon Faculty of Medicine and Biological Sciences of Yaoundé University of Yaoundé 1 Yaoundé Cameroon Gynaeco-Obstetrics and Paediatric Hospital of Yaoundé Yaoundé Cameroon Gynaeco-Obstetric and Paediatric Hospital of Douala Douala Cameroon Central Hospital of Yaoundé Yaoundé Cameroon.

Background: Quality control of care aims to reduce or eliminate unnecessary care and to improve the quality of those who are useful both in their indication and in their implementation. Objective: We conducted this study to assess the rate of caesarean section, the rate of irrelevant indications, materno-foetal morbidity and mortality, biases in the management in order to suggest corrective approaches. Methods: It was a cross-sectional study conducted in the gynaeco-obstetrics department of the Laquintinie Hospital of Douala over a period of 4 months from January 1 to April 30, 2017. We included all pregnant women who had a caesarean section and who gave consent to our study as well as new-borns from these caesareans. We excluded caesarean deliveries from other health structures and referred to Laquintinie Hospital due to morbid operative follow-up. The variables collected were grouped under 3 main headings: socio-demographic data, clinical data and post-operative follow-up. Results: A total of 281 caesarean sections were performed out of a total of 967 deliveries;a caesarean section rate of 29.06% in 4 months. After data mining, 250 caesarean sections were included in the study because 31 cases of caesarean deliveries were unusable. Referred pregnancies accounted for 46.8% of the total population and the most common reason for referral was stationary labour (23% of cases). All caesareans were performed by the gynaeco-obstetricians. Women who had caesarean deliveries were informed by the operator of the surgical procedure in 28.4% of cases and 27.6% were notified of the indication for surgery. The operative kit was present in 98% of cases. The operating room was available in 93% of cases. Caesareans were performed mostly in an emergency context (91.2%) with a median turnaround time of 214 minutes (3 h 56 mins). Mechanical dystocia was the major indication in our series (21.2%) and 29 indications were irrelevant (11.6%). Intraoperative complications occurred in 3.2%

关键词： Caesarean Section Practical Laquintinie Cameroon

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计及相关性的电-气-热综合能源系统概率最优能量流

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电工技术学报 2019年第5期34卷 1055-1067页

作者：韩佶苗世洪李超段偲默李姚旺华中科技大学电气与电子工程学院强电磁工程与新技术国家重点实验室武汉430074 华中科技大学电气与电子工程学院电力安全与高效湖北省重点实验室武汉430074

由电力系统、天然气系统和热力系统耦合构成的综合能源系统(IES)是"能源互联网"的重要组成部分,是构建更加经济、环保、高效能源系统的必经之路。该文提出了一种计及相关性的电-气-热IES概率最优能量流计算方法。首先,以IES运行成本为... 详细信息

由电力系统、天然气系统和热力系统耦合构成的综合能源系统(IES)是"能源互联网"的重要组成部分,是构建更加经济、环保、高效能源系统的必经之路。该文提出了一种计及相关性的电-气-热IES概率最优能量流计算方法。首先,以IES运行成本为优化目标,综合考虑电力系统、天然气系统、热力系统的运行约束及能量耦合约束,建立了IES最优能量流模型;针对IES中风电接入背景下的不确定性因素,并考虑其相关性,建立IES概率最优能量流模型,并采用基于Nataf变换的三点估计法对该模型进行求解。对由修改的IEEE 24节点电力系统、比利时20节点天然气系统和巴里岛32节点热力系统构成的IES进行仿真分析,仿真结果验证了该文所建立模型的可行性与有效性。

关键词：概率最优能量流综合能源系统相关性能量耦合

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