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Lycopene Supplem.ntation Attenuates Oxidative Stress Param.ters in the Plasm. of Hum.ns with Cad after Intense Exercise

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Food and Nutrition Sciences 2011年第4期2卷 241-248页

作者： m.rília C. Araujo Fernanda S. Soares merieli m. ronsani Luiz G. C. Rocha Lilian C. Vieira Luciano A. Silva Tales de Carvalho m.gnus Benetti Ricardo A. Pinho 不详

To investigate the effects of m.derate and intense exercise (m.,IE) and lycopene (L) supplem.ntation on oxidative stress biom.rkers in patients with CAD. Rehabilitation ***-two m.le volunteers with CAD (55.65 ? 2.27 years, 77.27 ? 3.95 kg, 171.9 ? 2.80 cm. were divided into four groups;m.-Placebo (n = 7), m. + L (n = 8), IE-Placebo (n = 8) and IE-L (n = 9). Blood sam.les (12 m.) were collected before supplem.ntation (one cereal bars – 15 m. of syn-thetic lycopene) and exercise (45 m.n plus 15 m.n of stretching, 3/wk) and after five weeks of supplem.ntation and 72 h after exercise. Nitrite/nitrate concentrations (NOx), lipoperoxidation (TBARS levels), protein carbonylation (PC) and superoxide dism.tase (SOD) and catalase (CAT) activity were assessed in plasm.. NOx decreased significantly in the m.-P, IE-P and m.-L groups at 72 h after exercise and increased in the IE-L 72 h after the last exercise session. The IE-L group dem.nstrated decreased TBARS at 72 h after the last exercise session. The level of PC increased only in EI-P at 72 h after the last exercise session, while only the EI-L group presented a reduction. SOD increased signifi-cantly in both placebo groups 72 h after the last exercise session and decreased in the m.-L group 72 h after in rela-tion to placebo groups. CAT increased in m.-P, IE-P and IE-L groups only at 72 h after the last exercise session. The lycopene supplem.ntation attenuates som. m.rkers of oxidative stress associated with IE Lycopene also had dissim.lar effects on som. m.rkers of oxidative stress in subjects undertaking m. versus IE.

关键词： Lycopene Coronary Artery Disease Oxidative Stress Nitric Oxide Intense Exercise

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