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烟曲霉外排泵唑类耐药研究进展

医学分子生物学杂志 2025年第1期22卷 97-100页

作者：王娟马彦山西医科大学第二医院皮肤性病科太原市030001

烟曲霉是一种广泛存在于自然界的机会性病原体,可引起侵袭性曲霉病,在免疫功能低下的患者中死亡率很高。三唑类药物是侵袭性曲霉病的一线治疗药物,然而近年来全球范围内烟曲霉唑类耐药分离株不断增多,极大地威胁到患者的生命健康。外排... 详细信息

烟曲霉是一种广泛存在于自然界的机会性病原体,可引起侵袭性曲霉病,在免疫功能低下的患者中死亡率很高。三唑类药物是侵袭性曲霉病的一线治疗药物,然而近年来全球范围内烟曲霉唑类耐药分离株不断增多,极大地威胁到患者的生命健康。外排泵由跨膜蛋白质组成,可以将不需要的物质排出细胞,对微生物的存活有着重要的保护作用,与此同时,研究表明它还介导了微生物的耐药。文章综述了近年来关于烟曲霉药物外排泵的功能及调控机制的研究进展,为深入理解烟曲霉耐药机制及筛选抗烟曲霉感染药物新靶点提供理论基础。

关键词：烟曲霉耐药外排泵

Wilson's Disease in China

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neuroscience Bulletin 2017年第3期33卷 323-330页

作者： juan-juan Xie Zhi-Ying Wu Department of neurology and Research Center of neurologyin the Second Affiliated Hospital and the Collaborative Innovation Center for Brain ScienceZhejiang University School of MedicineHangzhou 310009China

Wilson＇s disease（WD） is an autosomal recessive disorder of copper metabolism. Its incidence is higher in China than in western countries. ATP7 B is the causative gene and encodes a P-type ATPase, which participates in the synthesis of holoceruloplasmin and copper excretion. Disease-causing variants of ATP7 B disrupt the normal structure or function of the enzyme and cause copper deposition in multiple organs,leading to diverse clinical manifestations. Given the variety of presentations, misdiagnosis is not rare. Genetic diagnosis plays an important role and has gradually become a routine test in China. The first Chinese spectrum of disease-causing mutations of ATP7 B has been established. As a remediable hereditary disorder, most WD patients have a good prognosis with an early diagnosis and chelation treatment. However, clinical trials are relatively few in China, and most treatments are based on the experience of experts and evidences from other countries. It is necessary to study and develop appropriate regimens specific for Chinese WD patients.

关键词： Wilson’s Disease Copper Epidemiology Pathogenesis Management

Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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Ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri juan Gaitán Matías Mastrangelo Marcelo nosetto Pablo E.Villagra Ezequiel Balducci Martín Pinazo Roxana P.Eclesia Alejandra Von Wallis Sebastián Villarino Francisco Alaggia Marina González Polo Silvina Manrique Pablo A.Meglioli julián Rodríguez-Souilla Martín Mónaco Jimena E.Chaves Ariel Medina Ignacio Gasparri Eugenio Alvarez Arnesi María Paula Barral Axel von Müller norberto M.Pahr Josefina Uribe Echevarria Pedro Fernández Marina Morsucci Dardo López juan Manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La Manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco Laura Cavallero Gualberto Zalazar Guillermo Martínez Pastur Instituto nacional de Tecnología Agropecuaria (InTA) Universidad nacional de la Patagonia Austral (UnPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y Medioambiente (InIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en Energía no Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administración de Parques nacionales (APn) Parque Nacional Los Alerces Centro de Estudios Ambientales Integrados (CEAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（nDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United nations Framework Conven-tion on Climate Change（UnFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（REDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest Reference Emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google Earth Engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on Enhanced Vegetation Index（EVI） and land surface temperature（LST） images from Landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity native forest Climate change mitigation Modelling Resilience

Boundary Control of Coupled non-Constant Parameter Systems of Time Fractional PDEs with Different-Type Boundary Conditions

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Journal of Systems Science & Complexity 2023年第1期36卷 273-293页

作者： CHEn juan ZHUAnG Bo Aliyun School of Big Data Changzhou UniversityChangzhou 213164China School of Information Engineering Binzhou UniversityBinzhou 256600China

This paper addresses a boundary state feedback control problem for a coupled system of time fractional partial differential equations(PDEs)with non-constant(space-dependent)coefficients and different-type boundary conditions(BCs).The BCs could be heterogeneous-type or ***,this coupled system has different BCs at the uncontrolled side for heterogeneous-type and the same BCs at the uncontrolled side for *** main contribution is to extend PDE backstepping to the boundary control problem of time fractional PDEs with space-dependent parameters and different-type *** the backstepping transformation and the fractional Lyapunov method,the Mittag-Leffler stability of the closed-loop system is obtained.A numerical scheme is proposed to simulate the fractional case when kernel equations have not an explicit solution.

关键词： Boundary control coupled systems heterogeneous mittag-leffler stability time fractional PDEs with space-dependent coefficients

Deadly oasis:Recurrent annihilation of Cretaceous desert bryophyte colonies;the role of solar,climate and lithospheric forcing

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Geoscience Frontiers 2021年第1期12卷 1-12页

作者： juan Pedro Rodríguez-Lópeza Eduardo Barrón Daniel Peyrot Gary B.Hughes Department of Geology.Faculty of Science.United Arab Emirates University.50009.Al Ain Abu DhabiUnited Arab Emirates Instituto Geológico y Minero de Espana(IGME) Ríos Rosas 23E-28003MadridSpain School of Earth and Environment University of Western Australia.6101CrawleyWestern AustraliaAustralia Centre for Energy Geosciences University of Western Australia.6101CrawleyWestern AustraliaAustralia Physics Department University of CaliforniaSanta BarbaraCA93106USA

Many oases(wet interdunes)are sedimentary systems characterized by high-frequency water-level oscillations,marked changes in salinity and intense biological activity at their *** are considered to be one of the most challenging environments on Earth for ecosystem *** dynamic,depositional settings are usually unfavourable for fossilization and subsequent preservation of vegetal *** paper describes bryophyte(liverwort)assemblages occurring in three successive horizons interpreted to represent(i)recurrent early successional phases of biological soil crust colonization of wet interdune margins or(ii)exceptional preservation of floating or riparian liverworts in oasis pond waters associated with a progressive fall of the interdune water *** record of in situ colonization surfaces characterized by delicate(***-free)three-dimensional structures represents an exceptional type of preservation herein associated with a rapid variation in phreatic interdune water level and the subsequent establishment of anoxic and reducing *** occurrence of exceptionally preserved liverwort colonies coincides with the sedimentary record of,at least,three seismite levels in the *** gathered from the site suggests that the water table of the oasis was controlled by a combination of(i)a positive creation of accommodation space due to subsidence associated with movement on syn-sedimentary extensional faults,and(ii)the rise and fall of the oasis water table controlled by the oscillations of the groundwater system due to orbital changes which appear to drive the variability of the climate *** groundwater levels flooded the oasis soil crusts and lead to the exceptional recurrent preservation of liverwort colonies at the oasis ***,considering the hypothesis of floating or riparian liverworts in the oasis pond waters,the fall in the level of the oasis water table placed the floating liverworts in contact with the

关键词： Oasis Cretaceous Liverworts Colonies Extensional tectonics Solar cyclicity

Boron in Plants: Deficiency and Toxicity

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Journal of Integrative Plant Biology 2008年第10期50卷 1247-1255页

作者： juan J. Camacho-Cristóbal Jesús Rexach Agustín Gonzlez-Fontes Departamento de Fisiología Anatomía y Biología Celular Facultad de Ciencias Experimentales Universidad Pablo de OlavideE-41013 Sevilla Spain

Boron （B） is an essential nutrient for normal growth of higher plants, and B availability in soil and irrigation water is an important determinant of agricultural production. To date, a primordial function of B is undoubtedly its structural role in the ceil wall; however, there is increasing evidence for a possible role of B in other processes such as the maintenance of plasma membrane function and several metabolic pathways. In recent years, the knowledge of the molecular basis of B deficiency and toxicity responses in plants has advanced greatly. The aim of this review is to provide an update on recent findings related to these topics, which can contribute to a better understanding of the role of B in plants.

关键词： boron-binding molecules boron transporter cell wall-related genes gene expression nitrogen metabolism,

Use of recycled concrete aggregates in asphalt mixtures for pavements:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第5期9卷 725-741页

作者： juan Gabriel Bastidas-Martínez Fredy Alberto Reyes-Lizcano Hugo Alexander Rondón-Quintana Faculty of Engineering Universidad Piloto de ColombiaBogotáDC 110231Colombia Faculty of Engineering Pontificia Universidad JaverianaBogotáDC 110131Colombia Facultad del Medio Ambiente y Recursos naturales Universidad Distrital Francisco Joséde CaldasBogotáDC 110131Colombia

Large quantities of natural aggregates(nA)are required in the manufacturing of asphalt mixtures for *** extraction of nA generates high environmental impacts that negatively affect environmental preservation and *** alternative materials obtained in construction and demolition processes in civil construction worked have been studies as possible replacements for nA,with the purpose of reducing these environmental *** foregoing study presents a state of knowledge review referring to the use of recycled concrete aggregates(RCA)when these are used in the manufacturing of asphalt mixtures(mainly hot-mix asphalt HMA type).Environmental aspects are presented,as well as possible benefits and limitations of using RCA as replacements for nA in asphalt ***,it is not possible to establish a behavior pattern,since the characteristics of the RCA are very heterogeneous and vary from the original source of the *** is highlighted from the literature that RCA has a wide potential for use in the manufacture of asphalt mixtures,since in most studies,the mixtures with these materials comply the quality requirements contemplated by the construction specifications,mainly in low-volume ***,based on the literature review,some recommendations and suggestions are presented for future research.

关键词： Recycled concrete aggregates Asphalt mixtures Mechanical properties Volumetric composition

The Asian Lineage of Zika Virus: Transmission and Evolution in Asia and the Americas

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Virologica Sinica 2019年第1期34卷 1-8页

作者： Tao Hu juan Li Michael J.Carr Sebastián Duchêne Weifeng Shi Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Taishan Medical College Global Station for Zoonosis Control Global Institution for Collaborative Research and Education (GI-CoRE)Hokkaido University national Virus Reference Laboratory School of MedicineUniversity College Dublin Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology InstituteUniversity of Melbourne

Since first isolation in 1947 from the Zika forest in Uganda, Zika virus(ZIKV) has been principally known as a benign agent associated with sporadic human infections in a restricted number of African countries. However, during 2015–2016,an Asian lineage of ZIKV caused an unprecedentedly large outbreak in the Americas and sizeable numbers of exported cases across the globe. In this review, we critically appraise the recent advances in molecular epidemiological studies of ZIKV performed to date, and we highlight the pivotal role played by genomic surveillance in elucidating the origins,dissemination and evolution of the Asian lineage of ZIKV in Asia and in the Americas.

关键词： Zika virus(ZIKV) Asian lineage Transmission Evolution Re

Effect of Organo-Modified nanosepiolite on Fire Behaviors and Mechanical Performance of Polypropylene Composites

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Chinese Journal of Chemistry 2015年第2期33卷 285-291页

作者： Junhao Zhang Sergio de juan Antonio Esteban-Cubillo julio Santarén De-Yi Wang Madrid Institute for Advanced Studies of Materials(IMDEA-Materials) C/Eric Kandel2Getafe(Madrid)28906Spain Tolsa S.A.R.&D.Department Carretera de Madrid a Rivas Jarama3528031 MadridSpain

The objective of the study was to investigate the effect of the organo-modified nanosepiolite(OnSep)on improving the fire safety of polypropylene(PP).The composites based on PP,flame retardant master batch(MB-FR,25 wt%PP+50 wt%decabromodiphenyl ether(DBDPE)+25%antimony trioxide(ATO))and OnSep were prepared via melt *** results of the limiting oxygen index(LOI)and vertical burning rating(UL-94)test indicated that PP/40 wt%MB composites had no rating with seriously dripping phenomenon,while the LOI value was only ***,as 4 wt%OnSep was added in PP/40 wt%MB composites,the composites achieved UL94 V-0 rating and the LOI value was *** comparison,PP/50 wt%MB composites could not reach the V-0 rating *** TGA results revealed that the addition of OnSep enhanced the thermal stability of the PP/MB-FR *** cone calorimeter results indicated that the heat release rate,average mass loss rate,smoke production rate and smoke temperature of the PP/40 wt%MB-FR/4 wt%OnSep composites decreased in comparison with those of PP/40 wt%MB-FR ***,the Young modulus and impact strength were also much better improved with the increase of OnSep ***,the synergistic flame retardancy of OnSep in PP/MB-FR matrix significantly containing a halogen based flame retardant(DBDPE)significantly improved the fire safety and mechanical properties of the composites,and allowed to decrease the total amount of brominated fire retardants.

关键词： nanosepiolite polypropylene flame retardancy heat release rate